Phenotype Information for KK.Cg-Ay/J (002468)

JAX® Mice Strain - KK.Cg-Ay/J

Stock Number 002468

Yellow KK.Cg-Ay/J males (Ay/a genotype) develop type 2 diabetes with phenotypes that include:

  • Moderate obesity compared to ob or db mutant strains (Figure 1)
  • Progressive hyperglycemia (Figure 2 and Table 1)
  • Glucose intolerance by 8 weeks of age (Figure 3)

KK.Cg-Ay/J (002468) Body Weight

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Figure 1. Weekly body weight of male yellow (Ay/a) and black (a/a) mice. Values represent 18-33 mice per age.

KK.Cg-Ay/J (002468) Blood Glucose

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Figure 2. Non-fasting blood glucose of yellow (Ay/a) and black (a/a) male mice. The same groups of mice were tested each week using a OneTouch Ultra 2 handheld glucometer that was validated with a control solution on each day of use. Values represent 18-33 mice per age.

Table 1. Distribution of blood glucose values of yellow (Ay/a) mice. The individual glucose values used to create Figure 2 were grouped by age into the indicated ranges.

Glucose Range (mg/dL) Age (weeks)
4 8 12 16 20 24
< 250 63% 73% 56% 10% 5% 11%
250 – 349 31% 15% 24% 25% 25% 26%
350 – 449 6% 12% 16% 20% 45% 21%
> 450 0% 0% 4% 45% 25% 42%
Number of mice 32 26 25 20 20 19

KK.Cg-Ay/J (002468) Glucose Tolerance Test

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Figure 3. Glucose tolerance tests. Following a 16 hour fast, an initial glucose measurement was taken from submandibular blood and mice were administered 2 g/kg glucose via the IP route. Additional glucose measurements were made at 30, 60, 90 and 120 minutes post-administration. 5 mice were tested per genotype and age.