JAX Mouse Strain Datasheet - 000642

BKS.Cg-Dock7^m +/+ Lepr^db/J

Stock No:: 000642

Readily Available

Overview

Also Known As: BKS db

This strain is used to model phases I to III of diabetes type II and obesity. Mice homozygous for the diabetes spontaneous mutation (Lepr^db) manifest morbid obesity, chronic hyperglycemia, pancreatic beta cell atrophy and become hypoinsulinemic. Obesity starts at 3 to 4 weeks of age. Elevated plasma insulin begins at 10 to 14 days and elevated blood sugar at 4 to 8 weeks. Homozygous mice are polyphagic, polydipsic, and polyuric. The severity of disease on BKS background leads to uncontrolled rise in blood sugar, severe depletion of insulin-producing beta-cells of the pancreatic islets, peripheral neuropathy, myocardial disease and death by 10 months of age. Exogenous insulin fails to control blood glucose levels and gluconeogenic enzyme activity increases. Wound healing is delayed, and metabolic efficiency is increased.

Genetic overview

Genetic Background	Generation
000662 C57BLKS/J	F131 (05-AUG-14)

Dock7^m

Allele Type	Gene Symbol	Gene Name
Spontaneous	Dock7	dedicator of cytokinesis 7

Lepr^db

Allele Type	Gene Symbol	Gene Name
Spontaneous	Lepr	leptin receptor

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Research Applications

Diabetes and Obesity Research
Internal/Organ Research
Dermatology Research
Endocrine Deficiency Research
Immunology, Inflammation and Autoimmunity Research
Metabolism Research
Reproductive Biology Research

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Base Price

Starting at:

$93.16 Domestic price for female 4-week

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Details

Important Note

This strain is maintained with Dock7^m and Lepr^db in repulsion. Although these genes are tightly linked, there is a small possibility of recombination. The heterozygotes we distribute are presumed to be non-recombinant, but are untested.

Detailed Description

Mice homozygous for the diabetes spontaneous mutation (Lepr^db) become identifiably obese around three to four weeks of age. Elevations of plasma insulin begin at 10 to 14 days of age and of blood sugar at four to eight weeks. Homozygous mutant mice are polyphagic, polydipsic, and polyuric. The course of the disease is markedly influenced by genetic background. A number of features are observed on the C57BLKS background, including an uncontrolled rise in blood sugar, severe depletion of the insulin-producing beta-cells of the pancreatic islets, and death by 10 months of age. Exogenous insulin fails to control blood glucose levels and gluconeogenic enzyme activity increases. Peripheral neuropathy and myocardial disease are seen in C57BLKS-Lepr^db homozygotes. Wound healing is delayed, and metabolic efficiency is increased. Female homozygotes exhibit decreased uterine and ovarian weights, decreased ovarian hormone production and hypercytolipidemia in follicular granulosa and endometrial epithelial tissue layers (Garris et al., 2004, Garris et al., 2004).

Although normal in body weight, blood glucose, and plasma insulin, heterozygotes (Lepr^db/+) also have increased metabolic efficiency and can survive a prolonged fast longer than controls. Experiments involving destruction of the ventromedial nucleus of the hypothalamus suggest that Lepr^db may cause a defect in the hypothalamus. Steroid sulfotransferase enzymes, aberrantly expressed in diabetic mice, interact with the Lepr^db mutation as modifiers of gender differences in obesity-induced diabetes susceptibility. Because of the sterility of Lepr^db homozygotes, the misty (Dock7^m) mutation has been incorporated into stocks for maintenance of the diabetes mutation. The repulsion double heterozygote (Dock7^m +/+ Lepr^db) facilitates identification of heterozygotes for breeding, while the coupling double heterozygote, (Dock7^m Lepr^db/+ +) allows identification of homozygotes before the phenotype becomes severe.

The recessive misty mutation causes a mild dilution of coat color and on certain backgrounds a white tail tip often accompanied by a belly spot. Melanocytes from Dock7^m/Dock7^m mice have a highly dendritic shape, show deficient proliferation in culture and have much more melanin content. Fewer melanoblasts are found in primary cultures from Dock7^m/Dock7^m mice than from wildtype controls. Between two and five weeks of age, Dock7^m/Dock7^m mice are smaller than controls. At 35 days of age they are shorter, weigh 15% less on average, and have less inguinal adipose mass than controls. Misty homozygotes completely lack brown fat. Although platelet count, seratonin content and ATP content are normal, Dock7^m/Dock7^m homozygotes have an increased bleed time and reduced platelet ADP levels.(Woolley 1941 and 1945; Truett et al. 1998; Sviderskaya et al. 1998.)

Control Suggestions

Dock7^m +/+ Lepr^db (Heterozygote from the colony)
Dock7^m +/Dock7^m + from the colony
000662 C57BLKS/J

Additional Information

Considerations for Choosing Controls

Selected References

Chen H; Charlat O; Tartaglia LA; Woolf EA; Weng X; Ellis SJ; Lakey ND; Culpepper J; Moore KJ; Breitbart RE; Duyk GM; Tepper RI; Morgenstern JP. 1996. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84(3):491-5. PubMed: 8608603 MGI: J:31324
Chua SC Jr; Chung WK; Wu-Peng XS; Zhang Y; Liu SM; Tartaglia L; Leibel RL. 1996. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor [see comments] Science 271(5251):994-6. PubMed: 8584938 MGI: J:31419
Dardenne M; Savino W; Bach JF. 1984. Autoimmune mice develop antibodies to thymic hormone: production of anti-thymulin monoclonal autoantibodies from diabetic (db/db) and B/W mice. J Immunol 133(2):740-3. PubMed: 6539799 MGI: J:109953
Fantuzzi G; Faggioni R. 2000. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 68(4):437-46. PubMed: 11037963 MGI: J:109886
Gueorguiev M; Goth ML; Korbonits M. 2001. Leptin and puberty: a review. Pituitary 4(1-2):79-86. PubMed: 11824512 MGI: J:109856
Hummel KP; Dickie MM; Coleman DL. 1966. Diabetes, a new mutation in the mouse. Science 153(740):1127-8. PubMed: 5918576 MGI: J:5010
Kampfer H; Paulukat J; Muhl H; Wetzler C; Pfeilschifter J; Frank S. 2000. Lack of interferon-gamma production despite the presence of interleukin-18 during cutaneous wound healing. Mol Med 6(12):1016-27. PubMed: 11474118 MGI: J:109870
Lee GH; Proenca R; Montez JM; Carroll KM; Darvishzadeh JG; Lee JI; Friedman JM. 1996. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379(6566):632-5. PubMed: 8628397 MGI: J:31327
Leiter EH; Chapman HD. 1994. Obesity-induced diabetes (diabesity) in C57BL/KsJ mice produces aberrant trans-regulation of sex steroid sulfotransferase genes. J Clin Invest 93(5):2007-13. PubMed: 8182132 MGI: J:17991
Mandel MA; Mahmoud AA. 1978. Impairment of cell-mediated immunity in mutation diabetic mice (db/db). J Immunol 120(4):1375-7. PubMed: 347001 MGI: J:109964
Serreze DV; Leiter EH; Kuff EL; Jardieu P; Ishizaka K. 1988. Molecular mimicry between insulin and retroviral antigen p73. Development of cross-reactive autoantibodies in sera of NOD and C57BL/KsJ db/db mice. Diabetes 37(3):351-8. PubMed: 3286334 MGI: J:27625
Yoon JW; Leiter EH; Coleman DL; Kim MK; Pak CY; McArthur RG; Roncari DA. 1988. Genetic control of organ-reactive autoantibody production in mice by obesity (ob) diabetes (db) genes. Diabetes 37(9):1287-93. PubMed: 3044893 MGI: J:109940

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Genetics

Dock7^m

Allele Symbol: Dock7^m

Allele Name	misty
Allele Type	Spontaneous
Allele Synonym(s)	m
Gene Symbol and Name	Dock7, dedicator of cytokinesis 7
Gene Synonym(s)	3110056M06Rik; 3110056M06Rik; EIEE23; Gm430; LOC242555; RIKEN cDNA 3110056M06 gene; ZIR2; gene model 430, (NCBI); m; m; mKIAA1771; misty
Strain of Origin	DBA/J
Chromosome	4
Molecular Note	Crosses between mice homozygous for misty and for moonlight, which mapped to overlapping critical regions on Chr 4, demonstrated failure of the two mutations to complement one another. Once moonlight had been identified as a mutation of Dock7 (Dock7^mnlt), sequence analysis of this gene from misty mice revealed a retrotransposon LTR insertion following nucleotide 2045 (numbering from the A of the transcription initiation codon) that interrupts exon 18 and shifts the reading frame after codon 682 so that ten incorrect amino acids are incorporated into the protein before its premature termination.

Lepr^db

Allele Symbol: Lepr^db

Allele Name	diabetes
Allele Type	Spontaneous
Allele Synonym(s)	Lep^db; Lepr-; Lepr^db-1J; db; db/db; leprdb
Gene Symbol and Name	Lepr, leptin receptor
Gene Synonym(s)	CD295; Fa; LEP-R; LEPRD; LEPROT; Leprb; Modb1; OB-R; OB-RGRP; OBR; Obr; db; diabetes; leptin receptor gene-related protein; obese-like; obese-like; obl; obl
Strain of Origin	C57BLKS/J
Chromosome	4
General Note	Phenotypic Similarity to Human Syndrome: Gestational Diabetes J:219658
Molecular Note	A G-to-T transversion in this allele created a donor splice site that causes abnormal splicing and a 106 nt insertion in the transcript, leading to premature termination of the long cellular domain of the Ob-Rb splice form and loss of its signal transducing function.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
- Hyperglycemia
- Type 2 Diabetes (NIDDM)
Internal/Organ Research
- Wound Healing
  - delayed/impaired

Genotype: Dock7^m related

Dermatology Research
- Color and White Spotting Defects

Genotype: Lepr^db related

Diabetes and Obesity Research
- Hyperinsulinemia
- Impaired Wound Healing
- Insulin Resistance
- Obesity With Diabetes
Endocrine Deficiency Research
- Adipose Defects
- Hypothalamus/Pituitary Defects
- Pancreas Defects
Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency Associated with Other Defects
Internal/Organ Research
- Adipose Defects
Metabolism Research
Reproductive Biology Research
- Fertility Defects

Mammalian Phenotype Terms by Genotype

Genotype: Dock7^m/Dock7^m
BKS.Cg-Dock7^m +/+ Lepr^db/BomTac

behavior/neurological phenotype

behavior/neurological phenotype
- homozygous mutant and wild type control (C57BL/6J) mice exhibit similar locomotor activity; response in the tail-suspension test for depressive behavior; learning as measured by habituation of object exploration; working memory as measured using the Y maze; anxiety-like behavior in a light-dark transfer test; and preference for social familiarity/noveltye; anxiety-like behavior in a light-dark transfer test; and preference for social familiarity/novelty

Genotype: Lepr^db/Lepr⁺
involves: C57BLKS/J

cellular phenotype

maternal effect
- offspring born from heterozygous mothers with gestational diabetes have lower fasting insulin levels and worse glucose tolerance than offspring born from wild-type mothers
- wild-type males born to heterozygous mothers are heavier than wild-type mice born to wild-type mothers, but postnatal weight gain of female offspring is not affected by the maternal environment

homeostasis/metabolism phenotype

abnormal circulating insulin level
- 2.2X increase in fasting insulin during pregnancy compared to a 3X increase in controls
- leptin treatment results in a 14% reduction in insulin levels compared to a 45% reduction in controls

abnormal glucose homeostasis

abnormal hormone level
- elevated placental leptin levels in pregnant females

decreased circulating insulin level
- pregnant dams exhibit lower fasting insulin levels than wild-type mothers

impaired glucose tolerance
- 45-55% higher glucose levels after a glucose challenge but dramatically improved by leptin treatment and glucose levels reduced 33 and 30% in glucose tolerance tests at 30 and 60 minute time points
- both male and female heterozygous offspring have impaired glucose tolerance irrespective of maternal environment (heterozygous or wild-type mothers)
- females exhibit impaired glucose tolerance during pregnancy
- glucose levels 41% higher in a glucose tolerance test at 30 and at 60 minute time points
- profound glucose intolerance during pregnancy

increased circulating glucose level
- fasting glucose levels elevated 25% during pregnancy

increased circulating leptin level
- heterozygous offspring exhibit an increase in leptin levels at 6 months of age
- mothers exhibit higher circulating leptin levels than wild-type mothers

embryo phenotype

enlarged placenta
- placentas from heterozygous fetuses are larger than those of wild-type fetuses, irrespective of maternal genotype

behavior/neurological phenotype

increased food intake
- food intake 11% greater than controls during pregnancy
- leptin treatment suppresses food intake to near control levels

growth/size/body region phenotype

increased birth weight
- heterozygous fetuses carried by wild-type dams exhibit a 5% higher birth weight than wild-type littermates
- heterozygous fetuses from heterozygous mothers are 3% bigger than wild-type littermates
- however, wild-type pups from heterozygous mothers are no bigger than wild-type fetuses carried by wild-type mothers

increased body weight
- heterozygous pregnant dams are heavier than wild-type mothers at E18.5
- male and female heterozygous offspring from both normal and complicated pregnancies, are heavier than wild-type littermates at 3 and 6 months of age

increased susceptibility to weight gain
- 33% greater maternal weight gain
- birth weights significantly heavier than controls and unaffected by maternal leptin treatment unlike controls where maternal leptin treatment causes a decrease in birth weights
- maternal body weight at term 24% greater than controls

adipose tissue phenotype

increased total body fat amount
- 20% greater adipose tissue mass during pregnancy than in controls

Genotype: Lepr^db/Lepr⁺
BKS.Cg-Dock7^m +/+ Lepr^db/J

mortality/aging

extended life span
- Background Sensitivity - survival when deprived of food is longer rhan when in a C57BL/6 background
- increased survival when totally deprived of food than wild-type controls

Genotype: Lepr^db/Lepr^db
C57BLKS/J

adipose tissue phenotype

abnormal adipose tissue morphology
- increase in adipose tissue weight in both males and females

hematopoietic system phenotype

increased glycosylated hemoglobin level
- significant increase in the percentage of plasma glycosylated hemoglobin

cellular phenotype

abnormal aerobic respiration
- carbohydrate oxidation becomes reduced
- elevation of fatty acids in perfused hearts causes an increase in fatty acid oxidation combined with a reduction in glucose oxidation rates
- palmitate oxidation is elevated

abnormal respiratory electron transport chain
- state 3 respiration is elevated in cardiac mitochondria incubated with palmitoyl-carnitine but not with pyruvate

muscle phenotype

decreased cardiac muscle contractility
- hearts show a significant increase in the slope of the MV_O2-PVA (pressure volume area) regression line after elevation of fatty acids, suggesting a reduction in contractile efficiency

increased vasoconstriction
- hypercontractility corrollated with the levels of obesity, hyperglycemia, and hyperinsulinemia
- hypercontractility of smooth muscle in aortic strips due to either phenylephrine or serotonin
- maximal contractions increase with age rather than decrease as in controls

mortality/aging

increased sensitivity to induced morbidity/mortality
- homozygotes subjected to 30 and 45 min of left coronary artery occlusion show survival rates of 58% and 44%, respectively, at 28 days after reperfusion, compared to 100% and 88% in controls
- homozygotes subjected to 30, 45, and 60 min of left coronary artery ischemia-reperfusion exhibit survival rates of 71%, 53%, and 18%, respectively, at 24 h after reperfusion, much lower than in controls

liver/biliary system phenotype

increased liver weight

behavior/neurological phenotype

polyphagia

endocrine/exocrine gland phenotype

abnormal pancreatic beta cell morphology
- individual beta cell size is increased

abnormal pancreatic islet morphology
- islet mass and density are significantly increased compared to wild-type mice

renal/urinary system phenotype

increased kidney weight

growth/size/body region phenotype

increased body weight
- overweight by 4 weeks of age

obese

homeostasis/metabolism phenotype

abnormal glucose homeostasis
- diabetic phenotype appears earlier in males than in females

altered response to myocardial infarction
- homozygotes subjected to 45 min of ischemia display an increase in diastolic dimensions, significant dilatation of left ventricular end-systolic dimensions, a 30% reduction in fractional shortening, and an increase in cardiac hypertrophy, 28 days postreperfusion, indicating decreased tolerance to myocardial infarctionrfusion, indicating decreased tolerance to myocardial infarction

decreased body temperature

hyperglycemia
- by 8 weeks

hyperlipidemia

increased circulating cholesterol level

increased circulating free fatty acid level

increased circulating insulin level
- hyperinsulinemia by 8 weeks

increased circulating leptin level

increased circulating triglyceride level

increased glycosylated hemoglobin level
- significant increase in the percentage of plasma glycosylated hemoglobin

cardiovascular system phenotype

abnormal blood circulation
- reduced aortic flow

abnormal cardiovascular system physiology
- at low fatty acid supply, hearts consume 86% more oxygen (MV_O2) for noncontractile purposes compared with control hearts and a further increase in fatty acid supply has no effect on the already elevated unloaded MV_O2, indicating reduced cardiac efficiency in unloaded heartsced cardiac efficiency in unloaded hearts

abnormal myocardium layer morphology
- myocardial triacylglycerol content 2X that of controls at 10-18 weeks of age

altered response to myocardial infarction
- homozygotes subjected to 45 min of ischemia display an increase in diastolic dimensions, significant dilatation of left ventricular end-systolic dimensions, a 30% reduction in fractional shortening, and an increase in cardiac hypertrophy, 28 days postreperfusion, indicating decreased tolerance to myocardial infarctionrfusion, indicating decreased tolerance to myocardial infarction

cardiac ischemia
- reduced recovery of mechanical function after 13 minutes of ischemia and reperfusion

decreased cardiac muscle contractility
- hearts show a significant increase in the slope of the MV_O2-PVA (pressure volume area) regression line after elevation of fatty acids, suggesting a reduction in contractile efficiency

decreased cardiac output
- cardiac output is reduced in fatty acid perfused hearts

decreased heart rate
- intrinsic heart rates are reduced at all workloads

decreased systemic arterial systolic blood pressure
- decreased peak systolic pressure
- decreased peak systolic pressure X cardiac output
- decreased peak systolic pressure X heart rate

increased left ventricle diastolic pressure
- hearts show a significant increase in the slope of the MV_O2-PVA (pressure volume area) regression line after elevation of fatty acids, suggesting a reduction in contractile efficiency

increased vasoconstriction
- hypercontractility corrollated with the levels of obesity, hyperglycemia, and hyperinsulinemia
- hypercontractility of smooth muscle in aortic strips due to either phenylephrine or serotonin
- maximal contractions increase with age rather than decrease as in controls

Genotype: Lepr^db/Lepr^db
BKS.Cg-Dock7^m +/+ Lepr^db/J

homeostasis/metabolism phenotype

abnormal circulating cholesterol level

abnormal circulating glucose level

abnormal circulating lipid level
- Background Sensitivity - plasma lipid levels differ between young and old mutants unlike on the C57BL/6J background where levels are similar at both ages; 14-month old mice have lower triglycerides, HDL cholesterol and combined VLDL + LDL cholesterol levels than 14-week old mice, but have significantly higher plasma triglyceride levels but have significantly higher plasma triglyceride levels

albuminuria
- moderate albuminuria is observed at 26 weeks of age

decreased circulating glucose level
- affect of BDNF on blood glucose becomes progressively less as mice age
- brain derived neurotrophic factor (BDNF) causes a drop in blood glucose relative to controls 8 weeks after treatment
- glucose levels are reduced at all times tested when mice are placed on feeding restriction during the dark phase
- neurotrophin 3 also causes a drop in blood glucose but the glucose levels return to normal by 24 hours after treatment

decreased circulating insulin level
- BDNF causes a 50% reduction in plasma insulin relative to controls
- morning insulin levels lowered when feeding is restricted during the dark phase

decreased circulating triglyceride level
- triglyceride levels are reduced at all times tested when mice are placed on feeding restriction during the dark phase

decreased prostaglandin level
- in diabetic wounds, PGE2 level is consistently less than 50% of wild-type wounds at all times

decreased urine albumin level
- mutants treated with sRAGE do not show the increased albumin excretion seen in untreated mutants (0.11 ug albumin/ug creatinine vs 0.20 ug albumin/ ug creatinine); levels are not significantly different from control animals (0.08 ug albumin/ ug creatinine))

delayed wound healing
- T26A, a prostaglandin transporter inhibitor, topically applied to wounds shortened wound closure to 16 days in mutants, similar to untreated controls; T26A increased re-epithelialization, neovascularization, and blood flow in wounds
- wound healing is impaired, with an average wound closure time of 22 days, 7 days longer than in controls

hyperglycemia
- fasting blood glucose level is significantly higher than control at 26 weeks of age

improved glucose tolerance
- BDNF treatment causes a lower blood glucose level response in a glucose tolerance test

increased circulating HDL cholesterol level

increased circulating LDL cholesterol level

increased circulating VLDL cholesterol level

increased circulating cholesterol level
- fasting plasma total cholesterol concentration is increased 2 fold over controls

increased circulating glucose level
- blood glucose shows a progressive increase from 5 through 33 weeks

increased circulating triglyceride level
- triglyceride levels are elevated 1.5- to 2-fold

increased glucagon secretion
- increased secreation of glucagon by pancreatic cells in culture

cellular phenotype

abnormal axon extension
- axonal growth cone extension fails to occur for neurons treated in culture with 100ng/ml of leptin

growth/size/body region phenotype

increased body weight

obese
- become progressively obese starting at 5 weeks of age
- weight reaches 2.5X that of control mice by 3 months of age

weight loss
- body weight drops after 6 days on feeding restriction during the dark phase

renal/urinary system phenotype

albuminuria
- moderate albuminuria is observed at 26 weeks of age

decreased urine albumin level
- mutants treated with sRAGE do not show the increased albumin excretion seen in untreated mutants (0.11 ug albumin/ug creatinine vs 0.20 ug albumin/ ug creatinine); levels are not significantly different from control animals (0.08 ug albumin/ ug creatinine))

expanded mesangial matrix
- moderate mesangial expansion is observed in glomeruli at 26 weeks

increased creatinine clearance
- male mutants treated with sRAGE to achieve RAGE blockade display increased creatinine clearance (~5.1 ml/hour/100 x g body weight) compared to PBS-treated mutants (~3 ml/hour/100 x g body weight), approaching wild-type levels (6.7 ml/hour/100 x g body weight)ght)

nervous system phenotype

abnormal CNS synaptic transmission

abnormal axon extension
- axonal growth cone extension fails to occur for neurons treated in culture with 100ng/ml of leptin

abnormal axon morphology
- non significant shift toward smaller fiber diameter at 15 weeks of age
- shift of unmyelinated fibers to smaller diameters
- significantly shifted to smaller diameter fibers by 25 weeks in ventral roots, dorsal roots, sural nerve
- small numbers of very large unmyelinated fibers (up to 1.6 micrometers)
- smaller diameter nerve fibers in peroneal, phrenic and vagus nerves at 25 weeks but not significant

abnormal myelin sheath morphology
- number of myelin lamellae relative to nerve diameter is increased

abnormal nerve conduction
- insulin treatment results in improved conductance but only for the duration of treatment and control levels of conductance are never restored
- motor nerve conductance significantly lower than controls from 7 weeks of age onward
- no conductance improvement is seen in mice over 23 weeks in age due to insulin treatment
- velocity returns to and is maintained at prediabetic levels by 15 weeks of age whereas control mice show a continuous increase in velocity

abnormal nervous system morphology

absent long term depression
- CA1 hippocampal slices indicate no long term depression on recordings of excitatory post-synaptic potentials

decreased motor neuron number
- myelinated fiber density increases in most nerves (not the peroneal and phrenic nerves)
- myelinated fibers reduced in numbers at 25 weeks in the sural nerve
- unmyelinated fiber density increase in the sural, peroneal, and vagus nerves
- unmyelinated fibers reduced in numbers at 25 weeks in the vagus nerve

reduced long term potentiation
- CA1 hippocampal slices indicate brief post tetanic potentiation but no long term potentiation on recordings of excitatory post-synaptic potentials

behavior/neurological phenotype

abnormal circadian rhythm
- daily locomotor activity rhythmicity severely diminished at 13-14 weeks, 75% fail to show significant rhythmicity
- daily locomotor pattern becomes attenuated in 6-8 week old mice but rhythmicity is retained
- daily locomotor rhythmicity restored by feeding restriction during dark phase

abnormal food intake
- food intake is about 60% of control level

abnormal learning/memory/conditioning

abnormal spatial learning
- longer swimming distances than control mice in a Morris water maze test

abnormal spatial reference memory
- cross the original platform location less frequently than do controls in a Morris water maze test

vision/eye phenotype

abnormal eye electrophysiology
- delays in oscillatory potentials 1, 2, 3 although only the delay in "OP1" is significant
- prolonged latency of the b-wave in the retina

endocrine/exocrine gland phenotype

increased glucagon secretion
- increased secreation of glucagon by pancreatic cells in culture

cardiovascular system phenotype

abnormal myocardial fiber morphology
- dense bodies present in places normally occupied by mitochondria
- disrupted sarcomeres sometimes
- presence of many lipid droplets

abnormal vascular development
- dense bodies found in the smooth muscle of intramyocardial arteries

muscle phenotype

abnormal myocardial fiber morphology
- dense bodies present in places normally occupied by mitochondria
- disrupted sarcomeres sometimes
- presence of many lipid droplets

Genotype: Lepr^db/Lepr^db
BKS.Cg-Dock7^m +/+ Lepr^db/OlaHsd

digestive/alimentary phenotype

abnormal digestive system physiology
- transepithelial resistance in the epithelium is reduced, indictive of a disrupted mucosal barrier function

abnormal intestinal epithelium morphology
- reduced levels of occludin in intestinal sections
- zonula occludens 1 has a discontinuous distribution

immune system phenotype

abnormal acute inflammation
- higher levels of endotoxin are found in portal blood (entotoxemia)

abnormal chemokine secretion
- increased release of monocyte chemo attractant protein by hepatic stellate cells

increased interleukin-6 secretion
- increased release by hepatic stellate cells

increased susceptibility to endotoxin shock
- increased succeptibility of hepatic stellate cells to LPS

liver inflammation

liver/biliary system phenotype

liver inflammation

Genotype: Lepr^db/Lepr^db
involves: C57BLKS/J

homeostasis/metabolism phenotype

abnormal glucose homeostasis

abnormal vascular wound healing
- reduced neointimal area relative to controls 4 weeks after femoral artery injury
- vascular smooth muscle proliferation significantly reduced

decreased circulating glucose level
- mice treated with adenovirus expressing Adipor1 (1.5-fold increase in liver expression), show decreased plasma glucose compared to wild-type
- mice treated with an adenovirus expressing Adipor2 (5-fold increase in liver expression), show decreased plasma glucose compared to wild-type

decreased circulating insulin level
- mice treated with an adenovirus expressing Adipor 2 show improved glucose resistance and decreased plasma insulin level

hyperglycemia
- at 12 weeks
- diabetes is improved after treatment with an adenovirus expressing Adipor1 or Adipor2

impaired adaptive thermogenesis
- mutants become hypothermic after a 12 hour fast
- mutants housed at 4 degrees C for 3.5 hours cannot maintain their body temperature like wild-type and drop about 1 degree in body temperature every 30 min until they reach 34 degrees C, at which point they stabilize this temperature, indicating decreased sympathetic activitysympathetic activity

impaired glucose tolerance

increased circulating corticosterone level

increased circulating glucose level
- plasma fasting glucose is increased

increased circulating insulin level
- fasting insulin is increased

increased circulating leptin level

increased urine protein level
- in females when compared to female controls
- levels of protein in urine similar in males and females but levels in males lower than in male controls

insulin resistance
- mice treated with an adenovirus expressing Adipor1 or Adipor 2 show improved insulin resistance

cardiovascular system phenotype

abnormal vascular wound healing
- reduced neointimal area relative to controls 4 weeks after femoral artery injury
- vascular smooth muscle proliferation significantly reduced

decreased systemic arterial blood pressure

endocrine/exocrine gland phenotype

abnormal pancreatic beta cell physiology
- beta cells exhibit DNA damage unlike control cells

growth/size/body region phenotype

decreased body length
- mutants are about 5% shorter than controls

increased body weight
- by four weeks of age

obese

reproductive system phenotype

abnormal endometrium morphology
- basal membrane of epithelial cells displays a folded contour at locations where lipid accumulates
- increased volume and density of lipid inclusion vacuoles
- tissue norepinephrin levels elevated by 4 weeks of age and remain elevated

abnormal uterus morphology

decreased uterus weight
- 1/3 normal tissue weight by 12 weeks
- decreased relative to controls by 4 weeks of age

vision/eye phenotype

abnormal intraocular pressure
- modest but significant elevation of intraocular pressure

behavior/neurological phenotype

abnormal conditioned taste aversion behavior
- aversion response is more strongly generalized from saccharin to sucrose
- lower aversion threshold for sucrose than in controls
- recovery from conditioned taste aversion is more rapid than in controls

polydipsia

polyphagia

renal/urinary system phenotype

abnormal kidney calyx morphology
- calyceal dilation eventually develops

abnormal kidney papilla morphology
- eventually becomes flattened

abnormal renal glomerulus morphology
- basement membrane becomes thickened with age
- large quantites if immunoglobulin and complement are found in the mesangium

increased urine protein level
- in females when compared to female controls
- levels of protein in urine similar in males and females but levels in males lower than in male controls

polyuria

immune system phenotype

increased susceptibility to autoimmune diabetes
- T cells from homozygous mice but not those from heterozygous mice suppressed the beta cell response to glucose + theophylline

nervous system phenotype

abnormal hypothalamus physiology
- hypothalamic uptake of norepinephrine is decreased in males

adipose tissue phenotype

increased total body fat amount
- increase in total fat content

Genotype: Lepr^db/Lepr^db
BKS.Cg-Dock7^m +/+ Lepr^db/Jcl

endocrine/exocrine gland phenotype

abnormal pancreas physiology
- at 8 weeks, pancreatic islet cell proliferation is increased compared to in heterozygous mice
- however, pancreatic islet cell proliferation by 16 weeks is normal

increased pancreatic beta cell mass

increased pancreatic islet cell apoptosis
- pancreatic islet cell apoptosis is increased compared to in heterozygous mice

homeostasis/metabolism phenotype

hyperglycemia

increased circulating insulin level

adipose tissue phenotype

abnormal epididymal fat pad morphology
- the epididymal fat pad exhibits macrophage infiltration unlike in wild-type mice

cellular phenotype

increased pancreatic islet cell apoptosis
- pancreatic islet cell apoptosis is increased compared to in heterozygous mice

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Dock7^m/Dock7^m
B6.D(Cg)-Dock7^m

adipose tissue phenotype

abnormal brown adipose tissue mass
- appears to be completely absent in neonatal mice

decreased white adipose tissue amount
- mice have 21% less inguinal adipose mass

growth/size/body region phenotype

decreased body length
- mutants are 8% shorter

decreased body weight
- mutants weigh 15% less

hematopoietic system phenotype

decreased platelet ADP level
- however, the platelet count, and platelet serotonin and ATP levels are normal
- platelet ADP levels are low

homeostasis/metabolism phenotype

increased bleeding time

Genotype: Dock7^m/Dock7^m
DBA/J

pigmentation phenotype

diluted coat color
- coat color is not as diluted as that of homozygous dilute (Myo5a^d) or homozygous leaden (Mlph^ln) mice
- individual hairs have more cortical pigment than found in homozygous dilute or homozygous leaden mice

variable body spotting
- white tail tip with or without a white belly spot

integument phenotype

diluted coat color
- coat color is not as diluted as that of homozygous dilute (Myo5a^d) or homozygous leaden (Mlph^ln) mice
- individual hairs have more cortical pigment than found in homozygous dilute or homozygous leaden mice

variable body spotting
- white tail tip with or without a white belly spot

Genotype: Lepr^db/Lepr⁺
B6.Cg-Dock7^m +/+ Lepr^db/J

mortality/aging

extended life span
- Background Sensitivity - survival when deprived of food is not as long as when in a C57BLKsS background
- increased survival when totally deprived of food than wild-type controls

growth/size/body region phenotype

increased body weight
- slight but significant increase in body weight compared to wild-type mice

Genotype: Lepr^db/Lepr^db
involves: C57BL/6 * C57BLKS/J

reproductive system phenotype

abnormal female reproductive system morphology

absent estrous cycle

absent estrus

female infertility

homeostasis/metabolism phenotype

abnormal oxygen consumption
- oxygen consumption normalized to lean mass is increased compared to wild-type controls but oxygen consumption normalized to metabolic size is decreased compared to wild-type controls

hyperglycemia

impaired adaptive thermogenesis
- thermoregulation in response to cold exposure is severely impaired compared to wild-type controls

impaired glucose tolerance

increased circulating glucose level

increased circulating insulin level

increased circulating leptin level

insulin resistance

growth/size/body region phenotype

decreased body length

decreased lean body mass

increased body weight

obese
- early onset obesity starting from 4 weeks of age

adipose tissue phenotype

increased percent body fat/body weight

behavior/neurological phenotype

abnormal eating behavior

hypoactivity
- decreased activity in both the light and dark cycle

polyphagia

limbs/digits/tail phenotype

short femur

skeleton phenotype

short femur

Genotype: Lepr^db/Lepr^db
involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

renal/urinary system phenotype

abnormal kidney morphology
- total kidney collagen is increased in females by 96%

abnormal renal glomerulus morphology
- glomerular extracellular matrix (ECM) area in females is increased by 31% compared to wild-type female controls and female single Serpine1-deficient animals; however, when expressed as fractional glomerular ECM area, little difference is observed between any genotypeany genotype

Genotype: Lepr^db/Lepr^db
B6.BKS(D)-Lepr^db/J

homeostasis/metabolism phenotype

abnormal response/metabolism to endogenous compounds
- mice treated with leptin fail to exhibit a decrease in food intake unlike similarly treated wild-type mice

decreased body temperature

decreased carbon dioxide production

decreased oxygen consumption

impaired glucose tolerance

insulin resistance

behavior/neurological phenotype

abnormal behavior
- faster in food finding trials relative to controls

hypoactivity
- during the dark phase

renal/urinary system phenotype

glomerulosclerosis
- homozygotes develop significant glomerulosclerosis by 18 weeks of age

