APP Models
| MODEL | JAX # | TYPE | DESCRIPTION | SOURCE | NOMENCLATURE | REFERENCE |
|---|---|---|---|---|---|---|
| hAbeta | 33013 | knock-in | humanized Abeta 1-42 | MODEL-AD | B6.Cg-Appem1Adiuj/J | PMID:38187716 |
| floxed hAbeta | 31050 | knock-in | humanized Abeta 1-42 with loxP sites flanking exon 14 | MODEL-AD | B6J(Cg)-Apptm1.1Aduci/J | |
| APP-GR | 38920 | genome replacement | 350kB human APP construct replacing mouse App | Koob | B6J.B6N-Apptm1.1(APP)Mdk/J | PMID:38343132 |
| APP SAA | 34711 | knock-in | humanized Abeta 1-42 with Swedish, Arctic and Austrian mutations | Denali Therapeutics | B6.Cg-Apptm1.1Dnli/J | PMID:35690868 |