Our CRISPR/Cas mouse model creation service offers an all-in-one customized package, rapidly delivering KO and KI models for your research.
A syngeneic mouse model, also known as an allograft mouse tumor system, provides an effective approach for studying how cancer therapies perform in the presence of a functional immune system.
Example Study: Anti-Mouse PD1/CTLA4 in CT26 engrafted Balb/cJ
Mice: Female BALB/cJ at ~6 weeks of age
Cells: CT26 cells subcutaneously injected at 2.5x106 cells per mouse
Dosing: Mice were grouped into four groups: IgG control (n=10), Anti PD-1 (n=9), Anti CTLA-4 (n=10), and Anti PD-1 +Anti CTLA-4 (n=10). Mice were IP dosed as follows:
Measurements: Body weight/clinical observations/tumor volume measurements 2X-3X per week
Duration: Mice were taken down when tumor volume reached 2000mm3 or when the tumor became ulcerated
Study Results: Anti-Mouse PD1/CTLA4 in CT26 Engrafted Balb/cJ – Tumor Volume