Genotype: Lepr^db/Lepr^db
B6.Cg-Dock7^m +/+ Lepr^db/J

growth/size/body region phenotype

decreased body length
- snout to anus length is decreased by about 5% compared to wild-type mice

obese
- body weight is 10% and 20% more in males and females, respectively, compared to Leprr^tm1Mgmj homozygotes
- body weight is 2- to 3-fold more than in wild-type mice by 10 weeks of age
- develop progressive obesity
- increase in body weight becomes apparent at 4-6 weeks of age

hematopoietic system phenotype

abnormal leukocyte morphology

decreased leukocyte cell number
- decrease blood leukocyte numbers

increased neutrophil cell number
- increased numbers in bronchoalveolar lavage

nervous system phenotype

abnormal hypothalamus physiology

behavior/neurological phenotype

polyphagia

reduced male mating frequency

cardiovascular system phenotype

abnormal myocardial fiber morphology
- exhibit myocyte hypertrophy

heart left ventricle hypertrophy
- increase in left ventricle wall thickness and mass is seen by 6 months of age but not at 2 months of age
- induced weight loss via leptin infusion, but not via caloric restriction, partially resolves the hypertrophy

muscle phenotype

abnormal myocardial fiber morphology
- exhibit myocyte hypertrophy

homeostasis/metabolism phenotype

abnormal chemokine level
- elevated levels of eotaxin, keratinocyte cytokine, and monocyte chemotactic protein-1 (also elevated in serum) in bronchoalveolar lavage fluid

abnormal circulating cholesterol level

abnormal circulating lipid level
- Background Sensitivity - plasma lipid levels are similar at 3.5 and 14 months of age on the C57BL/6J background unlike on a C57BL/KsJ background
- HDL cholesterol and glucose levels increase concurrently

abnormal glucose homeostasis

abnormal hormone level
- female mice exhibit an increase in hypothalamic gonadotrophin releasing hormone compared to in wild-type mice

abnormal interleukin level
- elevated levels of IL-6 in bronchoalveolar lavage fluid

decreased adiponectin level
- decreased in serum

hyperglycemia

increased circulating HDL cholesterol level

increased circulating LDL cholesterol level

increased circulating VLDL cholesterol level

increased circulating cholesterol level
- fasting plasma total cholesterol concentration is increased 2 fold over controls

increased circulating glucose level

increased circulating insulin level

increased circulating interleukin-6 level
- elevated levels of IL-6 in serum

increased circulating leptin level

increased circulating triglyceride level
- triglyceride levels are elevated 1.5- to 2-fold

reproductive system phenotype

abnormal female reproductive system morphology
- atrophy of the reproductive organs

absent estrous cycle
- mice exhibit diestrous vaginal acyclicity or occasional metestrous acyclicity

absent estrus
- females never show signs of vaginal oestrous

anovulation

constricted vagina orifice

female infertility
- all females fail to reproduce

small uterus

respiratory system phenotype

abnormal functional residual capacity
- pressure volume curves shifted to the right
- reduced

abnormal lung compliance
- responsiveness to methacholine and serotonin is much greater than controls
- total lung resistance increases much more in response to ozone than in control mice

abnormal respiratory mechanics
- end-expiratory pause increases considerably less than in controls after ozone exposure

decreased pulmonary ventilation
- ventilation volumes decline with ozone exposure but to a lesser degree than for controls

lung inflammation
- elevated levels of eotaxin, Il6, keratinocyte cytokine, monocyte chemotactic protein-1, and neutrophiles in bronchoalveolar lavage as a result of ozone exposure
- elevated pulmonary levels of Il1beta mRNA 24 hours after ozone exposure
- elevated pulmonary levels of TNF mRNA 24 hours after ozone exposure but to a lesser extent than in controls
- ozone induces a nonsignificant elevation of TNFR2 levels
- ozone induces significantly elevated levels of TNFR1

immune system phenotype

abnormal chemokine level
- elevated levels of eotaxin, keratinocyte cytokine, and monocyte chemotactic protein-1 (also elevated in serum) in bronchoalveolar lavage fluid

abnormal interleukin level
- elevated levels of IL-6 in bronchoalveolar lavage fluid

abnormal leukocyte morphology

decreased leukocyte cell number
- decrease blood leukocyte numbers

increased circulating interleukin-6 level
- elevated levels of IL-6 in serum

increased neutrophil cell number
- increased numbers in bronchoalveolar lavage

lung inflammation
- elevated levels of eotaxin, Il6, keratinocyte cytokine, monocyte chemotactic protein-1, and neutrophiles in bronchoalveolar lavage as a result of ozone exposure
- elevated pulmonary levels of Il1beta mRNA 24 hours after ozone exposure
- elevated pulmonary levels of TNF mRNA 24 hours after ozone exposure but to a lesser extent than in controls
- ozone induces a nonsignificant elevation of TNFR2 levels
- ozone induces significantly elevated levels of TNFR1

neoplasm

increased metastatic potential
- increased metastasis to the lung of both melanoma cell lines and lung cancer cell lines initially injected in the tail vein

Genotype: Lepr^db/Lepr^db
FVB.BKS-Lepr^db

growth/size/body region phenotype

obese
- mice of both sexes are obese

homeostasis/metabolism phenotype

abnormal circulating glucose level
- Background Sensitivity - after a 2-day fast on refeeding with carbohydrate-free diet, female obese mice show a rise in glucose

hyperglycemia
- Background Sensitivity - obese mice have a prolonged period of hyperglycemia compared to obese B6.BKS-Lepr^db mice where glucose levels rarely exceed 250 mg/dl
- fasting mice are hyperglycemic at 3 months of age, while obese B6.BKS-Lepr^db fasted mice are euglycemic
- levels increase from 5 to 7 months in obese females to ~500 ng/ml, significantly higher than the males (~40 ng/ml) or obese B6.BKS-Lepr^db females (~50 ng/ml)

impaired glucose tolerance
- Background Sensitivity - at 7 months of age obese males are severely glucose intolerant with glucose levels of >400 mg/dl 90 minutes after glucose load compared to obese B6.BKS-Lepr^db mice clear glucose load by 90 min
- Background Sensitivity - obese mice show a rapid increase of blood glucose above 400 mg/dl with diminished rate of glucose clearance

increased circulating insulin level
- Background Sensitivity - at 3 months of age, females show a trend toward higher insulin levels compared to obese B6.BKS-Lepr^db females; at 5-7 months insulin levels (~500 ng/ml) are ~10-fold higher than levels in obese female obese B6.BKS-Lepr^db mice (~50 ng/ml)/ml)

insulin resistance
- at 7 months of age, 3U/kg of insulin does not alter circulating glucose levels, while in B6.BKS-Lepr mice, glucose decreases by 50% by 40 minutes; 12U/kg insulin does not cause a decrease in glucose in obese female mice on the FVB background
- at a dose of 3U/kg 6-week old mice show a diminished response to insulin
- circulating insulin levels in the fed state show that obese mice have exteme insulin resistance

endocrine/exocrine gland phenotype

increased pancreatic beta cell number
- obese mice show massive expansion of beta cells (744 insulin +ve cells/islet cross-section in obese vs 165 +ve cells in lean mice); there are 4.5-fold more cells per islet cross-section in obese mice

pancreatic islet hyperplasia
- some islets in obese mice have more than 1000 cells per cross section; such islets are absent in lean mice

renal/urinary system phenotype

abnormal renal glomerulus morphology
- at 7 months of age, obese mice show an increased mesangial matrix in most glomeruli compared to lean controls, resembling diabetic nephropathy; some small glomeruli have separated from the capsule with nearly obliterated microtubules

Phenotype Information

Body Weight Information - JAX^® Mice Strain BKS.Cg-Dock7^m +/+ Lepr^db/J (000642)

Phenotype details on BKS.Cg-Dock7^m +/+ Lepr^db/J

References

Chen H; Charlat O; Tartaglia LA; Woolf EA; Weng X; Ellis SJ; Lakey ND; Culpepper J; Moore KJ; Breitbart RE; Duyk GM; Tepper RI; Morgenstern JP. 1996. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84(3):491-5. PubMed: 8608603 MGI: J:31324
Chua SC Jr; Chung WK; Wu-Peng XS; Zhang Y; Liu SM; Tartaglia L; Leibel RL. 1996. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor [see comments] Science 271(5251):994-6. PubMed: 8584938 MGI: J:31419
Dardenne M; Savino W; Bach JF. 1984. Autoimmune mice develop antibodies to thymic hormone: production of anti-thymulin monoclonal autoantibodies from diabetic (db/db) and B/W mice. J Immunol 133(2):740-3. PubMed: 6539799 MGI: J:109953
Fantuzzi G; Faggioni R. 2000. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 68(4):437-46. PubMed: 11037963 MGI: J:109886
Gueorguiev M; Goth ML; Korbonits M. 2001. Leptin and puberty: a review. Pituitary 4(1-2):79-86. PubMed: 11824512 MGI: J:109856
Hummel KP; Dickie MM; Coleman DL. 1966. Diabetes, a new mutation in the mouse. Science 153(740):1127-8. PubMed: 5918576 MGI: J:5010
Kampfer H; Paulukat J; Muhl H; Wetzler C; Pfeilschifter J; Frank S. 2000. Lack of interferon-gamma production despite the presence of interleukin-18 during cutaneous wound healing. Mol Med 6(12):1016-27. PubMed: 11474118 MGI: J:109870
Lee GH; Proenca R; Montez JM; Carroll KM; Darvishzadeh JG; Lee JI; Friedman JM. 1996. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379(6566):632-5. PubMed: 8628397 MGI: J:31327
Leiter EH; Chapman HD. 1994. Obesity-induced diabetes (diabesity) in C57BL/KsJ mice produces aberrant trans-regulation of sex steroid sulfotransferase genes. J Clin Invest 93(5):2007-13. PubMed: 8182132 MGI: J:17991
Mandel MA; Mahmoud AA. 1978. Impairment of cell-mediated immunity in mutation diabetic mice (db/db). J Immunol 120(4):1375-7. PubMed: 347001 MGI: J:109964
Serreze DV; Leiter EH; Kuff EL; Jardieu P; Ishizaka K. 1988. Molecular mimicry between insulin and retroviral antigen p73. Development of cross-reactive autoantibodies in sera of NOD and C57BL/KsJ db/db mice. Diabetes 37(3):351-8. PubMed: 3286334 MGI: J:27625
Yoon JW; Leiter EH; Coleman DL; Kim MK; Pak CY; McArthur RG; Roncari DA. 1988. Genetic control of organ-reactive autoantibody production in mice by obesity (ob) diabetes (db) genes. Diabetes 37(9):1287-93. PubMed: 3044893 MGI: J:109940

Additional References

Bahary N; Leibel RL; Joseph L; Friedman JM. 1990. Molecular mapping of the mouse db mutation. Proc Natl Acad Sci U S A 87(21):8642-6. PubMed: 1978328 MGI: J:10819
Barinaga M. 1996. Researchers nail down leptin receptor [news; comment] Science 271(5251):913. PubMed: 8584929 MGI: J:31488
Bouchard G; Johnson D; Carver T; Paigen B; Carey MC. 2002. Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk. J Lipid Res 43(7):1105-13. PubMed: 12091495 MGI: J:88773
Cohen MP; Sharma K; Jin Y; Hud E; Wu VY; Tomaszewski J; Ziyadeh FN. 1995. Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists. A novel treatment strategy. J Clin Invest 95(5):2338-45. PubMed: 7738197 MGI: J:24919
Coleman DL. 1979. Obesity genes: beneficial effects in heterozygous mice. Science 203(4381):663-5. PubMed: 760211 MGI: J:6081
Coleman DL. 1978. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14(3):141-8. PubMed: 350680 MGI: J:5986
Coleman DL; Hummel KP. 1973. The influence of genetic background on the expression of the obese (Ob) gene in the mouse. Diabetologia 9(4):287-93. PubMed: 4588246 MGI: J:5400
Debray-Sachs M; Sai P; Boitard C; Assan R; Hamburger J. 1983. Anti-pancreatic immunity in genetically diabetic mice. Clin Exp Immunol 51(1):1-7. PubMed: 6339122 MGI: J:7005
Di Marzo V; Goparaju SK; Wang L; Liu J; Batkai S; Jarai Z; Fezza F; Miura GI; Palmiter RD; Sugiura T; Kunos G. 2001. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410(6830):822-5. PubMed: 11298451 MGI: J:68834
Fiedorek FT Jr; Kay ES. 1994. Mapping of PCR-based markers for mouse chromosome 4 on a backcross penetrant for the misty (m) mutation. Mamm Genome 5(8):479-85. PubMed: 7949731 MGI: J:20039
Garris DR. 1988. Reproductive tract and pancreatic norepinephrine levels in pre- and overt-diabetic C57BL/KsJ mice: relationship to body weight, blood glucose, serum insulin, and reproductive dysfunction. Proc Soc Exp Biol Med 189(1):79-83. PubMed: 3054905 MGI: J:35691
Giacomelli F; Wiener J. 1979. Primary myocardial disease in the diabetic mouse. An ultrastructural study. Lab Invest 40(4):460-73. PubMed: 431046 MGI: J:6115
Gilbertson DG; Duff ME; West JW; Kelly JD; Sheppard PO; Hofstrand PD; Gao Z; Shoemaker K; Bukowski TR; Moore M; Feldhaus AL; Humes JM; Palmer TE; Hart CE. 2001. Platelet-derived Growth Factor C (PDGF-C), a Novel Growth Factor That Binds to PDGF alpha and beta Receptor. J Biol Chem 276(29):27406-14. PubMed: 11297552 MGI: J:70550
Harris RB; Mitchell TD; Yan X; Simpson JS; Redmann SM Jr. 2001. Metabolic responses to leptin in obese db/db mice are strain dependent. Am J Physiol Regul Integr Comp Physiol 281(1):R115-32. PubMed: 11404285 MGI: J:70291
He H; Liu R; Desta T; Leone C; Gerstenfeld LC; Graves DT. 2004. Diabetes causes decreased osteoclastogenesis, reduced bone formation, and enhanced apoptosis of osteoblastic cells in bacteria stimulated bone loss. Endocrinology 145(1):447-52. PubMed: 14525917 MGI: J:87439
Herberg L; Coleman DL. 1977. Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism 26(1):59-99. PubMed: 834144 MGI: J:5759
Jacobi J; Jang JJ; Sundram U; Dayoub H; Fajardo LF; Cooke JP. 2002. Nicotine accelerates angiogenesis and wound healing in genetically diabetic mice. Am J Pathol 161(1):97-104. PubMed: 12107094 MGI: J:77831
Johnson LM; Sidman RL. 1979. A reproductive endocrine profile in the diabetes (db) mutant mouse. Biol Reprod 20(3):552-9. PubMed: 378276 MGI: J:6157
Kawai K; Sugimoto K; Nakashima K; Miura H; Ninomiya Y. 2000. Leptin as a modulator of sweet taste sensitivities in mice Proc Natl Acad Sci U S A 97(20):11044-9. PubMed: 10995460 MGI: J:64744
Leiter EH; Chapman HD; Coleman DL. 1989. The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. V. Interaction between the db gene and hepatic sex steroid sulfotransferases correlates with gender-dependent susceptibility to hyperglycemia. Endocrinology 124(2):912-22. PubMed: 2912706 MGI: J:26013
Leiter EH; Coleman DL; Eppig JJ. 1979. Endocrine pancreatic cells of postnatal diabetes (db) mice in cell culture. In Vitro 15(7):507-21. PubMed: 393618 MGI: J:6264
Manodori AB; Kuypers FA. 2002. Altered red cell turnover in diabetic mice. J Lab Clin Med 140(3):161-5. PubMed: 12271273 MGI: J:79265
Memon RA; Tecott LH; Nonogaki K; Beigneux A; Moser AH; Grunfeld C; Feingold KR. 2000. Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice [In Process Citation] Endocrinology 141(11):4021-31. PubMed: 11089532 MGI: J:65569
Norido F; Canella R; Zanoni R; Gorio A. 1984. Development of diabetic neuropathy in the C57BL/Ks (db/db) mouse and its treatment with gangliosides. Exp Neurol 83(2):221-32. PubMed: 6692864 MGI: J:7294
Peppa M; Brem H; Ehrlich P; Zhang JG; Cai W; Li Z; Croitoru A; Thung S; Vlassara H. 2003. Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice. Diabetes 52(11):2805-13. PubMed: 14578300 MGI: J:86304
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298
Robertson DM; Sima AA. 1980. Diabetic neuropathy in the mutant mouse [C57BL/ks(db/db)]: a morphometric study. Diabetes 29(1):60-7. PubMed: 6991317 MGI: J:6323
Schmidt RE; Dorsey DA; Beaudet LN; Frederick KE; Parvin CA; Plurad SB; Levisetti MG. 2003. Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: a new experimental model of diabetic autonomic neuropathy. Am J Pathol 163(5):2077-91. PubMed: 14578206 MGI: J:86318
Semeniuk LM; Kryski AJ; Severson DL. 2002. Echocardiographic assessment of cardiac function in diabetic db/db and transgenic db/db-hGLUT4 mice. Am J Physiol Heart Circ Physiol 283(3):H976-82. PubMed: 12181126 MGI: J:78898
Shao J; Yamashita H; Qiao L; Draznin B; Friedman JE. 2002. Phosphatidylinositol 3-kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus. Diabetes 51(1):19-29. PubMed: 11756318 MGI: J:73759
Sviderskaya EV; Novak EK; Swank RT; Bennett DC. 1998. The murine misty mutation: phenotypic effects on melanocytes, platelets and brown fat. Genetics 148(1):381-90. PubMed: 9475748 MGI: J:45425
Teixeira SR; Tappenden KA; Erdman JW Jr. 2003. Altering dietary protein type and quantity reduces urinary albumin excretion without affecting plasma glucose concentrations in BKS.cg-m +Lepr db/+Lepr db (db/db) mice. J Nutr 133(3):673-8. PubMed: 12612136 MGI: J:82219
Trayhurn P. 1979. Thermoregulation in the diabetic-obese (db/db) mouse. The role of non-shivering thermogenesis in energy balance. Pflugers Arch 380(3):227-32. PubMed: 573463 MGI: J:6202
Truett GE; Tempelman RJ; Walker JA; Wilson JK. 1998. Misty (m) affects growth traits. Am J Physiol 275(1 Pt 2):R29-32. PubMed: 9688956 MGI: J:48831
Ueki K; Kondo T; Kahn CR. 2004. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 24(12):5434-46. PubMed: 15169905 MGI: J:91027
Wang YX; Lee CH; Tiep S; Yu RT; Ham J; Kang H; Evans RM. 2003. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 113(2):159-70. PubMed: 12705865 MGI: J:83119
Wendt TM; Tanji N; Guo J; Kislinger TR; Qu W; Lu Y; Bucciarelli LG; Rong LL; Moser B; Markowitz GS; Stein G; Bierhaus A; Liliensiek B; Arnold B; Nawroth PP; Stern DM; D'Agati VD; Schmidt AM. 2003. RAGE Drives the Development of Glomerulosclerosis and Implicates Podocyte Activation in the Pathogenesis of Diabetic Nephropathy. Am J Pathol 162(4):1123-37. PubMed: 12651605 MGI: J:82491
Werner S; Breeden M; Hubner G; Greenhalgh DG; Longaker MT. 1994. Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse. J Invest Dermatol 103(4):469-73. PubMed: 7930669 MGI: J:20802
Won Hong S; Isono M; Chen S; Iglesias-De La Cruz MC; Han DC; Ziyadeh FN. 2001. Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse. Am J Pathol 158(5):1653-63. PubMed: 11337363 MGI: J:69101

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Gilbert RE; Thai K; Advani SL; Cummins CL; Kepecs DM; Schroer SA; Woo M; Zhang Y. 2015. SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes. Diabetologia 58(4):819-27. PubMed: 25563725 MGI: J:220749
Hamilton RT; Bhattacharya A; Walsh ME; Shi Y; Wei R; Zhang Y; Rodriguez KA; Buffenstein R; Chaudhuri AR; Van Remmen H. 2013. Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination. PLoS One 8(6):e65725. PubMed: 23750273 MGI: J:204258
Hirukawa H; Kaneto H; Shimoda M; Kimura T; Okauchi S; Obata A; Kohara K; Hamamoto S; Tawaramoto K; Hashiramoto M; Kaku K. 2015. Combination of DPP-4 inhibitor and PPARgamma agonist exerts protective effects on pancreatic beta-cells in diabetic db/db mice through the augmentation of IRS-2 expression. Mol Cell Endocrinol 413:49-60. PubMed: 26116826 MGI: J:227036
Iwakura H; Akamizu T; Ariyasu H; Irako T; Hosoda K; Nakao K; Kangawa K. 2007. Effects of ghrelin administration on decreased growth hormone status in obese animals. Am J Physiol Endocrinol Metab 293(3):E819-25. PubMed: 17595213 MGI: J:125421
Jung YJ; Choi HJ; Lee JE; Lee AS; Kang KP; Lee S; Park SK; Park TS; Jin HY; Lee SY; Kim DH; Kim W. 2012. The effects of designed angiopoietin-1 variant on lipid droplet diameter, vascular endothelial cell density and metabolic parameters in diabetic db/db mice. Biochem Biophys Res Commun 420(3):498-504. PubMed: 22430141 MGI: J:183490
Kanda Y; Shimoda M; Hamamoto S; Tawaramoto K; Kawasaki F; Hashiramoto M; Nakashima K; Matsuki M; Kaku K. 2010. Molecular mechanism by which pioglitazone preserves pancreatic beta-cells in obese diabetic mice: evidence for acute and chronic actions as a PPARgamma agonist. Am J Physiol Endocrinol Metab 298(2):E278-86. PubMed: 19920213 MGI: J:170065
Lee Y; Dominy JE; Choi YJ; Jurczak M; Tolliday N; Camporez JP; Chim H; Lim JH; Ruan HB; Yang X; Vazquez F; Sicinski P; Shulman GI; Puigserver P. 2014. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature 510(7506):547-51. PubMed: 24870244 MGI: J:213271
Li M; Wang X; Aa J; Qin W; Zha W; Ge Y; Liu L; Zheng T; Cao B; Shi J; Zhao C; Wang X; Yu X; Wang G; Liu Z. 2013. GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy. Am J Physiol Renal Physiol 304(11):F1317-24. PubMed: 23467425 MGI: J:197264
Loeffler I; Ruster C; Franke S; Liebisch M; Wolf G. 2013. Erythropoietin ameliorates podocyte injury in advanced diabetic nephropathy in the db/db mouse. Am J Physiol Renal Physiol 305(6):F911-8. PubMed: 23825071 MGI: J:200934
Long J; Badal SS; Ye Z; Wang Y; Ayanga BA; Galvan DL; Green NH; Chang BH; Overbeek PA; Danesh FR. 2016. Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy. J Clin Invest 126(11):4205-4218. PubMed: 27760051 MGI: J:239614
Marquard J; Otter S; Welters A; Stirban A; Fischer A; Eglinger J; Herebian D; Kletke O; Klemen MS; Stozer A; Wnendt S; Piemonti L; Kohler M; Ferrer J; Thorens B; Schliess F; Rupnik MS; Heise T; Berggren PO; Klocker N; Meissner T; Mayatepek E; Eberhard D; Kragl M; Lammert E. 2015. Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment. Nat Med 21(4):363-72. PubMed: 25774850 MGI: J:228179
Matoba K; Kawanami D; Tsukamoto M; Kinoshita J; Ito T; Ishizawa S; Kanazawa Y; Yokota T; Murai N; Matsufuji S; Utsunomiya K. 2014. Rho-kinase regulation of TNF-alpha-induced nuclear translocation of NF-kappaB RelA/p65 and M-CSF expression via p38 MAPK in mesangial cells. Am J Physiol Renal Physiol 307(5):F571-80. PubMed: 25007875 MGI: J:214236
Mazagova M; Buikema H; Landheer SW; Vavrinec P; Buiten Av; Henning RH; Deelman LE. 2013. Growth differentiation factor 15 impairs aortic contractile and relaxing function through altered caveolar signaling of the endothelium. Am J Physiol Heart Circ Physiol 304(5):H709-18. PubMed: 23262134 MGI: J:194601
Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1990. Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285] Genetics 125(2):421-30. PubMed: 2379821 MGI: J:29467
Neschen S; Scheerer M; Seelig A; Huypens P; Schultheiss J; Wu M; Wurst W; Rathkolb B; Suhre K; Wolf E; Beckers J; Hrabe de Angelis M. 2015. Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 inhibitor by suppressing endogenous glucose production in diabetic mice. Diabetes 64(1):284-90. PubMed: 25071027 MGI: J:225213
Neuhofer A; Zeyda M; Mascher D; Itariu BK; Murano I; Leitner L; Hochbrugger EE; Fraisl P; Cinti S; Serhan CN; Stulnig TM. 2013. Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. Diabetes 62(6):1945-56. PubMed: 23349501 MGI: J:208560
Nuno DW; Harrod JS; Lamping KG. 2009. Sex-dependent differences in Rho activation contribute to contractile dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol 297(4):H1469-77. PubMed: 19666843 MGI: J:154218
O'Neill CM; Lu C; Corbin KL; Sharma PR; Dula SB; Carter JD; Ramadan JW; Xin W; Lee JK; Nunemaker CS. 2013. Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice. Endocrinology 154(9):3077-88. PubMed: 23836031 MGI: J:202248
Olmsted-Davis E; Gannon FH; Ozen M; Ittmann MM; Gugala Z; Hipp JA; Moran KM; Fouletier-Dilling CM; Schumara-Martin S; Lindsey RW; Heggeness MH; Brenner MK; Davis AR. 2007. Hypoxic adipocytes pattern early heterotopic bone formation. Am J Pathol 170(2):620-32. PubMed: 17255330 MGI: J:117897
Park CW; Kim HW; Lim JH; Yoo KD; Chung S; Shin SJ; Chung HW; Lee SJ; Chae CB; Kim YS; Chang YS. 2009. Vascular endothelial growth factor inhibition by dRK6 causes endothelial apoptosis, fibrosis, and inflammation in the heart via the Akt/eNOS axis in db/db mice. Diabetes 58(11):2666-76. PubMed: 19675133 MGI: J:154385
San Martin A; Du P; Dikalova A; Lassegue B; Aleman M; Gongora MC; Brown K; Joseph G; Harrison DG; Taylor WR; Jo H; Griendling KK. 2007. Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes. Am J Physiol Heart Circ Physiol 292(5):H2073-82. PubMed: 17237245 MGI: J:125944
Schatteman GC; Awad O; Nau E; Wang C; Jiao C; Tomanek RJ; Dunnwald M. 2010. Lin- cells mediate tissue repair by regulating MCP-1/CCL-2. Am J Pathol 177(4):2002-10. PubMed: 20813969 MGI: J:165434
Shimoda M; Kanda Y; Hamamoto S; Tawaramoto K; Hashiramoto M; Matsuki M; Kaku K. 2011. The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes. Diabetologia :. PubMed: 21340625 MGI: J:169587
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. MGI: J:78801
Streicher C; Zeitz U; Andrukhova O; Rupprecht A; Pohl E; Larsson TE; Windisch W; Lanske B; Erben RG. 2012. Long-term Fgf23 deficiency does not influence aging, glucose homeostasis, or fat metabolism in mice with a nonfunctioning vitamin D receptor. Endocrinology 153(4):1795-805. PubMed: 22294750 MGI: J:183813
Sviderskaya EV; Novak EK; Swank RT; Bennett DC. 1998. The murine misty mutation: phenotypic effects on melanocytes, platelets and brown fat. Genetics 148(1):381-90. PubMed: 9475748 MGI: J:45425
Swank RT; Novak EK; McGarry MP; Rusiniak ME; Feng L. 1998. Mouse models of Hermansky Pudlak syndrome: a review. Pigment Cell Res 11(2):60-80. PubMed: 9585243 MGI: J:88018
Syeda MM; Jing X; Mirza RH; Yu H; Sellers RS; Chi Y. 2012. Prostaglandin transporter modulates wound healing in diabetes by regulating prostaglandin-induced angiogenesis. Am J Pathol 181(1):334-46. PubMed: 22609345 MGI: J:185546
Tocchetti CG; Caceres V; Stanley BA; Xie C; Shi S; Watson WH; O'Rourke B; Spadari-Bratfisch RC; Cortassa S; Akar FG; Paolocci N; Aon MA. 2012. GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice. Diabetes 61(12):3094-105. PubMed: 22807033 MGI: J:208512
Truett GE; Tempelman RJ; Walker JA; Wilson JK. 1998. Misty (m) affects growth traits. Am J Physiol 275(1 Pt 2):R29-32. PubMed: 9688956 MGI: J:48831
Velmurugan GV; Sundaresan NR; Gupta MP; White C. 2013. Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes. Cardiovasc Res 100(1):143-50. PubMed: 23715558 MGI: J:219478
Velmurugan GV; White C. 2012. Calcium homeostasis in vascular smooth muscle cells is altered in type 2 diabetes by Bcl-2 protein modulation of InsP3R calcium release channels. Am J Physiol Heart Circ Physiol 302(1):H124-34. PubMed: 22037186 MGI: J:181575
Wang H; Liu A; Kuo Y; Chi E; Yang X; Zhang L; Yang CS. 2016. Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation of Apc. Carcinogenesis 37(7):723-30. PubMed: 27207656 MGI: J:232782
Wendt TM; Tanji N; Guo J; Kislinger TR; Qu W; Lu Y; Bucciarelli LG; Rong LL; Moser B; Markowitz GS; Stein G; Bierhaus A; Liliensiek B; Arnold B; Nawroth PP; Stern DM; D'Agati VD; Schmidt AM. 2003. RAGE Drives the Development of Glomerulosclerosis and Implicates Podocyte Activation in the Pathogenesis of Diabetic Nephropathy. Am J Pathol 162(4):1123-37. PubMed: 12651605 MGI: J:82491
Woolley GW. 1945. Misty dilution in the mouse J Hered 36:269-70. MGI: J:311
Woolley GW. 1941. "Misty," a new coat color dilution in the mouse, Mus musculus. Am Naturalist 75:507-508. MGI: J:12159
Xu J; Wu W; Zhang L; Dorset-Martin W; Morris MW; Mitchell ME; Liechty KW. 2012. The role of microRNA-146a in the pathogenesis of the diabetic wound-healing impairment: correction with mesenchymal stem cell treatment. Diabetes 61(11):2906-12. PubMed: 22851573 MGI: J:208507
Yaguchi H; Togawa K; Moritani M; Itakura M. 2005. Identification of candidate genes in the type 2 diabetes modifier locus using expression QTL. Genomics 85(5):591-9. PubMed: 15820311 MGI: J:97535
Yamamoto N; Matsubara T; Sobue K; Tanida M; Kasahara R; Naruse K; Taniura H; Sato T; Suzuki K. 2012. Brain insulin resistance accelerates Abeta fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes. J Neurochem 121(4):619-28. PubMed: 22260232 MGI: J:184309
Yang G; Cancino GI; Zahr SK; Guskjolen A; Voronova A; Gallagher D; Frankland PW; Kaplan DR; Miller FD. 2016. A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring. Cell Rep 17(4):1022-1036. PubMed: 27760310 MGI: J:240757
Yang J; Park Y; Zhang H; Gao X; Wilson E; Zimmer W; Abbott L; Zhang C. 2009. Role of MCP-1 in tumor necrosis factor-alpha-induced endothelial dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol 297(4):H1208-16. PubMed: 19666844 MGI: J:154217
Yang Y; Gurung B; Wu T; Wang H; Stoffers DA; Hua X. 2010. Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene. Proc Natl Acad Sci U S A 107(47):20358-63. PubMed: 21059956 MGI: J:166586
Zhang H; Chen Q; Jiao T; Cui A; Sun X; Fang W; Xie L; Liu Y; Fang F; Chang Y. 2014. Involvement of KLF11 in hepatic glucose metabolism in mice via suppressing of PEPCK-C expression. PLoS One 9(2):e89552. PubMed: 24586865 MGI: J:213818
Zhong X; Chung AC; Chen HY; Dong Y; Meng XM; Li R; Yang W; Hou FF; Lan HY. 2013. miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes. Diabetologia 56(3):663-74. PubMed: 23292313 MGI: J:194766
Zimmermann C; Cederroth CR; Bourgoin L; Foti M; Nef S. 2012. Prevention of diabetes in db/db mice by dietary soy is independent of isoflavone levels. Endocrinology 153(11):5200-11. PubMed: 22962258 MGI: J:191798

