Custom Mouse Models

Work with the world leader in generating precision mouse models. JAX can generate the models you need for your research project, including custom genetically humanized mice.

micetech@jax.org | 1.800.422.6423 (US) | 1.207.288.5845 (International)

Project & Process Timeline

Work with the world leader in mouse model generation. We will:

Discuss your goals and develop a detailed strategy of how we will generate your model.
Provide you with regular updates on your project.
Develop a founder data packet and discuss the results with you.
Develop an N1 data packet (germ line competent and genetically validated) and discuss the results with you.
Deliver your N1 mice to you, or provide you with options to quickly expand your colony and cryopreserve your new strain.

timeline

Model Type	Timeline (Weeks)
Small and Large Knockins Including ROSA 26 locus	27 - 37
Gene Knockout Deletion KO, Indel-mediated KO	26 - 31
Conditional Knockout i.e. flox	33 - 37
Genetic Humanization SNP and plasmid based	27 - 37
Tool Development Reporter and TAG insertions	27 - 37

CRISPR Licenses

All JAX models generated with the CRISPR/Cas9 technology are under limited use licenses from both The Broad Institute, Inc. and Caribou Biosciences, Inc. View full license terms here.

Additional Services

Save time and effort when you opt for additional services, such as the rapid generation of large aged-matched cohorts of study-ready mutant mice. Additional services include:

Off-target effects analysis
Breeding services for further model characterization
Rapid generation of large cohorts through our Speed Expansion Service and regular delivery via Dedicated Supply
Cryopreservation of new CRISPR models
Pilot studies to characterize the expression of human immune cell protein, tumor proteins, or antigens in your model system
PK studies, including therapeutic antibody half-life evaluation
Preclinical efficacy studies with your compound

Custom Model Resources

Browse videos, case studies,
white papers, and more.

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