Phenotypes of LDLR & APOE Knockout Mice
When fed a western diet high in fat and cholesterol, mice with Apoe (B6.129P2-Apoetm1Unc/J, 002052) or Ldlr (B6.129S7-Ldlrtm1Her/J, 002207) mutations develop a spectrum of cardiovascular disease phenotypes that include:
- Severely elevated serum cholesterol and LDL in male and female Apoe and Ldlr knockout mice (Figure 1).
- Increased triglycerides and ApoB in male and female Ldlr knockout mice. ApoB levels were modestly elevated in male and female Apoe knockout mice (Figure 1).
- Male Apoe knockout mice have elevated triglycerides (Figure 1).
- Atherosclerosis in Apoe and Ldlr knockout males and females (Figure 2).
Many of these phenotypes also develop when mice are fed a chow diet, although to a lesser extent (Figure 1, 2). The Mouse Phenome Database contains longitudinal data from this study, including body weights and clinical chemistry after 4, 8, and 12 weeks on diet. Additionally, MPD includes cardiac pathology images and chemistries at older ages (Jaxpheno10 dataset).