| MODEL | JAX # | TYPE | DESCRIPTION | NOMENCLATURE | REFERENCE |
|---|
| Trem2 KO | 27197 | Knock-out | Deletion of 175bp introduces a stop codon at amino acid 17. | C57BL/6J-Trem2em2Adiuj/J | |
| Trem2*R47H | 27918 | Knock-in | Knock-in of R47H risk variant into mouse locus | C57BL/6J-Trem2em1Adiuj/J | PMID:37016304 |
| Trem2*R47HHSS | 33781 | Knock-in | Knock-in of R47H risk variant into mouse locus with humanized splice acceptor site | B6.Cg-Trem2em4Adiuj/J | |
| Trem2*R47HNSS | 34036 | Knock-in | Knock-in of R47H risk variant into mouse locus with normalized splice acceptor site | B6(SJL)-Trem2em1Aduci/J | PMID:36803190 |
| Trem2*Y38C | 29725 | Knock-in | Knock-in of Y38C risk variant into mouse locus | C57BL/6J-Trem2em3Adiuj/J | PMID:33115519 |
| Trem2*T96K | 40406 | Knock-in | Knock-in of T96K risk variant into mouse locus | C57BL/6J-Trem2em4Aduci/J | |
| Trem2*L211P | 40407 | Knock-in | Knock-in of L211P risk variant into mouse locus | C57BL/6J-Trem2em5Aduci/J | |
| hTREM2-KI | 38103 | Knock-in | Knock-in of human coding sequence replacing corresponding mouse sequence | C57BL/6J-Trem2em3(TREM2)Aduci/J | |
| hTREM2-R47H_KI | 37497 | Knock-in | Knock-in of human coding sequence with R47H risk variant replacing corresponding mouse sequence | C57BL/6-Trem2em2(TREM2*R47H)Aduci/J | |
| hTREM2*T96K | 40408 | Knock-in | Knock-in of human coding sequence with T96K risk variant replacing corresponding mouse sequence | C57BL/6J-Trem2em6(TREM2*T96K)Aduci/J | |
| hTREM2*L211P | 40409 | Knock-in | Knock-in of human coding sequence with L211P risk variant replacing corresponding mouse sequence | C57BL/6J-Trem2em7(TREM2*L211P)Aduci/J | |
| TREM2-GR wt | 39172 | Gene replacement | 280kB human TREM2 genomic region (also including TREM1, TREML1, TREML2, TREML4, NCR2) replacing the mouse Trem2 locus. | C57BL/6-Tc(HSA6)1Mdk/J | PMID: 38343132 |
| TREM2-GR*R47H | 39173 | Gene replacement | 280kB human TREM2 genomic region with the R47H AD risk variant (also including TREM1, TREML1, TREML2, TREML4, NCR2) replacing the mouse Trem2 locus. | C57BL/6-Tc(HSA6_TREM2*R47H)1Mdk/J | PMID: 38343132 |
| TREM2-GR rs9357347-C | 39174 | Gene replacement | 280kB human TREM2 genomic region with a protective non-coding SNP (also including TREM1, TREML1, TREML2, TREML4, NCR2) replacing the mouse Trem2 locus. | C57BL/6-Tc(HSA6*rs9357347-C)1Mdk/J | PMID: 38343132 |
