Powerful new tools allow researchers to investigate Alzheimer's disease today in ways that simply weren't possible only a few years ago. The Jackson Laboratory is looking for postdocs to join its researchers in using the power of human genomics and modern mouse genetics to understand the complex basis of Alzheimer’s disease.
Gareth Howell, Ph.D., and Greg Carter, Ph.D., have postdoctoral positions available in their labs. Working with colleagues specializing in neuroscience, genetics, genomics and computational biology, this research team is focused on three major areas of interest:
- Understanding the interactions between genetics, aging and environmental factors and how they conspire together to cause Alzheimer’s disease.
- Understanding the role of innate immune responses in Alzheimer’s disease onset and progression.
- Leveraging new data resources and genome technologies to develop the next generation of mouse models of late-onset Alzheimer’s disease for research and preclinical use.
The Howell Lab uses genetic and genomic approaches with mouse models to better understand particularly the early stages of disease as this provides the greatest opportunity for therapeutic intervention.
"Alzheimer’s disease is the HIV-AIDS of our age,” Howell says. “It’s front and center in so many people’s lives, directly or indirectly. So far, our mouse models have enabled understanding aspects of the biology of the disease. But we need better models now to identify and test the drugs that will work best against Alzheimer’s disease.”
The Carter Lab develops and applies advanced computational strategies to model the complex etiology of common diseases in humans and mouse models.
“Our multi-disciplinary approach, which combines advanced computational analysis and in vivo animal modeling, provides the tools to decipher the causes of Alzheimer’s disease by embracing its inherent complexity,” Carter said. “We think this position will especially appeal to creative scientists that have a passion to use new technologies to discover how genetics and environment conspire to cause common diseases,”
Applicants should have a Ph.D. (or equivalent degree) in genetics, neuroscience, computational biology or similar disciplines and be committed to solving biological problems.
Exceptional candidates will have the opportunity to apply to become a JAX Postdoctoral Scholar, a selective award addressing the national need for research scientists who are accomplished in the broadly defined fields of genetics and genomics. The award includes an independent research budget, travel funds, and a salary above standard postdoctoral scale.
Early diagnosis is important, but diet and exercise may be as critical.