Haley Fortin, BS, MB(ASCP)

Predoctoral Associate

Investigating the impact of regulatory variation on development through trans-regulation of 3D genome contacts.

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Location

Bar Harbor, ME

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Genetic variation between individuals in a population promotes distinct physical, behavioral, and molecular phenotypes. The molecular mechanisms by which genetic variation allows for differences in regulation of gene expression, remain poorly understood. Previous work from the Baker laboratory demonstrated genetic variation in mouse embryonic stem cells (mESCs), from C57BL/6J (B6) and DBA/2J (D2), impacts cell state transitions through chromatin regulation. Quantitative trait locus (QTL) mapping identified several trans-acting loci that co-regulate chromatin accessibility and gene expression. Currently, the role trans-regulation has on three-dimensional (3D) interactions as a mediator of this coordinated regulation is unknown. By leveraging the power of molecular techniques and genomics alongside genetically diverse biological samples, I am investigating how trans-regulation of chromatin impacts 3D interactions in development. Furthermore, I will expand on these observations to gain novel insight into understanding whether repressive factors, like KZFPs, can alter 3D genome contacts, how 3D interactions are regulated in trans, and the relationship between chromatin accessibility and 3D contacts.

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Haley Fortin on ORCID

Education and experience

Education

Tufts University and The Jackson Laboratory
PhD, Mammalian Genetics
Adv: Dr. Christopher Baker 2019-Present

Endicott College BS
Biology & Biotechnology
2010-2014

Experience

The Jackson Laboratory
Predoctoral Associate
Dr. Christopher Baker
2019-present

Veritas Genetics
Molecular Medical Technologist III
2014-2019