KOMP Embryo Lethal Phenotyping
I am currently working in the Murry Lab with the KOMP Embyro Phenotyping Project. The Knockout Mouse Project (KOMP) is a trans-National Institutes of Health (NIH) initiative that aims to generate a comprehensive and public resource comprised of mice containing a null mutation in every gene in the mouse genome. At least one third of all homozygous knockouts are expected to be embryonic lethal. My work with the KOMP project is to characterize these mouse models that are homozygous embryonic lethal and document phenotypes and at which point they become lethal. I capture basic information for more extensive subsequent analysis. All of the data that is collected is made public by the central Data Coordination Center Database.