Additional - Lepr^db related

Aasum E; Hafstad AD; Severson DL; Larsen TS. 2003. Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice. Diabetes 52(2):434-41. PubMed: 12540618 MGI: J:107138
Abe H; Uchida T; Hara A; Mizukami H; Komiya K; Koike M; Shigihara N; Toyofuku Y; Ogihara T; Uchiyama Y; Yagihashi S; Fujitani Y; Watada H. 2013. Exendin-4 improves beta-cell function in autophagy-deficient beta-cells. Endocrinology 154(12):4512-24. PubMed: 24105478 MGI: J:205147
Absood A; Gandomani B; Zaki A; Nasta V; Michail A; Habib PM; Hodish I. 2013. Insulin therapy for pre-hyperglycemic beta-cell endoplasmic reticulum crowding. PLoS One 8(2):e54351. PubMed: 23408938 MGI: J:198317
Adkison DL; Sundberg JP. 1991. Lipomatous hamartomas and choristomas in inbred laboratory mice. Vet Pathol 28(4):305-12. PubMed: 1949510 MGI: J:2714
Agarwal P; Srivastava R; Srivastava AK; Ali S; Datta M. 2013. miR-135a targets IRS2 and regulates insulin signaling and glucose uptake in the diabetic gastrocnemius skeletal muscle. Biochim Biophys Acta 1832(8):1294-303. PubMed: 23579070 MGI: J:202403
Ahima RS; Prabakaran D; Flier JS. 1998. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function. J Clin Invest 101(5):1020-7. PubMed: 9486972 MGI: J:118976
Akamatsu Y; Nishijima Y; Lee CC; Yang SY; Shi L; An L; Wang RK; Tominaga T; Liu J. 2015. Impaired Leptomeningeal Collateral Flow Contributes to the Poor Outcome following Experimental Stroke in the Type 2 Diabetic Mice. J Neurosci 35(9):3851-64. PubMed: 25740515 MGI: J:219934
Akasaka Y; Tsunoda M; Ogata T; Ide T; Murakami K. 2010. Direct evidence for leptin-induced lipid oxidation independent of long-form leptin receptor. Biochim Biophys Acta 1801(10):1115-22. PubMed: 20601111 MGI: J:165456
Akpinar P; Kuwajima S; Krutzfeldt J; Stoffel M. 2005. Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation. Cell Metab 2(6):385-97. PubMed: 16330324 MGI: J:129667
Al-Mashat HA; Kandru S; Liu R; Behl Y; Desta T; Graves DT. 2006. Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing. Diabetes 55(2):487-95. PubMed: 16443785 MGI: J:106866
Alberts P; Nilsson C; Selen G; Engblom LO; Edling NH; Norling S; Klingstrom G; Larsson C; Forsgren M; Ashkzari M; Nilsson CE; Fiedler M; Bergqvist E; Ohman B; Bjorkstrand E; Abrahmsen LB. 2003. Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology 144(11):4755-62. PubMed: 12960099 MGI: J:87239
Algamas-Dimantov A; Davidovsky D; Ben-Ari J; Kang JX; Peri I; Hertz R; Bar-Tana J; Schwartz B. 2012. Amelioration of diabesity-induced colorectal ontogenesis by omega-3 fatty acids in mice. J Lipid Res 53(6):1056-70. PubMed: 22357704 MGI: J:184929
Ali MI; Ketsawatsomkron P; Belin de Chantemele EJ; Mintz JD; Muta K; Salet C; Black SM; Tremblay ML; Fulton DJ; Marrero MB; Stepp DW. 2009. Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone. Circ Res 105(10):1013-22. PubMed: 19797171 MGI: J:169952
Alipio Z; Liao W; Roemer EJ; Waner M; Fink LM; Ward DC; Ma Y. 2010. Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells. Proc Natl Acad Sci U S A 107(30):13426-31. PubMed: 20616080 MGI: J:162403
Allen RJ Jr; Soares MA; Haberman ID; Szpalski C; Schachar J; Lin CD; Nguyen PD; Saadeh PB; Warren SM. 2014. Combination therapy accelerates diabetic wound closure. PLoS One 9(3):e92667. PubMed: 24651576 MGI: J:215069
Alonso-Magdalena P; Ropero AB; Garcia-Arevalo M; Soriano S; Quesada I; Muhammed SJ; Salehi A; Gustafsson JA; Nadal A. 2013. Antidiabetic actions of an estrogen receptor beta selective agonist. Diabetes 62(6):2015-25. PubMed: 23349481 MGI: J:208572
Altarejos JY; Goebel N; Conkright MD; Inoue H; Xie J; Arias CM; Sawchenko PE; Montminy M. 2008. The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med 14(10):1112-7. PubMed: 18758446 MGI: J:142448
Altomonte J; Cong L; Harbaran S; Richter A; Xu J; Meseck M; Dong HH. 2004. Foxo1 mediates insulin action on apoC-III and triglyceride metabolism. J Clin Invest 114(10):1493-503. PubMed: 15546000 MGI: J:94423
Amin A; Choi SK; Galan M; Kassan M; Partyka M; Kadowitz P; Henrion D; Trebak M; Belmadani S; Matrougui K. 2012. Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice. J Pathol 227(2):165-74. PubMed: 22081301 MGI: J:183318
Amin AH; Abd Elmageed ZY; Nair D; Partyka MI; Kadowitz PJ; Belmadani S; Matrougui K. 2010. Modified multipotent stromal cells with epidermal growth factor restore vasculogenesis and blood flow in ischemic hind-limb of type II diabetic mice. Lab Invest 90(7):985-96. PubMed: 20440273 MGI: J:162143
Anzawa R; Bernard M; Tamareille S; Baetz D; Confort-Gouny S; Gascard JP; Cozzone P; Feuvray D. 2006. Intracellular sodium increase and susceptibility to ischaemia in hearts from type 2 diabetic db/db mice. Diabetologia 49(3):598-606. PubMed: 16425033 MGI: J:107891
Aoki K; Saito T; Satoh S; Mukasa K; Kaneshiro M; Kawasaki S; Okamura A; Sekihara H. 1999. Dehydroepiandrosterone suppresses the elevated hepatic glucose-6-phosphatase and fructose-1,6-bisphosphatase activities in C57BL/Ksj-db/db mice: comparison with troglitazone. Diabetes 48(8):1579-85. PubMed: 10426376 MGI: J:56421
Ardestani A; Sauter NS; Paroni F; Dharmadhikari G; Cho JH; Lupi R; Marchetti P; Oberholzer J; Conte JK; Maedler K. 2011. Neutralizing Interleukin-1{beta} (IL-1{beta}) Induces {beta}-Cell Survival by Maintaining PDX1 Protein Nuclear Localization. J Biol Chem 286(19):17144-55. PubMed: 21393239 MGI: J:172695
Ariyasu H; Takaya K; Hosoda H; Iwakura H; Ebihara K; Mori K; Ogawa Y; Hosoda K; Akamizu T; Kojima M; Kangawa K; Nakao K. 2002. Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin. Endocrinology 143(9):3341-50. PubMed: 12193546 MGI: J:81463
Arounleut P; Bowser M; Upadhyay S; Shi XM; Fulzele S; Johnson MH; Stranahan AM; Hill WD; Isales CM; Hamrick MW. 2013. Absence of functional leptin receptor isoforms in the POUND (Lepr(db/lb)) mouse is associated with muscle atrophy and altered myoblast proliferation and differentiation. PLoS One 8(8):e72330. PubMed: 23967295 MGI: J:204438
Arroba AI; Valverde AM. 2015. Inhibition of Protein Tyrosine Phosphatase 1B Improves IGF-I Receptor Signaling and Protects Against Inflammation-Induced Gliosis in the Retina. Invest Ophthalmol Vis Sci 56(13):8031-44. PubMed: 26720454 MGI: J:231029
Asahara S; Matsuda T; Kido Y; Kasuga M. 2009. Increased ribosomal biogenesis induces pancreatic beta cell failure in mice model of type 2 diabetes. Biochem Biophys Res Commun 381(3):367-71. PubMed: 19309774 MGI: J:147192
Asai J; Takenaka H; Hirakawa S; Sakabe J; Hagura A; Kishimoto S; Maruyama K; Kajiya K; Kinoshita S; Tokura Y; Katoh N. 2012. Topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis. Am J Pathol 181(6):2217-24. PubMed: 23138019 MGI: J:192238
Asai J; Takenaka H; Kusano KF; Ii M; Luedemann C; Curry C; Eaton E; Iwakura A; Tsutsumi Y; Hamada H; Kishimoto S; Thorne T; Kishore R; Losordo DW. 2006. Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation 113(20):2413-24. PubMed: 16702471 MGI: J:122447
Atkinson RD; Coenen KR; Plummer MR; Gruen ML; Hasty AH. 2008. Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice. Am J Physiol Endocrinol Metab 294(2):E284-90. PubMed: 18029445 MGI: J:133332
Awazawa M; Futami T; Sakada M; Kaneko K; Ohsugi M; Nakaya K; Terai A; Suzuki R; Koike M; Uchiyama Y; Kadowaki T; Ueki K. 2014. Deregulation of pancreas-specific oxidoreductin ERO1beta in the pathogenesis of diabetes mellitus. Mol Cell Biol 34(7):1290-9. PubMed: 24469402 MGI: J:213523
Awazawa M; Ueki K; Inabe K; Yamauchi T; Kaneko K; Okazaki Y; Bardeesy N; Ohnishi S; Nagai R; Kadowaki T. 2009. Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway. Biochem Biophys Res Commun 382(1):51-6. PubMed: 19254698 MGI: J:147384
Awazawa M; Ueki K; Inabe K; Yamauchi T; Kubota N; Kaneko K; Kobayashi M; Iwane A; Sasako T; Okazaki Y; Ohsugi M; Takamoto I; Yamashita S; Asahara H; Akira S; Kasuga M; Kadowaki T. 2011. Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway. Cell Metab 13(4):401-12. PubMed: 21459325 MGI: J:172246
Baba M; Wada J; Eguchi J; Hashimoto I; Okada T; Yasuhara A; Shikata K; Kanwar YS; Makino H. 2005. Galectin-9 inhibits glomerular hypertrophy in db/db diabetic mice via cell-cycle-dependent mechanisms. J Am Soc Nephrol 16(11):3222-34. PubMed: 16177004 MGI: J:116853
Badal SS; Wang Y; Long J; Corcoran DL; Chang BH; Truong LD; Kanwar YS; Overbeek PA; Danesh FR. 2016. miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy. Nat Commun 7:12076. PubMed: 27350436 MGI: J:240064
Bagi Z; Erdei N; Toth A; Li W; Hintze TH; Koller A; Kaley G. 2005. Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins. Arterioscler Thromb Vasc Biol 25(8):1610-6. PubMed: 15947245 MGI: J:114331
Bagi Z; Koller A; Kaley G. 2004. PPARgamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes. Am J Physiol Heart Circ Physiol 286(2):H742-8. PubMed: 14551045 MGI: J:87610
Bahary N; Leibel RL; Joseph L; Friedman JM. 1990. Molecular mapping of the mouse db mutation. Proc Natl Acad Sci U S A 87(21):8642-6. PubMed: 1978328 MGI: J:10819
Bailly-Maitre B; Belgardt BF; Jordan SD; Coornaert B; von Freyend MJ; Kleinridders A; Mauer J; Cuddy M; Kress CL; Willmes D; Essig M; Hampel B; Protzer U; Reed JC; Bruning JC. 2010. Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance. J Biol Chem 285(9):6198-207. PubMed: 19996103 MGI: J:159765
Balland E; Dam J; Langlet F; Caron E; Steculorum S; Messina A; Rasika S; Falluel-Morel A; Anouar Y; Dehouck B; Trinquet E; Jockers R; Bouret SG; Prevot V. 2014. Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Cell Metab 19(2):293-301. PubMed: 24506870 MGI: J:210650
Balthasar N; Coppari R; McMinn J; Liu SM; Lee CE; Tang V; Kenny CD; McGovern RA; Chua SC Jr; Elmquist JK; Lowell BB. 2004. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42(6):983-91. PubMed: 15207242 MGI: J:106354
Bandyopadhyay GK; Lu M; Avolio E; Siddiqui JA; Gayen JR; Wollam J; Vu CU; Chi NW; O'Connor DT; Mahata SK. 2015. Pancreastatin-dependent inflammatory signaling mediates obesity-induced insulin resistance. Diabetes 64(1):104-16. PubMed: 25048197 MGI: J:230116
Banks AS; Kim-Muller JY; Mastracci TL; Kofler NM; Qiang L; Haeusler RA; Jurczak MJ; Laznik D; Heinrich G; Samuel VT; Shulman GI; Papaioannou VE; Accili D. 2011. Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metab 14(5):587-97. PubMed: 22055502 MGI: J:179687
Banks AS; Kon N; Knight C; Matsumoto M; Gutierrez-Juarez R; Rossetti L; Gu W; Accili D. 2008. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab 8(4):333-41. PubMed: 18840364 MGI: J:143422
Bannon P; Wood S; Restivo T; Campbell L; Hardman MJ; Mace KA. 2013. Diabetes induces stable intrinsic changes to myeloid cells that contribute to chronic inflammation during wound healing in mice. Dis Model Mech 6(6):1434-47. PubMed: 24057002 MGI: J:202832
Barile GR; Pachydaki SI; Tari SR; Lee SE; Donmoyer CM; Ma W; Rong LL; Buciarelli LG; Wendt T; Horig H; Hudson BI; Qu W; Weinberg AD; Yan SF; Schmidt AM. 2005. The RAGE axis in early diabetic retinopathy. Invest Ophthalmol Vis Sci 46(8):2916-24. PubMed: 16043866 MGI: J:103714
Barinaga M. 1996. Researchers nail down leptin receptor [news; comment] Science 271(5251):913. PubMed: 8584929 MGI: J:31488
Barouch LA; Berkowitz DE; Harrison RW; O'Donnell CP; Hare JM. 2003. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation 108(6):754-9. PubMed: 12885755 MGI: J:103063
Barouch LA; Gao D; Chen L; Miller KL; Xu W; Phan AC; Kittleson MM; Minhas KM; Berkowitz DE; Wei C; Hare JM. 2006. Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circ Res 98(1):119-24. PubMed: 16339484 MGI: J:118064
Bates SH; Dundon TA; Seifert M; Carlson M; Maratos-Flier E; Myers MG Jr. 2004. LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes 53(12):3067-73. PubMed: 15561935 MGI: J:94585
Bates SH; Kulkarni RN; Seifert M; Myers MG Jr. 2005. Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab 1(3):169-78. PubMed: 16054060 MGI: J:129847
Bates SH; Stearns WH; Dundon TA; Schubert M; Tso AW; Wang Y; Banks AS; Lavery HJ; Haq AK; Maratos-Flier E; Neel BG; Schwartz MW; Myers MG Jr. 2003. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421(6925):856-9. PubMed: 12594516 MGI: J:82334
Batra A; Pietsch J; Fedke I; Glauben R; Okur B; Stroh T; Zeitz M; Siegmund B. 2007. Leptin-dependent toll-like receptor expression and responsiveness in preadipocytes and adipocytes. Am J Pathol 170(6):1931-41. PubMed: 17525261 MGI: J:122150
Battiprolu PK; Hojayev B; Jiang N; Wang ZV; Luo X; Iglewski M; Shelton JM; Gerard RD; Rothermel BA; Gillette TG; Lavandero S; Hill JA. 2012. Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. J Clin Invest 122(3):1109-18. PubMed: 22326951 MGI: J:184484
Baumgart J; Wisniewski HG; Amlacher R; Zhukovskaya NV; Rentz E. 1989. Age-dependent antileukemic action and suppression of immune response by 1,4-benzoquinone-guanylhydrazone-thiosemicarbazone (ambazone) in mice. Neoplasma 36(4):393-400. PubMed: 2770926 MGI: J:27903
Begin-Heick N. 1992. Alpha-subunits of Gs and Gi in adipocyte plasma membranes of genetically diabetic (db/db) mice. Am J Physiol 263(1 Pt 1):C121-9. PubMed: 1322037 MGI: J:2110
Begin-Heick N. 1994. Liver beta-adrenergic receptors, G proteins, and adenylyl cyclase activity in obesity-diabetes syndromes. Am J Physiol 266(6 Pt 1):C1664-72. PubMed: 8023896 MGI: J:18963
Belke DD; Larsen TS; Gibbs EM; Severson DL. 2001. Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter. Am J Physiol Endocrinol Metab 280(3):E420-7. PubMed: 11171596 MGI: J:134584
Belmadani S; Palen DI; Gonzalez-Villalobos RA; Boulares HA; Matrougui K. 2008. Elevated epidermal growth factor receptor phosphorylation induces resistance artery dysfunction in diabetic db/db mice. Diabetes 57(6):1629-37. PubMed: 18319304 MGI: J:136927
Bensellam M; Maxwell EL; Chan JY; Luzuriaga J; West PK; Jonas JC; Gunton JE; Laybutt DR. 2016. Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells. Diabetologia 59(7):1492-502. PubMed: 27039902 MGI: J:235869
Berk PD; Zhou S; Kiang C; Stump DD; Fan X; Bradbury MW. 1999. Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents. J Biol Chem 274(40):28626-31. PubMed: 10497230 MGI: J:57965
Bermudez DM; Herdrich BJ; Xu J; Lind R; Beason DP; Mitchell ME; Soslowsky LJ; Liechty KW. 2011. Impaired biomechanical properties of diabetic skin implications in pathogenesis of diabetic wound complications. Am J Pathol 178(5):2215-23. PubMed: 21514435 MGI: J:171585
Bertola A; Ciucci T; Rousseau D; Bourlier V; Duffaut C; Bonnafous S; Blin-Wakkach C; Anty R; Iannelli A; Gugenheim J; Tran A; Bouloumie A; Gual P; Wakkach A. 2012. Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients. Diabetes 61(9):2238-47. PubMed: 22596049 MGI: J:208457
Beyaz S; Mana MD; Roper J; Kedrin D; Saadatpour A; Hong SJ; Bauer-Rowe KE; Xifaras ME; Akkad A; Arias E; Pinello L; Katz Y; Shinagare S; Abu-Remaileh M; Mihaylova MM; Lamming DW; Dogum R; Guo G; Bell GW; Selig M; Nielsen GP; Gupta N; Ferrone CR; Deshpande V; Yuan GC; Orkin SH; Sabatini DM; Yilmaz OH. 2016. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature 531(7592):53-8. PubMed: 26935695 MGI: J:229664
Bindom SM; Hans CP; Xia H; Boulares AH; Lazartigues E. 2010. Angiotensin I-converting enzyme type 2 (ACE2) gene therapy improves glycemic control in diabetic mice. Diabetes 59(10):2540-8. PubMed: 20660625 MGI: J:169343
Bjorbaek C; Elmquist JK; Frantz JD; Shoelson SE; Flier JS. 1998. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1(4):619-25. PubMed: 9660946 MGI: J:119803
Blum B; Roose AN; Barrandon O; Maehr R; Arvanites AC; Davidow LS; Davis JC; Peterson QP; Rubin LL; Melton DA. 2014. Reversal of beta cell de-differentiation by a small molecule inhibitor of the TGFbeta pathway. Elife 3:e02809. PubMed: 25233132 MGI: J:218054
Boardman N; Hafstad AD; Larsen TS; Severson DL; Aasum E. 2009. Increased O2 cost of basal metabolism and excitation-contraction coupling in hearts from type 2 diabetic mice. Am J Physiol Heart Circ Physiol 296(5):H1373-9. PubMed: 19286944 MGI: J:150888
Boardman NT; Larsen TS; Severson DL; Essop MF; Aasum E. 2011. Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling. Am J Physiol Heart Circ Physiol :. PubMed: 21335471 MGI: J:169593
Bodary PF; Shen Y; Ohman M; Bahrou KL; Vargas FB; Cudney SS; Wickenheiser KJ; Myers MG Jr; Eitzman DT. 2007. Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance. Arterioscler Thromb Vasc Biol 27(1):70-6. PubMed: 17095713 MGI: J:135034
Bogdanov P; Corraliza L; A Villena J; Carvalho AR; Garcia-Arumi J; Ramos D; Ruberte J; Simo R; Hernandez C. 2014. The db/db mouse: a useful model for the study of diabetic retinal neurodegeneration. PLoS One 9(5):e97302. PubMed: 24837086 MGI: J:216333
Boillot D; Assan R; Dardenne M; Debray-Sachs M; Bach JF. 1986. T-lymphopenia and T-cell imbalance in diabetic db/db mice. Diabetes 35(2):198-203. PubMed: 3510925 MGI: J:109948
Bonal CB; Baronnier DE; Pot C; Benkhoucha M; Schwab ME; Lalive PH; Herrera PL. 2013. Nogo-A downregulation improves insulin secretion in mice. Diabetes 62(5):1443-52. PubMed: 23274909 MGI: J:208581
Bostrom KI; Jumabay M; Matveyenko A; Nicholas SB; Yao Y. 2011. Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. Circ Res 108(4):446-57. PubMed: 21193740 MGI: J:183498
Botta A; Laher I; Beam J; Decoffe D; Brown K; Halder S; Devlin A; Gibson DL; Ghosh S. 2013. Short term exercise induces PGC-1alpha, ameliorates inflammation and increases mitochondrial membrane proteins but fails to increase respiratory enzymes in aging diabetic hearts. PLoS One 8(8):e70248. PubMed: 23936397 MGI: J:205777
Botusan IR; Sunkari VG; Savu O; Catrina AI; Grunler J; Lindberg S; Pereira T; Yla-Herttuala S; Poellinger L; Brismar K; Catrina SB. 2008. Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice. Proc Natl Acad Sci U S A 105(49):19426-31. PubMed: 19057015 MGI: J:142033
Bouchard G; Johnson D; Carver T; Paigen B; Carey MC. 2002. Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk. J Lipid Res 43(7):1105-13. PubMed: 12091495 MGI: J:88773
Boudina S; Sena S; Theobald H; Sheng X; Wright JJ; Hu XX; Aziz S; Johnson JI; Bugger H; Zaha VG; Abel ED. 2007. Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes 56(10):2457-66. PubMed: 17623815 MGI: J:126567
Bouret SG; Bates SH; Chen S; Myers MG Jr; Simerly RB. 2012. Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits. J Neurosci 32(4):1244-52. PubMed: 22279209 MGI: J:180585
Boyer F; Diotel N; Girard D; Rondeau P; Essop MF; Bourdon E. 2016. Enhanced oxidative stress in adipose tissue from diabetic mice, possible contribution of glycated albumin. Biochem Biophys Res Commun 473(1):154-60. PubMed: 27012202 MGI: J:234865
Brem H; Tomic-Canic M; Entero H; Hanflik AM; Wang VM; Fallon JT; Ehrlich HP. 2007. The synergism of age and db/db genotype impairs wound healing. Exp Gerontol 42(6):523-31. PubMed: 17275236 MGI: J:123188
Brezniceanu ML; Lau CJ; Godin N; Chenier I; Duclos A; Ethier J; Filep JG; Ingelfinger JR; Zhang SL; Chan JS. 2010. Reactive oxygen species promote caspase-12 expression and tubular apoptosis in diabetic nephropathy. J Am Soc Nephrol 21(6):943-54. PubMed: 20299359 MGI: J:185843
Brezniceanu ML; Liu F; Wei CC; Chenier I; Godin N; Zhang SL; Filep JG; Ingelfinger JR; Chan JS. 2008. Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cells. Diabetes 57(2):451-9. PubMed: 17977949 MGI: J:132449
Brown RL; Breeden MP; Greenhalgh DG. 1994. PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse. J Surg Res 56(6):562-70. PubMed: 8015312 MGI: J:19344
Brun P; Castagliuolo I; Leo VD; Buda A; Pinzani M; Palu G; Martines D. 2007. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 292(2):G518-25. PubMed: 17023554 MGI: J:124815
Buettner C; Pocai A; Muse ED; Etgen AM; Myers MG Jr; Rossetti L. 2006. Critical role of STAT3 in leptin's metabolic actions. Cell Metab 4(1):49-60. PubMed: 16814732 MGI: J:129709
Bunger L; Forsting J; McDonald KL; Horvat S; Duncan J; Hochscheid S; Baile CA; Hill WG; Speakman JR. 2003. Long-term divergent selection on fatness in mice indicates a regulation system independent of leptin production and reception. FASEB J 17(1):85-7. PubMed: 12424222 MGI: J:118012
Burke SJ; Karlstad MD; Regal KM; Sparer TE; Lu D; Elks CM; Grant RW; Stephens JM; Burk DH; Collier JJ. 2015. CCL20 is elevated during obesity and differentially regulated by NF-kappaB subunits in pancreatic beta-cells. Biochim Biophys Acta 1849(6):637-52. PubMed: 25882704 MGI: J:230538
Busso N; So A; Chobaz-Peclat V; Morard C; Martinez-Soria E; Talabot-Ayer D; Gabay C. 2002. Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol 168(2):875-82. PubMed: 11777985 MGI: J:73743
Calcutt NA; Smith DR; Frizzi K; Sabbir MG; Chowdhury SK; Mixcoatl-Zecuatl T; Saleh A; Muttalib N; Van der Ploeg R; Ochoa J; Gopaul A; Tessler L; Wess J; Jolivalt CG; Fernyhough P. 2017. Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy. J Clin Invest 127(2):608-622. PubMed: 28094765 MGI: J:239823
Calvert JW; Gundewar S; Jha S; Greer JJ; Bestermann WH; Tian R; Lefer DJ. 2008. Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling. Diabetes 57(3):696-705. PubMed: 18083782 MGI: J:132319
Campbell JE; Ussher JR; Mulvihill EE; Kolic J; Baggio LL; Cao X; Liu Y; Lamont BJ; Morii T; Streutker CJ; Tamarina N; Philipson LH; Wrana JL; MacDonald PE; Drucker DJ. 2016. TCF1 links GIPR signaling to the control of beta cell function and survival. Nat Med 22(1):84-90. PubMed: 26642437 MGI: J:233177
Campo GM; Avenoso A; Micali A; Nastasi G; Squadrito F; Altavilla D; Bitto A; Polito F; Rinaldi MG; Calatroni A; D'Ascola A; Campo S. 2010. High-molecular weight hyaluronan reduced renal PKC activation in genetically diabetic mice. Biochim Biophys Acta 1802(11):1118-30. PubMed: 20713153 MGI: J:170003
Cang X; Wang X; Liu P; Wu X; Yan J; Chen J; Wu G; Jin Y; Xu F; Su J; Wan C; Wang X. 2016. PINK1 alleviates palmitate induced insulin resistance in HepG2 cells by suppressing ROS mediated MAPK pathways. Biochem Biophys Res Commun 478(1):431-8. PubMed: 27423393 MGI: J:238665
Cao L; Lin EJ; Cahill MC; Wang C; Liu X; During MJ. 2009. Molecular therapy of obesity and diabetes by a physiological autoregulatory approach. Nat Med 15(4):447-54. PubMed: 19270710 MGI: J:149375
Carley AN; Severson DL. 2005. Fatty acid metabolism is enhanced in type 2 diabetic hearts. Biochim Biophys Acta 1734(2):112-26. PubMed: 15904868 MGI: J:99066
Carr CL; Qi Y; Davidson B; Chadderdon S; Jayaweera AR; Belcik JT; Benner C; Xie A; Lindner JR. 2011. Dysregulated selectin expression and monocyte recruitment during ischemia-related vascular remodeling in diabetes mellitus. Arterioscler Thromb Vasc Biol 31(11):2526-33. PubMed: 21885854 MGI: J:191457
Catanuto P; Doublier S; Lupia E; Fornoni A; Berho M; Karl M; Striker GE; Xia X; Elliot S. 2009. 17 beta-estradiol and tamoxifen upregulate estrogen receptor beta expression and control podocyte signaling pathways in a model of type 2 diabetes. Kidney Int 75(11):1194-201. PubMed: 19279558 MGI: J:162696
Chakroborty D; Sarkar C; Lu K; Bhat M; Dasgupta PS; Basu S. 2016. Activation of Dopamine D1 Receptors in Dermal Fibroblasts Restores Vascular Endothelial Growth Factor-A Production by These Cells and Subsequent Angiogenesis in Diabetic Cutaneous Wound Tissues. Am J Pathol 186(9):2262-70. PubMed: 27422612 MGI: J:235147
Chan JY; Luzuriaga J; Bensellam M; Biden TJ; Laybutt DR. 2013. Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in beta-cell gene expression and progression to diabetes. Diabetes 62(5):1557-68. PubMed: 23274897 MGI: J:208583
Chan JY; Luzuriaga J; Maxwell EL; West PK; Bensellam M; Laybutt DR. 2015. The balance between adaptive and apoptotic unfolded protein responses regulates beta-cell death under ER stress conditions through XBP1, CHOP and JNK. Mol Cell Endocrinol 413:189-201. PubMed: 26135354 MGI: J:227034
Chanda D; Kim YH; Li T; Misra J; Kim DK; Kim JR; Kwon J; Jeong WI; Ahn SH; Park TS; Koo SH; Chiang JY; Lee CH; Choi HS. 2013. Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH. PLoS One 8(7):e68845. PubMed: 23894352 MGI: J:204381
Chang J; Li Y; Huang Y; Lam KS; Hoo RL; Wong WT; Cheng KK; Wang Y; Vanhoutte PM; Xu A. 2010. Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway. Diabetes 59(11):2949-59. PubMed: 20802255 MGI: J:169726
Chaput E; Saladin R; Silvestre M; Edgar AD. 2000. Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight. Biochem Biophys Res Commun 271(2):445-50. PubMed: 10799317 MGI: J:62209
Chavey C; Lazennec G; Lagarrigue S; Clape C; Iankova I; Teyssier J; Annicotte JS; Schmidt J; Mataki C; Yamamoto H; Sanches R; Guma A; Stich V; Vitkova M; Jardin-Watelet B; Renard E; Strieter R; Tuthill A; Hotamisligil GS; Vidal-Puig A; Zorzano A; Langin D; Fajas L. 2009. CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab 9(4):339-49. PubMed: 19356715 MGI: J:148169
Cheang WS; Wong WT; Tian XY; Yang Q; Lee HK; He GW; Yao X; Huang Y. 2011. Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice. Cardiovasc Res 92(2):267-75. PubMed: 21875904 MGI: J:191702
Chen C; Huang K; Hao J; Huang J; Yang Z; Xiong F; Liu P; Huang H. 2016. Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. Mol Cell Endocrinol 427:45-56. PubMed: 26948947 MGI: J:241185
Chen HC; Stone SJ; Zhou P; Buhman KK; Farese RV Jr. 2002. Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue. Diabetes 51(11):3189-95. PubMed: 12401709 MGI: J:107180
Chen J; Chen S; Chen Y; Zhang C; Wang J; Zhang W; Liu G; Zhao B; Chen Y. 2011. Circulating endothelial progenitor cells and cellular membrane microparticles in db/db diabetic mouse: possible implications in cerebral ischemic damage. Am J Physiol Endocrinol Metab 301(1):E62-71. PubMed: 21505143 MGI: J:182069
Chen J; Fu R; Cui Y; Li YS; Pan JR; Liu JL; Luo HS; Yin JD; Li DF; Cui S. 2013. LIM-homeodomain transcription factor Isl-1 mediates the effect of leptin on insulin secretion in mice. J Biol Chem 288(17):12395-405. PubMed: 23504315 MGI: J:198384
Chen J; Guo Y; Zeng W; Huang L; Pang Q; Nie L; Mu J; Yuan F; Feng B. 2014. ER stress triggers MCP-1 expression through SET7/9-induced histone methylation in the kidneys of db/db mice. Am J Physiol Renal Physiol 306(8):F916-25. PubMed: 24452638 MGI: J:208335
Chen J; Li H; Addabbo F; Zhang F; Pelger E; Patschan D; Park HC; Kuo MC; Ni J; Gobe G; Chander PN; Nasjletti A; Goligorsky MS. 2009. Adoptive transfer of syngeneic bone marrow-derived cells in mice with obesity-induced diabetes: selenoorganic antioxidant ebselen restores stem cell competence. Am J Pathol 174(2):701-11. PubMed: 19147816 MGI: J:144186
Chen J; Liang L; Zhan L; Zhou Y; Zheng L; Sun X; Gong J; Sui H; Jiang R; Zhang F; Zhang L. 2014. ZiBuPiYin recipe protects db/db mice from diabetes-associated cognitive decline through improving multiple pathological changes. PLoS One 9(3):e91680. PubMed: 24614172 MGI: J:215122
Chen J; Ning R; Zacharek A; Cui C; Cui X; Yan T; Venkat P; Zhang Y; Chopp M. 2016. MiR-126 Contributes to Human Umbilical Cord Blood Cell-Induced Neurorestorative Effects After Stroke in Type-2 Diabetic Mice. Stem Cells 34(1):102-13. PubMed: 26299579 MGI: J:232881
Chen JX; Zeng H; Reese J; Aschner JL; Meyrick B. 2012. Overexpression of angiopoietin-2 impairs myocardial angiogenesis and exacerbates cardiac fibrosis in the diabetic db/db mouse model. Am J Physiol Heart Circ Physiol 302(4):H1003-12. PubMed: 22180648 MGI: J:183820
Chen L; Endler A; Uchida K; Horiguchi S; Morizane Y; Iijima O; Toi M; Shibasaki F. 2010. Int6/eIF3e silencing promotes functional blood vessel outgrowth and enhances wound healing by upregulating hypoxia-induced factor 2alpha expression. Circulation 122(9):910-9. PubMed: 20713899 MGI: J:178586
Chen Q; Takahashi Y; Oka K; Ma JX. 2016. Functional Differences of Very-Low-Density Lipoprotein Receptor Splice Variants in Regulating Wnt Signaling. Mol Cell Biol 36(20):2645-54. PubMed: 27528615 MGI: J:236304
Chen S; Okahara F; Osaki N; Shimotoyodome A. 2015. Increased GIP signaling induces adipose inflammation via a HIF-1alpha-dependent pathway and impairs insulin sensitivity in mice. Am J Physiol Endocrinol Metab 308(5):E414-25. PubMed: 25537494 MGI: J:219759
Chen S; Qian J; Shi X; Gao T; Liang T; Liu C. 2014. Control of hepatic gluconeogenesis by the promyelocytic leukemia zinc finger protein. Mol Endocrinol 28(12):1987-98. PubMed: 25333514 MGI: J:218284
Chen S; Zhang W; Tang C; Tang X; Liu L; Liu C. 2014. Vanin-1 is a key activator for hepatic gluconeogenesis. Diabetes 63(6):2073-85. PubMed: 24550194 MGI: J:229332
Chen W; Xia Y; Zhao X; Wang H; Chen W; Yu M; Li Y; Ye H; Zhang Y. 2012. The critical role of Astragalus polysaccharides for the improvement of PPRAalpha-mediated lipotoxicity in diabetic cardiomyopathy. PLoS One 7(10):e45541. PubMed: 23049681 MGI: J:191956
Chen WL; Kang CH; Wang SG; Lee HM. 2012. alpha-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase. Diabetologia 55(6):1824-35. PubMed: 22456698 MGI: J:183536
Cheng AM; Rizzo-DeLeon N; Wilson CL; Lee WJ; Tateya S; Clowes AW; Schwartz MW; Kim F. 2014. Vasodilator-stimulated phosphoprotein protects against vascular inflammation and insulin resistance. Am J Physiol Endocrinol Metab 307(7):E571-9. PubMed: 25117404 MGI: J:215575
Cheng CW; Villani V; Buono R; Wei M; Kumar S; Yilmaz OH; Cohen P; Sneddon JB; Perin L; Longo VD. 2017. Fasting-Mimicking Diet Promotes Ngn3-Driven beta-Cell Regeneration to Reverse Diabetes. Cell 168(5):775-788.e12. PubMed: 28235195 MGI: J:239668
Cheng H; Fan X; Moeckel GW; Harris RC. 2011. Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression. J Am Soc Nephrol 22(7):1240-51. PubMed: 21737546 MGI: J:179350
Cheng H; Wang H; Fan X; Paueksakon P; Harris RC. 2012. Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice. Kidney Int 82(11):1176-83. PubMed: 22785174 MGI: J:198167
Cheng HT; Dauch JR; Hayes JM; Yanik BM; Feldman EL. 2012. Nerve growth factor/p38 signaling increases intraepidermal nerve fiber densities in painful neuropathy of type 2 diabetes. Neurobiol Dis 45(1):280-7. PubMed: 21872660 MGI: J:179844
Cheng KK; Lam KS; Wang Y; Huang Y; Carling D; Wu D; Wong C; Xu A. 2007. Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes 56(5):1387-94. PubMed: 17287464 MGI: J:122100
Cheng L; Han X; Shi Y. 2009. A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice. Am J Physiol Endocrinol Metab 297(6):E1276-82. PubMed: 19773578 MGI: J:159566
Cheng Z; Guo S; Copps K; Dong X; Kollipara R; Rodgers JT; Depinho RA; Puigserver P; White MF. 2009. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med 15(11):1307-11. PubMed: 19838201 MGI: J:154295
Cheung SY; Huang Y; Kwan HY; Chung HY; Yao X. 2015. Activation of transient receptor potential vanilloid 3 channel suppresses adipogenesis. Endocrinology 156(6):2074-86. PubMed: 25774551 MGI: J:222171
Cheung W; Yu PX; Little BM; Cone RD; Marks DL; Mak RH. 2005. Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin Invest 115(6):1659-65. PubMed: 15931394 MGI: J:99198
