Humanized PBMC mice are used as in vivo models to study and evaluate compounds for infectious diseases and graft rejection research. This model has the fastest engraftment rate using adult peripheral blood mononuclear cells and enables short-term studies requiring a strong effector and memory T cell function. Created with adult peripheral blood mononuclear cells, engrafting quickly and enabling short-term studies requiring mature human T cells.
hu-PBMC-NSG MHC I/II Double Knockout
Humanized PBMC-NSG MHC I/II Double Knockout mouse model has a significantly decreased xeno-GvHD relative to the PBMC humanized NSG mouse model, making it more suitable for immuno-oncology studies. This model is available humanized with pre-characterized PBMC donors for human immune cell engraftment kinetics. May be best used with cell lines or PDX models with reliable growth (PMID30383447)
hu-PBMC-NSG MHC I/II Double Knockout (742516)
||NSG-(KbDb)null (IA)null (025216)
|Human Cytokine Expression
- Enables short-term studies requiring human T cells
- Strong effector and memory T cell function
- Significantly decreased xeno-GvHD vs PBMC-humanized NSG making this model more suitable for immuno-oncology purposes.
- Humanized with pre-characterized PBMC donors for human immune cell engraftment kinetics.
- May be best used with cell lines or PDX models with reliable growth. (PMID30383447)
||>75-100d post-engraftment (Donor and Irradiation Dependent)
||T cells (HLA-restricted CD4 and CD8), Natural Killer cells
||Predominantly CD3+ T cells, with some NK cells
Female NSG™ mice are injected with human peripheral blood mononuclear cells (hu-PBMCs). Mice can be shipped to the customer within days of engraftment. Engraftment (principally T cells) can increase over time, but it is limited by the development of graft-versus-host disease.
Study-ready cohorts of hu-PBMC humanized mice are provided upon request, either for shipment to your institution or for enrollment in customized drug efficacy studies executed by our In Vivo Services scientists.
Contact Technical Support
We distribute NSG™ mice under an agreement with the NIH. NSG™ mice are available to non-profit research institutions under an MTA. Companies and for profit entities require a license prior to shipping. Many companies already have a license that includes engrafted NSG™ mice. To confirm that your company is covered or for new license inquiries, please contact:
Director, Technology Transfer
The Jackson Laboratory