CD34+ Humanized NSG-SGM3-IL15 Mice

Appearance & Care

CD34+ hu-NSG-SGM3-IL15 Mouse - The Jackson Laboratory

While CD34+ hematopoietic stem cell humanized mice do have a human-like immune system on-board, it is not fully functional. These mice should still be handled very carefully and treated as an immuno-deficient strain. We are glad to offer the following resources to help you care for highly immuno-deficient strains like NSG™. Additionally, you should be sure to check with your institution regarding requirements for housing mice with engrafted human tissue.

Animal Health Reports

RB03 (Maximum)

Phenotype Information

CD34 Humanized S-15 mice demonstrate engraftment of CD45 cells as compared to parental strains following transplantation
CD34 Humanized S-15 mice demonstrate differentiation of mature natural killer cells as compared to parental strains following transplantation

Figure 1. CD34 Humanized S-15 mice demonstrate engraftment of CD45 cells (left) and differentiation of mature natural killer cells (right) as compared to parental strains following transplantation.

CD34 Humanized S-15 mice demonstrate presence of CD33+ myeloid progenitor cells at 8 weeks at similar levels as to CD34 humanized NSG-SGM3 parental strains
CD34 Humanized S-15 mice demonstrate presence of CD14+ monocytes at 8 weeks at similar levels as to CD34 humanized NSG-SGM3 parental strains

Figure 2. CD34 Humanized S-15 mice demonstrate presence of CD33+ myeloid progenitor cells (left) and CD14+ monocytes (right) at 8 weeks at similar levels as to CD34 humanized NSG-SGM3 parental strains.

CD34 Humanized S-15 mice demonstrate presence of CD4+ cells in a similar manner to their CD34 humanized SGM3 parental strain
CD34 Humanized S-15 mice demonstrate presence of CD8+ cells in a similar manner to their CD34 humanized SGM3 parental strain
CD34 Humanized S-15 mice demonstrate presence of T regulatory cells in a similar manner to their CD34 humanized SGM3 parental strain

Figure 3. CD34 Humanized S-15 mice demonstrate presence of CD4+, CD8+, and T regulatory cells in a similar manner to its CD34 humanized SGM3 parental strain.

CD34 Humanized S-15 mice demonstrate successful transplantation of patient-derived PS4050 melanoma
CD34 Humanized S-15 mice demonstrate successful transplantation of cell-line derived MDA-MB-231 breast cancer cells

Figure 4. CD34 Humanized S-15 mice demonstrate successful transplantation of patient-derived PS4050 melanoma (left) and cell-line derived MDA-MB-231 breast cancer cells (right).

References & Resources

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Licensing Information

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Email: techtran@jax.org

Ordering

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Complete our Humanized Mouse Order Form using the link above (reference stock number 703321)

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