In support of our mission to bring cutting-edge mouse models and services to the global scientific community in the shared quest to promote human health, JAX has risen to the challenges resulting from the novel coronavirus pandemic.
In March of this year, we announced the first COVID-19 mouse model, the K18-hACE2 transgenic mouse, which can be successfully infected with the SARS CoV-2 virus. These mice provide a high throughput screen for testing therapeutics, including recent preclinical testing of patient convalescent plasma, vaccines, monoclonal antibodies, as well as the studies involving co-infection of SARS-CoV-2 and influenza. We continue to offer this model at cost to keep this important research affordable and moving forward.
Now, it is our pleasure to announce that, in addition to the first K18-hACE2 model, we have developed and will be offering two additional models. From prevention to studying the long term efforts of infection, JAX is the only place you can find the ideal solution for your research needs.
Below you can see the portfolio of available COVID-19 models with the specific utility of each. Speak to a JAX expert today!
Official Strain Nomenclature | B6.Cg-Tg(K18-ACE2)2Prlmn/J 34860 Order Now |
NOD.Cg-Tg(K18-ACE2)2Prlmn Prkdcscid Il2rgtm1Wjl/J 34901 Register Interest |
B6.Cg-Tg(K18-ACE2)2Prlmn Tg(FCGRT)32Dcr Fcgrttm1Dcr/J 34902 Pre-order Now |
B6.Cg-Tg(K18-ACE2)2Prlmn Ifnar1tm1.2Ees/J 35041 Pre-order Now |
C.Cg-Tg(K18-ACE2)2Prlmn/J 35247 Register Interest |
B6.129S2(Cg)-Ace2tm1(ACE2)Dwnt/J 35000 Order Now |
C57BL/6-Ace2tm1.1(ACE2)Mdk/J 35800 Pre-Order Now |
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Popular/Common Name | K18-hACE2 | NSG K18-hACE2 | K18-hACE2 ; FcRn-/- hFcRn (32) Tg | K18-hACE2 ; Ifnar1 | K18-hACE2 on BALB/cJ | hACE2-KI | humanized Ace2 KI, ACE2-GR |
Strain Utility |
K18-hACE2 transgenic mice can be infected with SARS-CoV-2 virus, resulting in severe illness characterized by weight loss, rapid breathing, hunched posture and inactivity. Additionally, viral infection results in lesions in the lungs determined by post-infection pathology, as well as chemokine/cytokine storm traits observed in human patients and viral replication in the gut and heart. These mice provide a high throughput screen for testing therapeutics, including recent preclinical testing of patient convalescent plasma, vaccines, monoclonal antibodies as well as the studies involving dual infection of Sars-CoV-2 and influenza. Importantly, these mice respond to viral challenge in a dose dependent manner allowing for the study of both severe acute respiratory disease in mice challenged with high viral titers, as well as long term affects from low dose mild infections where mice recover from infection. |
NSG.K18-hACE2 mice express human ACE2, the receptor used SARS-CoV2 to gain cellular entry. The addition of the NSG background may result in reduced immune response and increased susceptibility to SARS-CoV viral infection. In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype of Stock No. 034901 could vary from that originally described for the C57BL/6 K18-hACE2 transgenic mice (Stock No. 034860). We may modify the strain description if necessary as published results become available. This K18-hACE2 transgene is also available on C57BL/6J genetic background as Stock No. 034860. |
K18-hACE2;FcRn-/-hFcRn(32)Tg mice expresses human ACE2 and human FcRn, and lacks the endogenous mouse FcRn gene. Expression of human ACE2 allows the SARS-CoV-2 virus to enter its target cells, and the replacement of the expression of mouse FcRn with its human counterpart provides researchers with an accurate prediction of antibody stability (Avery, et al, 2016; Tam, et al, 2013). Combining these two humanizations allows researchers to predict the ability of therapeutic monoclonal antibodies to block the spreading of SARS-CoV-2 infection in vivo. |
BALBcJ.K18-hACE2 mice express human ACE2, the receptor used SARS-CoV2 to gain cellular entry. In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype of Stock No. 035247 could vary from that originally described for the C57BL/6 K18-hACE2 transgenic mice (Stock No. 034860). We may modify the strain description if necessary as published results become available. This K18-hACE2 transgene is also available on C57BL/6J genetic background as Stock No. 034860. |
K18-hACE2 ; Ifnar1- mice express human ACE2 and a muation in Ifnar1 resulting in the knocout of the gene. Expression of human ACE2 allows for infection of mice with the SARS-CoV-2 virus; the knocout of Ifnar1 may result in reduced immune response and increased susceptibility to SARS-CoV-2 viral infection during preclinical studies. |
hACE2-KI mice express human ACE2 in place of mouse Ace2 directed by the endogenous regulatory elements of the mouse Ace2 locus. High SARS-CoV2 viral variants loads were detected in nasal conchae and lungs of hACE2-KI mice, indicating this model supports efficient viral replication after infection. Additionally, strategically placed loxP sites around the hACE2 cDNA sequence allow for cre-recombination in a tissue-specific manner to delete hACE2 where desired. This model may be useful in examining the effects of SARS-CoV2 infection in one tissue or cell type while protecting another, and with the decreased severity may elucidate long-term effects of viral exposure. |
The endogenous mouse Ace2 gene is replaced by the human ACE2 gene in the ACE2-GR mice. These mice express human ACE2 in place of mouse Ace2. |
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