JAX Notes April 01, 1999

Tumor necrosis factor superfamily members: nomenclature update and models

In the late 1990s, the mouse and human nomenclature committees and basic researchers met and combined efforts to standardize the nomenclature of the tumor necrosis factor (TNF) superfamily. New nomenclature was adopted to reflect the genetic and functional relationships among numerous ligands and receptors. The Jackson Laboratory distributes a number of mice with targeted mutations ("knockout") for these TNF superfamily members.

Table 1 outlines the relevant nomenclature changes to assist you in strain selection and identification. Tumor necrosis factor (TNF) is a member of the TNF ligand superfamily that also includes lymphotoxins alpha (LTA) and beta (LTB), tumor necrosis factor (ligand) superfamily, member 5 (TNFSF5) and the FAS ligand (FASL). One of the most important functions of TNF is its selective cytotoxic effect on tumor cells. In addition to inducing cell necrosis in tumor cells, TNF induces apoptosis in non-cancerous cells (e.g., hepatocytes and T cells).

The TNF receptor superfamily is a group of type 1-membrane proteins containing characteristic cysteine-rich repeats in the extracellular domain. Family members include TNFRSF1, TNFRSF2, TNFRSF5, FAS antigen, NGFR, and others. These molecules are involved in the regulation of cell growth, survival or death. The multiple biological activities of TNF are mediated by TNFRSF1 (55 Kd) and TNFRSF2 (75 Kd). TNFRSF1 plays a decisive role in the host’s defense against microorganisms and their pathogenic factors and may also play a role in atherosclerosis. TNFSF5 binds its receptor, TNFRSF5, on B lymphocytes and regulates cell growth and development.

Table 1: TNF Superfamily Nomenclature Changes

Former
Gene
Symbol
Revised
Gene
Symbol
Revised Gene Name
(Common Name)
Strain Name Stock
Number

Cd40

Tnfrsf5

tumor necrosis factor
receptor superfamily,
member 5
(CD40 antigen)

BALB/cAnNcr-Tnfrsf5tm1Kik
C57BL/6Ncr-Tnfrsf5tm1Kik

002927
002928

Cd40l

Tnfsf5

tumor necrosis factor
ligand superfamily,
member 5
(CD40 ligand)

B6,129S-Tnfsf5tm1lmx
C57BL/6J-Tnfsf5tm1lmx

002428
002770

Tnfa

Tnf

tumor necrosis factor

B6,129-Tnftm1Gkl

003008

Tnfb

Lta

lymphotoxin A

B6,129S-Ltatm1Dch
C57BL/6J-Ltatm1Dch

002257
002258

Tnfr1

Tnfrsf1a

tumor necrosis factor
receptor superfamily,
member 1a (p55)

C57BL/6-Tnfrsf1atm1Mak
C57BL/6-Tnfrsf1atm1lmx

002818
003242

Tnfr2

Tnfrsf1b

tumor necrosis factor
receptor superfamily,
member 1b (p75)

C57BL/6-Tnfrsf1btm1Mwm
C57BL/6-Tnfrsf1btm1lmx

002620
003246

Tnfr1 Tnfr2

Tnfrsf1a
Tnfrsf1b

tumor necrosis factor
receptor superfamily, members 1a and 1b

C57BL/6-Tnfrsf1atm1lmx
Tnfrsf1btm1lmx

003243