Cell humanized mice are generated by engrafting human immune cells into mice with compromised or ablated murine immune function. These models are used to evaluate human immune cells in vivo, study therapeutic interventions, and produce predictive data for the clinic.
Choose JAX cell humanized mice for
Models stably engrafted with human cord blood-derived hematopoietic stem cells (HSCs) enable long-term in vivo longitudinal studies of human immune system response and cell development.
Human peripheral blood mononuclear cell-engrafted (PBMC) models are perfect for short-term studies of mature T cell functionality, including in vivo CAR generation, immuno-oncology, and graft-versus-host disease studies.
Leverage validated mouse model systems paired with JAX’s expertise in complex, preclinical study design - customized to your translational research goals.
PBMC-engrafted models provide a rapid, mature immune cell engraftment, making them ideal for short-term studies focused on effector T cell function, HIV infection, graft-vs-host disease, and rapidly progressing immuno-oncology applications such as in vivo CAR generation. Because these T cells are already developmentally mature, PBMC engrafted models enable patient specific responses, but have limited experimental windows due to potential xenogeneic GvHD.
CD34+ hematopoietic stem cell (HSC)-engrafted models develop a full, multilineage human immune system, supporting long-term studies across immunology, infectious disease, immuno-oncology, and hematopoiesis. These mice provide sustained, stable human immune cell reconstitution including T, B, myeloid, and NK cell populations. This enables deeper mechanistic studies, combination immunotherapy evaluation, and disease modeling requiring durable immune function.
Preclinical studies will often utilize each of these models throughout the course of a long-term study, as the insights they deliver can be appropriate to unique phases or goals of a project. Speak with JAX scientific experts to learn more about the use of each model within your complex study design. We are here to help!
View this informative webinar to learn how these models were used to evaluate the efficacy of a putative antibody therapeutic and how they may eliminate the need for testing in non-human primates.