Chiarreotto-Ropelle EC; Pauli LS; Katashima CK; Pimentel GD; Picardi PK; Silva VR; de Souza CT; Prada PO; Cintra DE; Carvalheira JB; Ropelle ER; Pauli JR. 2013. Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and leptin signaling in obese rats. Am J Physiol Endocrinol Metab 305(5):E649-59. PubMed: 23880311 MGI: J:203888
Chiellini C; Costa M; Novelli SE; Amri EZ; Benzi L; Bertacca A; Cohen P; Del Prato S; Friedman JM; Maffei M. 2003. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. J Cell Physiol 195(2):309-21. PubMed: 12652657 MGI: J:106181
Chin M; Isono M; Isshiki K; Araki S; Sugimoto T; Guo B; Sato H; Haneda M; Kashiwagi A; Koya D. 2005. Estrogen and Raloxifene, a Selective Estrogen Receptor Modulator, Ameliorate Renal Damage in db/db Mice. Am J Pathol 166(6):1629-36. PubMed: 15920148 MGI: J:98819
Cho KW; Zhou Y; Sheng L; Rui L. 2011. Lipocalin-13 regulates glucose metabolism by both insulin-dependent and insulin-independent mechanisms. Mol Cell Biol 31(3):450-7. PubMed: 21135134 MGI: J:170422
Cho YR; Lim JH; Kim MY; Kim TW; Hong BY; Kim YS; Chang YS; Kim HW; Park CW. 2014. Therapeutic effects of fenofibrate on diabetic peripheral neuropathy by improving endothelial and neural survival in db/db mice. PLoS One 9(1):e83204. PubMed: 24392081 MGI: J:212216
Chodavarapu H; Grobe N; Somineni HK; Salem ES; Madhu M; Elased KM. 2013. Rosiglitazone treatment of type 2 diabetic db/db mice attenuates urinary albumin and angiotensin converting enzyme 2 excretion. PLoS One 8(4):e62833. PubMed: 23646149 MGI: J:200870
Choe SS; Choi AH; Lee JW; Kim KH; Chung JJ; Park J; Lee KM; Park KG; Lee IK; Kim JB. 2007. Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells. Diabetes 56(6):1534-43. PubMed: 17369526 MGI: J:126465
Choe SS; Shin KC; Ka S; Lee YK; Chun JS; Kim JB. 2014. Macrophage HIF-2alpha ameliorates adipose tissue inflammation and insulin resistance in obesity. Diabetes 63(10):3359-71. PubMed: 24947359 MGI: J:230173
Choi D; Oh KJ; Han HS; Yoon YS; Jung CY; Kim ST; Koo SH. 2012. Protein arginine methyltransferase 1 regulates hepatic glucose production in a FoxO1-dependent manner. Hepatology 56(4):1546-56. PubMed: 22532369 MGI: J:236666
Choi D; Schroer SA; Lu SY; Wang L; Wu X; Liu Y; Zhang Y; Gaisano HY; Wagner KU; Wu H; Retnakaran R; Woo M. 2010. Erythropoietin protects against diabetes through direct effects on pancreatic beta cells. J Exp Med 207(13):2831-42. PubMed: 21149549 MGI: J:176862
Choi JW; Jo A; Kim M; Park HS; Chung SS; Kang S; Park KS. 2016. BNIP3 is essential for mitochondrial bioenergetics during adipocyte remodelling in mice. Diabetologia 59(3):571-81. PubMed: 26693709 MGI: J:232589
Choi SK; Galan M; Partyka M; Trebak M; Belmadani S; Matrougui K. 2012. Chronic inhibition of epidermal growth factor receptor tyrosine kinase and extracellular signal-regulated kinases 1 and 2 (ERK1/2) augments vascular response to limb ischemia in type 2 diabetic mice. Am J Pathol 180(1):410-8. PubMed: 22067908 MGI: J:180167
Chong AC; Greendyk RA; Zeltser LM. 2015. Distinct networks of leptin- and insulin-sensing neurons regulate thermogenic responses to nutritional and cold challenges. Diabetes 64(1):137-46. PubMed: 25125486 MGI: J:230229
Choo HJ; Kim JH; Kwon OB; Lee CS; Mun JY; Han SS; Yoon YS; Yoon G; Choi KM; Ko YG. 2006. Mitochondria are impaired in the adipocytes of type 2 diabetic mice. Diabetologia 49(4):784-91. PubMed: 16501941 MGI: J:107887
Chou JC; Rollins SD; Ye M; Batlle D; Fawzi AA. 2014. Endothelin receptor-A antagonist attenuates retinal vascular and neuroretinal pathology in diabetic mice. Invest Ophthalmol Vis Sci 55(4):2516-25. PubMed: 24644048 MGI: J:229807
Choudhary AK; Rennie J; Cairns C; Borthwick G; Hughes J; Morton NM; Kluth D; Conway BR. 2013. Administration of heme arginate ameliorates murine type 2 diabetes independently of heme oxygenase activity. PLoS One 8(10):e78209. PubMed: 24205160 MGI: J:209235
Chow SZ; Speck M; Yoganathan P; Nackiewicz D; Hansen AM; Ladefoged M; Rabe B; Rose-John S; Voshol PJ; Lynn FC; Herrera PL; Muller W; Ellingsgaard H; Ehses JA. 2014. Glycoprotein 130 receptor signaling mediates alpha-cell dysfunction in a rodent model of type 2 diabetes. Diabetes 63(9):2984-95. PubMed: 24812426 MGI: J:229838
Chu KY; Lau T; Carlsson PO; Leung PS. 2006. Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes. Diabetes 55(2):367-74. PubMed: 16443769 MGI: J:106880
Chu ZL; Jones RM; He H; Carroll C; Gutierrez V; Lucman A; Moloney M; Gao H; Mondala H; Bagnol D; Unett D; Liang Y; Demarest K; Semple G; Behan DP; Leonard J. 2007. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology 148(6):2601-9. PubMed: 17289847 MGI: J:174048
Chua S Jr; Li Y; Liu SM; Liu R; Chan KT; Martino J; Zheng Z; Susztak K; D'Agati VD; Gharavi AG. 2010. A susceptibility gene for kidney disease in an obese mouse model of type II diabetes maps to chromosome 8. Kidney Int 78(5):453-62. PubMed: 20520596 MGI: J:184261
Chua S Jr; Liu SM; Li Q; Yang L; Thassanapaff VT; Fisher P. 2002. Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB- Lepr (db)) and obese (DBA- Lep (ob)) mice. Diabetologia 45(7):976-90. PubMed: 12136396 MGI: J:78850
Chuang PY; Dai Y; Liu R; He H; Kretzler M; Jim B; Cohen CD; He JC. 2011. Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus. PLoS One 6(8):e23566. PubMed: 21858169 MGI: J:176360
Chung WK; Belfi K; Chua M; Wiley J; Mackintosh R; Nicolson M; Boozer CN; Leibel RL. 1998. Heterozygosity for Lep(ob) or Lep(rdb) affects body composition and leptin homeostasis in adult mice. Am J Physiol 274(4 Pt 2):R985-90. PubMed: 9575960 MGI: J:47168
Cinti S; Mitchell G; Barbatelli G; Murano I; Ceresi E; Faloia E; Wang S; Fortier M; Greenberg AS; Obin MS. 2005. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46(11):2347-55. PubMed: 16150820 MGI: J:104779
Claflin KE; Sandgren JA; Lambertz AM; Weidemann BJ; Littlejohn NK; Burnett CM; Pearson NA; Morgan DA; Gibson-Corley KN; Rahmouni K; Grobe JL. 2017. Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism. J Clin Invest 127(4):1414-1424. PubMed: 28263184 MGI: J:243376
Clapham JC; Coulthard VH; Moore GB. 2001. Concordant mRNA Expression of UCP-3, but Not UCP-2, with Mitochondrial Thioesterase-1 in Brown Adipose Tissue and Skeletal Muscle in db/db Diabetic Mice. Biochem Biophys Res Commun 287(5):1058-62. PubMed: 11587528 MGI: J:72433
Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics 12(5-6):601-13. PubMed: 6971254 MGI: J:6485
Cleary MP; Hu X; Grossmann ME; Juneja SC; Dogan S; Grande JP; Maihle NJ. 2007. Prevention of mammary tumorigenesis by intermittent caloric restriction: does caloric intake during refeeding modulate the response? Exp Biol Med (Maywood) 232(1):70-80. PubMed: 17202587 MGI: J:129353
Cleary MP; Juneja SC; Phillips FC; Hu X; Grande JP; Maihle NJ. 2004. Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors. Exp Biol Med (Maywood) 229(2):182-93. PubMed: 14734797 MGI: J:102011
Cochran BJ; Ryder WJ; Parmar A; Tang S; Reilhac A; Arthur A; Charil A; Hamze H; Barter PJ; Kritharides L; Meikle SR; Gregoire MC; Rye KA. 2016. In vivo PET imaging with [(18)F]FDG to explain improved glucose uptake in an apolipoprotein A-I treated mouse model of diabetes. Diabetologia 59(9):1977-84. PubMed: 27193916 MGI: J:236054
Cohen MP; Clements RS; Cohen JA; Shearman CW. 1996. Prevention of decline in renal function in the diabetic db/db mouse. Diabetologia 39(3):270-4. PubMed: 8721771 MGI: J:31848
Cohen MP; Clements RS; Cohen JA; Shearman CW. 1996. Glycated albumin promotes a generalized vasculopathy in the db/db mouse. Biochem Biophys Res Commun 218(1):72-5. PubMed: 8573179 MGI: J:30654
Cohen MP; Sharma K; Guo J; Eltayeb BO; Ziyadeh FN. 1998. The renal TGF-beta system in the db/db mouse model of diabetic nephropathy. Exp Nephrol 6(3):226-33. PubMed: 9639038 MGI: J:49923
Cohen MP; Sharma K; Jin Y; Hud E; Wu VY; Tomaszewski J; Ziyadeh FN. 1995. Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists. A novel treatment strategy. J Clin Invest 95(5):2338-45. PubMed: 7738197 MGI: J:24919
Coleman DL. 1979. Obesity genes: beneficial effects in heterozygous mice. Science 203(4381):663-5. PubMed: 760211 MGI: J:6081
Coleman DL. 1978. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14(3):141-8. PubMed: 350680 MGI: J:5986
Coleman DL. 1982. Thermogenesis in diabetes-obesity syndromes in mutant mice. Diabetologia 22(3):205-11. PubMed: 7075918 MGI: J:6756
Coleman DL. 1980. Acetone metabolism in mice: increased activity in mice heterozygous for obesity genes. Proc Natl Acad Sci U S A 77(1):290-3. PubMed: 6928621 MGI: J:6278
Coleman DL; Hummel KP. 1973. The influence of genetic background on the expression of the obese (Ob) gene in the mouse. Diabetologia 9(4):287-93. PubMed: 4588246 MGI: J:5400
Collins S; Surwit RS. 1996. Pharmacologic manipulation of ob expression in a dietary model of obesity. J Biol Chem 271(16):9437-40. PubMed: 8621612 MGI: J:33332
Collins SJ; Alexander SL; Lopez-Guisa JM; Cai X; Maruvada R; Chua SC; Zhang G; Okamura DM; Matsuo S; Eddy AA. 2006. Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice. Nephron Exp Nephrol 104(1):e23-34. PubMed: 16735799 MGI: J:127478
Crepin D; Benomar Y; Riffault L; Amine H; Gertler A; Taouis M. 2014. The over-expression of miR-200a in the hypothalamus of ob/ob mice is linked to leptin and insulin signaling impairment. Mol Cell Endocrinol 384(1-2):1-11. PubMed: 24394757 MGI: J:211951
Csiszar A; Labinskyy N; Pinto JT; Ballabh P; Zhang H; Losonczy G; Pearson K; de Cabo R; Pacher P; Zhang C; Ungvari Z. 2009. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol 297(1):H13-20. PubMed: 19429820 MGI: J:151104
Cucak H; Grunnet LG; Rosendahl A. 2014. Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization. J Leukoc Biol 95(1):149-60. PubMed: 24009176 MGI: J:209543
Cui X; Chopp M; Zacharek A; Ye X; Roberts C; Chen J. 2011. Angiopoietin/Tie2 pathway mediates type 2 diabetes induced vascular damage after cerebral stroke. Neurobiol Dis 43(1):285-92. PubMed: 21515377 MGI: J:173206
Cui Y; Qiao A; Jiao T; Zhang H; Xue Y; Zou Y; Cui A; Fang F; Chang Y. 2016. The hepatic FOXQ1 transcription factor regulates glucose metabolism in mice. Diabetologia 59(10):2229-39. PubMed: 27421728 MGI: J:237057
Cushman T; Kim N; Hoyt R; Traish AM. 2009. Estradiol restores diabetes-induced reductions in sex steroid receptor expression and distribution in the vagina of db/db mouse model. J Steroid Biochem Mol Biol 114(3-5):186-94. PubMed: 19429450 MGI: J:150367
Dabkowski ER; Baseler WA; Williamson CL; Powell M; Razunguzwa TT; Frisbee JC; Hollander JM. 2010. Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes. Am J Physiol Heart Circ Physiol 299(2):H529-40. PubMed: 20543078 MGI: J:163865
Dai Y; Zhao X; Chen P; Yu Y; Wang Y; Xie L. 2015. Neuropeptide FF Promotes Recovery of Corneal Nerve Injury Associated With Hyperglycemia. Invest Ophthalmol Vis Sci 56(13):7754-65. PubMed: 26641552 MGI: J:231046
Dalboge LS; Almholt DL; Neerup TS; Vassiliadis E; Vrang N; Pedersen L; Fosgerau K; Jelsing J. 2013. Characterisation of age-dependent beta cell dynamics in the male db/db mice. PLoS One 8(12):e82813. PubMed: 24324833 MGI: J:211164
Dang Z; Maselli D; Spinetti G; Sangalli E; Carnelli F; Rosa F; Seganfreddo E; Canal F; Furlan A; Paccagnella A; Paiola E; Lorusso B; Specchia C; Albiero M; Cappellari R; Avogaro A; Falco A; Quaini F; Ou K; Rodriguez-Arabaolaza I; Emanueli C; Sambataro M; Fadini GP; Madeddu P. 2015. Sensory neuropathy hampers nociception-mediated bone marrow stem cell release in mice and patients with diabetes. Diabetologia 58(11):2653-62. PubMed: 26358583 MGI: J:230077
Darisipudi MN; Kulkarni OP; Sayyed SG; Ryu M; Migliorini A; Sagrinati C; Parente E; Vater A; Eulberg D; Klussmann S; Romagnani P; Anders HJ. 2011. Dual Blockade of the Homeostatic Chemokine CXCL12 and the Proinflammatory Chemokine CCL2 Has Additive Protective Effects on Diabetic Kidney Disease. Am J Pathol 179(1):116-24. PubMed: 21703397 MGI: J:173594
Dasgupta S; Bhattacharya S; Maitra S; Pal D; Majumdar SS; Datta A; Bhattacharya S. 2011. Mechanism of lipid induced insulin resistance: activated PKCepsilon is a key regulator. Biochim Biophys Acta 1812(4):495-506. PubMed: 21236337 MGI: J:169870
Dauch JR; Yanik BM; Hsieh W; Oh SS; Cheng HT. 2012. Neuron-astrocyte signaling network in spinal cord dorsal horn mediates painful neuropathy of type 2 diabetes. Glia 60(9):1301-15. PubMed: 22573263 MGI: J:185612
Davis RC; Schadt EE; Cervino AC; Peterfy M; Lusis AJ. 2005. Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility. Diabetes 54(4):1191-9. PubMed: 15793261 MGI: J:109430
Davis RC; Van Nas A; Castellani LW; Zhao Y; Zhou Z; Wen P; Yu S; Qi H; Rosales M; Schadt EE; Broman KW; Peterfy M; Lusis AJ. 2011. Systems Genetics of Susceptibility to Obesity-Induced Diabetes in Mice. Physiol Genomics :. PubMed: 22010005 MGI: J:177553
Davis RC; van Nas A; Bennett B; Orozco L; Pan C; Rau CD; Eskin E; Lusis AJ. 2013. Genome-wide association mapping of blood cell traits in mice. Mamm Genome 24(3-4):105-18. PubMed: 23417284 MGI: J:195203
De Rosa V; Procaccini C; Cali G; Pirozzi G; Fontana S; Zappacosta S; La Cava A; Matarese G. 2007. A Key Role of Leptin in the Control of Regulatory T Cell Proliferation. Immunity 26(2):241-255. PubMed: 17307705 MGI: J:118425
DeRubertis FR; Craven PA; Melhem MF; Salah EM. 2004. Attenuation of renal injury in db/db mice overexpressing superoxide dismutase: evidence for reduced superoxide-nitric oxide interaction. Diabetes 53(3):762-8. PubMed: 14988262 MGI: J:88385
Deb DK; Sun T; Wong KE; Zhang Z; Ning G; Zhang Y; Kong J; Shi H; Chang A; Li YC. 2010. Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes. Kidney Int 77(11):1000-9. PubMed: 20182412 MGI: J:184275
Debray-Sachs M; Sai P; Boitard C; Assan R; Hamburger J. 1983. Anti-pancreatic immunity in genetically diabetic mice. Clin Exp Immunol 51(1):1-7. PubMed: 6339122 MGI: J:7005
Del Rey A; Roggero E; Randolf A; Mahuad C; McCann S; Rettori V; Besedovsky HO. 2006. IL-1 resets glucose homeostasis at central levels. Proc Natl Acad Sci U S A 103(43):16039-44. PubMed: 17035503 MGI: J:115278
Demarco VG; Ford DA; Henriksen EJ; Aroor AR; Johnson MS; Habibi J; Ma L; Yang M; Albert CJ; Lally JW; Ford CA; Prasannarong M; Hayden MR; Whaley-Connell AT; Sowers JR. 2013. Obesity-related alterations in cardiac lipid profile and nondipping blood pressure pattern during transition to diastolic dysfunction in male db/db mice. Endocrinology 154(1):159-71. PubMed: 23142808 MGI: J:192822
Dentin R; Liu Y; Koo SH; Hedrick S; Vargas T; Heredia J; Yates J rd; Montminy M. 2007. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449(7160):366-9. PubMed: 17805301 MGI: J:126351
Deshpande SD; Putta S; Wang M; Lai JY; Bitzer M; Nelson RG; Lanting LL; Kato M; Natarajan R. 2013. Transforming growth factor-beta-induced cross talk between p53 and a microRNA in the pathogenesis of diabetic nephropathy. Diabetes 62(9):3151-62. PubMed: 23649518 MGI: J:208963
Dey I; Midha N; Singh G; Forsyth A; Walsh SK; Singh B; Kumar R; Toth C; Midha R. 2013. Diabetic Schwann cells suffer from nerve growth factor and neurotrophin-3 underproduction and poor associability with axons. Glia 61(12):1990-9. PubMed: 24123456 MGI: J:202935
Dhar M; Zhu M; Impey S; Lambert TJ; Bland T; Karatsoreos IN; Nakazawa T; Appleyard SM; Wayman GA. 2014. Leptin induces hippocampal synaptogenesis via CREB-regulated microRNA-132 suppression of p250GAP. Mol Endocrinol 28(7):1073-87. PubMed: 24877561 MGI: J:215336
Dib LH; Ortega MT; Fleming SD; Chapes SK; Melgarejo T. 2014. Bone marrow leptin signaling mediates obesity-associated adipose tissue inflammation in male mice. Endocrinology 155(1):40-6. PubMed: 24169547 MGI: J:207715
Dinel AL; Andre C; Aubert A; Ferreira G; Laye S; Castanon N. 2011. Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome. PLoS One 6(9):e24325. PubMed: 21949705 MGI: J:177681
Ding H; Howarth AG; Pannirselvam M; Anderson TJ; Severson DL; Wiehler WB; Triggle CR; Tuana BS. 2005. Endothelial dysfunction in Type 2 diabetes correlates with deregulated expression of the tail-anchored membrane protein SLMAP. Am J Physiol Heart Circ Physiol 289(1):H206-11. PubMed: 15764684 MGI: J:115429
Ding Y; Yuan S; Liu X; Mao P; Zhao C; Huang Q; Zhang R; Fang Y; Song Q; Yuan D; Xie P; Liu Y; Liu Q. 2014. Protective effects of astragaloside IV on db/db mice with diabetic retinopathy. PLoS One 9(11):e112207. PubMed: 25411784 MGI: J:225292
Do OH; Gunton JE; Gaisano HY; Thorn P. 2016. Changes in beta cell function occur in prediabetes and early disease in the Lepr (db) mouse model of diabetes. Diabetologia 59(6):1222-30. PubMed: 27048248 MGI: J:234803
Do OH; Low JT; Gaisano HY; Thorn P. 2014. The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells. Diabetologia 57(7):1400-9. PubMed: 24705605 MGI: J:213753
Dodd GT; Worth AA; Nunn N; Korpal AK; Bechtold DA; Allison MB; Myers MG Jr; Statnick MA; Luckman SM. 2014. The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus. Cell Metab 20(4):639-49. PubMed: 25176149 MGI: J:215557
Dominguez Rieg JA; Chirasani VR; Koepsell H; Senapati S; Mahata SK; Rieg T. 2016. Regulation of intestinal SGLT1 by catestatin in hyperleptinemic type 2 diabetic mice. Lab Invest 96(1):98-111. PubMed: 26552046 MGI: J:228070
Dominy JE Jr; Lee Y; Jedrychowski MP; Chim H; Jurczak MJ; Camporez JP; Ruan HB; Feldman J; Pierce K; Mostoslavsky R; Denu JM; Clish CB; Yang X; Shulman GI; Gygi SP; Puigserver P. 2012. The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Mol Cell 48(6):900-13. PubMed: 23142079 MGI: J:193985
Dong H; Huang H; Yun X; Kim DS; Yue Y; Wu H; Sutter A; Chavin KD; Otterbein LE; Adams DB; Kim YB; Wang H. 2014. Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation. Endocrinology 155(3):818-28. PubMed: 24424052 MGI: J:208806
Dong YF; Liu L; Kataoka K; Nakamura T; Fukuda M; Tokutomi Y; Nako H; Ogawa H; Kim-Mitsuyama S. 2010. Aliskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetes. Diabetologia 53(1):180-91. PubMed: 19894030 MGI: J:156549
Dray C; Debard C; Jager J; Disse E; Daviaud D; Martin P; Attane C; Wanecq E; Guigne C; Bost F; Tanti JF; Laville M; Vidal H; Valet P; Castan-Laurell I. 2010. Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans. Am J Physiol Endocrinol Metab 298(6):E1161-9. PubMed: 20233941 MGI: J:162878
Du K; Herzig S; Kulkarni RN; Montminy M. 2003. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300(5625):1574-7. PubMed: 12791994 MGI: J:113933
Ducy P; Amling M; Takeda S; Priemel M; Schilling AF; Beil FT; Shen J; Vinson C; Rueger JM; Karsenty G. 2000. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100(2):197-207. PubMed: 10660043 MGI: J:60001
Edgel KA; McMillen TS; Wei H; Pamir N; Houston BA; Caldwell MT; Mai PO; Oram JF; Tang C; Leboeuf RC. 2012. Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice. Biochim Biophys Acta 1821(3):425-34. PubMed: 22179025 MGI: J:182453
Edwards JL; Quattrini A; Lentz SI; Figueroa-Romero C; Cerri F; Backus C; Hong Y; Feldman EL. 2010. Diabetes regulates mitochondrial biogenesis and fission in mouse neurons. Diabetologia 53(1):160-9. PubMed: 19847394 MGI: J:156553
Eguchi J; Wada J; Hida K; Zhang H; Matsuoka T; Baba M; Hashimoto I; Shikata K; Ogawa N; Makino H. 2005. Identification of adipocyte adhesion molecule (ACAM), a novel CTX gene family, implicated in adipocyte maturation and development of obesity. Biochem J 387(Pt 2):343-53. PubMed: 15563274 MGI: J:117533
Ekim Ustunel B; Friedrich K; Maida A; Wang X; Krones-Herzig A; Seibert O; Sommerfeld A; Jones A; Sijmonsma TP; Sticht C; Gretz N; Fleming T; Nawroth PP; Stremmel W; Rose AJ; Berriel-Diaz M; Bluher M; Herzig S. 2016. Control of diabetic hyperglycaemia and insulin resistance through TSC22D4. Nat Commun 7:13267. PubMed: 27827363 MGI: J:242722
El Khoury NB; Gratuze M; Petry F; Papon MA; Julien C; Marcouiller F; Morin F; Nicholls SB; Calon F; Hebert SS; Marette A; Planel E. 2016. Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice. Neurobiol Dis 88:55-65. PubMed: 26777665 MGI: J:230873
Eller K; Kirsch A; Wolf AM; Sopper S; Tagwerker A; Stanzl U; Wolf D; Patsch W; Rosenkranz AR; Eller P. 2011. Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy. Diabetes 60(11):2954-62. PubMed: 21911743 MGI: J:189498
Eller P; Eller K; Kirsch AH; Patsch JJ; Wolf AM; Tagwerker A; Stanzl U; Kaindl R; Kahlenberg V; Mayer G; Patsch JR; Rosenkranz AR. 2011. A murine model of phosphate nephropathy. Am J Pathol 178(5):1999-2006. PubMed: 21514417 MGI: J:171593
Ellingsgaard H; Hauselmann I; Schuler B; Habib AM; Baggio LL; Meier DT; Eppler E; Bouzakri K; Wueest S; Muller YD; Hansen AM; Reinecke M; Konrad D; Gassmann M; Reimann F; Halban PA; Gromada J; Drucker DJ; Gribble FM; Ehses JA; Donath MY. 2011. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med 17(11):1481-9. PubMed: 22037645 MGI: J:179825
Elrod JW; Duranski MR; Langston W; Greer JJ; Tao L; Dugas TR; Kevil CG; Champion HC; Lefer DJ. 2006. eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling. Circ Res 99(1):78-85. PubMed: 16763164 MGI: J:123669
Endo H; Hosono K; Uchiyama T; Sakai E; Sugiyama M; Takahashi H; Nakajima N; Wada K; Takeda K; Nakagama H; Nakajima A. 2011. Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis. Gut 60(10):1363-71. PubMed: 21406387 MGI: J:194453
Engberding N; San Martin A; Martin-Garrido A; Koga M; Pounkova L; Lyons E; Lassegue B; Griendling KK. 2009. Insulin-like growth factor-1 receptor expression masks the antiinflammatory and glucose uptake capacity of insulin in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 29(3):408-15. PubMed: 19122171 MGI: J:159785
Ennequin G; Boisseau N; Caillaud K; Chavanelle V; Etienne M; Li X; Sirvent P. 2015. Neuregulin 1 Improves Glucose Tolerance in db/db Mice. PLoS One 10(7):e0130568. PubMed: 26230680 MGI: J:238601
Erdei N; Bagi Z; Edes I; Kaley G; Koller A. 2007. H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in Type 2 diabetic mice. Am J Physiol Heart Circ Physiol 292(1):H649-56. PubMed: 16997891 MGI: J:119955
Erion JR; Wosiski-Kuhn M; Dey A; Hao S; Davis CL; Pollock NK; Stranahan AM. 2014. Obesity elicits interleukin 1-mediated deficits in hippocampal synaptic plasticity. J Neurosci 34(7):2618-31. PubMed: 24523551 MGI: J:206938
Esterhazy D; Stutzer I; Wang H; Rechsteiner MP; Beauchamp J; Dobeli H; Hilpert H; Matile H; Prummer M; Schmidt A; Lieske N; Boehm B; Marselli L; Bosco D; Kerr-Conte J; Aebersold R; Spinas GA; Moch H; Migliorini C; Stoffel M. 2011. Bace2 Is a beta Cell-Enriched Protease that Regulates Pancreatic beta Cell Function and Mass. Cell Metab 14(3):365-77. PubMed: 21907142 MGI: J:176653
Eto H; Suga H; Inoue K; Aoi N; Kato H; Araki J; Doi K; Higashino T; Yoshimura K. 2011. Adipose Injury-Associated Factors Mitigate Hypoxia in Ischemic Tissues through Activation of Adipose-Derived Stem/Progenitor/Stromal Cells and Induction of Angiogenesis. Am J Pathol 178(5):2322-32. PubMed: 21514444 MGI: J:171579
Faggioni R; Fantuzzi G; Gabay C; Moser A; Dinarello CA; Feingold KR ; Grunfeld C. 1999. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol 276(1 Pt 2):R136-42. PubMed: 9887187 MGI: J:52477
Faggioni R; Fuller J; Moser A; Feingold KR; Grunfeld C. 1997. LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice. Am J Physiol 273(1 Pt 2):R181-6. PubMed: 9249548 MGI: J:41966
Fajardo RJ; Karim L; Calley VI; Bouxsein ML. 2014. A review of rodent models of type 2 diabetic skeletal fragility. J Bone Miner Res 29(5):1025-40. PubMed: 24585709 MGI: J:233235
Fang RC; Kryger ZB; Buck DW 2nd; De la Garza M; Galiano RD; Mustoe TA. 2010. Limitations of the db/db mouse in translational wound healing research: Is the NONcNZO10 polygenic mouse model superior? Wound Repair Regen 18(6):605-13. PubMed: 20955341 MGI: J:165705
Favero G; Rezzani R; Rodella LF. 2014. Sirtuin 6 nuclear localization at cortical brain level of young diabetic mice: an immunohistochemical study. Acta Histochem 116(1):272-7. PubMed: 24063863 MGI: J:219046
Feliers D; Duraisamy S; Faulkner JL; Duch J; Lee AV; Abboud HE; Choudhury GG; Kasinath BS. 2001. Activation of renal signaling pathways in db/db mice with type 2 diabetes. Kidney Int 60(2):495-504. PubMed: 11473632 MGI: J:109871
Feng D; Youn DY; Zhao X; Gao Y; Quinn WJ 3rd; Xiaoli AM; Sun Y; Birnbaum MJ; Pessin JE; Yang F. 2015. mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). PLoS One 10(6):e0126240. PubMed: 26042770 MGI: J:233814
Ferry G; Tellier E; Try A; Gres S; Naime I; Simon MF; Rodriguez M; Boucher J; Tack I; Gesta S; Chomarat P; Dieu M; Raes M; Galizzi JP; Valet P; Boutin JA; Saulnier-Blache JS. 2003. Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity. J Biol Chem 278(20):18162-9. PubMed: 12642576 MGI: J:83593
Figler RA; Wang G; Srinivasan S; Jung DY; Zhang Z; Pankow JS; Ravid K; Fredholm B; Hedrick CC; Rich SS; Kim JK; LaNoue KF; Linden J. 2011. Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans. Diabetes 60(2):669-79. PubMed: 21270276 MGI: J:169783
Finan B; Yang B; Ottaway N; Smiley DL; Ma T; Clemmensen C; Chabenne J; Zhang L; Habegger KM; Fischer K; Campbell JE; Sandoval D; Seeley RJ; Bleicher K; Uhles S; Riboulet W; Funk J; Hertel C; Belli S; Sebokova E; Conde-Knape K; Konkar A; Drucker DJ; Gelfanov V; Pfluger PT; Muller TD; Perez-Tilve D; DiMarchi RD; Tschop MH. 2015. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nat Med 21(1):27-36. PubMed: 25485909 MGI: J:227947
Finck BN; Gropler MC; Chen Z; Leone TC; Croce MA; Harris TE; Lawrence JC Jr; Kelly DP. 2006. Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab 4(3):199-210. PubMed: 16950137 MGI: J:129744
Flach RJ; Qin H; Zhang L; Bennett AM. 2011. Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27. J Biol Chem 286(25):22195-202. PubMed: 21521693 MGI: J:174820
Flaquer M; Franquesa M; Vidal A; Bolanos N; Torras J; Lloberas N; Herrero-Fresneda I; Grinyo JM; Cruzado JM. 2012. Hepatocyte growth factor gene therapy enhances infiltration of macrophages and may induce kidney repair in db/db mice as a model of diabetes. Diabetologia 55(7):2059-68. PubMed: 22460762 MGI: J:186732
Fontaine DA; Davis DB. 2016. Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium. Diabetes 65(1):25-33. PubMed: 26696638 MGI: J:231066
Friedman DJ; Talbert ME; Bowden DW; Freedman BI; Mukanya Y; Enjyoji K; Robson SC. 2009. Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease. Diabetes 58(4):999-1006. PubMed: 19095759 MGI: J:150976
Friedman JE; Sun Y; Ishizuka T; Farrell CJ; McCormack SE; Herron LM; Hakimi P; Lechner P; Yun JS. 1997. Phosphoenolpyruvate carboxykinase (GTP) gene transcription and hyperglycemia are regulated by glucocorticoids in genetically obese db/db transgenic mice. J Biol Chem 272(50):31475-81. PubMed: 9395482 MGI: J:44631
Fujimoto S; Goda T; Mochizuki K. 2011. In vivo evidence of enhanced di-methylation of histone H3 K4 on upregulated genes in adipose tissue of diabetic db/db mice. Biochem Biophys Res Commun 404(1):223-7. PubMed: 21110946 MGI: J:167452
Fujita H; Yagishita N; Aratani S; Saito-Fujita T; Morota S; Yamano Y; Hansson MJ; Inazu M; Kokuba H; Sudo K; Sato E; Kawahara K; Nakajima F; Hasegawa D; Higuchi I; Sato T; Araya N; Usui C; Nishioka K; Nakatani Y; Maruyama I; Usui M; Hara N; Uchino H; Elmer E; Nishioka K; Nakajima T. 2015. The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1beta. EMBO J 34(8):1042-55. PubMed: 25698262 MGI: J:220710
Fujita Y; Yanagida H; Mimori T; Jin ZX; Sakai T; Kawanami T; Sawaki T; Masaki Y; Fukushima T; Okazaki T; Umehara H. 2012. Prevention of fasting-mediated bone marrow atrophy by leptin administration. Cell Immunol 273(1):52-8. PubMed: 22196379 MGI: J:181367
Fulton S; Pissios P; Manchon RP; Stiles L; Frank L; Pothos EN; Maratos-Flier E; Flier JS. 2006. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 51(6):811-22. PubMed: 16982425 MGI: J:113646
Furusawa Y; Uruno A; Yagishita Y; Higashi C; Yamamoto M. 2014. Nrf2 induces fibroblast growth factor 21 in diabetic mice. Genes Cells 19(12):864-78. PubMed: 25270507 MGI: J:230324
Gaddy DF; Riedel MJ; Pejawar-Gaddy S; Kieffer TJ; Robbins PD. 2010. In vivo expression of HGF/NK1 and GLP-1 From dsAAV vectors enhances pancreatic ss-cell proliferation and improves pathology in the db/db mouse model of diabetes. Diabetes 59(12):3108-16. PubMed: 20841608 MGI: J:170210
Gaens KH; Goossens GH; Niessen PM; van Greevenbroek MM; van der Kallen CJ; Niessen HW; Rensen SS; Buurman WA; Greve JW; Blaak EE; van Zandvoort MA; Bierhaus A; Stehouwer CD; Schalkwijk CG. 2014. Nepsilon-(carboxymethyl)lysine-receptor for advanced glycation end product axis is a key modulator of obesity-induced dysregulation of adipokine expression and insulin resistance. Arterioscler Thromb Vasc Biol 34(6):1199-208. PubMed: 24723555 MGI: J:222900
Gambhir D; Ananth S; Veeranan-Karmegam R; Elangovan S; Hester S; Jennings E; Offermanns S; Nussbaum JJ; Smith SB; Thangaraju M; Ganapathy V; Martin PM. 2012. GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy. Invest Ophthalmol Vis Sci 53(4):2208-17. PubMed: 22427566 MGI: J:196849
Gao D; Nong S; Huang X; Lu Y; Zhao H; Lin Y; Man Y; Wang S; Yang J; Li J. 2010. The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways. J Biol Chem 285(39):29965-73. PubMed: 20647313 MGI: J:166388
Gao G; Zhang B; Ramesh G; Betterly D; Tadagavadi RK; Wang W; Reeves WB. 2013. TNF-alpha mediates increased susceptibility to ischemic AKI in diabetes. Am J Physiol Renal Physiol 304(5):F515-21. PubMed: 23283990 MGI: J:193268
Gao P; Li L; Ji L; Wei Y; Li H; Shang G; Zhao Z; Chen Q; Jiang T; Zhang N. 2014. Nrf2 ameliorates diabetic nephropathy progression by transcriptional repression of TGFbeta1 through interactions with c-Jun and SP1. Biochim Biophys Acta 1839(11):1110-20. PubMed: 25046864 MGI: J:218484
Gao Q; Wolfgang MJ; Neschen S; Morino K; Horvath TL; Shulman GI; Fu XY. 2004. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A 101(13):4661-6. PubMed: 15070774 MGI: J:89242
Gao X; Belmadani S; Picchi A; Xu X; Potter BJ; Tewari-Singh N; Capobianco S; Chilian WM; Zhang C. 2007. Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice. Circulation 115(2):245-54. PubMed: 17200442 MGI: J:129770
Gao X; Zhang H; Schmidt AM; Zhang C. 2008. AGE/RAGE produces endothelial dysfunction in coronary arterioles in Type 2 diabetic mice. Am J Physiol Heart Circ Physiol 295(2):H491-8. PubMed: 18539754 MGI: J:138204
Gao Y; Ottaway N; Schriever SC; Legutko B; Garcia-Caceres C; de la Fuente E; Mergen C; Bour S; Thaler JP; Seeley RJ; Filosa J; Stern JE; Perez-Tilve D; Schwartz MW; Tschop MH; Yi CX. 2014. Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia 62(1):17-25. PubMed: 24166765 MGI: J:203061
Garcia CC; Potian JG; Hognason K; Thyagarajan B; Sultatos LG; Souayah N; Routh VH; McArdle JJ. 2012. Acetylcholinesterase deficiency contributes to neuromuscular junction dysfunction in type 1 diabetic neuropathy. Am J Physiol Endocrinol Metab 303(4):E551-61. PubMed: 22739110 MGI: J:187409
