Mitfmi-vit homozygotes show a slow progressive loss of photoreceptor cells, cosegregating with the gradual depigmentation. The outer plexiform layer is significantly thinner by 4 months, and the rows of photoreceptor cells are lost at a rate of about one per month beginning at 2 months of age. Retinal detachment is observed in some vitiligo mice.
Gene | Mouse Chromosome | Human Chromosome | Retinal ONL disappear by | Strains |
|---|---|---|---|---|
Mitfmi-vit | 6 | 3p14 | 10 | C57BL/6J-Mitfmi-vit |