Motor neuron degeneration mnd

Motor neuron degeneration (mnd)

In homozygous mnd mice, the retinal degeneration occurs before neuromuscular dysfunction. The retinal degeneration was nearly complete by 6 months of age, but the motor neuron abnormalities began around 6 months of age. It is a good model for human Batten diseases, and its expression is clearly recessive.


Mouse Chromosome

Human Chromosome

Retinal ONL disappear by


mnd 8 8p or 13q 6 B6.KB2-mnd