The Jackson Laboratory is home to thousands of genetically engineered mouse strains from every region of the research spectrum. Many of these strains are products of the most preeminent programs in biology today.
This effort, led by Dr. Hongkui Zeng, has created and made available dozens of neuronal cell type-specific cre-expressing and reporter strains. Cre expression has been characterized using in situ hybridization.
This program has also developed many strains for optogenetic research that express channelrhodopsin, halorhodopsin, and archaerhodopsin variants, calcium- or glutamate-reporter proteins, and voltage indicators. Many of these are expressed in a cre-dependent manner.
The goal of this program is to engineer genetically encoded tools for measuring and controlling neuronal activity in the intact brain. The JAX repository distributes mouse models expressing these protein sensors of neuronal function.