Bladder cancer

We provide access to many bladder cancer PDX models, including muscle-invasive options. Models are currently available for efficacy testing of your candidate compound by our study directors or for distribution to your facility. For most of our bladder PDX tumors, gene expression data and genomic data, standard of care data and pathology images are available through the Mouse Tumor Biology Database.

Featured bladder cancer PDX models

Model name Diagnosis Known mutations
TM00015

Urothelial Carcinoma Invasive

PIK3CA, TP53 variants

TM00016

Urothelial Carcinoma Invasive

RB1, TP53 variants

TM00020

Urothelial Carcinoma

TP53

TM00021

Urothelial Carcinoma

ATM

TM00024

Urothelial Carcinoma

TP53; Variant and other data

TM00025

Urothelial Carcinoma

FLT3

TM00026

Urothelial Carcinoma

PTPN11

Additional bladder cancer PDX models are available in the Mouse Tumor Biology Database.

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The histopathology images shown below reveal that the overall morphology and structure of JAX PDX tumors, engrafted in NSG™ mice, which are maintained at low-passage resemble the primary tumor from patients. The images below correspond to a primary tumor high-grade invasive urothelial bladder carcinoma (TM00016-PT) and the corresponding low-passage PDX tumor (TM00016-P1).

TM00016-PT

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