Whether you need inbred, outbred, or B6J nude mice, JAX has you covered. Maintained at industry-leading health standards and competitively priced, JAX nude mice are the best route to getting your experimental data faster.
Mice homozygous for the Foxn1nu spontaneous mutation lack a transcriptional factor necessary for development of thymic epithelia and normal hair development. Mutants are athymic, preventing normal T cell development. B cell activity is limited to production of IgM due to a lack of functional CD4 helper T cells. Lack of functional CD8 T cells leads to a loss of T cell-mediated cytotoxic activity.
NU/J (002019) — Inbred Nude: These Foxn1nu mutant mice have a unique homogenous genetic background allowing highly consistent and reproducible growth of many allogeneic tumors and cell lines.
J:NU (007850) — Outbred Nude: These Foxn1nu mutant mice have a heterogeneous genetic background where all other alleles are segregating. These mice may support growth of tumors and cell lines that do not grow on other strains.
B6.Cg-Foxn1nu/J (000819) — B6 Nude: These mice have the Foxn1nu mutation fully congenic on the C57BL/6J inbred genetic background. They may be useful in adoptive transfer of B6-derived immune cells and genetic crosses with other genetically modified strains with a B6 genetic background.