Garcia-Vicente S; Yraola F; Marti L; Gonzalez-Munoz E; Garcia-Barrado MJ; Canto C; Abella A; Bour S; Artuch R; Sierra C; Brandi N; Carpene C; Moratinos J; Camps M; Palacin M; Testar X; Guma A; Albericio F; Royo M; Mian A; Zorzano A. 2007. Oral insulin-mimetic compounds that act independently of insulin. Diabetes 56(2):486-93. PubMed: 17259395 MGI: J:121956
Garris DR. 2004. Ultrastructural analysis of progressive endometrial hypercytolipidemia induced by obese (ob/ob) and diabetes (db/db) genotype mutations: structural basis of female reproductive tract involution. Tissue Cell 36(1):19-28. PubMed: 14729450 MGI: J:102445
Garris DR. 1995. Developmental and regional changes in brain norepinephrine levels in diabetic C57BL/KsJ mice: effects of estradiol and progesterone. Brain Res Dev Brain Res 89(2):314-9. PubMed: 8612335 MGI: J:29832
Garris DR; Garris BL. 2003. Diabetes-induced, progressive endometrial involution characterization of periluminal epithelial lipoatrophy. Diabetes 52(1):51-8. PubMed: 12502493 MGI: J:80996
Garris DR; Garris BL. 2003. Diabetes (db/db) mutation-induced ovarian involution: progressive hypercytolipidemia. Exp Biol Med (Maywood) 228(9):1040-50. PubMed: 14530513 MGI: J:103053
Garris DR; Garris BL. 2004. Genomic modulation of diabetes (db/db) and obese (ob/ob) mutation-induced hypercytolipidemia: cytochemical basis of female reproductive tract involution. Cell Tissue Res 316(2):233-41. PubMed: 15024641 MGI: J:105101
Garris DR; Garris BL; Novikova L; Lau YS. 2005. Structural, metabolic and endocrine analysis of the diabetes (db/db) hypogonadal syndrome: relationship to hypophyseal hypercytolipidemia. Cell Tissue Res 319(3):501-12. PubMed: 15672265 MGI: J:105149
Ge F; Zhou S; Hu C; Lobdell H th; Berk PD. 2010. Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice. Am J Physiol Gastrointest Liver Physiol 299(4):G855-66. PubMed: 20595619 MGI: J:165834
Gerin I; Louis GW; Zhang X; Prestwich TC; Kumar TR; Myers MG Jr; Macdougald OA; Nothnick WB. 2009. Hyperphagia and obesity in female mice lacking tissue inhibitor of metalloproteinase-1. Endocrinology 150(4):1697-704. PubMed: 19036876 MGI: J:158084
Getchell TV; Kwong K; Saunders CP; Stromberg AJ; Getchell ML. 2006. Leptin regulates olfactory-mediated behavior in ob/ob mice. Physiol Behav 87(5):848-56. PubMed: 16549076 MGI: J:112820
Giacomelli F; Wiener J. 1979. Primary myocardial disease in the diabetic mouse. An ultrastructural study. Lab Invest 40(4):460-73. PubMed: 431046 MGI: J:6115
Gibbs EM; Stock JL; McCoid SC; Stukenbrok HA; Pessin JE; Stevenson RW; Milici AJ; McNeish JD. 1995. Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). J Clin Invest 95(4):1512-8. PubMed: 7706456 MGI: J:109916
Gibran NS; Jang YC; Isik FF; Greenhalgh DG; Muffley LA; Underwood RA; Usui ML; Larsen J; Smith DG; Bunnett N; Ansel JC; Olerud JE. 2002. Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus. J Surg Res 108(1):122-8. PubMed: 12443724 MGI: J:102980
Gilbert RE; Thai K; Advani SL; Cummins CL; Kepecs DM; Schroer SA; Woo M; Zhang Y. 2015. SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes. Diabetologia 58(4):819-27. PubMed: 25563725 MGI: J:220749
Gimeno RE; Dembski M; Weng X; Deng N; Shyjan AW; Gimeno CJ; Iris F; Ellis SJ; Woolf EA; Tartaglia LA. 1997. Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes 46(5):900-6. PubMed: 9133562 MGI: J:40062
Giordano A; Murano I; Mondini E; Perugini J; Smorlesi A; Severi I; Barazzoni R; Scherer PE; Cinti S. 2013. Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis. J Lipid Res 54(9):2423-36. PubMed: 23836106 MGI: J:200764
Girousse A; Tavernier G; Valle C; Moro C; Mejhert N; Dinel AL; Houssier M; Roussel B; Besse-Patin A; Combes M; Mir L; Monbrun L; Bezaire V; Prunet-Marcassus B; Waget A; Vila I; Caspar-Bauguil S; Louche K; Marques MA; Mairal A; Renoud ML; Galitzky J; HolmC; Mouisel E; Thalamas C; Viguerie N; Sulpice T; Burcelin R; Arner P; Langin D. 2013. Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass. PLoS Biol 11(2):e1001485. PubMed: 23431266 MGI: J:194519
Gloaguen I; Costa P; Demartis A; Lazzaro D; Di Marco A; Graziani R ; Paonessa G ; Chen F ; Rosenblum CI ; Van der Ploeg LH ; Cortese R ; Ciliberto G ; Laufer R. 1997. Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc Natl Acad Sci U S A 94(12):6456-61. PubMed: 9177239 MGI: J:40976
Goldberg R; Rubinstein AM; Gil N; Hermano E; Li JP; van der Vlag J; Atzmon R; Meirovitz A; Elkin M. 2014. Role of heparanase-driven inflammatory cascade in pathogenesis of diabetic nephropathy. Diabetes 63(12):4302-13. PubMed: 25008182 MGI: J:230140
Gomez JA; Rutkowski DT. 2016. Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression. Elife 5:. PubMed: 27938665 MGI: J:239449
Gomez-Valades AG; Mendez-Lucas A; Vidal-Alabro A; Blasco FX; Chillon M; Bartrons R; Bermudez J; Perales JC. 2008. Pck1 gene silencing in the liver improves glycemia control, insulin sensitivity, and dyslipidemia in db/db mice. Diabetes 57(8):2199-210. PubMed: 18443203 MGI: J:141320
Goncalves AC; Tank J; Diedrich A; Hilzendeger A; Plehm R; Bader M; Luft FC; Jordan J; Gross V. 2009. Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction. Hypertension 53(2):387-92. PubMed: 19029483 MGI: J:165006
Goncalves GH; Li W; Garcia AV; Figueiredo MS; Bjorbaek C. 2014. Hypothalamic agouti-related peptide neurons and the central melanocortin system are crucial mediators of leptin's antidiabetic actions. Cell Rep 7(4):1093-103. PubMed: 24813890 MGI: J:211797
Gonzalez A; Andre-Schmutz I; Carnaud C; Mathis D; Benoist C. 2001. Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat Immunol 2(12):1117-25. PubMed: 11713466 MGI: J:109860
Gonzalez S; Berthelot J; Jiner J; Perrin-Tricaud C; Fernando R; Chrast R; Lenaers G; Tricaud N. 2016. Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies. J Clin Invest 126(3):1023-38. PubMed: 26878172 MGI: J:232421
Gonzalez-Quesada C; Cavalera M; Biernacka A; Kong P; Lee DW; Saxena A; Frunza O; Dobaczewski M; Shinde A; Frangogiannis NG. 2013. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation. Circ Res 113(12):1331-44. PubMed: 24081879 MGI: J:221465
Gove ME; Rhodes DH; Pini M; van Baal JW; Sennello JA; Fayad R; Cabay RJ; Myers MG Jr; Fantuzzi G. 2009. Role of leptin receptor-induced STAT3 signaling in modulation of intestinal and hepatic inflammation in mice. J Leukoc Biol 85(3):491-6. PubMed: 19052144 MGI: J:146076
Graewin SJ; Lee KH; Tran KQ; Goldblatt MI; Svatek CL; Nakeeb A; Pitt HA. 2004. Leptin-resistant obese mice do not form biliary crystals on a high cholesterol diet. J Surg Res 122(2):145-9. PubMed: 15555610 MGI: J:101794
Gravaghi C; Bo J; Laperle KM; Quimby F; Kucherlapati R; Edelmann W; Lamprecht SA. 2008. Obesity enhances gastrointestinal tumorigenesis in Apc-mutant mice. Int J Obes (Lond) 32(11):1716-9. PubMed: 18725892 MGI: J:142259
Graves DT; Naguib G; Lu H; Leone C; Hsue H; Krall E. 2005. Inflammation is more persistent in type 1 diabetic mice. J Dent Res 84(4):324-8. PubMed: 15790737 MGI: J:112485
Graw JA; Yu B; Rezoagli E; Warren HS; Buys ES; Bloch DB; Zapol WM. 2017. Endothelial dysfunction inhibits the ability of haptoglobin to prevent hemoglobin-induced hypertension. Am J Physiol Heart Circ Physiol 312(6):H1120-H1127. PubMed: 28314763 MGI: J:242856
Greer JJ; Ware DP; Lefer DJ. 2006. Myocardial infarction and heart failure in the db/db diabetic mouse. Am J Physiol Heart Circ Physiol 290(1):H146-53. PubMed: 16113078 MGI: J:104790
Grice EA; Snitkin ES; Yockey LJ; Bermudez DM; Liechty KW; Segre JA. 2010. Longitudinal shift in diabetic wound microbiota correlates with prolonged skin defense response. Proc Natl Acad Sci U S A 107(33):14799-804. PubMed: 20668241 MGI: J:163594
Grochot-Przeczek A; Lach R; Mis J; Skrzypek K; Gozdecka M; Sroczynska P; Dubiel M; Rutkowski A; Kozakowska M; Zagorska A; Walczynski J; Was H; Kotlinowski J; Drukala J; Kurowski K; Kieda C; Herault Y; Dulak J; Jozkowicz A. 2009. Heme oxygenase-1 accelerates cutaneous wound healing in mice. PLoS One 4(6):e5803. PubMed: 19495412 MGI: J:150205
Gropler MC; Harris TE; Hall AM; Wolins NE; Gross RW; Han X; Chen Z; Finck BN. 2009. Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice. J Biol Chem 284(11):6763-72. PubMed: 19136718 MGI: J:148371
Grove KJ; Voziyan PA; Spraggins JM; Wang S; Paueksakon P; Harris RC; Hudson BG; Caprioli RM. 2014. Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles. J Lipid Res 55(7):1375-1385. PubMed: 24864273 MGI: J:214997
Gruen ML; Hao M; Piston DW; Hasty AH. 2007. Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis. Am J Physiol Cell Physiol 293(5):C1481-8. PubMed: 17728393 MGI: J:128699
Gruen ML; Plummer MR; Zhang W; Posey KA; Linton M; Fazio S; Hasty AH. 2005. Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. J Lipid Res 46(9):2007-14. PubMed: 15995171 MGI: J:100492
Guarini G; Ohanyan VA; Kmetz JG; DelloStritto DJ; Thoppil RJ; Thodeti CK; Meszaros JG; Damron DS; Bratz IN. 2012. Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels. Am J Physiol Heart Circ Physiol 303(2):H216-23. PubMed: 22610171 MGI: J:189028
Guinez C; Filhoulaud G; Rayah-Benhamed F; Marmier S; Dubuquoy C; Dentin R; Moldes M; Burnol AF; Yang X; Lefebvre T; Girard J; Postic C. 2011. O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver. Diabetes 60(5):1399-413. PubMed: 21471514 MGI: J:171811
Gundewar S; Calvert JW; Elrod JW; Lefer DJ. 2007. Cytoprotective effects of N,N,N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetes. Am J Physiol Heart Circ Physiol 293(4):H2462-71. PubMed: 17630348 MGI: J:126117
Guo K; Mogen J; Struzzi S; Zhang Y. 2009. Preadipocyte transplantation: an in vivo study of direct leptin signaling on adipocyte morphogenesis and cell size. Am J Physiol Regul Integr Comp Physiol 296(5):R1339-47. PubMed: 19193947 MGI: J:148045
Guo L; Zhou SR; Wei XB; Liu Y; Chang XX; Liu Y; Ge X; Dou X; Huang HY; Qian SW; Li X; Lei QY; Gao X; Tang QQ. 2016. Acetylation of Mitochondrial Trifunctional Protein alpha-Subunit Enhances Its Stability To Promote Fatty Acid Oxidation and Is Decreased in Nonalcoholic Fatty Liver Disease. Mol Cell Biol 36(20):2553-67. PubMed: 27457618 MGI: J:236308
Guo M; Ricardo SD; Deane JA; Shi M; Cullen-McEwen L; Bertram JF. 2005. A stereological study of the renal glomerular vasculature in the db/db mouse model of diabetic nephropathy. J Anat 207(6):813-21. PubMed: 16367807 MGI: J:112821
Guo S; Dai C; Guo M; Taylor B; Harmon JS; Sander M; Robertson RP; Powers AC; Stein R. 2013. Inactivation of specific beta cell transcription factors in type 2 diabetes. J Clin Invest :. PubMed: 23863625 MGI: J:201414
Guo Z; Su W; Allen S; Pang H; Daugherty A; Smart E; Gong MC. 2005. COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice. Cardiovasc Res 67(4):723-35. PubMed: 15885672 MGI: J:106597
Gutkowska J; Broderick TL; Bogdan D; Wang D; Lavoie JM; Jankowski M. 2009. Downregulation of oxytocin and natriuretic peptides in diabetes: possible implications in cardiomyopathy. J Physiol 587(Pt 19):4725-36. PubMed: 19675071 MGI: J:176789
Guzman J; Jauregui AN; Merscher-Gomez S; Maiguel D; Muresan C; Mitrofanova A; Diez-Sampedro A; Szust J; Yoo TH; Villarreal R; Pedigo C; Molano RD; Johnson K; Kahn B; Hartleben B; Huber TB; Saha J; Burke GW 3rd; Abel ED; Brosius FC; Fornoni A. 2014. Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy. Diabetes 63(2):701-14. PubMed: 24101677 MGI: J:209030
Ha TS; Barnes JL; Stewart JL; Ko CW; Miner JH; Abrahamson DR; Sanes JR; Kasinath BS. 1999. Regulation of renal laminin in mice with type II diabetes. J Am Soc Nephrol 10(9):1931-9. PubMed: 10477145 MGI: J:103217
Habegger KM; Stemmer K; Cheng C; Muller TD; Heppner KM; Ottaway N; Holland J; Hembree JL; Smiley D; Gelfanov V; Krishna R; Arafat AM; Konkar A; Belli S; Kapps M; Woods SC; Hofmann SM; D'Alessio D; Pfluger PT; Perez-Tilve D; Seeley RJ; Konishi M; Itoh N;Kharitonenkov A; Spranger J; DiMarchi RD; Tschop MH. 2013. Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes 62(5):1453-63. PubMed: 23305646 MGI: J:208580
Hafstad AD; Khalid AM; How OJ; Larsen TS; Aasum E. 2007. Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice. Am J Physiol Endocrinol Metab 292(5):E1288-94. PubMed: 17213470 MGI: J:121240
Hafstad AD; Solevag GH; Severson DL; Larsen TS; Aasum E. 2006. Perfused hearts from Type 2 diabetic (db/db) mice show metabolic responsiveness to insulin. Am J Physiol Heart Circ Physiol 290(5):H1763-9. PubMed: 16327015 MGI: J:108594
Halaas JL; Gajiwala KS; Maffei M; Cohen SL; Chait BT; Rabinowitz D; Lallone RL; Burley SK; Friedman JM. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene [see comments] Science 269(5223):543-6. PubMed: 7624777 MGI: J:29161
Hall ME; Maready MW; Hall JE; Stec DE. 2014. Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation. Am J Physiol Endocrinol Metab 307(3):E316-25. PubMed: 24939734 MGI: J:215497
Ham M; Lee JW; Choi AH; Jang H; Choi G; Park J; Kozuka C; Sears DD; Masuzaki H; Kim JB. 2013. Macrophage glucose-6-phosphate dehydrogenase stimulates proinflammatory responses with oxidative stress. Mol Cell Biol 33(12):2425-35. PubMed: 23572562 MGI: J:204495
Hamdani N; Hervent AS; Vandekerckhove L; Matheeussen V; Demolder M; Baerts L; De Meester I; Linke WA; Paulus WJ; De Keulenaer GW. 2014. Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4. Cardiovasc Res 104(3):423-31. PubMed: 25341892 MGI: J:230314
Hamilton RT; Bhattacharya A; Walsh ME; Shi Y; Wei R; Zhang Y; Rodriguez KA; Buffenstein R; Chaudhuri AR; Van Remmen H. 2013. Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination. PLoS One 8(6):e65725. PubMed: 23750273 MGI: J:204258
Han J; Murthy R; Wood B; Song B; Wang S; Sun B; Malhi H; Kaufman RJ. 2013. ER stress signalling through eIF2alpha and CHOP, but not IRE1alpha, attenuates adipogenesis in mice. Diabetologia 56(4):911-24. PubMed: 23314846 MGI: J:195432
Han KL; Choi JS; Lee JY; Song J; Joe MK; Jung MH; Hwang JK. 2008. Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes. Diabetes 57(3):737-45. PubMed: 18065517 MGI: J:132456
Han S; Akiyama TE; Previs SF; Herath K; Roddy TP; Jensen KK; Guan HP; Murphy BA; McNamara LA; Shen X; Strapps W; Hubbard BK; Pinto S; Li C; Li J. 2013. Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice. J Lipid Res 54(10):2615-22. PubMed: 23828778 MGI: J:202630
Han YM; Kang GM; Byun K; Ko HW; Kim J; Shin MS; Kim HK; Gil SY; Yu JH; Lee B; Kim MS. 2014. Leptin-promoted cilia assembly is critical for normal energy balance. J Clin Invest 124(5):2193-7. PubMed: 24667636 MGI: J:212773
Harmon JS; Bogdani M; Parazzoli SD; Mak SS; Oseid EA; Berghmans M; Leboeuf RC; Robertson RP. 2009. beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice. Endocrinology 150(11):4855-62. PubMed: 19819955 MGI: J:158220
Harris RB. 1999. Parabiosis between db/db and ob/ob or db/+ mice. Endocrinology 140(1):138-45. PubMed: 9886818 MGI: J:114258
Harris RB. 2015. In vivo evidence for unidentified leptin-induced circulating factors that control white fat mass. Am J Physiol Regul Integr Comp Physiol 309(12):R1499-511. PubMed: 26468261 MGI: J:237589
Harris RB; Mitchell TD; Yan X; Simpson JS; Redmann SM Jr. 2001. Metabolic responses to leptin in obese db/db mice are strain dependent. Am J Physiol Regul Integr Comp Physiol 281(1):R115-32. PubMed: 11404285 MGI: J:70291
Harrod JS; Rada CC; Pierce SL; England SK; Lamping KG. 2011. Altered contribution of RhoA/Rho kinase signaling in contractile activity of myometrium in leptin receptor-deficient mice. Am J Physiol Endocrinol Metab 301(2):E362-9. PubMed: 21558549 MGI: J:182059
Hasegawa K; Wakino S; Simic P; Sakamaki Y; Minakuchi H; Fujimura K; Hosoya K; Komatsu M; Kaneko Y; Kanda T; Kubota E; Tokuyama H; Hayashi K; Guarente L; Itoh H. 2013. Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. Nat Med 19(11):1496-504. PubMed: 24141423 MGI: J:203764
Hayakawa M; Itoh M; Ohta K; Li S; Ueda M; Wang MX; Nishida E; Islam S; Suzuki C; Ohzawa K; Kobori M; Inuzuka T; Nakagawa T. 2015. Quercetin reduces eIF2alpha phosphorylation by GADD34 induction. Neurobiol Aging 36(9):2509-18. PubMed: 26070242 MGI: J:226287
He F; Peng F; Xia X; Zhao C; Luo Q; Guan W; Li Z; Yu X; Huang F. 2014. MiR-135a promotes renal fibrosis in diabetic nephropathy by regulating TRPC1. Diabetologia 57(8):1726-36. PubMed: 24908566 MGI: J:214738
He H; Liu R; Desta T; Leone C; Gerstenfeld LC; Graves DT. 2004. Diabetes causes decreased osteoclastogenesis, reduced bone formation, and enhanced apoptosis of osteoblastic cells in bacteria stimulated bone loss. Endocrinology 145(1):447-52. PubMed: 14525917 MGI: J:87439
He M; Pan H; Xiao C; Pu M. 2013. Roles for redox signaling by NADPH oxidase in hyperglycemia-induced heme oxygenase-1 expression in the diabetic retina. Invest Ophthalmol Vis Sci 54(6):4092-101. PubMed: 23633655 MGI: J:215441
Hellmann J; Zhang MJ; Tang Y; Rane M; Bhatnagar A; Spite M. 2013. Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production. J Immunol 191(3):1383-92. PubMed: 23785121 MGI: J:205443
Henao-Mejia J; Elinav E; Jin C; Hao L; Mehal WZ; Strowig T; Thaiss CA; Kau AL; Eisenbarth SC; Jurczak MJ; Camporez JP; Shulman GI; Gordon JI; Hoffman HM; Flavell RA. 2012. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482(7384):179-85. PubMed: 22297845 MGI: J:181354
Herberg L; Coleman DL. 1977. Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism 26(1):59-99. PubMed: 834144 MGI: J:5759
Hileman SM; Pierroz DD; Masuzaki H; Bjorbaek C; El-Haschimi K; Banks WA; Flier JS. 2002. Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 143(3):775-83. PubMed: 11861497 MGI: J:109736
Hinder LM; Vincent AM; Hayes JM; McLean LL; Feldman EL. 2013. Apolipoprotein E knockout as the basis for mouse models of dyslipidemia-induced neuropathy. Exp Neurol 239:102-10. PubMed: 23059459 MGI: J:196993
Hirai S; Ohyane C; Kim YI; Lin S; Goto T; Takahashi N; Kim CS; Kang J; Yu R; Kawada T. 2014. Involvement of mast cells in adipose tissue fibrosis. Am J Physiol Endocrinol Metab 306(3):E247-55. PubMed: 24326418 MGI: J:208372
Hirata A; Maeda N; Hiuge A; Hibuse T; Fujita K; Okada T; Kihara S; Funahashi T; Shimomura I. 2009. Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice. Cardiovasc Res 84(1):164-72. PubMed: 19505930 MGI: J:172486
Hirata A; Maeda N; Nakatsuji H; Hiuge-Shimizu A; Okada T; Funahashi T; Shimomura I. 2012. Contribution of glucocorticoid-mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction. Biochem Biophys Res Commun 419(2):182-7. PubMed: 22326264 MGI: J:182606
Hirose Y; Hata K; Kuno T; Yoshida K; Sakata K; Yamada Y; Tanaka T; Reddy BS; Mori H. 2004. Enhancement of development of azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice. Carcinogenesis 25(5):821-5. PubMed: 14729596 MGI: J:89550
Hirukawa H; Kaneto H; Shimoda M; Kimura T; Okauchi S; Obata A; Kohara K; Hamamoto S; Tawaramoto K; Hashiramoto M; Kaku K. 2015. Combination of DPP-4 inhibitor and PPARgamma agonist exerts protective effects on pancreatic beta-cells in diabetic db/db mice through the augmentation of IRS-2 expression. Mol Cell Endocrinol 413:49-60. PubMed: 26116826 MGI: J:227036
Hodgin JB; Nair V; Zhang H; Randolph A; Harris RC; Nelson RG; Weil EJ; Cavalcoli JD; Patel JM; Brosius FC 3rd; Kretzler M. 2013. Identification of cross-species shared transcriptional networks of diabetic nephropathy in human and mouse glomeruli. Diabetes 62(1):299-308. PubMed: 23139354 MGI: J:208605
Hodgson KA; Govan BL; Walduck AK; Ketheesan N; Morris JL. 2013. Impaired early cytokine responses at the site of infection in a murine model of type 2 diabetes and melioidosis comorbidity. Infect Immun 81(2):470-7. PubMed: 23208607 MGI: J:192559
Hoffmann DC; Textoris C; Oehme F; Klaassen T; Goppelt A; Romer A; Fugmann B; Davidson JM; Werner S; Krieg T; Eming SA. 2011. Pivotal role for alpha1-antichymotrypsin in skin repair. J Biol Chem 286(33):28889-901. PubMed: 21693707 MGI: J:175923
Holmstrom MH; Iglesias-Gutierrez E; Zierath JR; Garcia-Roves PM. 2012. Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab 302(6):E731-9. PubMed: 22252943 MGI: J:184641
Hong S; Tian H; Lu Y; Laborde JM; Muhale FA; Wang Q; Alapure BV; Serhan CN; Bazan NG. 2014. Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes. Am J Physiol Cell Physiol 307(11):C1058-67. PubMed: 25273880 MGI: J:223587
Hoshino A; Ariyoshi M; Okawa Y; Kaimoto S; Uchihashi M; Fukai K; Iwai-Kanai E; Ikeda K; Ueyama T; Ogata T; Matoba S. 2014. Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic beta-cell function in diabetes. Proc Natl Acad Sci U S A 111(8):3116-21. PubMed: 24516131 MGI: J:206823
How OJ; Aasum E; Severson DL; Chan WY; Essop MF; Larsen TS. 2006. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. Diabetes 55(2):466-73. PubMed: 16443782 MGI: J:106871
Howard AC; McNeil AK; Xiong F; Xiong WC; McNeil PL. 2011. A novel cellular defect in diabetes: membrane repair failure. Diabetes 60(11):3034-43. PubMed: 21940783 MGI: J:189473
Hsu FL; Huang CF; Chen YW; Yen YP; Wu CT; Uang BJ; Yang RS; Liu SH. 2013. Antidiabetic effects of pterosin A, a small-molecular-weight natural product, on diabetic mouse models. Diabetes 62(2):628-38. PubMed: 23069626 MGI: J:208614
Hu X; Wu R; Jiang Z; Wang L; Chen P; Zhang L; Yang L; Wu Y; Chen H; Chen H; Xu Y; Zhou Y; Huang X; Webster KA; Yu H; Wang J. 2014. Leptin signaling is required for augmented therapeutic properties of mesenchymal stem cells conferred by hypoxia preconditioning. Stem Cells 32(10):2702-13. PubMed: 24989835 MGI: J:218496
Hu Y; Chen Y; Ding L; He X; Takahashi Y; Gao Y; Shen W; Cheng R; Chen Q; Qi X; Boulton ME; Ma JX. 2013. Pathogenic role of diabetes-induced PPAR-alpha down-regulation in microvascular dysfunction. Proc Natl Acad Sci U S A 110(38):15401-6. PubMed: 24003152 MGI: J:201158
Hu Z; Lee IH; Wang X; Sheng H; Zhang L; Du J; Mitch WE. 2007. PTEN expression contributes to the regulation of muscle protein degradation in diabetes. Diabetes 56(10):2449-56. PubMed: 17623817 MGI: J:126566
Huang A; Yang YM; Feher A; Bagi Z; Kaley G; Sun D. 2012. Exacerbation of endothelial dysfunction during the progression of diabetes: role of oxidative stress. Am J Physiol Regul Integr Comp Physiol 302(6):R674-81. PubMed: 22262308 MGI: J:182636
Huang Y; Border WA; Yu L; Zhang J; Lawrence DA; Noble NA. 2008. A PAI-1 mutant, PAI-1R, slows progression of diabetic nephropathy. J Am Soc Nephrol 19(2):329-38. PubMed: 18216319 MGI: J:149930
Huby AC; Antonova G; Groenendyk J; Gomez-Sanchez CE; Bollag WB; Filosa JA; Belin de Chantemele EJ. 2015. Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis. Circulation 132(22):2134-45. PubMed: 26362633 MGI: J:239049
Huh JY; Kim JI; Park YJ; Hwang IJ; Lee YS; Sohn JH; Lee SK; Alfadda AA; Kim SS; Choi SH; Lee DS; Park SH; Seong RH; Choi CS; Kim JB. 2013. A novel function of adipocytes in lipid antigen presentation to iNKT cells. Mol Cell Biol 33(2):328-39. PubMed: 23149942 MGI: J:194102
Huh JY; Kim Y; Jeong J; Park J; Kim I; Huh KH; Kim YS; Woo HA; Rhee SG; Lee KJ; Ha H. 2012. Peroxiredoxin 3 is a key molecule regulating adipocyte oxidative stress, mitochondrial biogenesis, and adipokine expression. Antioxid Redox Signal 16(3):229-43. PubMed: 21902452 MGI: J:228860
Hui X; Zhu W; Wang Y; Lam KS; Zhang J; Wu D; Kraegen EW; Li Y; Xu A. 2009. Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice. J Biol Chem 284(21):14050-7. PubMed: 19336396 MGI: J:150507
Hummel KP; Chapman DB. 1970. Location of diabetes (db) in Linkage Group VIII. Mouse News Lett 42:29. MGI: J:13504
Huo L; Gamber K; Greeley S; Silva J; Huntoon N; Leng XH; Bjorbaek C. 2009. Leptin-dependent control of glucose balance and locomotor activity by POMC neurons. Cell Metab 9(6):537-47. PubMed: 19490908 MGI: J:149825
Hur J; O'Brien PD; Nair V; Hinder LM; McGregor BA; Jagadish HV; Kretzler M; Brosius FC 3rd; Feldman EL. 2016. Transcriptional networks of murine diabetic peripheral neuropathy and nephropathy: common and distinct gene expression patterns. Diabetologia 59(6):1297-306. PubMed: 27000313 MGI: J:234707
Hutchinson KR; Lord CK; West TA; Stewart JA Jr. 2013. Cardiac fibroblast-dependent extracellular matrix accumulation is associated with diastolic stiffness in type 2 diabetes. PLoS One 8(8):e72080. PubMed: 23991045 MGI: J:205959
Huynh FK; Levi J; Denroche HC; Gray SL; Voshol PJ; Neumann UH; Speck M; Chua SC; Covey SD; Kieffer TJ. 2010. Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance. Diabetes 59(12):3032-40. PubMed: 20876720 MGI: J:170191
Huynh K; Kiriazis H; Du XJ; Love JE; Jandeleit-Dahm KA; Forbes JM; McMullen JR; Ritchie RH. 2012. Coenzyme Q(10) attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes. Diabetologia 55(5):1544-53. PubMed: 22374176 MGI: J:183248
Ichinose K; Maeshima Y; Yamamoto Y; Kinomura M; Hirokoshi K; Kitayama H; Takazawa Y; Sugiyama H; Yamasaki Y; Agata N; Makino H. 2006. 2-(8-hydroxy-6-methoxy-1-oxo-1h-2-benzopyran-3-yl) propionic acid, an inhibitor of angiogenesis, ameliorates renal alterations in obese type 2 diabetic mice. Diabetes 55(5):1232-42. PubMed: 16644677 MGI: J:108664
Ii M; Nishimura H; Kusano KF; Qin G; Yoon YS; Wecker A; Asahara T; Losordo DW. 2005. Neuronal nitric oxide synthase mediates statin-induced restoration of vasa nervorum and reversal of diabetic neuropathy. Circulation 112(1):93-102. PubMed: 15983249 MGI: J:116383
Ijaz A; Tejada T; Catanuto P; Xia X; Elliot SJ; Lenz O; Jauregui A; Saenz MO; Molano RD; Pileggi A; Ricordi C; Fornoni A. 2009. Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes. Kidney Int 75(4):381-8. PubMed: 18971923 MGI: J:162711
Ikeda N; Inoguchi T; Sonoda N; Fujii M; Takei R; Hirata E; Yokomizo H; Zheng J; Maeda Y; Kobayashi K; Takayanagi R. 2011. Biliverdin protects against the deterioration of glucose tolerance in db/db mice. Diabetologia 54(8):2183-91. PubMed: 21614569 MGI: J:173324
Ikeda Y; Enomoto H; Tajima S; Izawa-Ishizawa Y; Kihira Y; Ishizawa K; Tomita S; Tsuchiya K; Tamaki T. 2013. Dietary iron restriction inhibits progression of diabetic nephropathy in db/db mice. Am J Physiol Renal Physiol 304(7):F1028-36. PubMed: 23389454 MGI: J:195416
Ikejima S; Sasaki S; Sashinami H; Mori F; Ogawa Y; Nakamura T; Abe Y; Wakabayashi K; Suda T; Nakane A. 2005. Impairment of host resistance to Listeria monocytogenes infection in liver of db/db and ob/ob mice. Diabetes 54(1):182-9. PubMed: 15616027 MGI: J:105107
Ilkun O; Wilde N; Tuinei J; Pires KM; Zhu Y; Bugger H; Soto J; Wayment B; Olsen C; Litwin SE; Abel ED. 2015. Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome. J Mol Cell Cardiol 85:104-16. PubMed: 26004364 MGI: J:225751
Imajo K; Fujita K; Yoneda M; Nozaki Y; Ogawa Y; Shinohara Y; Kato S; Mawatari H; Shibata W; Kitani H; Ikejima K; Kirikoshi H; Nakajima N; Saito S; Maeyama S; Watanabe S; Wada K; Nakajima A. 2012. Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling. Cell Metab 16(1):44-54. PubMed: 22768838 MGI: J:187402
Inoki K; Mori H; Wang J; Suzuki T; Hong S; Yoshida S; Blattner SM; Ikenoue T; Ruegg MA; Hall MN; Kwiatkowski DJ; Rastaldi MP; Huber TB; Kretzler M; Holzman LB; Wiggins RC; Guan KL. 2011. mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest 121(6):2181-96. PubMed: 21606597 MGI: J:174017
Inoue T; Kobayashi K; Inoguchi T; Sonoda N; Maeda Y; Hirata E; Fujimura Y; Miura D; Hirano K; Takayanagi R. 2013. Downregulation of adipose triglyceride lipase in the heart aggravates diabetic cardiomyopathy in db/db mice. Biochem Biophys Res Commun 438(1):224-9. PubMed: 23886955 MGI: J:210766
Iqbal J; Li X; Chang BH; Chan L; Schwartz GJ; Chua SC Jr; Hussain MM. 2010. An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption. J Lipid Res 51(7):1929-42. PubMed: 20164094 MGI: J:162835
Isoe T; Makino Y; Mizumoto K; Sakagami H; Fujita Y; Honjo J; Takiyama Y; Itoh H; Haneda M. 2010. High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein. Kidney Int 78(1):48-59. PubMed: 20375990 MGI: J:184270
Israel DD; Sheffer-Babila S; de Luca C; Jo YH; Liu SM; Xia Q; Spergel DJ; Dun SL; Dun NJ; Chua SC Jr. 2012. Effects of leptin and melanocortin signaling interactions on pubertal development and reproduction. Endocrinology 153(5):2408-19. PubMed: 22408174 MGI: J:184987
Itateyama E; Chiba S; Sakata T; Yoshimatsu H. 2003. Hypothalamic neuronal histamine in genetically obese animals: its implication of leptin action in the brain. Exp Biol Med (Maywood) 228(10):1132-7. PubMed: 14610251 MGI: J:103056
Iwakura H; Akamizu T; Ariyasu H; Irako T; Hosoda K; Nakao K; Kangawa K. 2007. Effects of ghrelin administration on decreased growth hormone status in obese animals. Am J Physiol Endocrinol Metab 293(3):E819-25. PubMed: 17595213 MGI: J:125421
Jacovetti C; Jimenez V; Ayuso E; Laybutt R; Peyot ML; Prentki M; Bosch F; Regazzi R. 2015. Contribution of Intronic miR-338-3p and Its Hosting Gene AATK to Compensatory beta-Cell Mass Expansion. Mol Endocrinol 29(5):693-702. PubMed: 25751313 MGI: J:231642
Jager J; Gremeaux T; Gonzalez T; Bonnafous S; Debard C; Laville M; Vidal H; Tran A; Gual P; Le Marchand-Brustel Y; Cormont M; Tanti JF. 2010. Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis. Diabetes 59(1):61-70. PubMed: 19808894 MGI: J:164170
James AN; Ryan JP; Crowell MD; Parkman HP. 2004. Regional gastric contractility alterations in a diabetic gastroparesis mouse model: effects of cholinergic and serotoninergic stimulation. Am J Physiol Gastrointest Liver Physiol 287(3):G612-9. PubMed: 15107299 MGI: J:96077
Jang H; Lee GY; Selby CP; Lee G; Jeon YG; Lee JH; Cheng KK; Titchenell P; Birnbaum MJ; Xu A; Sancar A; Kim JB. 2016. SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding. Nat Commun 7:12180. PubMed: 27412556 MGI: J:240830
Januszyk M; Sorkin M; Glotzbach JP; Vial IN; Maan ZN; Rennert RC; Duscher D; Thangarajah H; Longaker MT; Butte AJ; Gurtner GC. 2014. Diabetes irreversibly depletes bone marrow-derived mesenchymal progenitor cell subpopulations. Diabetes 63(9):3047-56. PubMed: 24740572 MGI: J:229868
Jaworski K; Ahmadian M; Duncan RE; Sarkadi-Nagy E; Varady KA; Hellerstein MK; Lee HY; Samuel VT; Shulman GI; Kim KH; de Val S; Kang C; Sul HS. 2009. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nat Med 15(2):159-68. PubMed: 19136964 MGI: J:239202
Jeong HW; Lee JW; Kim WS; Choe SS; Kim KH; Park HS; Shin HJ; Lee GY; Shin D; Lee H; Lee JH; Choi EB; Lee HK; Chung H; Park SB; Park KS; Kim HS; Ro S; Kim JB. 2011. A newly identified CG301269 improves lipid and glucose metabolism without body weight gain through activation of peroxisome proliferator-activated receptor alpha and gamma. Diabetes 60(2):496-506. PubMed: 21270261 MGI: J:169786
Jiang L; You J; Yu X; Gonzalez L; Yu Y; Wang Q; Yang G; Li W; Li C; Liu Y. 2008. Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. Proc Natl Acad Sci U S A 105(47):18619-24. PubMed: 19015522 MGI: J:142218
Jiang T; Wang XX; Scherzer P; Wilson P; Tallman J; Takahashi H; Li J; Iwahashi M; Sutherland E; Arend L; Levi M. 2007. Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy. Diabetes 56(10):2485-93. PubMed: 17660268 MGI: J:126553
