Mice homozygous for the Foxn1^nu spontaneous mutation lack a transcriptional factor necessary for development of thymic epithelia and normal hair development. Mutants are athymic, preventing normal T cell development. B cell activity is limited to production of IgM due to a lack of functional CD4 helper T cells. Lack of functional CD8 T cells leads to a loss of T cell-mediated cytotoxic activity.

• NU/J (002019) — Inbred Nude: These Foxn1^nu mutant mice have a unique homogenous genetic background allowing highly consistent and reproducible growth of many allogeneic tumors and cell lines. 
• J:NU (007850) — Outbred Nude: These Foxn1^nu mutant mice have a heterogeneous genetic background where all other alleles are segregating. These mice may support growth of tumors and cell lines that do not grow on other strains. 
• B6.Cg-Foxn1^nu/J (000819) — B6 Nude: These mice have the Foxn1^nu mutation fully congenic on the C57BL/6J inbred genetic background. They may be useful in adoptive transfer of B6-derived immune cells and genetic crosses with other genetically modified strains with a B6 genetic background.

Order Now

To order, visit our online order form, email orderquest@jax.org, or call 1-800-422-6423 (US, Canada & Puerto Rico) or 1-207-288-5845 (from any location).