“Hairless" (Hrhr) mice develop a syndrome characterized by loss of hair after growth of the first pelage, rudimentary mammary gland development, abnormal growth of the nails and a high incidence of thymic lymphomas (2,3).
The "rhino" mutation (e.g. Hrrh-J) is allelic with "hairless" and is a more severe manifestation of the "hairless” mutation (1).
Four features characterize the skin of these mutants:
1. Mann, S.J. (1971). Hair loss and cyst formation in hairless and rhino mutant mice, Anat. Rec. 170:485-499.
2. Meier, H., Myers, D.D., Huebner, R.J. (1969). Genetic control by the hr-locus of susceptibility and resistance to leukemia. Proc. Natl. Acad. Sci. USA 63:759-766.
3. Morrissey, P.J., Parkinson, D.R., Schwartz, R.S., Waksal, S.D. (1980). Immunologic abnormalities in HRS/J mice. Specific deficit in T cell lymphocyte helper function in a mutant mouse. J. Immunol. 125:1558-1562.
4. Sundberg, J.P., Dunstan, R.W., Compton, J.G., (in press). Hairless mouse, HRS/J-hr/hr. in Integumentary system, Monographs on pathology of laboratory animals. Jones, T.C., Mohr, U., Hunt, R.D. (Eds.), Springer-Verlag, Heidelberg.