Jimenez-Palomares M; Ramos-Rodriguez JJ; Lopez-Acosta JF; Pacheco-Herrero M; Lechuga-Sancho AM; Perdomo G; Garcia-Alloza M; Cozar-Castellano I. 2012. Increased Abeta production prompts the onset of glucose intolerance and insulin resistance. Am J Physiol Endocrinol Metab 302(11):E1373-80. PubMed: 22414803 MGI: J:186924
Jin S; Chang C; Zhang L; Liu Y; Huang X; Chen Z. 2015. Chlorogenic acid improves late diabetes through adiponectin receptor signaling pathways in db/db mice. PLoS One 10(4):e0120842. PubMed: 25849026 MGI: J:233416
Johnson DR; O'Connor JC; Hartman ME; Tapping RI; Freund GG. 2007. Acute hypoxia activates the neuroimmune system, which diabetes exacerbates. J Neurosci 27(5):1161-6. PubMed: 17267571 MGI: J:117904
Johnson LM; Sidman RL. 1979. A reproductive endocrine profile in the diabetes (db) mutant mouse. Biol Reprod 20(3):552-9. PubMed: 378276 MGI: J:6157
Jones SP; Girod WG; Granger DN; Palazzo AJ; Lefer DJ. 1999. Reperfusion injury is not affected by blockade of P-selectin in the diabetic mouse heart. Am J Physiol 277(2 Pt 2):H763-9. PubMed: 10444504 MGI: J:56871
Joost HG; Schurmann A. 2014. The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models. Mamm Genome 25(9-10):401-12. PubMed: 24752583 MGI: J:216848
Jordan SD; Kruger M; Willmes DM; Redemann N; Wunderlich FT; Bronneke HS; Merkwirth C; Kashkar H; Olkkonen VM; Bottger T; Braun T; Seibler J; Bruning JC. 2011. Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat Cell Biol 13(4):434-46. PubMed: 21441927 MGI: J:176266
Jun JI; Kim KH; Lau LF. 2015. The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing. Nat Commun 6:7386. PubMed: 26077348 MGI: J:223027
Jung TW; Choi HY; Lee SY; Hong HC; Yang SJ; Yoo HJ; Youn BS; Baik SH; Choi KM. 2013. Salsalate and Adiponectin Improve Palmitate-Induced Insulin Resistance via Inhibition of Selenoprotein P through the AMPK-FOXO1alpha Pathway. PLoS One 8(6):e66529. PubMed: 23825542 MGI: J:203458
Jung UJ; Park YB; Kim SR; Choi MS. 2012. Supplementation of persimmon leaf ameliorates hyperglycemia, dyslipidemia and hepatic fat accumulation in type 2 diabetic mice. PLoS One 7(11):e49030. PubMed: 23145054 MGI: J:195029
Jung YJ; Choi HJ; Lee JE; Lee AS; Kang KP; Lee S; Park SK; Park TS; Jin HY; Lee SY; Kim DH; Kim W. 2012. The effects of designed angiopoietin-1 variant on lipid droplet diameter, vascular endothelial cell density and metabolic parameters in diabetic db/db mice. Biochem Biophys Res Commun 420(3):498-504. PubMed: 22430141 MGI: J:183490
Jurczak MJ; Lee HY; Birkenfeld AL; Jornayvaz FR; Frederick DW; Pongratz RL; Zhao X; Moeckel GW; Samuel VT; Whaley JM; Shulman GI; Kibbey RG. 2011. SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic {beta}-Cell Function. Diabetes 60(3):890-8. PubMed: 21357472 MGI: J:169747
Ka SM; Yeh YC; Huang XR; Chao TK; Hung YJ; Yu CP; Lin TJ; Wu CC; Lan HY; Chen A. 2012. Kidney-targeting Smad7 gene transfer inhibits renal TGF-beta/MAD homologue (SMAD) and nuclear factor kappaB (NF-kappaB) signalling pathways, and improves diabetic nephropathy in mice. Diabetologia 55(2):509-19. PubMed: 22086159 MGI: J:181806
Kaddai V; Jager J; Gonzalez T; Najem-Lendom R; Bonnafous S; Tran A; Le Marchand-Brustel Y; Gual P; Tanti JF; Cormont M. 2009. Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans. Diabetologia 52(5):932-40. PubMed: 19219422 MGI: J:148209
Kaiyala KJ; Morton GJ; Leroux BG; Ogimoto K; Wisse B; Schwartz MW. 2010. Identification of body fat mass as a major determinant of metabolic rate in mice. Diabetes 59(7):1657-66. PubMed: 20413511 MGI: J:169354
Kamagate A; Qu S; Perdomo G; Su D; Kim DH; Slusher S; Meseck M; Dong HH. 2008. FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice. J Clin Invest 118(6):2347-64. PubMed: 18497885 MGI: J:137715
Kampfer H; Pfeilschifter J; Frank S. 2003. Expression and activity of arginase isoenzymes during normal and diabetes-impaired skin repair. J Invest Dermatol 121(6):1544-51. PubMed: 14675208 MGI: J:120040
Kanda H; Tateya S; Tamori Y; Kotani K; Hiasa K; Kitazawa R; Kitazawa S; Miyachi H; Maeda S; Egashira K; Kasuga M. 2006. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116(6):1494-505. PubMed: 16691291 MGI: J:110277
Kanda Y; Shimoda M; Hamamoto S; Tawaramoto K; Kawasaki F; Hashiramoto M; Nakashima K; Matsuki M; Kaku K. 2010. Molecular mechanism by which pioglitazone preserves pancreatic beta-cells in obese diabetic mice: evidence for acute and chronic actions as a PPARgamma agonist. Am J Physiol Endocrinol Metab 298(2):E278-86. PubMed: 19920213 MGI: J:170065
Kang MK; Li J; Kim JL; Gong JH; Kwak SN; Park JH; Lee JY; Lim SS; Kang YH. 2012. Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration. Am J Physiol Renal Physiol 303(7):F1060-9. PubMed: 22791342 MGI: J:188528
Kang YS; Lee MH; Song HK; Ko GJ; Kwon OS; Lim TK; Kim SH; Han SY; Han KH; Lee JE; Han JY; Kim HK; Cha DR. 2010. CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice. Kidney Int 78(9):883-94. PubMed: 20686445 MGI: J:184253
Kapodistria K; Tsilibary EP; Politis P; Moustardas P; Charonis A; Kitsiou P. 2015. Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling. Mol Cell Endocrinol 400:112-28. PubMed: 25448064 MGI: J:220285
Kapur S; Amoui M; Kesavan C; Wang X; Mohan S; Baylink DJ; Lau KH. 2010. Leptin receptor (Lepr) is a negative modulator of bone mechanosensitivity and genetic variations in Lepr may contribute to the differential osteogenic response to mechanical stimulation in the C57BL/6J and C3H/HeJ pair of mouse strains. J Biol Chem 285(48):37607-18. PubMed: 20851886 MGI: J:167342
Kassan M; Choi SK; Galan M; Bishop A; Umezawa K; Trebak M; Belmadani S; Matrougui K. 2013. Enhanced NF-kappaB activity impairs vascular function through PARP-1-, SP-1-, and COX-2-dependent mechanisms in type 2 diabetes. Diabetes 62(6):2078-87. PubMed: 23349490 MGI: J:208566
Kassan M; Choi SK; Galan M; Lee YH; Trebak M; Matrougui K. 2014. Enhanced p22phox expression impairs vascular function through p38 and ERK1/2 MAP kinase-dependent mechanisms in type 2 diabetic mice. Am J Physiol Heart Circ Physiol 306(7):H972-80. PubMed: 24486509 MGI: J:210088
Kato M; Putta S; Wang M; Yuan H; Lanting L; Nair I; Gunn A; Nakagawa Y; Shimano H; Todorov I; Rossi JJ; Natarajan R. 2009. TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN. Nat Cell Biol 11(7):881-9. PubMed: 19543271 MGI: J:154956
Kato M; Wang M; Chen Z; Bhatt K; Oh HJ; Lanting L; Deshpande S; Jia Y; Lai JY; O'Connor CL; Wu Y; Hodgin JB; Nelson RG; Bitzer M; Natarajan R. 2016. An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy. Nat Commun 7:12864. PubMed: 27686049 MGI: J:242362
Kawashima S; Matsuoka TA; Kaneto H; Tochino Y; Kato K; Yamamoto K; Yamamoto T; Matsuhisa M; Shimomura I. 2011. Effect of alogliptin, pioglitazone and glargine on pancreatic beta-cells in diabetic db/db mice. Biochem Biophys Res Commun 404(1):534-40. PubMed: 21144823 MGI: J:167443
Kawauchi K; Araki K; Tobiume K; Tanaka N. 2009. Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification. Proc Natl Acad Sci U S A 106(9):3431-6. PubMed: 19202066 MGI: J:146455
Khalid AM; Hafstad AD; Larsen TS; Severson DL; Boardman NT; Hagve M; Berge RK; Aasum E. 2011. Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice. Am J Physiol Heart Circ Physiol :. PubMed: 21421822 MGI: J:170448
Khan S; Abu Jawdeh BG; Goel M; Schilling WP; Parker MD; Puchowicz MA; Yadav SP; Harris RC; El-Meanawy A; Hoshi M; Shinlapawittayatorn K; Deschenes I; Ficker E; Schelling JR. 2014. Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis. J Clin Invest 124(3):1057-68. PubMed: 24531551 MGI: J:209728
Khang R; Park C; Shin JH. 2015. Dysregulation of parkin in the substantia nigra of db/db and high-fat diet mice. Neuroscience 294:182-92. PubMed: 25779963 MGI: J:222286
Khanna S; Biswas S; Shang Y; Collard E; Azad A; Kauh C; Bhasker V; Gordillo GM; Sen CK; Roy S. 2010. Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice. PLoS One 5(3):e9539. PubMed: 20209061 MGI: J:158700
Kharitonenkov A; Shiyanova TL; Koester A; Ford AM; Micanovic R; Galbreath EJ; Sandusky GE; Hammond LJ; Moyers JS; Owens RA; Gromada J; Brozinick JT; Hawkins ED; Wroblewski VJ; Li DS; Mehrbod F; Jaskunas SR; Shanafelt AB. 2005. FGF-21 as a novel metabolic regulator. J Clin Invest 115(6):1627-35. PubMed: 15902306 MGI: J:99202
Khor VK; Tong MH; Qian Y; Song WC. 2008. Gender-specific expression and mechanism of regulation of estrogen sulfotransferase in adipose tissues of the mouse. Endocrinology 149(11):5440-8. PubMed: 18669602 MGI: J:145807
Kim B; Backus C; Oh S; Hayes JM; Feldman EL. 2009. Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes. Endocrinology 150(12):5294-301. PubMed: 19819959 MGI: J:158219
Kim DH; Perdomo G; Zhang T; Slusher S; Lee S; Phillips BE; Fan Y; Giannoukakis N; Gramignoli R; Strom S; Ringquist S; Dong HH. 2011. FoxO6 integrates insulin signaling with gluconeogenesis in the liver. Diabetes 60(11):2763-74. PubMed: 21940782 MGI: J:189474
Kim DH; Zhang T; Lee S; Calabuig-Navarro V; Yamauchi J; Piccirillo A; Fan Y; Uppala R; Goetzman E; Dong HH. 2014. FoxO6 integrates insulin signaling with MTP for regulating VLDL production in the liver. Endocrinology 155(4):1255-67. PubMed: 24437489 MGI: J:209497
Kim DI; Park MJ; Heo YR; Park SH. 2015. Metformin ameliorates lipotoxicity-induced mesangial cell apoptosis partly via upregulation of glucagon like peptide-1 receptor (GLP-1R). Arch Biochem Biophys 584:90-7. PubMed: 26302449 MGI: J:230762
Kim DK; Kim YH; Hynx D; Wang Y; Yang KJ; Ryu D; Kim KS; Yoo EK; Kim JS; Koo SH; Lee IK; Chae HZ; Park J; Lee CH; Biddinger SB; Hemmings BA; Choi HS. 2014. PKB/Akt phosphorylation of ERRgamma contributes to insulin-mediated inhibition of hepatic gluconeogenesis. Diabetologia 57(12):2576-85. PubMed: 25205222 MGI: J:219690
Kim DK; Nam BY; Li JJ; Park JT; Lee SH; Kim DH; Kim JY; Kang HY; Han SH; Yoo TH; Han DS; Kang SW. 2012. Translationally controlled tumour protein is associated with podocyte hypertrophy in a mouse model of type 1 diabetes. Diabetologia 55(4):1205-17. PubMed: 22311416 MGI: J:182524
Kim HS; Ullevig SL; Zamora D; Lee CF; Asmis R. 2012. Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment. Proc Natl Acad Sci U S A 109(41):E2803-12. PubMed: 22991462 MGI: J:190103
Kim HW; Lee JE; Cha JJ; Hyun YY; Kim JE; Lee MH; Song HK; Nam DH; Han JY; Han SY; Han KH; Kang YS; Cha DR. 2013. Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in db/db mice. Endocrinology 154(9):3366-76. PubMed: 23825123 MGI: J:202258
Kim JE; Lee MH; Nam DH; Song HK; Kang YS; Lee JE; Kim HW; Cha JJ; Hyun YY; Han SY; Han KH; Han JY; Cha DR. 2013. Celastrol, an NF-kappaB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice. PLoS One 8(4):e62068. PubMed: 23637966 MGI: J:200556
Kim JG; Baggio LL; Bridon DP; Castaigne JP; Robitaille MF; Jette L; Benquet C; Drucker DJ. 2003. Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo. Diabetes 52(3):751-9. PubMed: 12606517 MGI: J:82421
Kim JI; Huh JY; Sohn JH; Choe SS; Lee YS; Lim CY; Jo A; Park SB; Han W; Kim JB. 2015. Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Mol Cell Biol 35(10):1686-99. PubMed: 25733684 MGI: J:224416
Kim JW; You YH; Jung S; Suh-Kim H; Lee IK; Cho JH; Yoon KH. 2013. miRNA-30a-5p-mediated silencing of Beta2/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models. Diabetologia 56(4):847-55. PubMed: 23338554 MGI: J:196417
Kim KM; Lee KS; Lee GY; Jin H; Durrance ES; Park HS; Choi SH; Park KS; Kim YB; Jang HC; Lim S. 2015. Anti-diabetic efficacy of KICG1338, a novel glycogen synthase kinase-3beta inhibitor, and its molecular characterization in animal models of type 2 diabetes and insulin resistance. Mol Cell Endocrinol 409:1-10. PubMed: 25802191 MGI: J:224151
Kim KS; Egan JM; Jang HJ. 2014. Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways. Diabetologia 57(10):2117-25. PubMed: 25016595 MGI: J:218123
Kim W; Doyle ME; Liu Z; Lao Q; Shin YK; Carlson OD; Kim HS; Thomas S; Napora JK; Lee EK; Moaddel R; Wang Y; Maudsley S; Martin B; Kulkarni RN; Egan JM. 2011. Cannabinoids inhibit insulin receptor signaling in pancreatic beta-cells. Diabetes 60(4):1198-209. PubMed: 21346174 MGI: J:171758
Kim YD; Kim SG; Hwang SL; Choi HS; Bae JH; Song DK; Im SS. 2014. B-cell translocation gene 2 regulates hepatic glucose homeostasis via induction of orphan nuclear receptor Nur77 in diabetic mouse model. Diabetes 63(6):1870-80. PubMed: 24647738 MGI: J:229803
Kim-Muller JY; Zhao S; Srivastava S; Mugabo Y; Noh HL; Kim YR; Madiraju SR; Ferrante AW; Skolnik EY; Prentki M; Accili D. 2014. Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice. Cell Metab 20(4):593-602. PubMed: 25264246 MGI: J:215526
Kimura K; Yamada T; Matsumoto M; Kido Y; Hosooka T; Asahara S; Matsuda T; Ota T; Watanabe H; Sai Y; Miyamoto K; Kaneko S; Kasuga M; Inoue H. 2012. Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation. Diabetes 61(1):61-73. PubMed: 22124464 MGI: J:191536
Kitazawa M; Nagano M; Masumoto KH; Shigeyoshi Y; Natsume T; Hashimoto S. 2011. Angiopoietin-like 2, a circadian gene, improves type 2 diabetes through potentiation of insulin sensitivity in mice adipocytes. Endocrinology 152(7):2558-67. PubMed: 21586562 MGI: J:174882
Kleinridders A; Lauritzen HP; Ussar S; Christensen JH; Mori MA; Bross P; Kahn CR. 2013. Leptin regulation of Hsp60 impacts hypothalamic insulin signaling. J Clin Invest :. PubMed: 24084737 MGI: J:203991
Knebel B; Hartwig S; Haas J; Lehr S; Goeddeke S; Susanto F; Bohne L; Jacob S; Koellmer C; Nitzgen U; Muller-Wieland D; Kotzka J. 2015. Peroxisomes compensate hepatic lipid overflow in mice with fatty liver. Biochim Biophys Acta 1851(7):965-76. PubMed: 25790917 MGI: J:230549
Ko SH; Lee JK; Lee HJ; Ye SK; Kim HS; Chung MH. 2014. 8-Oxo-2'-deoxyguanosine ameliorates features of metabolic syndrome in obese mice. Biochem Biophys Res Commun 443(2):610-6. PubMed: 24333420 MGI: J:211863
Kobayashi K; Forte TM; Taniguchi S; Ishida BY; Oka K; Chan L. 2000. The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding. Metabolism 49(1):22-31. PubMed: 10647060 MGI: J:59345
Kobayashi M; Kikuchi O; Sasaki T; Kim HJ; Yokota-Hashimoto H; Lee YS; Amano K; Kitazumi T; Susanti VY; Kitamura YI; Kitamura T. 2012. FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and beta-cell-specific FoxO1 knockout mice. Am J Physiol Endocrinol Metab 302(5):E603-13. PubMed: 22215655 MGI: J:184645
Koch C; Augustine RA; Steger J; Ganjam GK; Benzler J; Pracht C; Lowe C; Schwartz MW; Shepherd PR; Anderson GM; Grattan DR; Tups A. 2010. Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. J Neurosci 30(48):16180-7. PubMed: 21123564 MGI: J:166745
Koga M; Engberding N; Dikalova AE; Chang KH; Seidel-Rogol B; Long JS; Lassegue B; Jo H; Griendling KK. 2013. The bone morphogenic protein inhibitor, noggin, reduces glycemia and vascular inflammation in db/db mice. Am J Physiol Heart Circ Physiol 305(5):H747-55. PubMed: 23812391 MGI: J:202268
Koh A; Lee MN; Yang YR; Jeong H; Ghim J; Noh J; Kim J; Ryu D; Park S; Song P; Koo SH; Leslie NR; Berggren PO; Choi JH; Suh PG; Ryu SH. 2013. C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy. Mol Cell Biol 33(8):1608-20. PubMed: 23401856 MGI: J:203319
Koh EH; Park JY; Park HS; Jeon MJ; Ryu JW; Kim M; Kim SY; Kim MS; Kim SW; Park IS; Youn JH; Lee KU. 2007. Essential role of mitochondrial function in adiponectin synthesis in adipocytes. Diabetes 56(12):2973-81. PubMed: 17827403 MGI: J:132424
Koka S; Aluri HS; Xi L; Lesnefsky EJ; Kukreja RC. 2014. Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1alpha signaling. Am J Physiol Heart Circ Physiol 306(11):H1558-68. PubMed: 24727492 MGI: J:213130
Kondo T; Sasaki K; Matsuyama R; Morino-Koga S; Adachi H; Suico MA; Kawashima J; Motoshima H; Furukawa N; Kai H; Araki E. 2012. Hyperthermia with mild electrical stimulation protects pancreatic beta-cells from cell stresses and apoptosis. Diabetes 61(4):838-47. PubMed: 22362176 MGI: J:196732
Kondo Y; Hasegawa G; Okada H; Senmaru T; Fukui M; Nakamura N; Sawada M; Kitawaki J; Okanoue T; Kishimoto Y; Amano A; Maruyama N; Obayashi H; Ishigami A. 2013. Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet. PLoS One 8(6):e65698. PubMed: 23755269 MGI: J:204249
Kong X; Banks A; Liu T; Kazak L; Rao RR; Cohen P; Wang X; Yu S; Lo JC; Tseng YH; Cypess AM; Xue R; Kleiner S; Kang S; Spiegelman BM; Rosen ED. 2014. IRF4 is a key thermogenic transcriptional partner of PGC-1alpha. Cell 158(1):69-83. PubMed: 24995979 MGI: J:214637
Konstantopoulos N; Molero JC; McGee SL; Spolding B; Connor T; de Vries M; Wanyonyi S; Fahey R; Morrison S; Swinton C; Jones S; Cooper A; Garcia-Guerra L; Foletta VC; Krippner G; Andrikopoulos S; Walder KR. 2012. Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo. Diabetes 61(8):2146-54. PubMed: 22586591 MGI: J:208458
Koo SH; Flechner L; Qi L; Zhang X; Screaton RA; Jeffries S; Hedrick S; Xu W; Boussouar F; Brindle P; Takemori H; Montminy M. 2005. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437(7062):1109-11. PubMed: 16148943 MGI: J:102116
Korrapati MC; Howell LH; Shaner BE; Megyesi JK; Siskind LJ; Schnellmann RG. 2013. Suramin: a potential therapy for diabetic nephropathy. PLoS One 8(9):e73655. PubMed: 24040012 MGI: J:206049
Kosugi T; Nakayama T; Heinig M; Zhang L; Yuzawa Y; Sanchez-Lozada LG; Roncal C; Johnson RJ; Nakagawa T. 2009. Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice. Am J Physiol Renal Physiol 297(2):F481-8. PubMed: 19458127 MGI: J:150741
Koya D; Haneda M; Nakagawa H; Isshiki K; Sato H; Maeda S; Sugimoto T; Yasuda H; Kashiwagi A; Ways DK; King GL; Kikkawa R. 2000. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J 14(3):439-47. PubMed: 10698958 MGI: J:60932
Kraus D; Yang Q; Kong D; Banks AS; Zhang L; Rodgers JT; Pirinen E; Pulinilkunnil TC; Gong F; Wang YC; Cen Y; Sauve AA; Asara JM; Peroni OD; Monia BP; Bhanot S; Alhonen L; Puigserver P; Kahn BB. 2014. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature 508(7495):258-62. PubMed: 24717514 MGI: J:208844
Kubo F; Miyatsuka T; Sasaki S; Takahara M; Yamamoto Y; Shimo N; Watada H; Kaneto H; Gannon M; Matsuoka TA; Shimomura I. 2016. Sustained expression of GLP-1 receptor differentially modulates beta-cell functions in diabetic and nondiabetic mice. Biochem Biophys Res Commun 471(1):68-74. PubMed: 26854076 MGI: J:233324
Kudo T; Akiyama M; Kuriyama K; Sudo M; Moriya T; Shibata S. 2004. Night-time restricted feeding normalises clock genes and Pai-1 gene expression in the db/db mouse liver. Diabetologia 47(8):1425-36. PubMed: 15309293 MGI: J:91813
Kulkarni RN; Wang ZL; Wang RM; Hurley JD; Smith DM; Ghatei MA ; Withers DJ ; Gardiner JV ; Bailey CJ ; Bloom SR. 1997. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest 100(11):2729-36. PubMed: 9389736 MGI: J:45259
Kumar M; Roe K; Nerurkar PV; Namekar M; Orillo B; Verma S; Nerurkar VR. 2012. Impaired virus clearance, compromised immune response and increased mortality in type 2 diabetic mice infected with West Nile virus. PLoS One 7(8):e44682. PubMed: 22953001 MGI: J:191646
Kumari R; Willing LB; Patel SD; Baskerville KA; Simpson IA. 2011. Increased cerebral matrix metalloprotease-9 activity is associated with compromised recovery in the diabetic db/db mouse following a stroke. J Neurochem 119(5):1029-40. PubMed: 21923664 MGI: J:178368
Kumashiro N; Tamura Y; Uchida T; Ogihara T; Fujitani Y; Hirose T; Mochizuki H; Kawamori R; Watada H. 2008. Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance. Diabetes 57(8):2083-91. PubMed: 18487450 MGI: J:141684
Kumpers P; Gueler F; Rong S; Mengel M; Tossidou I; Peters I; Haller H; Schiffer M. 2007. Leptin is a coactivator of TGF-beta in unilateral ureteral obstructive kidney disease. Am J Physiol Renal Physiol 293(4):F1355-62. PubMed: 17686962 MGI: J:145120
Kunath A; Hesselbarth N; Gericke M; Kern M; Dommel S; Kovacs P; Stumvoll M; Bluher M; Kloting N. 2016. Repin1 deficiency improves insulin sensitivity and glucose metabolism in db/db mice by reducing adipose tissue mass and inflammation. Biochem Biophys Res Commun 478(1):398-402. PubMed: 27402271 MGI: J:238672
Kuramoto K; Sakai F; Yoshinori N; Nakamura TY; Wakabayashi S; Kojidani T; Haraguchi T; Hirose F; Osumi T. 2014. Deficiency of a lipid droplet protein, perilipin 5, suppresses myocardial lipid accumulation, thereby preventing type 1 diabetes-induced heart malfunction. Mol Cell Biol 34(14):2721-31. PubMed: 24820416 MGI: J:223685
Lackey DE; Lynch CJ; Olson KC; Mostaedi R; Ali M; Smith WH; Karpe F; Humphreys S; Bedinger DH; Dunn TN; Thomas AP; Oort PJ; Kieffer DA; Amin R; Bettaieb A; Haj FG; Permana P; Anthony TG; Adams SH. 2013. Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. Am J Physiol Endocrinol Metab 304(11):E1175-87. PubMed: 23512805 MGI: J:198119
Lam QL; Liu S; Cao X; Lu L. 2006. Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells. Eur J Immunol 36(12):3118-30. PubMed: 17125143 MGI: J:117089
Lam QL; Wang S; Ko OK; Kincade PW; Lu L. 2010. Leptin signaling maintains B-cell homeostasis via induction of Bcl-2 and Cyclin D1. Proc Natl Acad Sci U S A 107(31):13812-7. PubMed: 20643953 MGI: J:163456
Lambin S; van Bree R; Caluwaerts S; Vercruysse L; Vergote I; Verhaeghe J. 2007. Adipose tissue in offspring of Lepr(db/+) mice: early-life environment vs. genotype. Am J Physiol Endocrinol Metab 292(1):E262-71. PubMed: 16954332 MGI: J:116980
Laposky AD; Bradley MA; Williams DL; Bass J; Turek FW. 2008. Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic mice. Am J Physiol Regul Integr Comp Physiol 295(6):R2059-66. PubMed: 18843095 MGI: J:141951
Latreille M; Hausser J; Stutzer I; Zhang Q; Hastoy B; Gargani S; Kerr-Conte J; Pattou F; Zavolan M; Esguerra JL; Eliasson L; Rulicke T; Rorsman P; Stoffel M. 2014. MicroRNA-7a regulates pancreatic beta cell function. J Clin Invest 124(6):2722-35. PubMed: 24789908 MGI: J:212929
Lau GJ; Godin N; Maachi H; Lo CS; Wu SJ; Zhu JX; Brezniceanu ML; Chenier I; Fragasso-Marquis J; Lattouf JB; Ethier J; Filep JG; Ingelfinger JR; Nair V; Kretzler M; Cohen CD; Zhang SL; Chan JS. 2012. Bcl-2-modifying factor induces renal proximal tubular cell apoptosis in diabetic mice. Diabetes 61(2):474-84. PubMed: 22210314 MGI: J:196786
Lau JK; Zhang X; Yu J. 2017. Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances. J Pathol 241(1):36-44. PubMed: 27757953 MGI: J:241733
Laybutt DR; Preston AM; Akerfeldt MC; Kench JG; Busch AK; Biankin AV; Biden TJ. 2007. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 50(4):752-763. PubMed: 17268797 MGI: J:119770
Lee CH; Olson P; Hevener A; Mehl I; Chong LW; Olefsky JM; Gonzalez FJ; Ham J; Kang H; Peters JM; Evans RM. 2006. PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A 103(9):3444-9. PubMed: 16492734 MGI: J:107250
Lee CH; Reifsnyder PC; Naggert JK; Wasserfall C; Atkinson MA; Chen J; Leiter EH. 2005. Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: I. Pathophysiological analysis. Diabetes 54(9):2525-32. PubMed: 16123339 MGI: J:118305
Lee HJ; Chung K; Lee H; Lee K; Lim JH; Song J. 2011. Downregulation of mitochondrial lon protease impairs mitochondrial function and causes hepatic insulin resistance in human liver SK-HEP-1 cells. Diabetologia :. PubMed: 21347624 MGI: J:169584
Lee J; Liu J; Feng X; Salazar Hernandez MA; Mucka P; Ibi D; Choi JW; Ozcan U. 2016. Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice. Nat Med 22(9):1023-32. PubMed: 27479085 MGI: J:240346
Lee JH; Gao J; Kosinski PA; Elliman SJ; Hughes TE; Gromada J; Kemp DM. 2013. Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice. Biochem Biophys Res Commun 430(3):1109-13. PubMed: 23261432 MGI: J:193848
Lee JT; Huang Z; Pan K; Zhang HJ; Woo CW; Xu A; Wong CM. 2016. Adipose-derived lipocalin 14 alleviates hyperglycaemia by suppressing both adipocyte glycerol efflux and hepatic gluconeogenesis in mice. Diabetologia 59(3):604-13. PubMed: 26592241 MGI: J:232508
Lee JW; Choi AH; Ham M; Kim JW; Choe SS; Park J; Lee GY; Yoon KH; Kim JB. 2011. G6PD up-regulation promotes pancreatic beta-cell dysfunction. Endocrinology 152(3):793-803. PubMed: 21248143 MGI: J:173877
Lee MH; Lee JU; Joung KH; Kim YK; Ryu MJ; Lee SE; Kim SJ; Chung HK; Choi MJ; Chang JY; Lee SH; Kweon GR; Kim HJ; Kim KS; Kim SM; Jo YS; Park J; Cheng SY; Shong M. 2015. Thyroid dysfunction associated with follicular cell steatosis in obese male mice and humans. Endocrinology 156(3):1181-93. PubMed: 25555091 MGI: J:221925
Lee S; Park Y; Dellsperger KC; Zhang C. 2011. Exercise training improves endothelial function via adiponectin-dependent and independent pathways in type 2 diabetic mice. Am J Physiol Heart Circ Physiol :. PubMed: 21602470 MGI: J:173343
Lee S; Zhang H; Chen J; Dellsperger KC; Hill MA; Zhang C. 2012. Adiponectin abates diabetes-induced endothelial dysfunction by suppressing oxidative stress, adhesion molecules, and inflammation in type 2 diabetic mice. Am J Physiol Heart Circ Physiol 303(1):H106-15. PubMed: 22561304 MGI: J:189055
Lee SH; Huang H; Choi K; Lee DH; Shi J; Liu T; Chun KH; Seo JA; Lima IS; Zabolotny JM; Wei L; Kim YB. 2014. ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance. Am J Physiol Endocrinol Metab 306(3):E332-43. PubMed: 24326423 MGI: J:208371
Lee W; Ham J; Kwon HC; Kim YK; Kim SN. 2013. Anti-diabetic effect of amorphastilbol through PPARalpha/gamma dual activation in db/db mice. Biochem Biophys Res Commun 432(1):73-9. PubMed: 23376064 MGI: J:198057
Lee WJ; Sheu WH; Liu SH; Yi YC; Chen WC; Lin SY; Liang KW; Shen CC; Yeh HY; Lin LY; Tsai YC; Tien HR; Lee MR; Yang TJ; Sheu ML. 2014. Nepsilon-carboxymethyllysine-mediated endoplasmic reticulum stress promotes endothelial cell injury through Nox4/MKP-3 interaction. Free Radic Biol Med 74:294-306. PubMed: 25014566 MGI: J:220140
Lee Y; Dominy JE; Choi YJ; Jurczak M; Tolliday N; Camporez JP; Chim H; Lim JH; Ruan HB; Yang X; Vazquez F; Sicinski P; Shulman GI; Puigserver P. 2014. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature 510(7506):547-51. PubMed: 24870244 MGI: J:213271
Lee YE; Kim JW; Lee EM; Ahn YB; Song KH; Yoon KH; Kim HW; Park CW; Li G; Liu Z; Ko SH. 2012. Chronic resveratrol treatment protects pancreatic islets against oxidative stress in db/db mice. PLoS One 7(11):e50412. PubMed: 23226280 MGI: J:195562
Leibowitz MD; Fievet C; Hennuyer N; Peinado-Onsurbe J; Duez H; Bergera J; Cullinan CA; Sparrow CP; Baffic J; Berger GD; Santini C; Marquis RW; Tolman RL; Smith RG; Moller DE; Auwerx J. 2000. Activation of PPARdelta alters lipid metabolism in db/db mice. FEBS Lett 473(3):333-6. PubMed: 10818235 MGI: J:115317
Leiter EH. 1981. The influence of genetic background on the expression of mutations at the diabetes locus in the mouse IV. Male lethal syndrome in CBA/Lt mice. Diabetes 30(12):1035-44. PubMed: 7030829 MGI: J:109958
Leiter EH; Chapman HD; Coleman DL. 1989. The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. V. Interaction between the db gene and hepatic sex steroid sulfotransferases correlates with gender-dependent susceptibility to hyperglycemia. Endocrinology 124(2):912-22. PubMed: 2912706 MGI: J:26013
Leiter EH; Coleman DL; Eppig JJ. 1979. Endocrine pancreatic cells of postnatal diabetes (db) mice in cell culture. In Vitro 15(7):507-21. PubMed: 393618 MGI: J:6264
Leiter EH; Coleman DL; Ingram DK; Reynolds MA. 1983. Influence of dietary carbohydrate on the induction of diabetes in C57BL/KsJ-db/db diabetes mice. J Nutr 113(1):184-95. PubMed: 6337242 MGI: J:109957
Leiter EH; Kuff EL. 1984. Intracisternal Type A particles in murine pancreatic B cells. Immunocytochemical demonstration of increased antigen (p73) in genetically diabetic mice. Am J Pathol 114(1):46-55. PubMed: 6362424 MGI: J:7287
Leiter EH; Prochazka M; Shultz LD. 1987. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice. J Immunol 138(10):3224-9. PubMed: 3553324 MGI: J:32752
Lemke U; Krones-Herzig A; Diaz MB; Narvekar P; Ziegler A; Vegiopoulos A; Cato AC; Bohl S; Klingmuller U; Screaton RA; Muller-Decker K; Kersten S; Herzig S. 2008. The glucocorticoid receptor controls hepatic dyslipidemia through Hes1. Cell Metab 8(3):212-23. PubMed: 18762022 MGI: J:139669
Lemos MP; Rhee KY; McKinney JD. 2011. Expression of the leptin receptor outside of bone marrow-derived cells regulates tuberculosis control and lung macrophage MHC expression. J Immunol 187(7):3776-84. PubMed: 21859958 MGI: J:179346
Lerea JS; Ring LE; Hassouna R; Chong AC; Szigeti-Buck K; Horvath TL; Zeltser LM. 2016. Reducing Adiposity in a Critical Developmental Window Has Lasting Benefits in Mice. Endocrinology 157(2):666-78. PubMed: 26587784 MGI: J:233625
Levi J; Huynh FK; Denroche HC; Neumann UH; Glavas MM; Covey SD; Kieffer TJ. 2012. Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGF binding protein-2 (IGFBP-2) in ob/ob mice. Diabetologia 55(3):752-62. PubMed: 22202803 MGI: J:181709
Levine DZ; Iacovitti M. 2006. Real-time measurement of kidney tubule fluid nitric oxide concentrations in early diabetes: disparate changes in different rodent models. Nitric Oxide 15(1):87-92. PubMed: 16510300 MGI: J:112767
Levine DZ; Iacovitti M; Robertson SJ. 2008. Modulation of single-nephron GFR in the db/db mouse model of type 2 diabetes mellitus. II. Effects of renal mass reduction. Am J Physiol Regul Integr Comp Physiol 294(6):R1840-6. PubMed: 18417648 MGI: J:137624
Levine DZ; Iacovitti M; Robertson SJ; Mokhtar GA. 2006. Modulation of single-nephron GFR in the db/db mouse model of type 2 diabetes mellitus. Am J Physiol Regul Integr Comp Physiol 290(4):R975-81. PubMed: 16339386 MGI: J:128685
Li J; Wang JJ; Yu Q; Chen K; Mahadev K; Zhang SX. 2010. Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice: role of NADPH oxidase 4. Diabetes 59(6):1528-38. PubMed: 20332345 MGI: J:169356
Li K; Zhang J; Yu J; Liu B; Guo Y; Deng J; Chen S; Wang C; Guo F. 2015. MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4. J Biol Chem 290(13):8185-95. PubMed: 25657009 MGI: J:220551
Li M; Wang X; Aa J; Qin W; Zha W; Ge Y; Liu L; Zheng T; Cao B; Shi J; Zhao C; Wang X; Yu X; Wang G; Liu Z. 2013. GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy. Am J Physiol Renal Physiol 304(11):F1317-24. PubMed: 23467425 MGI: J:197264
Li R; Xie J; Wu H; Li G; Chen J; Chen Q; Wang L; Xu B. 2016. Syndecan-4 shedding impairs macrovascular angiogenesis in diabetes mellitus. Biochem Biophys Res Commun 474(1):15-21. PubMed: 27018253 MGI: J:234858
Li R; Xu X; Chen C; Wang Y; Gruzdev A; Zeldin DC; Wang DW. 2015. CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPARgamma. Am J Physiol Endocrinol Metab 308(4):E270-82. PubMed: 25389363 MGI: J:219302
Li S; Sun Y; Liang CP; Thorp EB; Han S; Jehle AW; Saraswathi V; Pridgen B; Kanter JE; Li R; Welch CL; Hasty AH; Bornfeldt KE; Breslow JL; Tabas I; Tall AR. 2009. Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet. Circ Res 105(11):1072-82. PubMed: 19834009 MGI: J:170144
