APP Models

MODEL	JAX #	TYPE	DESCRIPTION	SOURCE	NOMENCLATURE	REFERENCE
hAbeta	33013	knock-in	humanized Abeta 1-42	MODEL-AD	B6.Cg-App^em1Adiuj/J	PMID:38187716
floxed hAbeta	31050	knock-in	humanized Abeta 1-42 with loxP sites flanking exon 14	MODEL-AD	B6J(Cg)-App^tm1.1Aduci/J	PMID:33893290
APP-GR	38920	genome replacement	350kB human APP construct replacing mouse App	Koob	B6J.B6N-App^{tm1.1(APP)Mdk}/J	PMID:38343132
APP^SAA	34711	knock-in	humanized Abeta 1-42 with Swedish, Arctic and Austrian mutations	Denali Therapeutics	B6.Cg-App^tm1.1Dnli/J	PMID:35690868
APOE4/APP^SAA	39775	knock-in	humanized Aβ sequence with Swedish, Arctic and Austrian mutations; humanized APOE4	Sasner	B6.Cg-Apoe^{tm1.1(APOE*4)Adiuj}App^tm1.1Dnli/MSasnJ
APP^SDI	39773	knock-in	humanized Abeta 1-42 with Swedish, Dutch, and Iowa mutations	Sasner	B6.Cg-App^{em7(hAbeta,SDI)Msasn}/Msasn
APP^SFL	39774	knock-in	humanized Abeta 1-42 with Swedish, Florida, and London mutations	Sasner	B6.Cg-App^{em8(hAbeta,SFL)Msasn}/Msasn
hAbeta-Swe-loxp-KI	39630	knock-in	humanized Abeta 1-42 with Swedish mutation and loxP sites flanking exon 16	MacGregor	B6(Cg)-App^em1Aduci/J
hAbeta-Swe-Ibe-loxp-KI	39631	knock-in	humanized Abeta 1-42 with Swedish and Iberian mutations and loxP sites flanking exon16	MacGregor	B6(Cg)-App^em2Aduci/J