Frequently Asked Questions
In which mouse models were engraftment levels tested?
The currently available models are confirmed to engraft in the NSG™-SGM3 mice.
What engraftment levels do you typically see?
Greater than 5% AML in the peripheral blood of NSG™-SGM3 mice 10-16 weeks post engraftment.
How many AML engrafted mice can be included per order or on study with JAX?
A minimum of 15 mice is required. Approximately 100-500 mice in total can be engrafted depending on the model of interest.
What are passaged AML models?
Some AML tumor models in our portfolio were passaged in vivo. This approach allows JAX to continuously supply the models and retain inventory for use in further studies at later dates if needed.
How long does it take to confirm AML engraftment?
The average time to confirm AML engraftment in the peripheral blood of NSG™-SGM3 mice is 8 weeks post injection.
Elizabeth C. Townsend, et al. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in
Mice, Cancer Cell, Volume 29, Issue 4, 2016, Pages 574-586, ISSN 1535-6108
Wunderlich et al. 2010. Leukemia. 24(10):1785-8. [PMID: 20686503]