Li SL; Reddy MA; Cai Q; Meng L; Yuan H; Lanting L; Natarajan R. 2006. Enhanced proatherogenic responses in macrophages and vascular smooth muscle cells derived from diabetic db/db mice. Diabetes 55(9):2611-9. PubMed: 16936211 MGI: J:116589
Li X; Grundy SM; Patel SB. 1997. Obesity in db and ob animals leads to impaired hepatic very low density lipoprotein secretion and differential secretion of apolipoprotein B-48 and B-100. J Lipid Res 38(7):1277-88. PubMed: 9254055 MGI: J:41954
Li X; Shan J; Chang W; Kim I; Bao J; Lee HJ; Zhang X; Samuel VT; Shulman GI; Liu D; Zheng JJ; Wu D. 2012. Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism. Proc Natl Acad Sci U S A 109(28):11402-7. PubMed: 22733757 MGI: J:186402
Li XL; Aou S; Oomura Y; Hori N; Fukunaga K; Hori T. 2002. Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience 113(3):607-15. PubMed: 12150780 MGI: J:109401
Li YY; Yu LF; Zhang LN; Qiu BY; Su MB; Wu F; Chen DK; Pang T; Gu M; Zhang W; Ma WP; Jiang HW; Li JY; Nan FJ; Li J. 2013. Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicol Appl Pharmacol 273(2):325-34. PubMed: 24055643 MGI: J:205155
Li Z; Xu G; Qin Y; Zhang C; Tang H; Yin Y; Xiang X; Li Y; Zhao J; Mulholland M; Zhang W. 2014. Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARgamma signaling pathway. Proc Natl Acad Sci U S A 111(36):13163-8. PubMed: 25157160 MGI: J:216395
Liang CF; Liu JT; Wang Y; Xu A; Vanhoutte PM. 2013. Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4. Arterioscler Thromb Vasc Biol 33(4):777-84. PubMed: 23413427 MGI: J:217972
Liao YJ; Ueno M; Nakagawa T; Huang C; Kanenishi K; Onodera M; Sakamoto H. 2005. Oxidative damage in cerebral vessels of diabetic db/db mice. Diabetes Metab Res Rev 21(6):554-9. PubMed: 16021652 MGI: J:106606
Like AA; Lavine RL; Poffenbarger PL; Chick WL. 1972. Studies in the diabetic mutant mouse. VI. Evolution of glomerular lesions and associated proteinuria. Am J Pathol 66(2):193-224. PubMed: 5009970 MGI: J:5257
Lim AK; Ma FY; Nikolic-Paterson DJ; Thomas MC; Hurst LA; Tesch GH. 2009. Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice. Diabetologia 52(8):1669-79. PubMed: 19466391 MGI: J:151451
Lim AK; Nikolic-Paterson DJ; Ma FY; Ozols E; Thomas MC; Flavell RA; Davis RJ; Tesch GH. 2009. Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice. Diabetologia 52(2):347-58. PubMed: 19066844 MGI: J:144365
Lin Z; Tian H; Lam KS; Lin S; Hoo RC; Konishi M; Itoh N; Wang Y; Bornstein SR; Xu A; Li X. 2013. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab 17(5):779-89. PubMed: 23663741 MGI: J:199269
Liu F; Song R; Feng Y; Guo J; Chen Y; Zhang Y; Chen T; Wang Y; Huang Y; Li CY; Cao C; Zhang Y; Hu X; Xiao RP. 2015. Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor alpha. Circulation 131(9):795-804. PubMed: 25637627 MGI: J:234132
Liu H; Yu J; Xia T; Xiao Y; Zhang Q; Liu B; Guo Y; Deng J; Deng Y; Chen S; Naray-Fejes-Toth A; Fejes-Toth G; Guo F. 2014. Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2). Biochem J 464(2):281-9. PubMed: 25222560 MGI: J:217818
Liu J; Zhou B; Yan M; Huang R; Wang Y; He Z; Yang Y; Dai C; Wang Y; Zhang F; Zhai Q. 2016. CLOCK and BMAL1 Regulate Muscle Insulin Sensitivity via SIRT1 in Male Mice. Endocrinology 157(6):2259-69. PubMed: 27035655 MGI: J:234964
Liu R; Bal HS; Desta T; Behl Y; Graves DT. 2006. Tumor necrosis factor-alpha mediates diabetes-enhanced apoptosis of matrix-producing cells and impairs diabetic healing. Am J Pathol 168(3):757-64. PubMed: 16507891 MGI: J:106478
Liu R; Zhong Y; Li X; Chen H; Jim B; Zhou MM; Chuang PY; He JC. 2014. Role of transcription factor acetylation in diabetic kidney disease. Diabetes 63(7):2440-53. PubMed: 24608443 MGI: J:229493
Liu S; Brown JD; Stanya KJ; Homan E; Leidl M; Inouye K; Bhargava P; Gangl MR; Dai L; Hatano B; Hotamisligil GS; Saghatelian A; Plutzky J; Lee CH. 2013. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature 502(7472):550-4. PubMed: 24153306 MGI: J:206752
Liu Y; Li D; Zhang Y; Sun R; Xia M. 2014. Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction. Am J Physiol Endocrinol Metab 306(8):E975-88. PubMed: 24595303 MGI: J:212281
Liu Y; Nakagawa Y; Wang Y; Sakurai R; Tripathi PV; Lutfy K; Friedman TC. 2005. Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice. Diabetes 54(1):32-40. PubMed: 15616008 MGI: J:105084
Liu Y; Yu Y; Matarese G; La Cava A. 2012. Cutting edge: fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus. J Immunol 188(5):2070-3. PubMed: 22291185 MGI: J:181358
Liu Z; Tanabe K; Bernal-Mizrachi E; Permutt MA. 2008. Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation. Diabetologia 51(4):623-31. PubMed: 18219478 MGI: J:137936
Lloyd DJ; St Jean DJ Jr; Kurzeja RJ; Wahl RC; Michelsen K; Cupples R; Chen M; Wu J; Sivits G; Helmering J; Komorowski R; Ashton KS; Pennington LD; Fotsch C; Vazir M; Chen K; Chmait S; Zhang J; Liu L; Norman MH; Andrews KL; Bartberger MD; Van G; GalbreathEJ; Vonderfecht SL; Wang M; Jordan SR; Veniant MM; Hale C. 2013. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature 504(7480):437-40. PubMed: 24226772 MGI: J:207760
Lo JC; Ljubicic S; Leibiger B; Kern M; Leibiger IB; Moede T; Kelly ME; Chatterjee Bhowmick D; Murano I; Cohen P; Banks AS; Khandekar MJ; Dietrich A; Flier JS; Cinti S; Bluher M; Danial NN; Berggren PO; Spiegelman BM. 2014. Adipsin is an adipokine that improves beta cell function in diabetes. Cell 158(1):41-53. PubMed: 24995977 MGI: J:214638
Loeffler I; Ruster C; Franke S; Liebisch M; Wolf G. 2013. Erythropoietin ameliorates podocyte injury in advanced diabetic nephropathy in the db/db mouse. Am J Physiol Renal Physiol 305(6):F911-8. PubMed: 23825071 MGI: J:200934
Loffreda S; Yang SQ; Lin HZ; Karp CL; Brengman ML; Wang DJ; Klein AS; Bulkley GB; Bao C; Noble PW; Lane MD; Diehl AM. 1998. Leptin regulates proinflammatory immune responses. FASEB J 12(1):57-65. PubMed: 9438411 MGI: J:115105
Long J; Badal SS; Ye Z; Wang Y; Ayanga BA; Galvan DL; Green NH; Chang BH; Overbeek PA; Danesh FR. 2016. Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy. J Clin Invest 126(11):4205-4218. PubMed: 27760051 MGI: J:239614
Long J; Wang Y; Wang W; Chang BH; Danesh FR. 2010. Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions. J Biol Chem 285(30):23457-65. PubMed: 20501654 MGI: J:165835
Lord GM; Matarese G; Howard JK; Baker RJ; Bloom SR; Lechler RI. 1998. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394(6696):897-901. PubMed: 9732873 MGI: J:49623
Low H; Hoang A; Forbes J; Thomas M; Lyons JG; Nestel P; Bach LA; Sviridov D. 2012. Advanced glycation end-products (AGEs) and functionality of reverse cholesterol transport in patients with type 2 diabetes and in mouse models. Diabetologia 55(9):2513-21. PubMed: 22572804 MGI: J:189046
Lu A; Miao M; Schoeb TR; Agarwal A; Murphy-Ullrich JE. 2011. Blockade of TSP1-Dependent TGF-beta Activity Reduces Renal Injury and Proteinuria in a Murine Model of Diabetic Nephropathy. Am J Pathol 178(6):2573-86. PubMed: 21641382 MGI: J:173296
Lu FL; Johnston RA; Flynt L; Theman TA; Terry RD; Schwartzman IN; Lee A; Shore SA. 2006. Increased pulmonary responses to acute ozone exposure in obese db/db mice. Am J Physiol Lung Cell Mol Physiol 290(5):L856-65. PubMed: 16373670 MGI: J:115772
Lu H; Raptis M; Black E; Stan M; Amar S; Graves DT. 2004. Influence of diabetes on the exacerbation of an inflammatory response in cardiovascular tissue. Endocrinology 145(11):4934-9. PubMed: 15284196 MGI: J:105615
Lu Y; Liu X; Jiao Y; Xiong X; Wang E; Wang X; Zhang Z; Zhang H; Pan L; Guan Y; Cai D; Ning G; Li X. 2014. Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARalpha. J Clin Invest 124(8):3501-13. PubMed: 25003192 MGI: J:213849
Lu Y; Xiong X; Wang X; Zhang Z; Li J; Shi G; Yang J; Zhang H; Ning G; Li X. 2013. Yin Yang 1 promotes hepatic gluconeogenesis through upregulation of glucocorticoid receptor. Diabetes 62(4):1064-73. PubMed: 23193188 MGI: J:208597
Luan B; Zhao J; Wu H; Duan B; Shu G; Wang X; Li D; Jia W; Kang J; Pei G. 2009. Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance. Nature 457(7233):1146-9. PubMed: 19122674 MGI: J:145752
Luna LG; Coady K. 2016. Quantification of X. laevis vitellogenin by liquid chromatography tandem mass spectrometry. Ecotoxicol Environ Saf 124:296-302. PubMed: 26562177 MGI: J:232356
Luo N; Liu SM; Liu H; Li Q; Xu Q; Sun X; Davis B; Li J; Chua S Jr. 2006. Allelic variation on chromosome 5 controls beta-cell mass expansion during hyperglycemia in leptin receptor-deficient diabetes mice. Endocrinology 147(5):2287-95. PubMed: 16484328 MGI: J:129660
Luttrell IP; Swee M; Starcher B; Parks WC; Chitaley K. 2008. Erectile dysfunction in the type II diabetic db/db mouse: impaired venoocclusion with altered cavernosal vasoreactivity and matrix. Am J Physiol Heart Circ Physiol 294(5):H2204-11. PubMed: 18326798 MGI: J:135785
Ly A; Scheerer MF; Zukunft S; Muschet C; Merl J; Adamski J; de Angelis MH; Neschen S; Hauck SM; Ueffing M. 2014. Retinal proteome alterations in a mouse model of type 2 diabetes. Diabetologia 57(1):192-203. PubMed: 24078137 MGI: J:206487
Lynch CJ; Zhou Q; Shyng SL; Heal DJ; Cheetham SC; Dickinson K; Gregory P; Firnges M; Nordheim U; Goshorn S; Reiche D; Turski L; Antel J. 2012. Some cannabinoid receptor ligands and their distomers are direct-acting openers of SUR1 K(ATP) channels. Am J Physiol Endocrinol Metab 302(5):E540-51. PubMed: 22167524 MGI: J:184649
Ma DL; Chen FQ; Xu WJ; Yue WZ; Yuan G; Yang Y. 2015. Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice. J Neurochem 135(2):301-8. PubMed: 26183127 MGI: J:226075
MacLean PS; Bower JF; Vadlamudi S; Osborne JN; Bradfield JF; Burden HW; Bensch WH; Kauffman RF; Barakat HA. 2003. Cholesteryl ester transfer protein expression prevents diet-induced atherosclerotic lesions in male db/db mice. Arterioscler Thromb Vasc Biol 23(8):1412-5. PubMed: 12791674 MGI: J:109846
Madan R; Guo X; Naylor C; Buonomo EL; Mackay D; Noor Z; Concannon P; Scully KW; Pramoonjago P; Kolling GL; Warren CA; Duggal P; Petri WA Jr. 2014. Role of leptin-mediated colonic inflammation in defense against Clostridium difficile colitis. Infect Immun 82(1):341-9. PubMed: 24166957 MGI: J:206187
Madhusudhan T; Wang H; Dong W; Ghosh S; Bock F; Thangapandi VR; Ranjan S; Wolter J; Kohli S; Shahzad K; Heidel F; Krueger M; Schwenger V; Moeller MJ; Kalinski T; Reiser J; Chavakis T; Isermann B. 2015. Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy. Nat Commun 6:6496. PubMed: 25754093 MGI: J:221890
Madiehe AM; Mitchell TD; Harris RB. 2003. Hyperleptinemia and reduced TNF-alpha secretion cause resistance of db/db mice to endotoxin. Am J Physiol Regul Integr Comp Physiol 284(3):R763-70. PubMed: 12571077 MGI: J:82497
Maffei M; Fei H; Lee GH; Dani C; Leroy P; Zhang Y; Proenca R; Negrel R; Ailhaud G; Friedman JM. 1995. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci U S A 92(15):6957-60. PubMed: 7624352 MGI: J:27422
Mahdipour E; Charnock JC; Mace KA. 2011. Hoxa3 promotes the differentiation of hematopoietic progenitor cells into proangiogenic Gr-1+CD11b+ myeloid cells. Blood 117(3):815-26. PubMed: 20974673 MGI: J:168405
Makino H; Miyamoto Y; Sawai K; Mori K; Mukoyama M; Nakao K; Yoshimasa Y; Suga S. 2006. Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone. Diabetes 55(10):2747-56. PubMed: 17003339 MGI: J:116575
Maness LM; Banks WA; Kastin AJ. 2000. Persistence of blood-to-brain transport of leptin in obese leptin-deficient and leptin receptor-deficient mice Brain Res 873(1):165-7. PubMed: 10915826 MGI: J:63732
Manodori AB; Kuypers FA. 2002. Altered red cell turnover in diabetic mice. J Lab Clin Med 140(3):161-5. PubMed: 12271273 MGI: J:79265
Mao HZ; Roussos ET; Peterfy M. 2006. Genetic analysis of the diabetes-prone C57BLKS/J mouse strain reveals genetic contribution from multiple strains. Biochim Biophys Acta 1762(4):440-6. PubMed: 16481151 MGI: J:108762
Mao T; Shao M; Qiu Y; Huang J; Zhang Y; Song B; Wang Q; Jiang L; Liu Y; Han JD; Cao P; Li J; Gao X; Rui L; Qi L; Li W; Liu Y. 2011. PKA phosphorylation couples hepatic inositol-requiring enzyme 1{alpha} to glucagon signaling in glucose metabolism. Proc Natl Acad Sci U S A 108(38):15852-7. PubMed: 21911379 MGI: J:176645
Marcel N; Sarin A. 2016. Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells. Elife 5:. PubMed: 27267497 MGI: J:234085
Martinez-Botas J; Anderson JB; Tessier D; Lapillonne A; Chang BH; Quast MJ; Gorenstein D; Chen KH; Chan L. 2000. Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice Nat Genet 26(4):474-9. PubMed: 11101849 MGI: J:66267
Maruyama K; Asai J; Ii M; Thorne T; Losordo DW; D'Amore PA. 2007. Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol 170(4):1178-91. PubMed: 17392158 MGI: J:120123
Masaki T; Yoshimatsu H; Chiba S; Sakata T. 2000. Impaired response of UCP family to cold exposure in diabetic (db/db) mice Am J Physiol Regul Integr Comp Physiol 279(4):R1305-9. PubMed: 11003997 MGI: J:65231
Masjkur J; Arps-Forker C; Poser SW; Nikolakopoulou P; Toutouna L; Chenna R; Chavakis T; Chatzigeorgiou A; Chen LS; Dubrovska A; Choudhary P; Uphues I; Mark M; Bornstein SR; Androutsellis-Theotokis A. 2014. Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release. J Biol Chem 289(51):35503-16. PubMed: 25371201 MGI: J:218260
Mathew R; Futterweit S; Valderrama E; Tarectecan AA; Bylander JE; Bond JS; Trachtman H. 2005. Meprin-alpha in chronic diabetic nephropathy: interaction with the renin-angiotensin axis. Am J Physiol Renal Physiol 289(4):F911-21. PubMed: 15942051 MGI: J:101223
Matoba K; Kawanami D; Tsukamoto M; Kinoshita J; Ito T; Ishizawa S; Kanazawa Y; Yokota T; Murai N; Matsufuji S; Utsunomiya K. 2014. Rho-kinase regulation of TNF-alpha-induced nuclear translocation of NF-kappaB RelA/p65 and M-CSF expression via p38 MAPK in mesangial cells. Am J Physiol Renal Physiol 307(5):F571-80. PubMed: 25007875 MGI: J:214236
Matsuda T; Kido Y; Asahara S; Kaisho T; Tanaka T; Hashimoto N; Shigeyama Y; Takeda A; Inoue T; Shibutani Y; Koyanagi M; Hosooka T; Matsumoto M; Inoue H; Uchida T; Koike M; Uchiyama Y; Akira S; Kasuga M. 2010. Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. J Clin Invest 120(1):115-26. PubMed: 19955657 MGI: J:156725
Matsunuma A; Horiuchi N. 2007. Leptin attenuates gene expression for renal 25-hydroxyvitamin D3-1alpha-hydroxylase in mice via the long form of the leptin receptor. Arch Biochem Biophys 463(1):118-27. PubMed: 17400175 MGI: J:123347
Matsuoka TA; Kaneto H; Miyatsuka T; Yamamoto T; Yamamoto K; Kato K; Shimomura I; Stein R; Matsuhisa M. 2010. Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes. Diabetes 59(7):1709-20. PubMed: 20424231 MGI: J:169353
Mauer SM; Steffes MW; Michael AF; Brown DM. 1976. Studies of diabetic nephropathy in animals and man. Diabetes 25(2 SUPPL):850-7. PubMed: 823065 MGI: J:30970
Mauldin JP; Srinivasan S; Mulya A; Gebre A; Parks JS; Daugherty A; Hedrick CC. 2006. Reduction in ABCG1 in Type 2 diabetic mice increases macrophage foam cell formation. J Biol Chem 281(30):21216-24. PubMed: 16723355 MGI: J:116456
Mazagova M; Buikema H; Landheer SW; Vavrinec P; Buiten Av; Henning RH; Deelman LE. 2013. Growth differentiation factor 15 impairs aortic contractile and relaxing function through altered caveolar signaling of the endothelium. Am J Physiol Heart Circ Physiol 304(5):H709-18. PubMed: 23262134 MGI: J:194601
Mazagova M; Buikema H; van Buiten A; Duin M; Goris M; Sandovici M; Henning RH; Deelman LE. 2013. Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes. Am J Physiol Renal Physiol 305(9):F1249-64. PubMed: 23986522 MGI: J:202996
McCommis KS; Chen Z; Fu X; McDonald WG; Colca JR; Kletzien RF; Burgess SC; Finck BN. 2015. Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling. Cell Metab 22(4):682-94. PubMed: 26344101 MGI: J:236436
McMurtry AL; Cho K; Young LJ; Nelson CF; Greenhalgh DG. 1999. Expression of HSP70 in healing wounds of diabetic and nondiabetic mice. J Surg Res 86(1):36-41. PubMed: 10452866 MGI: J:58046
Meissner M; Herrema H; van Dijk TH; Gerding A; Havinga R; Boer T; Muller M; Reijngoud DJ; Groen AK; Kuipers F. 2011. Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. PLoS One 6(11):e24564. PubMed: 22087215 MGI: J:180987
Memon RA; Grunfeld C; Moser AH; Feingold KR. 1994. Fatty acid synthesis in obese insulin resistant diabetic mice. Horm Metab Res 26(2):85-7. PubMed: 8200619 MGI: J:17499
Memon RA; Tecott LH; Nonogaki K; Beigneux A; Moser AH; Grunfeld C; Feingold KR. 2000. Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice [In Process Citation] Endocrinology 141(11):4021-31. PubMed: 11089532 MGI: J:65569
Meng L; Park J; Cai Q; Lanting L; Reddy MA; Natarajan R. 2010. Diabetic conditions promote binding of monocytes to vascular smooth muscle cells and their subsequent differentiation. Am J Physiol Heart Circ Physiol 298(3):H736-45. PubMed: 20008269 MGI: J:158441
Meng ZX; Wang L; Xiao Y; Lin JD. 2014. The Baf60c/Deptor pathway links skeletal muscle inflammation to glucose homeostasis in obesity. Diabetes 63(5):1533-45. PubMed: 24458360 MGI: J:229282
Menne J; Shushakova N; Bartels J; Kiyan Y; Laudeley R; Haller H; Park JK; Meier M. 2013. Dual inhibition of classical protein kinase C-alpha and protein kinase C-beta isoforms protects against experimental murine diabetic nephropathy. Diabetes 62(4):1167-74. PubMed: 23434935 MGI: J:208673
Mima A; Arai H; Matsubara T; Abe H; Nagai K; Tamura Y; Torikoshi K; Araki M; Kanamori H; Takahashi T; Tominaga T; Matsuura M; Iehara N; Fukatsu A; Kita T; Doi T. 2008. Urinary Smad1 is a novel marker to predict later onset of mesangial matrix expansion in diabetic nephropathy. Diabetes 57(6):1712-22. PubMed: 18285555 MGI: J:136929
Mirza RE; Fang MM; Ennis WJ; Koh TJ. 2013. Blocking interleukin-1beta induces a healing-associated wound macrophage phenotype and improves healing in type 2 diabetes. Diabetes 62(7):2579-87. PubMed: 23493576 MGI: J:208666
Mirza RE; Fang MM; Novak ML; Urao N; Sui A; Ennis WJ; Koh TJ. 2015. Macrophage PPARgamma and impaired wound healing in type 2 diabetes. J Pathol 236(4):433-44. PubMed: 25875529 MGI: J:225544
Mirza RE; Fang MM; Weinheimer-Haus EM; Ennis WJ; Koh TJ. 2014. Sustained inflammasome activity in macrophages impairs wound healing in type 2 diabetic humans and mice. Diabetes 63(3):1103-14. PubMed: 24194505 MGI: J:208998
Mishra R; Emancipator SN; Kern TS; Simonson MS. 2006. Association between endothelin-1 and collagen deposition in db/db diabetic mouse kidneys. Biochem Biophys Res Commun 339(1):65-70. PubMed: 16297859 MGI: J:103793
Mishra R; Emancipator SN; Miller C; Kern T; Simonson MS. 2004. Adipose differentiation-related protein and regulators of lipid homeostasis identified by gene expression profiling in the murine db/db diabetic kidney. Am J Physiol Renal Physiol 286(5):F913-21. PubMed: 15075187 MGI: J:113762
Miyazawa-Hoshimoto S; Takahashi K; Bujo H; Hashimoto N; Yagui K; Saito Y. 2005. Roles of degree of fat deposition and its localization on VEGF expression in adipocytes. Am J Physiol Endocrinol Metab 288(6):E1128-36. PubMed: 15613686 MGI: J:115460
Mizuno TM; Kleopoulos SP; Bergen HT; Roberts JL; Priest CA; Mobbs CV. 1998. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47(2):294-7. PubMed: 9519731 MGI: J:45531
Mohan S; Reddick RL; Musi N; Horn DA; Yan B; Prihoda TJ; Natarajan M; Abboud-Werner SL. 2008. Diabetic eNOS knockout mice develop distinct macro- and microvascular complications. Lab Invest 88(5):515-28. PubMed: 18391994 MGI: J:134351
Moien-Afshari F; Ghosh S; Elmi S; Khazaei M; Rahman MM; Sallam N; Laher I. 2008. Exercise restores coronary vascular function independent of myogenic tone or hyperglycemic status in db/db mice. Am J Physiol Heart Circ Physiol 295(4):H1470-80. PubMed: 18641279 MGI: J:141281
Moien-Afshari F; Ghosh S; Khazaei M; Kieffer TJ; Brownsey RW; Laher I. 2008. Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice. Diabetologia 51(7):1327-37. PubMed: 18437348 MGI: J:137918
Moraes-Vieira PM; Larocca RA; Bassi EJ; Peron JP; Andrade-Oliveira V; Wasinski F; Araujo R; Thornley T; Quintana FJ; Basso AS; Strom TB; Camara NO. 2014. Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells. Eur J Immunol 44(3):794-806. PubMed: 24271843 MGI: J:209083
Mordwinkin NM; Meeks CJ; Jadhav SS; Espinoza T; Roda N; diZerega GS; Louie SG; Rodgers KE. 2012. Angiotensin-(1-7) administration reduces oxidative stress in diabetic bone marrow. Endocrinology 153(5):2189-97. PubMed: 22434085 MGI: J:185172
Mori A; Sakurai H; Choo MK; Obi R; Koizumi K; Yoshida C; Shimada Y; Saiki I. 2006. Severe pulmonary metastasis in obese and diabetic mice. Int J Cancer 119(12):2760-7. PubMed: 16998795 MGI: J:117826
Mori H; Prestwich TC; Reid MA; Longo KA; Gerin I; Cawthorn WP; Susulic VS; Krishnan V; Greenfield A; Macdougald OA. 2012. Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition. J Clin Invest 122(7):2405-16. PubMed: 22728933 MGI: J:190767
Mori J; Patel VB; Ramprasath T; Alrob OA; Desaulniers J; Scholey JW; Lopaschuk GD; Oudit GY. 2014. Angiotensin 1-7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation, and lipotoxicity. Am J Physiol Renal Physiol 306(8):F812-21. PubMed: 24553436 MGI: J:208413
Moritani M; Togawa K; Yaguchi H; Fujita Y; Yamaguchi Y; Inoue H; Kamatani N; Itakura M. 2006. Identification of diabetes susceptibility loci in db mice by combined quantitative trait loci analysis and haplotype mapping. Genomics 88(6):719-30. PubMed: 16919419 MGI: J:116038
Morton NM; Beltram J; Carter RN; Michailidou Z; Gorjanc G; McFadden C; Barrios-Llerena ME; Rodriguez-Cuenca S; Gibbins MT; Aird RE; Moreno-Navarrete JM; Munger SC; Svenson KL; Gastaldello A; Ramage L; Naredo G; Zeyda M; Wang ZV; Howie AF; Saari A; Sipila P; Stulnig TM; Gudnason V; Kenyon CJ; Seckl JR; Walker BR; Webster SP; Dunbar DR; Churchill GA; Vidal-Puig A; Fernandez-Real JM; Emilsson V; Horvat S. 2016. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med 22(7):771-9. PubMed: 27270587 MGI: J:236030
Mu J; Pinkstaff J; Li Z; Skidmore L; Li N; Myler H; Dallas-Yang Q; Putnam AM; Yao J; Bussell S; Wu M; Norman TC; Rodriguez CG; Kimmel B; Metzger JM; Manibusan A; Lee D; Zaller DM; Zhang BB; DiMarchi RD; Berger JP; Axelrod DW. 2012. FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents. Diabetes 61(2):505-12. PubMed: 22210323 MGI: J:196783
Mukai T; Nagao Y; Nishioka S; Hayashi T; Shimizu S; Ono A; Sakagami Y; Watanabe S; Ueda Y; Hara M; Tokudome K; Kato R; Matsumura Y; Ohno Y. 2013. Preferential suppression of limbic Fos expression by intermittent hypoxia in obese diabetic mice. Neurosci Res 77(4):202-7. PubMed: 24144732 MGI: J:204965
Muller KA; Ryals JM; Feldman EL; Wright DE. 2008. Abnormal muscle spindle innervation and large-fiber neuropathy in diabetic mice. Diabetes 57(6):1693-701. PubMed: 18362211 MGI: J:136902
Munzberg H; Jobst EE; Bates SH; Jones J; Villanueva E; Leshan R; Bjornholm M; Elmquist J; Sleeman M; Cowley MA; Myers MG Jr. 2007. Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling. J Neurosci 27(1):69-74. PubMed: 17202473 MGI: J:117213
Murano I; Barbatelli G; Parisani V; Latini C; Muzzonigro G; Castellucci M; Cinti S. 2008. Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res 49(7):1562-8. PubMed: 18390487 MGI: J:138458
Mzhavia N; Yu S; Ikeda S; Chu TT; Goldberg I; Dansky HM. 2008. Neuronatin: a new inflammation gene expressed on the aortic endothelium of diabetic mice. Diabetes 57(10):2774-83. PubMed: 18591389 MGI: J:141898
Nadif R; Dilworth MR; Sibley CP; Baker PN; Davidge ST; Gibson JM; Aplin JD; Westwood M. 2015. The maternal environment programs postnatal weight gain and glucose tolerance of male offspring, but placental and fetal growth are determined by fetal genotype in the Leprdb/+ model of gestational diabetes. Endocrinology 156(1):360-6. PubMed: 25353183 MGI: J:219658
Nakae J; Cao Y; Hakuno F; Takemori H; Kawano Y; Sekioka R; Abe T; Kiyonari H; Tanaka T; Sakai J; Takahashi S; Itoh H. 2012. Novel repressor regulates insulin sensitivity through interaction with Foxo1. EMBO J 31(10):2275-95. PubMed: 22510882 MGI: J:184684
Nakagawa T; Tsuchida A; Itakura Y; Nonomura T; Ono M; Hirota F; Inoue T; Nakayama C; Taiji M; Noguchi H. 2000. Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. Diabetes 49(3):436-44. PubMed: 10868966 MGI: J:60912
Nakagawa Y; Shimano H; Yoshikawa T; Ide T; Tamura M; Furusawa M; Yamamoto T; Inoue N; Matsuzaka T; Takahashi A; Hasty AH; Suzuki H; Sone H; Toyoshima H; Yahagi N; Yamada N. 2006. TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nat Med 12(1):107-113. PubMed: 16327801 MGI: J:104468
Nakahara K; Bannai M; Maruyama K; Suzuki Y; Okame R; Murakami N. 2013. Characterization of a novel genetically obese mouse model demonstrating early onset hyperphagia and hyperleptinemia. Am J Physiol Endocrinol Metab 305(3):E451-63. PubMed: 23736543 MGI: J:203210
Nakamura A; Togashi Y; Orime K; Sato K; Shirakawa J; Ohsugi M; Kubota N; Kadowaki T; Terauchi Y. 2012. Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions. Diabetologia 55(6):1745-54. PubMed: 22456697 MGI: J:185166
Nakamura Y; Kaneto H; Miyatsuka T; Matsuoka TA; Matsuhisa M; Node K; Hori M; Yamasaki Y. 2006. Marked increase of insulin gene transcription by suppression of the Rho/Rho-kinase pathway. Biochem Biophys Res Commun 350(1):68-73. PubMed: 16996478 MGI: J:114522
Nakanishi N; Nakagawa Y; Tokushige N; Aoki N; Matsuzaka T; Ishii K; Yahagi N; Kobayashi K; Yatoh S; Takahashi A; Suzuki H; Urayama O; Yamada N; Shimano H. 2009. The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice. Biochem Biophys Res Commun 385(4):492-6. PubMed: 19460359 MGI: J:151242
Nakatani Y; Kaneto H; Kawamori D; Hatazaki M; Miyatsuka T; Matsuoka TA; Kajimoto Y; Matsuhisa M; Yamasaki Y; Hori M. 2004. Modulation of the JNK pathway in liver affects insulin resistance status. J Biol Chem 279(44):45803-9. PubMed: 15331609 MGI: J:119058
Nakayama M; Inoguchi T; Sonta T; Maeda Y; Sasaki S; Sawada F; Tsubouchi H; Sonoda N; Kobayashi K; Sumimoto H; Nawata H. 2005. Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist. Biochem Biophys Res Commun 332(4):927-33. PubMed: 15922295 MGI: J:99119
Nam DH; Lee MH; Kim JE; Song HK; Kang YS; Lee JE; Kim HW; Cha JJ; Hyun YY; Kim SH; Han SY; Han KH; Han JY; Cha DR. 2012. Blockade of cannabinoid receptor 1 improves insulin resistance, lipid metabolism, and diabetic nephropathy in db/db mice. Endocrinology 153(3):1387-96. PubMed: 22234468 MGI: J:182560
Narvekar P; Berriel Diaz M; Krones-Herzig A; Hardeland U; Strzoda D; Stohr S; Frohme M; Herzig S. 2009. Liver-specific loss of lipolysis-stimulated lipoprotein receptor triggers systemic hyperlipidemia in mice. Diabetes 58(5):1040-9. PubMed: 19188430 MGI: J:151130
Nayak B; Xie P; Akagi S; Yang Q; Sun L; Wada J; Thakur A; Danesh FR; Chugh SS; Kanwar YS. 2005. Modulation of renal-specific oxidoreductase/myo-inositol oxygenase by high-glucose ambience. Proc Natl Acad Sci U S A 102(50):17952-7. PubMed: 16330753 MGI: J:104390
Nesca V; Guay C; Jacovetti C; Menoud V; Peyot ML; Laybutt DR; Prentki M; Regazzi R. 2013. Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes. Diabetologia 56(10):2203-12. PubMed: 23842730 MGI: J:203300
Neschen S; Scheerer M; Seelig A; Huypens P; Schultheiss J; Wu M; Wurst W; Rathkolb B; Suhre K; Wolf E; Beckers J; Hrabe de Angelis M. 2015. Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 inhibitor by suppressing endogenous glucose production in diabetic mice. Diabetes 64(1):284-90. PubMed: 25071027 MGI: J:225213
Neuhofer A; Zeyda M; Mascher D; Itariu BK; Murano I; Leitner L; Hochbrugger EE; Fraisl P; Cinti S; Serhan CN; Stulnig TM. 2013. Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. Diabetes 62(6):1945-56. PubMed: 23349501 MGI: J:208560
Nicholas SB; Liu J; Kim J; Ren Y; Collins AR; Nguyen L; Hsueh WA. 2010. Critical role for osteopontin in diabetic nephropathy. Kidney Int 77(7):588-600. PubMed: 20130530 MGI: J:184276
Ninichuk V; Khandoga AG; Segerer S; Loetscher P; Schlapbach A; Revesz L; Feifel R; Khandoga A; Krombach F; Nelson PJ; Schlondorff D; Anders HJ. 2007. The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice. Am J Pathol 170(4):1267-76. PubMed: 17392166 MGI: J:120121
Nishimura S; Manabe I; Nagasaki M; Hosoya Y; Yamashita H; Fujita H; Ohsugi M; Tobe K; Kadowaki T; Nagai R; Sugiura S. 2007. Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes 56(6):1517-26. PubMed: 17389330 MGI: J:126464
Nishimura Y; Ii M; Qin G; Hamada H; Asai J; Takenaka H; Sekiguchi H; Renault MA; Jujo K; Katoh N; Kishimoto S; Ito A; Kamide C; Kenny J; Millay M; Misener S; Thorne T; Losordo DW. 2012. CXCR4 antagonist AMD3100 accelerates impaired wound healing in diabetic mice. J Invest Dermatol 132(3 Pt 1):711-20. PubMed: 22048734 MGI: J:183173
Nishina PM; Lowe S; Wang J; Paigen B. 1994. Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. Metabolism 43(5):549-53. PubMed: 8177042 MGI: J:18161
Nishina PM; Naggert JK; Verstuyft J; Paigen B. 1994. Atherosclerosis in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. Metabolism 43(5):554-8. PubMed: 8177043 MGI: J:19043
Nonogaki K; Kaji T; Ohba Y; Sumii M; Wakameda M; Tamari T. 2009. Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice. Biochem Biophys Res Commun 386(2):311-5. PubMed: 19523439 MGI: J:151527
Nonogaki K; Nozue K; Oka Y. 2007. Social isolation affects the development of obesity and type 2 diabetes in mice. Endocrinology 148(10):4658-66. PubMed: 17640995 MGI: J:129468
Nonogaki K; Ohba Y; Sumii M; Oka Y. 2008. Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice. Biochem Biophys Res Commun 372(1):186-90. PubMed: 18477467 MGI: J:136954
Nuno DW; Harrod JS; Lamping KG. 2009. Sex-dependent differences in Rho activation contribute to contractile dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol 297(4):H1469-77. PubMed: 19666843 MGI: J:154218
O'Connor JC; Satpathy A; Hartman ME; Horvath EM; Kelley KW; Dantzer R; Johnson RW; Freund GG. 2005. IL-1beta-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes. J Immunol 174(8):4991-7. PubMed: 15814729 MGI: J:98153
O'Connor JC; Sherry CL; Guest CB; Freund GG. 2007. Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3. J Immunol 178(11):6886-93. PubMed: 17513737 MGI: J:147843
O'Neill CM; Lu C; Corbin KL; Sharma PR; Dula SB; Carter JD; Ramadan JW; Xin W; Lee JK; Nunemaker CS. 2013. Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice. Endocrinology 154(9):3077-88. PubMed: 23836031 MGI: J:202248
Oakes ND; Thalen P; Aasum E; Edgley A; Larsen T; Furler SM; Ljung B; Severson D. 2006. Cardiac metabolism in mice: tracer method developments and in vivo application revealing profound metabolic inflexibility in diabetes. Am J Physiol Endocrinol Metab 290(5):E870-81. PubMed: 16352676 MGI: J:108411
Oh KJ; Park J; Kim SS; Oh H; Choi CS; Koo SH. 2012. TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver. PLoS Genet 8(9):e1002986. PubMed: 23028378 MGI: J:190447
