Human peripheral blood mononuclear cell-engrafted NSG™ and NSG™-SGM3 mice are perfect for short-term experiments requiring mature T cells, including HIV infection, immuno-oncology, and graft-versus-host disease studies.
Humanized PBMC mice are used as in vivo models to study and evaluate compounds for infectious diseases and graft rejection research. This model has the fastest engraftment rate using adult peripheral blood mononuclear cells and enables short-term studies requiring a strong effector and memory T cell function. Created with adult peripheral blood mononuclear cells, engrafting quickly and enabling short-term studies requiring mature human T cells.
|Base Strain||NSGTM (005557)||NSGTM-SGM3 (013062)|
|Human Cytokine Expression||N/A||SCF, GM-CSF, IL3|
|Lifespan||Short-term <3month||Short-term <3 months
|Immune Development||T cells (HLA-restricted CD4 and CD8), Natural Killer cells||Coming soon|
|Availability||Readily Available||Readily Available|
Female NSG™ mice are injected with human peripheral blood mononuclear cells (hu-PBMCs). Mice can be shipped to the customer within days of engraftment. Engraftment (principally T cells) can increase over time, but it is limited by the development of graft-versus-host disease.
Study-ready cohorts of hu-PBMC humanized mice are provided upon request, either for shipment to your institution or for enrollment in customized drug efficacy studies executed by our In Vivo Services scientists.
We distribute NSG™ mice under an agreement with the NIH. NSG™ mice are available to non-profit research institutions under an MTA. Companies and for profit entities require a license prior to shipping. Many companies already have a license that includes engrafted NSG™ mice. To confirm that your company is covered or for new license inquiries, please contact:
Director, Technology Transfer
The Jackson Laboratory
Looking for blogs, on-demand videos and livestreams that JAX about Humanized mice? Visit our humanized mouse content hub for all the latest JAX humanized mouse resources.
Onco-Hu® Models are a robust immuno-oncology platform for efficacy testing of novel immunotherapies targeting T cells and myeloid cells to help destroy cancers in vivo.
Get experimental data up to 80% faster with PDX Live™ tumors. This valuable off-the-shelf resource can save your project more than 6-12 weeks time.
These cookies are required for basic site operations.
Allow Essential cookies
Analytics cookies are used to analyze web traffic to improve the user experience.
Allow Analytics cookies
Allow Marketing cookies