The Jackson Laboratory

The Global Mouse Models for COVID-19 Consortium (GMMCC)

Mouse model resources and facilities to study SARS-CoV-2
Official website: www.mousecovid.org

COVID-19 is an infectious disease caused by a new coronavirus, SARS-CoV-2. As of August 1, 2020, the World Health Organization (WHO) reported infections in over 17.5 million people worldwide causing over 680,000 deaths. Developing and deploying preventative vaccines, reduced opportunistic infection strategies, and clinical therapeutics is benefiting from worldwide cooperation of the biomedical research and translational communities in both academia and industry.

The mouse is a valuable tool as an experimental model organism to improve our understanding of SARS-CoV-2 infection, colonization, pathogenesis, and host response mechanisms. The mouse can also be used to assess potential preventative, disease modifying, and therapeutic approaches. During the SARS outbreak in 2003 caused by the SARS-CoV-1 virus, the development of a strain of mice carrying a human ACE2 gene (the receptor for Coronavirus) which was susceptible to SARS-CoV-1 proved valuable in the study of SARS. This strain will also be vital for studies of SARS-CoV-2.

Research into coronaviruses has also identified several other genes that are either involved in infection, colonization, host response, and disease pathogenesis. Mouse strains carrying mutations in these genes will also be an important part of the toolkit for studying SARS-CoV-2 and potentially revealing new preventative, disease-modifying, or therapeutic approaches.

Using the mouse as a model system, employing its comparative genetics to humans and its facile genetic engineering, provides the research community with a model system that can provide valuable insights into SARS-CoV-2 and a platform for infection, colonization, and therapeutic studies.

Aims of The Global Mouse Models for COVID-19 Consortium

Mouse genetics, genomics, and functional assessment centres and repositories around the world have come together to form a consortium to underpin global research into SARS-CoV-2 by the efficient delivery of relevant mouse strains, mouse genetics expertise, and robust outcome and therapeutic effect and safety testing platforms.

  1. Provide up-to-date information and details of the availability and accessibility of mutant mouse strains relevant to SARS-CoV2;
  2. Provide information on current projects that are designing and generating new mutant mouse strains for infection, colonization, and disease-relevant host genes; and
  3. Provide information on facilities and expertise that are available to support and enhance COVID-19 research (e.g. biological containment mouse facilities) and validated SARS-CoV2 infectious challenge model systems and testing platforms.

The Global Mouse Models for COVID-19 Consortium – A Global Partnership of Mouse Genetics, Genomics, and Functional Assessment Centres

The GMMCC is comprised of 24 institutes and centres that represent a formidable collection of resources and expertise in mouse genetics, genomics, and response to pathogen research that are able to serve worldwide research into SARS-CoV2.

The GMMCC includes a number of well-established public mouse genetics consortia that provide design, production, and functional analysis of genetic mutation (IMPC, INFRAFRONTIER) and archiving and distribution of mutant mouse strains and resources  of mouse for biomedical research (AMMRA based in Asia, INFRAFRONTIER-EMMA based in Europe, the MMRRC in the US, and the CMMR in Canada; see Table 1).

The Global Mouse Models for COVID-19 Consortium – Mouse Resources for Coronavirus Research

Links to current mouse strains available from some of our members. These summaries are updated regularly.

Mouse Genome Informatics, US
Mouse Models for Coronavirus Research

Mutant Mouse Resource and Research Centers, US
MMRRC Mouse Models for COVID-19 Research

Institutes

Institute

Country

Contact person

Email

The Americas

The Jackson Laboratory

US

Ken Fasman

[email protected]

Baylor College of Medicine

US

Mary Dickinson

[email protected]

UC Davis

US

Kent Lloyd

[email protected]

The Centre for Phenogenomics (TCP)

Canada

Lauryl Nutter

[email protected]

Europe

Wellcome Trust Sanger Institute

UK

David Adams

[email protected]

Universitat Autònoma de Barcelona

Spain

Fatima Bosch

[email protected]

MRC Harwell

UK

Steve Brown, Annie Mallon, Sara Wells

[email protected]

European Bioinformatics Institute

UK

Paul Flicek, Helen Parkinson

[email protected][email protected]

Helmholtz-Zentrum Muenchen

Germany

Martin Hrabe de Angelis

[email protected]

CNR Monterotondo

Italy

Fabio Mammano

[email protected]

PHENOMIN, Strasbourg

France

Yann Herault

[email protected]

Czech centre for Phenogenomics, IMG

Czech Republic

Radislav Sedlacek, Jan Rozman

[email protected][email protected]

QMUL- Queen Mary University London

UK

Damian Smedley

[email protected]

Australia

Phenomics Australia

Australia

Michael Dobbie

[email protected]

Africa

PCDDP North-West University

South Africa

Anne Grobler

[email protected]

Asia

MARC Nanjing University

PRC

Xiang Gao

[email protected]

Indian Institutes of Science Education and Research, Pune

India

Sanjeev Galande

[email protected]

RIKEN BioResource Research Center

Japan

Toshihiko Shiroishi

[email protected]

Korea Mouse Phenotype Consortium

South Korea

Je Kyung Seong

[email protected]

National Laboratory Animal Center, National Applied Research Laboratories (NARLabs)

Taiwan

Genie Chin Hsian-Jean

[email protected]

CAM-SU Genomic Resource Center, Soochow University

PRC

Ying Xu

[email protected]

Organisations

Organisation

Country

Contact person

Email

Asian Mouse Mutagenesis Resource Association (AMMRA)

Asia & Australia

Leo Wang

[email protected]

Canadian Mouse Mutant Repository (CMMR)

Canada

Yulia Katsman

[email protected]

European Mouse Mutant Archive (EMMA)

Europe

Martin Hrabe de Angelis

[email protected]

The International Mouse Phenotyping Consortium (IMPC)

International

Steve Brown

[email protected]

INFRAFRONTIER

Europe

Martin Hrabe de Angelis

[email protected]

Mutant Mouse Resource and Research Center (MMRRC)

US

Christoph Lossin

[email protected]

National Institutes of Health (NIH)

US

Colin Fletcher

[email protected]

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