Breast Cancer

Over 20 unique breast cancer PDX models are currently available within our PDX model cancer collection, including the most common and therapeutically relevant breast cancer diagnoses. Our models using NSG™ (005557) mice have distinct advantages as hosts for human breast tumors, preserving the biological characteristics of the original tumor. In addition, NSG™ mice support the robust growth of ER+ breast tumors that historically have been difficult to develop using other mouse models.

Breast cancer clinical markers:

Additional breast cancer models are available in the Mouse Tumor Biology Database. Mice engrafted with breast PDX samples are available for efficacy testing at JAX In Vivo Services or for distribution to your facility. For most of our breast PDX tumors, gene expression data and genomic data, standard of care data and pathology images are available through the Mouse Tumor Biology Database.

Featured breast cancer PDX models

Model name Diagnosis Tumor markers Additional detail
TM00089

Carcinoma

ER-/PR-/HER2-

Variant data

TM00090

Carcinoma

ER-/PR-/HER2-

Variant data

TM00091

Invasive Ductal Carcinoma

ER-/PR-/HER2-

BRCA1

TM00095

Invasive Ductal Carcinoma


Variant data

TM00096

Mixed Ductal Carcinoma

ER-/PR-/HER2-; AURKA, NRAS & TP53

Variant data

TM00097

Ductal Carcinoma

ER-/PR-/HER2-; TP53 & KRAS

Variant data

TM00098

Ductal Carcinoma

ER-/PR-/HER2-

Variant data

TM00099

Invasive Ductal Carcinoma

ER-/PR-/HER2-; TP53, ATM, KDR (VEGFR2),

Variant data

TM00107

Metastatic Adenocarcinoma

ER+/-/PR-/HER2-

TP53

TM00386

Carcinoma

ER+/PR+/HER2-

Variant data

TM00999

Invasive Ductal Carcinoma

ER-/PR-/HER2-

Variant data

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