STZ-Induced Diabetes

Streptozotocin (STZ) is a chemical used for the destruction of insulin-producing cells and for the generation of Type 1 Diabetes phenotypes in mice. The Jackson Laboratory has extensive experience creating a variety of STZ-induced Diabetes models to facilitate your metabolic research.

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Key benefits

  • Protocols designed and tested by JAX scientists
  • STZ-treated immunodeficient mice are ideal preclinical models for testing human cellular therapies for diabetes
  • Alternative diabetes models using NSGC57BL/6J, and NOD scid strains
  • JAX experts handle and properly dispose of harmful streptozotocin, including byproducts found in mouse excretions
  • Diabetes modeling can be integrated with Efficacy Testing Services and histology services, as needed

Capabilities

  • Standard protocols of streptozotocin (STZ) injections are used to induce diabetes in NSGC57BL/6J, or NOD scid males
  • Customizable diabetes models using other JAX strains, different STZ doses, and more options, after our feasibility assessment   
  • Each injected mouse is periodically weighed, glucose levels measured, recorded, and shipped with your research cohorts
  • Only diabetic mice with non-fasted blood glucose levels of at least 250 mg/dl are shipped
  • We can also inject neonatal C57BL/6J pups for non-alcoholic steatohepatitis (NASH) research and other projects

Get started with our STZ-induced Diabetes quote form.

STZ Induction Statisticsa

Glucose range
(mg/dL)
C57BL/6J NOD scid NSG
250 - 349 26% 14% 8%
350 - 449 43% 18% 32%
> 450 31% 67% 57%
Average Glucose +/- St Dev (# Mice) 414 +/- 93 (1573) 484 +/- 92 (49) 473 +/- 91 (73)
Success rateb 91% 100% 97%c

a Non-fasting glucose was measured 14-16 days after the first injection.  Data are for guidance only. 
b Defined as the percentage of injected mice with glucose exceeding 250 mg/dL; non-diabetic mice are not shipped and are not included in the table above.
c The 3% (2 mice) of non-diabetic mice were diabetic when re-tested at 3 and 4 weeks.

Additional phenotypic data from STZ-induced C57BL/6J, NOD scid, and NSG mice

Pricing, ordering, and other frequently asked questions