This CRISPR/Cas9-generated knock-out mutant of the Trem2, triggering receptor expressed on myeloid cells 2, gene introduces a Y38C point mutation. The targeted Trem2 gene encodes a protein that is part of a receptor signaling complex with TYRO protein tyrosine kinase binding protein, and that activates macrophages and dendritic cells during immune responses. Loss-of-function variants of the TREM2 gene are associated with Alzheimer's Disease. Homozygotes are viable and fertile. As the mice are characterized, we will modify the strain description and add phenotype data.

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This CRISPR/Cas9 generated mutant of the Trem2 gene carries the Y38C point mutation which has been shown to increase Alzheimer's disease risk.

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