Our CRISPR/Cas9 mouse model generation service offers an all-in-one customized package, rapidly delivering KO and KI models on various backgrounds for your research.
If the mouse model you need doesn't exist, we can build it for you. JAX can rapidly create the model you need on the genetic background you want using our CRISPR/Cas9 gene editing, traditional transgenic microinjection, and ES cell-based techniques.
Genome editing with CRISPR/Cas9 enables the generation of new mouse models with unprecedented speed and simplicity. The Jackson Laboratory was an early adopter of CRISPR/Cas9 technology for mouse model development, and in this brief article we describe the technology and lessons learned to generate knockouts and knockins in more than a dozen different genetic backgrounds.
Protect your valuable strains from unfortunate events. JAX Cryopreservation Services offer fast and reliable recovery of archived embryos and sperm so you can feel assured about the safety of your strains.
Need dozens or hundreds of age-matched mice fast? Speed expansion via IVF rapidly develops mouse colonies at a specified and opportunistic pathogen-free status.
As an early adopter of the CRISPR/Cas9 technology, The Jackson Laboratory has been exploring the capabilities and limitations of the technology for generating mouse models. We can help you design the model you need and produce it on the genetic background of your choice by leveraging our 85+ years of mouse experience and our 8,500 mouse models.
Our Breeding Services makes managing your mouse colonies easy and affordable. We'll make sure you get the mice you need when you need them.
Donating your strain to JAX fulfills NIH obligations to share mice with other scientists while significantly reducing the cost of maintaining your mouse models.