Oh KS; Kim M; Lee J; Kim MJ; Nam YS; Ham JE; Shin SS; Lee CM; Yoon M. 2006. Liver PPARalpha and UCP2 are involved in the regulation of obesity and lipid metabolism by swim training in genetically obese db/db mice. Biochem Biophys Res Commun 345(3):1232-1239. PubMed: 16716264 MGI: J:109651
Oh SS; Sullivan KA; Wilkinson JE; Backus C; Hayes JM; Sakowski SA; Feldman EL. 2012. Neurodegeneration and early lethality in superoxide dismutase 2-deficient mice: A comprehensive analysis of the central and peripheral nervous systems. Neuroscience 212:201-13. PubMed: 22516022 MGI: J:184680
Ohanyan VA; Guarini G; Thodeti CK; Talasila PK; Raman P; Haney RM; Meszaros JG; Damron DS; Bratz IN. 2011. Endothelin-mediated in vivo pressor responses following TRPV1 activation. Am J Physiol Heart Circ Physiol 301(3):H1135-42. PubMed: 21705674 MGI: J:176905
Ohshima N; Kudo T; Yamashita Y; Mariggio S; Araki M; Honda A; Nagano T; Isaji C; Kato N; Corda D; Izumi T; Yanaka N. 2015. New Members of the Mammalian Glycerophosphodiester Phosphodiesterase Family: GDE4 AND GDE7 PRODUCE LYSOPHOSPHATIDIC ACID BY LYSOPHOSPHOLIPASE D ACTIVITY. J Biol Chem 290(7):4260-71. PubMed: 25528375 MGI: J:217869
Ohta R; Shigemura N; Sasamoto K; Koyano K; Ninomiya Y. 2003. Conditioned taste aversion learning in leptin-receptor-deficient db/db mice. Neurobiol Learn Mem 80(2):105-12. PubMed: 12932425 MGI: J:85127
Okada-Iwabu M; Yamauchi T; Iwabu M; Honma T; Hamagami K; Matsuda K; Yamaguchi M; Tanabe H; Kimura-Someya T; Shirouzu M; Ogata H; Tokuyama K; Ueki K; Nagano T; Tanaka A; Yokoyama S; Kadowaki T. 2013. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503(7477):493-9. PubMed: 24172895 MGI: J:206748
Okamoto K; Kakuma T; Fukuchi S; Masaki T; Sakata T; Yoshimatsu H. 2006. Sterol regulatory element binding protein (SREBP)-1 expression in brain is affected by age but not by hormones or metabolic changes. Brain Res 1081(1):19-27. PubMed: 16554040 MGI: J:108103
Ono M; Ichihara J; Nonomura T; Itakura Y; Taiji M; Nakayama C ; Noguchi H. 1997. Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice. Biochem Biophys Res Commun 238(2):633-7. PubMed: 9299565 MGI: J:43162
Osborn O; Sanchez-Alavez M; Brownell SE; Ross B; Klaus J; Dubins J; Beutler B; Conti B; Bartfai T. 2010. Metabolic characterization of a mouse deficient in all known leptin receptor isoforms. Cell Mol Neurobiol 30(1):23-33. PubMed: 19582570 MGI: J:166105
Ostertag A; Jones A; Rose AJ; Liebert M; Kleinsorg S; Reimann A; Vegiopoulos A; Berriel Diaz M; Strzoda D; Yamamoto M; Satoh T; Akira S; Herzig S. 2010. Control of adipose tissue inflammation through TRB1. Diabetes 59(8):1991-2000. PubMed: 20522600 MGI: J:169640
Ostler JE; Maurya SK; Dials J; Roof SR; Devor ST; Ziolo MT; Periasamy M. 2014. Effects of insulin resistance on skeletal muscle growth and exercise capacity in type 2 diabetic mouse models. Am J Physiol Endocrinol Metab 306(6):E592-605. PubMed: 24425761 MGI: J:211605
Otoda T; Takamura T; Misu H; Ota T; Murata S; Hayashi H; Takayama H; Kikuchi A; Kanamori T; Shima KR; Lan F; Takeda T; Kurita S; Ishikura K; Kita Y; Iwayama K; Kato K; Uno M; Takeshita Y; Yamamoto M; Tokuyama K; Iseki S; Tanaka K; Kaneko S. 2013. Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver. Diabetes 62(3):811-24. PubMed: 23209186 MGI: J:208595
Ottaway N; Mahbod P; Rivero B; Norman LA; Gertler A; D'Alessio DA; Perez-Tilve D. 2015. Diet-induced obese mice retain endogenous leptin action. Cell Metab 21(6):877-82. PubMed: 25980347 MGI: J:226133
Ozaki KI; Awazu M; Tamiya M; Iwasaki Y; Harada A; Kugisaki S; Tanimura S; Kohno M. 2016. Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes. Am J Physiol Endocrinol Metab 310(8):E643-E651. PubMed: 26860984 MGI: J:237317
Ozcan L; Ergin AS; Lu A; Chung J; Sarkar S; Nie D; Myers MG Jr; Ozcan U. 2009. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 9(1):35-51. PubMed: 19117545 MGI: J:144347
Padmalayam I; Hasham S; Saxena U; Pillarisetti S. 2009. Lipoic acid synthase (LASY): a novel role in inflammation, mitochondrial function, and insulin resistance. Diabetes 58(3):600-8. PubMed: 19074983 MGI: J:146930
Pagel-Langenickel I; Bao J; Joseph JJ; Schwartz DR; Mantell BS; Xu X; Raghavachari N; Sack MN. 2008. PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle. J Biol Chem 283(33):22464-72. PubMed: 18579525 MGI: J:139876
Palmer G; Aurrand-Lions M; Contassot E; Talabot-Ayer D; Ducrest-Gay D; Vesin C; Chobaz-Peclat V; Busso N; Gabay C. 2006. Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db mice. J Immunol 177(5):2899-907. PubMed: 16920925 MGI: J:139552
Panaro BL; Tough IR; Engelstoft MS; Matthews RT; Digby GJ; Moller CL; Svendsen B; Gribble F; Reimann F; Holst JJ; Holst B; Schwartz TW; Cox HM; Cone RD. 2014. The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. Cell Metab 20(6):1018-29. PubMed: 25453189 MGI: J:218759
Pande M; Hur J; Hong Y; Backus C; Hayes JM; Oh SS; Kretzler M; Feldman EL. 2011. Transcriptional profiling of diabetic neuropathy in the BKS db/db mouse: a model of type 2 diabetes. Diabetes 60(7):1981-9. PubMed: 21617178 MGI: J:186750
Papathanassoglou E; El-Haschimi K; Li XC; Matarese G; Strom T; Mantzoros C. 2006. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol 176(12):7745-52. PubMed: 16751422 MGI: J:132347
Park CW; Kim HW; Lim JH; Yoo KD; Chung S; Shin SJ; Chung HW; Lee SJ; Chae CB; Kim YS; Chang YS. 2009. Vascular endothelial growth factor inhibition by dRK6 causes endothelial apoptosis, fibrosis, and inflammation in the heart via the Akt/eNOS axis in db/db mice. Diabetes 58(11):2666-76. PubMed: 19675133 MGI: J:154385
Park J; Kusminski CM; Chua SC; Scherer PE. 2010. Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo. Am J Pathol 177(6):3133-44. PubMed: 21056997 MGI: J:167629
Park J; Rho HK; Kim KH; Choe SS; Lee YS; Kim JB. 2005. Overexpression of glucose-6-phosphate dehydrogenase is associated with lipid dysregulation and insulin resistance in obesity. Mol Cell Biol 25(12):5146-57. PubMed: 15923630 MGI: J:99224
Park JT; Kato M; Lanting L; Castro N; Nam BY; Wang M; Kang SW; Natarajan R. 2014. Repression of let-7 by transforming growth factor-beta1-induced Lin28 upregulates collagen expression in glomerular mesangial cells under diabetic conditions. Am J Physiol Renal Physiol 307(12):F1390-403. PubMed: 25354942 MGI: J:216763
Park KW; Waki H; Villanueva CJ; Monticelli LA; Hong C; Kang S; Macdougald OA; Goldrath AW; Tontonoz P. 2008. Inhibitor of DNA Binding 2 Is a Small Molecule-Inducible Modulator of Peroxisome Proliferator-Activated Receptor-{gamma} Expression and Adipocyte Differentiation. Mol Endocrinol 22(9):2038-48. PubMed: 18562627 MGI: J:138276
Park S; Bivona BJ; Feng Y; Lazartigues E; Harrison-Bernard LM. 2008. Intact renal afferent arteriolar autoregulatory responsiveness in db/db mice. Am J Physiol Renal Physiol 295(5):F1504-11. PubMed: 18753291 MGI: J:140999
Park S; Rich J; Hanses F; Lee JC. 2009. Defects in innate immunity predispose C57BL/6J-Leprdb/Leprdb mice to infection by Staphylococcus aureus. Infect Immun 77(3):1008-14. PubMed: 19103772 MGI: J:145718
Park SA; Raghunathan VK; Shah NM; Teixeira L; Motta MJ; Covert J; Dubielzig R; Schurr M; Isseroff RR; Abbott NL; McAnulty J; Murphy CJ. 2014. PDGF-BB does not accelerate healing in diabetic mice with splinted skin wounds. PLoS One 9(8):e104447. PubMed: 25121729 MGI: J:223152
Park SY; Kim KH; Seo KW; Bae JU; Kim YH; Lee SJ; Lee WS; Kim CD. 2014. Resistin derived from diabetic perivascular adipose tissue up-regulates vascular expression of osteopontin via the AP-1 signalling pathway. J Pathol 232(1):87-97. PubMed: 24089355 MGI: J:203984
Park Y; Capobianco S; Gao X; Falck JR; Dellsperger KC; Zhang C. 2008. Role of EDHF in type 2 diabetes-induced endothelial dysfunction. Am J Physiol Heart Circ Physiol 295(5):H1982-8. PubMed: 18790831 MGI: J:142608
Pasek RC; Gannon M. 2013. Advancements and challenges in generating accurate animal models of gestational diabetes mellitus. Am J Physiol Endocrinol Metab 305(11):E1327-38. PubMed: 24085033 MGI: J:204991
Pasko KL; Salvin SB; Winkelstein A. 1981. Mechanisms in the in vivo release of lymphokines. V. Responses in alloxan-treated and genetically diabetic mice. Cell Immunol 62(1):205-19. PubMed: 7261069 MGI: J:109959
Peake BF; Nicholson CK; Lambert JP; Hood RL; Amin H; Amin S; Calvert JW. 2013. Hydrogen sulfide preconditions the db/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent manner. Am J Physiol Heart Circ Physiol 304(9):H1215-24. PubMed: 23479260 MGI: J:197535
Pedersen KB; Chodavarapu H; Porretta C; Robinson LK; Lazartigues E. 2015. Dynamics of ADAM17-Mediated Shedding of ACE2 Applied to Pancreatic Islets of Male db/db Mice. Endocrinology 156(12):4411-25. PubMed: 26441236 MGI: J:232746
Peier AM; Desai K; Hubert J; Du X; Yang L; Qian Y; Kosinski JR; Metzger JM; Pocai A; Nawrocki AR; Langdon RB; Marsh DJ. 2011. Effects of peripherally administered neuromedin u on energy and glucose homeostasis. Endocrinology 152(7):2644-54. PubMed: 21586559 MGI: J:174883
Peiris H; Duffield MD; Fadista J; Jessup CF; Kashmir V; Genders AJ; McGee SL; Martin AM; Saiedi M; Morton N; Carter R; Cousin MA; Kokotos AC; Oskolkov N; Volkov P; Hough TA; Fisher EM; Tybulewicz VL; Busciglio J; Coskun PE; Becker A; Belichenko PV; Mobley WC; Ryan MT; Chan JY; Laybutt DR; Coates PT; Yang S; Ling C; Groop L; Pritchard MA; Keating DJ. 2016. A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to beta-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genet 12(5):e1006033. PubMed: 27195491 MGI: J:231889
Peng Y; Liu J; Shi L; Tang Y; Gao D; Long J; Liu J. 2016. Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons. J Neurochem 137(5):701-13. PubMed: 26926143 MGI: J:233765
Peppa M; Brem H; Ehrlich P; Zhang JG; Cai W; Li Z; Croitoru A; Thung S; Vlassara H. 2003. Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice. Diabetes 52(11):2805-13. PubMed: 14578300 MGI: J:86304
Pereira L; Matthes J; Schuster I; Valdivia HH; Herzig S; Richard S; Gomez AM. 2006. Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db/db type 2 diabetic mice. Diabetes 55(3):608-15. PubMed: 16505222 MGI: J:106859
Persson MF; Franzen S; Catrina SB; Dallner G; Hansell P; Brismar K; Palm F. 2012. Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes. Diabetologia 55(5):1535-43. PubMed: 22311417 MGI: J:183273
Petrolonis AJ; Yang Q; Tummino PJ; Fish SM; Prack AE; Jain S; Parsons TF; Li P; Dales NA; Ge L; Langston SP; Schuller AG; An WF; Tartaglia LA; Chen H; Hong SB. 2004. Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP). J Biol Chem 279(14):13976-83. PubMed: 14722102 MGI: J:124542
Pfalzer AC; Nesbeth PD; Parnell LD; Iyer LK; Liu Z; Kane AV; Chen CY; Tai AK; Bowman TA; Obin MS; Mason JB; Greenberg AS; Choi SW; Selhub J; Paul L; Crott JW. 2015. Diet- and Genetically-Induced Obesity Differentially Affect the Fecal Microbiome and Metabolome in Apc1638N Mice. PLoS One 10(8):e0135758. PubMed: 26284788 MGI: J:242882
Picard F; Wanatabe M; Schoonjans K; Lydon J; O'Malley BW; Auwerx J. 2002. Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation. Proc Natl Acad Sci U S A 99(24):15644-8. PubMed: 12438645 MGI: J:125584
Pietramaggiori G; Scherer SS; Alperovich M; Chen B; Orgill DP; Wagers AJ. 2009. Improved cutaneous healing in diabetic mice exposed to healthy peripheral circulation. J Invest Dermatol 129(9):2265-74. PubMed: 19295612 MGI: J:153493
Pilarczyk M; Mateuszuk L; Rygula A; Kepczynski M; Chlopicki S; Baranska M; Kaczor A. 2014. Endothelium in spots--high-content imaging of lipid rafts clusters in db/db mice. PLoS One 9(8):e106065. PubMed: 25166908 MGI: J:221074
Piroli GG; Manuel AM; Walla MD; Jepson MJ; Brock JW; Rajesh MP; Tanis RM; Cotham WE; Frizzell N. 2014. Identification of protein succination as a novel modification of tubulin. Biochem J 462(2):231-45. PubMed: 24909641 MGI: J:215323
Plante E; Menaouar A; Danalache BA; Broderick TL; Jankowski M; Gutkowska J. 2014. Treatment with brain natriuretic peptide prevents the development of cardiac dysfunction in obese diabetic db/db mice. Diabetologia 57(6):1257-67. PubMed: 24595856 MGI: J:210888
Platt TL; Beckett TL; Kohler K; Niedowicz DM; Murphy MP. 2016. Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease. Neuroscience 315:162-74. PubMed: 26701291 MGI: J:231179
Pourhoseini S; Seth RK; Das S; Dattaroy D; Kadiiska MB; Xie G; Michelotti GA; Nagarkatti M; Diehl AM; Chatterjee S. 2015. Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis. PLoS One 10(2):e0116780. PubMed: 25658689 MGI: J:242398
Prakash R; Johnson M; Fagan SC; Ergul A. 2013. Cerebral neovascularization and remodeling patterns in two different models of type 2 diabetes. PLoS One 8(2):e56264. PubMed: 23441170 MGI: J:196067
Procaccini C; De Rosa V; Galgani M; Abanni L; Cali G; Porcellini A; Carbone F; Fontana S; Horvath TL; La Cava A; Matarese G. 2010. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity 33(6):929-41. PubMed: 21145759 MGI: J:167293
Procaccini C; De Rosa V; Galgani M; Carbone F; Cassano S; Greco D; Qian K; Auvinen P; Cali G; Stallone G; Formisano L; La Cava A; Matarese G. 2012. Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses. J Immunol 189(6):2941-53. PubMed: 22904304 MGI: J:189915
Qi L; Heredia JE; Altarejos JY; Screaton R; Goebel N; Niessen S; Macleod IX; Liew CW; Kulkarni RN; Bain J; Newgard C; Nelson M; Evans RM; Yates J; Montminy M. 2006. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 312(5781):1763-6. PubMed: 16794074 MGI: J:110012
Qu S; Altomonte J; Perdomo G; He J; Fan Y; Kamagate A; Meseck M; Dong HH. 2006. Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism. Endocrinology 147(12):5641-52. PubMed: 16997836 MGI: J:129563
Radigan KA; Morales-Nebreda L; Soberanes S; Nicholson T; Nigdelioglu R; Cho T; Chi M; Hamanaka RB; Misharin AV; Perlman H; Budinger GR; Mutlu GM. 2014. Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages. PLoS One 9(9):e108138. PubMed: 25232724 MGI: J:220638
Rahmouni K; Haynes WG; Morgan DA; Mark AL. 2003. Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin. J Neurosci 23(14):5998-6004. PubMed: 12853417 MGI: J:84443
Raizada MK; Tan G; Fellows RE. 1980. Fibroblastic cultures from the diabetic db/db mouse. Demonstration of decreased insulin receptors and impaired responses to insulin. J Biol Chem 255(19):9149-55. PubMed: 6997311 MGI: J:6370
Rajala MW; Patterson CM; Opp JS; Foltin SK; Young VB; Myers MG Jr. 2014. Leptin acts independently of food intake to modulate gut microbial composition in male mice. Endocrinology 155(3):748-57. PubMed: 24424041 MGI: J:208812
Raju SV; Zheng M; Schuleri KH; Phan AC; Bedja D; Saraiva RM; Yiginer O; Vandegaer K; Gabrielson KL; O'donnell CP; Berkowitz DE; Barouch LA; Hare JM. 2006. Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity. Proc Natl Acad Sci U S A 103(11):4222-7. PubMed: 16537512 MGI: J:107586
Rashid MA; Lee S; Tak E; Lee J; Choi TG; Lee JW; Kim JB; Youn JH; Kang I; Ha J; Kim SS. 2010. Carbonyl reductase 1 protects pancreatic beta-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity. Free Radic Biol Med 49(10):1522-33. PubMed: 20728534 MGI: J:165860
Rasmussen BA; Breen DM; Duca FA; Cote CD; Zadeh-Tahmasebi M; Filippi BM; Lam TK. 2014. Jejunal leptin-PI3K signaling lowers glucose production. Cell Metab 19(1):155-61. PubMed: 24361011 MGI: J:210553
Ravnskjaer K; Hogan MF; Lackey D; Tora L; Dent SY; Olefsky J; Montminy M. 2013. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest 123(10):4318-28. PubMed: 24051374 MGI: J:204007
Reaux-Le Goazigo A; Bodineau L; De Mota N; Jeandel L; Chartrel N; Knauf C; Raad C; Valet P; Llorens-Cortes C. 2011. Apelin and the proopiomelanocortin system: a new regulatory pathway of hypothalamic alpha-MSH release. Am J Physiol Endocrinol Metab 301(5):E955-66. PubMed: 21846903 MGI: J:182172
Reddy MA; Chen Z; Park JT; Wang M; Lanting L; Zhang Q; Bhatt K; Leung A; Wu X; Putta S; Saetrom P; Devaraj S; Natarajan R. 2014. Regulation of inflammatory phenotype in macrophages by a diabetes-induced long noncoding RNA. Diabetes 63(12):4249-61. PubMed: 25008173 MGI: J:230147
Reine TM; Grondahl F; Jenssen TG; Hadler-Olsen E; Prydz K; Kolset SO. 2013. Reduced sulfation of chondroitin sulfate but not heparan sulfate in kidneys of diabetic db/db mice. J Histochem Cytochem 61(8):606-16. PubMed: 23757342 MGI: J:214192
Reyes M; Steinhelper ME; Alvarez JA; Escobedo D; Pearce J; Valvano JW; Pollock BH; Wei CL; Kottam A; Altman D; Bailey S; Thomsen S; Lee S; Colston JT; Oh JH; Freeman GL; Feldman MD. 2006. Impact of physiological variables and genetic background on myocardial frequency-resistivity relations in the intact beating murine heart. Am J Physiol Heart Circ Physiol 291(4):H1659-69. PubMed: 16699072 MGI: J:116438
Rieg T; Gerasimova M; Murray F; Masuda T; Tang T; Rose M; Drucker DJ; Vallon V. 2012. Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice. Am J Physiol Renal Physiol 303(7):F963-71. PubMed: 22832924 MGI: J:188634
Rincon-Choles H; Vasylyeva TL; Pergola PE; Bhandari B; Bhandari K; Zhang JH; Wang W; Gorin Y; Barnes JL; Abboud HE. 2006. ZO-1 expression and phosphorylation in diabetic nephropathy. Diabetes 55(4):894-900. PubMed: 16567508 MGI: J:108596
Rinella ME; Elias MS; Smolak RR; Fu T; Borensztajn J; Green RM. 2008. Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet. J Lipid Res 49(5):1068-76. PubMed: 18227531 MGI: J:135349
Ring LE; Zeltser LM. 2010. Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels. J Clin Invest 120(8):2931-41. PubMed: 20592471 MGI: J:163776
Robertson DM; Sima AA. 1980. Diabetic neuropathy in the mutant mouse [C57BL/ks(db/db)]: a morphometric study. Diabetes 29(1):60-7. PubMed: 6991317 MGI: J:6323
Robertson S; Ishida-Takahashi R; Tawara I; Hu J; Patterson CM; Jones JC; Kulkarni RN; Myers MG Jr. 2010. Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions. Diabetes 59(4):782-90. PubMed: 20068132 MGI: J:164339
Rodgers JT; Haas W; Gygi SP; Puigserver P. 2010. Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. Cell Metab 11(1):23-34. PubMed: 20074525 MGI: J:157003
Rodriguez AR; Plascencia-Villa G; Witt CM; Yu JJ; Jose-Yacaman M; Chambers JP; Perry G; Guentzel MN; Arulanandam BP. 2015. Chlamydia pneumoniae promotes dysfunction of pancreatic beta cells. Cell Immunol 295(2):83-91. PubMed: 25863744 MGI: J:229697
Rohm M; Sommerfeld A; Strzoda D; Jones A; Sijmonsma TP; Rudofsky G; Wolfrum C; Sticht C; Gretz N; Zeyda M; Leitner L; Nawroth PP; Stulnig TM; Diaz MB; Vegiopoulos A; Herzig S. 2013. Transcriptional cofactor TBLR1 controls lipid mobilization in white adipose tissue. Cell Metab 17(4):575-85. PubMed: 23499424 MGI: J:198124
Rojek AM; Skowronski MT; Fuchtbauer EM; Fuchtbauer AC; Fenton RA; Agre P; Frokiaer J; Nielsen S. 2007. Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice. Proc Natl Acad Sci U S A 104(9):3609-14. PubMed: 17360690 MGI: J:123742
Rong JX; Qiu Y; Hansen MK; Zhu L; Zhang V; Xie M; Okamoto Y; Mattie MD; Higashiyama H; Asano S; Strum JC; Ryan TE. 2007. Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone. Diabetes 56(7):1751-60. PubMed: 17456854 MGI: J:126457
Rong X; Albert CJ; Hong C; Duerr MA; Chamberlain BT; Tarling EJ; Ito A; Gao J; Wang B; Edwards PA; Jung ME; Ford DA; Tontonoz P. 2013. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab 18(5):685-97. PubMed: 24206663 MGI: J:206173
Ropelle ER; Pauli JR; Fernandes MF; Rocco SA; Marin RM; Morari J; Souza KK; Dias MM; Gomes-Marcondes MC; Gontijo JA; Franchini KG; Velloso LA; Saad MJ; Carvalheira JB. 2008. A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss. Diabetes 57(3):594-605. PubMed: 18057094 MGI: J:132294
Roth D; Piekarek M; Paulsson M; Christ H; Krieg T; Bloch W; Davidson JM; Eming SA. 2006. Plasmin modulates vascular endothelial growth factor-A-mediated angiogenesis during wound repair. Am J Pathol 168(2):670-84. PubMed: 16436680 MGI: J:106500
Rueda A; Fernandez-Velasco M; Benitah JP; Gomez AM. 2013. Abnormal Ca2+ spark/STOC coupling in cerebral artery smooth muscle cells of obese type 2 diabetic mice. PLoS One 8(1):e53321. PubMed: 23301060 MGI: J:195818
Ruiz R; Jideonwo V; Ahn M; Surendran S; Tagliabracci VS; Hou Y; Gamble A; Kerner J; Irimia-Dominguez JM; Puchowicz MA; DePaoli-Roach A; Hoppel C; Roach P; Morral N. 2014. Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver. J Biol Chem 289(9):5510-7. PubMed: 24398675 MGI: J:213021
Russo HM; Wickenheiser KJ; Luo W; Ohman MK; Franchi L; Wright AP; Bodary PF; Nunez G; Eitzman DT. 2010. P-selectin glycoprotein ligand-1 regulates adhesive properties of the endothelium and leukocyte trafficking into adipose tissue. Circ Res 107(3):388-97. PubMed: 20558823 MGI: J:175038
Saadat N; Iglayreger HB; Myers MG Jr; Bodary P; Gupta SV. 2012. Differences in metabolomic profiles of male db/db and s/s, leptin receptor mutant mice. Physiol Genomics 44(6):374-81. PubMed: 22318992 MGI: J:182608
Saaristo A; Tammela T; Farkkila A; Karkkainen M; Suominen E; Yla-Herttuala S; Alitalo K. 2006. Vascular endothelial growth factor-C accelerates diabetic wound healing. Am J Pathol 169(3):1080-7. PubMed: 16936280 MGI: J:144401
Sabeva NS; Rouse EJ; Graf GA. 2007. Defects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver. J Biol Chem 282(31):22397-405. PubMed: 17561514 MGI: J:124801
Saez-Lopez C; Rivera-Gimenez M; Hernandez C; Simo R; Selva DM. 2015. SHBG-C57BL/ksJ-db/db: A New Mouse Model to Study SHBG Expression and Regulation During Obesity Development. Endocrinology 156(12):4571-81. PubMed: 26441241 MGI: J:232827
Sahai A; Malladi P; Pan X; Paul R; Melin-Aldana H; Green RM; Whitington PF. 2004. Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin. Am J Physiol Gastrointest Liver Physiol 287(5):G1035-43. PubMed: 15256362 MGI: J:96143
Saito H; Yamamoto Y; Yamamoto H. 2012. Diabetes alters subsets of endothelial progenitor cells that reside in blood, bone marrow, and spleen. Am J Physiol Cell Physiol 302(6):C892-901. PubMed: 22159079 MGI: J:183453
Sakai K; Nomura T; Ina Y. 2006. Enhancement of bio-protective functions by low dose/dose-rate radiation. Dose Response 4(4):327-32. PubMed: 18648588 MGI: J:140414
Sakai T; Nambu T; Katoh M; Uehara S; Fukuroda T; Nishikibe M. 2009. Up-regulation of protease-activated receptor-1 in diabetic glomerulosclerosis. Biochem Biophys Res Commun 384(2):173-9. PubMed: 19401193 MGI: J:152435
Saleh J; Blevins JE; Havel PJ; Barrett JA; Gietzen DW; Cianflone K. 2001. Acylation stimulating protein (ASP) acute effects on postprandial lipemia and food intake in rodents. Int J Obes Relat Metab Disord 25(5):705-13. PubMed: 11360154 MGI: J:69140
Salzberg SP; Filsoufi F; Anyanwu A; von Harbou K; Karlof E; Carpentier A; Dansky HM; Adams DH. 2006. Increased neointimal formation after surgical vein grafting in a murine model of type 2 diabetes. Circulation 114(1 Suppl):I302-7. PubMed: 16820590 MGI: J:122888
San Martin A; Du P; Dikalova A; Lassegue B; Aleman M; Gongora MC; Brown K; Joseph G; Harrison DG; Taylor WR; Jo H; Griendling KK. 2007. Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes. Am J Physiol Heart Circ Physiol 292(5):H2073-82. PubMed: 17237245 MGI: J:125944
Sano K; Kawashima M; Ito A; Inaba T; Morimoto K; Watanabe M; Tsubota K. 2014. Aerobic exercise increases tear secretion in type 2 diabetic mice. Invest Ophthalmol Vis Sci 55(7):4287-94. PubMed: 24876288 MGI: J:230007
Sansbury BE; Cummins TD; Tang Y; Hellmann J; Holden CR; Harbeson MA; Chen Y; Patel RP; Spite M; Bhatnagar A; Hill BG. 2012. Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype. Circ Res 111(9):1176-89. PubMed: 22896587 MGI: J:212630
Sarkar K; Fox-Talbot K; Steenbergen C; Bosch-Marce M; Semenza GL. 2009. Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice. Proc Natl Acad Sci U S A 106(44):18769-74. PubMed: 19841279 MGI: J:154677
Sarnyai Z; Jashar C; Olivier B. 2015. Modeling combined schizophrenia-related behavioral and metabolic phenotypes in rodents. Behav Brain Res 276:130-42. PubMed: 24747658 MGI: J:223607
Sartoretto JL; Jin BY; Bauer M; Gertler FB; Liao R; Michel T. 2009. Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart. Am J Physiol Heart Circ Physiol 297(5):H1697-710. PubMed: 19734360 MGI: J:154317
Sasaki T; Kikuchi O; Shimpuku M; Susanti VY; Yokota-Hashimoto H; Taguchi R; Shibusawa N; Sato T; Tang L; Amano K; Kitazumi T; Kuroko M; Fujita Y; Maruyama J; Lee YS; Kobayashi M; Nakagawa T; Minokoshi Y; Harada A; Yamada M; Kitamura T. 2014. Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice. Diabetologia 57(4):819-31. PubMed: 24374551 MGI: J:209418
Sasaki T; Kinoshita Y; Matsui S; Kakuta S; Yokota-Hashimoto H; Kinoshita K; Iwasaki Y; Kinoshita T; Yada T; Amano N; Kitamura T. 2015. N-methyl-d-aspartate receptor coagonist d-serine suppresses intake of high-preference food. Am J Physiol Regul Integr Comp Physiol 309(5):R561-75. PubMed: 26157056 MGI: J:227303
Sato C; Shikata K; Hirota D; Sasaki M; Nishishita S; Miyamoto S; Kodera R; Ogawa D; Tone A; Kataoka HU; Wada J; Kajitani N; Makino H. 2011. P-selectin glycoprotein ligand-1 deficiency is protective against obesity-related insulin resistance. Diabetes 60(1):189-99. PubMed: 20971965 MGI: J:170158
Saucillo DC; Gerriets VA; Sheng J; Rathmell JC; Maciver NJ. 2014. Leptin metabolically licenses T cells for activation to link nutrition and immunity. J Immunol 192(1):136-44. PubMed: 24273001 MGI: J:207097
Sauerhofer S; Yuan G; Braun GS; Deinzer M; Neumaier M; Gretz N; Floege J; Kriz W; van der Woude F; Moeller MJ. 2007. L-carnosine, a substrate of carnosinase-1, influences glucose metabolism. Diabetes 56(10):2425-32. PubMed: 17601992 MGI: J:126574
Savinova OV; Sugiyama F; Martin JE; Tomarev SI; Paigen BJ; Smith RS; John SW. 2001. Intraocular pressure in genetically distinct mice: an update and strain survey. BMC Genet 2(1):12. PubMed: 11532192 MGI: J:82879
Sawada N; Jiang A; Takizawa F; Safdar A; Manika A; Tesmenitsky Y; Kang KT; Bischoff J; Kalwa H; Sartoretto JL; Kamei Y; Benjamin LE; Watada H; Ogawa Y; Higashikuni Y; Kessinger CW; Jaffer FA; Michel T; Sata M; Croce K; Tanaka R; Arany Z. 2014. Endothelial PGC-1alpha mediates vascular dysfunction in diabetes. Cell Metab 19(2):246-58. PubMed: 24506866 MGI: J:210653
Saxena A; Shoeb M; Tammali R; Ramana KV; Srivastava SK. 2014. Aldose reductase inhibition suppresses azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice. Cancer Lett 355(1):141-7. PubMed: 25218594 MGI: J:216990
Sayyed SG; Hagele H; Kulkarni OP; Endlich K; Segerer S; Eulberg D; Klussmann S; Anders HJ. 2009. Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes. Diabetologia 52(11):2445-54. PubMed: 19707743 MGI: J:154473
Scarlett JM; Rojas JM; Matsen ME; Kaiyala KJ; Stefanovski D; Bergman RN; Nguyen HT; Dorfman MD; Lantier L; Wasserman DH; Mirzadeh Z; Unterman TG; Morton GJ; Schwartz MW. 2016. Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents. Nat Med 22(7):800-6. PubMed: 27213816 MGI: J:239768
Schatteman GC; Awad O; Nau E; Wang C; Jiao C; Tomanek RJ; Dunnwald M. 2010. Lin- cells mediate tissue repair by regulating MCP-1/CCL-2. Am J Pathol 177(4):2002-10. PubMed: 20813969 MGI: J:165434
Schiavinato A; Morandin AR; Guidolin D; Lini E; Nunzi MG; Fiori MG. 1991. Perineurium of sciatic nerve in normal and diabetic rodents: freeze-fracture study of intercellular junctional complexes. J Neurocytol 20(6):459-70. PubMed: 1869883 MGI: J:27540
Schiekofer S; Galasso G; Sato K; Kraus BJ; Walsh K. 2005. Impaired revascularization in a mouse model of type 2 diabetes is associated with dysregulation of a complex angiogenic-regulatory network. Arterioscler Thromb Vasc Biol 25(8):1603-9. PubMed: 15920034 MGI: J:114319
Schiffer M; Susztak K; Ranalletta M; Raff AC; Bottinger EP; Charron MJ. 2005. Localization of the GLUT8 glucose transporter in murine kidney and regulation in vivo in nondiabetic and diabetic conditions. Am J Physiol Renal Physiol 289(1):F186-93. PubMed: 15741607 MGI: J:98933
Schmidt RE; Dorsey DA; Beaudet LN; Frederick KE; Parvin CA; Plurad SB; Levisetti MG. 2003. Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: a new experimental model of diabetic autonomic neuropathy. Am J Pathol 163(5):2077-91. PubMed: 14578206 MGI: J:86318
Schmitz-Peiffer C; Laybutt DR; Burchfield JG; Gurisik E; Narasimhan S; Mitchell CJ; Pedersen DJ; Braun U; Cooney GJ; Leitges M; Biden TJ. 2007. Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. Cell Metab 6(4):320-8. PubMed: 17908560 MGI: J:130026
Schneider JG; Finck BN; Ren J; Standley KN; Takagi M; Maclean KH; Bernal-Mizrachi C; Muslin AJ; Kastan MB; Semenkovich CF. 2006. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab 4(5):377-89. PubMed: 17084711 MGI: J:129761
Schroeder-Gloeckler JM; Rahman SM; Janssen RC; Qiao L; Shao J; Roper M; Fischer SJ; Lowe E; Orlicky DJ; McManaman JL; Palmer C; Gitomer WL; Huang W; O'Doherty RM; Becker TC; Klemm DJ; Jensen DR; Pulawa LK; Eckel RH; Friedman JE. 2007. CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. J Biol Chem 282(21):15717-29. PubMed: 17387171 MGI: J:122719
Schwartz MW; Baskin DG; Bukowski TR; Kuijper JL; Foster D; Lasser G; Prunkard DE; Porte D Jr; Woods SC; Seeley RJ; Weigle DS. 1996. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45(4):531-5. PubMed: 8603777 MGI: J:32265
Semeniuk LM; Kryski AJ; Severson DL. 2002. Echocardiographic assessment of cardiac function in diabetic db/db and transgenic db/db-hGLUT4 mice. Am J Physiol Heart Circ Physiol 283(3):H976-82. PubMed: 12181126 MGI: J:78898
Shafrir E; Ziv E. 2009. A useful list of spontaneously arising animal models of obesity and diabetes. Am J Physiol Endocrinol Metab 296(6):E1450-2. PubMed: 19468077 MGI: J:149667
Shao J; Yamashita H; Qiao L; Draznin B; Friedman JE. 2002. Phosphatidylinositol 3-kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus. Diabetes 51(1):19-29. PubMed: 11756318 MGI: J:73759
Shapiro NI; Khankin EV; Van Meurs M; Shih SC; Lu S; Yano M; Castro PR; Maratos-Flier E; Parikh SM; Karumanchi SA; Yano K. 2010. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol 185(1):517-24. PubMed: 20519646 MGI: J:161431
Sharma A; Singh AK; Warren J; Thangapazham RL; Maheshwari RK. 2006. Differential regulation of angiogenic genes in diabetic wound healing. J Invest Dermatol 126(10):2323-31. PubMed: 16874314 MGI: J:112626
Sharma K; McCue P; Dunn SR. 2003. Diabetic kidney disease in the db/db mouse. Am J Physiol Renal Physiol 284(6):F1138-44. PubMed: 12736165 MGI: J:83903
Sharma RB; O'Donnell AC; Stamateris RE; Ha B; McCloskey KM; Reynolds PR; Arvan P; Alonso LC. 2015. Insulin demand regulates beta cell number via the unfolded protein response. J Clin Invest 125(10):3831-46. PubMed: 26389675 MGI: J:226393
Shearer J; Ross KD; Hughey CC; Johnsen VL; Hittel DS; Severson DL. 2011. Exercise training does not correct abnormal cardiac glycogen accumulation in the db/db mouse model of type 2 diabetes. Am J Physiol Endocrinol Metab 301(1):E31-9. PubMed: 21386062 MGI: J:182078
Sheffer-Babila S; Sun Y; Israel DD; