LRRK2 N2081D SNV/SNV

Product Code: JIPSC1564

Background

Genetics

Gene

LRRK2

Condition

Parkinson disease, autosomal dominant

Allele Charactertistics

Autosomal Dominant

View Information in ClinVar

Derived from Cell Line

JIPSC1000_KOLF2.1J

Genomic Features

Genomic Coordinate (GRCh38)

chr12:40346884 (+)

dbSNP

rs33995883

Genomic Sequence

GGTAGAATAGTAGAGGGTTTGAAGTTTCCA[A/G]ATGAGTTTGATGAATTAGAAATACAAGGAA
View With Genome Browser

Gene Editing Reagents

Nuclease

SpCas9

Protospacer Sequence

TCTAATTCATCAAACTCATT

Donor Template

GTTTACTACTCTATGACATTTTGACAACTGGAGGTAGAATAGTAGAGGGTTTGAAGTTTCCAGATGAGTTTGATGAATTAGAAATACAAGGAAAATTACC

DNA Primers for Sequence Validation

PCR Forward

CAGGTTAAAGTGAGTTGGAGTGAAG

PCR Reverse

ATGTGGAGTTCTAACAGCAATTTCC

Sanger Sequencing Primer

GCCTCCTTGGATGTATGAGC

Quality Control Data

Certification of Quality Analysis

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Sequencing