Phenotype Information for KK.Cg-Ay/J (002468)
JAX® Mice Strain - KK.Cg-Ay/J
Stock Number 002468
Yellow KK.Cg-Ay/J males (Ay/a genotype) develop type 2 diabetes with phenotypes that include:
- Moderate obesity compared to ob or db mutant strains (Figure 1)
- Progressive hyperglycemia (Figure 2 and Table 1)
- Glucose intolerance by 8 weeks of age (Figure 3)
KK.Cg-Ay/J (002468) Body Weight
Figure 1. Weekly body weight of male yellow (Ay/a) and black (a/a) mice. Values represent 18-33 mice per age.
KK.Cg-Ay/J (002468) Blood Glucose
Figure 2. Non-fasting blood glucose of yellow (Ay/a) and black (a/a) male mice. The same groups of mice were tested each week using a OneTouch Ultra 2 handheld glucometer that was validated with a control solution on each day of use. Values represent 18-33 mice per age.
Table 1. Distribution of blood glucose values of yellow (Ay/a) mice. The individual glucose values used to create Figure 2 were grouped by age into the indicated ranges.
| Glucose Range (mg/dL) | Age (weeks) | |||||
|---|---|---|---|---|---|---|
| 4 | 8 | 12 | 16 | 20 | 24 | |
| < 250 | 63% | 73% | 56% | 10% | 5% | 11% |
| 250 – 349 | 31% | 15% | 24% | 25% | 25% | 26% |
| 350 – 449 | 6% | 12% | 16% | 20% | 45% | 21% |
| > 450 | 0% | 0% | 4% | 45% | 25% | 42% |
| Number of mice | 32 | 26 | 25 | 20 | 20 | 19 |
KK.Cg-Ay/J (002468) Glucose Tolerance Test
Figure 3. Glucose tolerance tests. Following a 16 hour fast, an initial glucose measurement was taken from submandibular blood and mice were administered 2 g/kg glucose via the IP route. Additional glucose measurements were made at 30, 60, 90 and 120 minutes post-administration. 5 mice were tested per genotype and age.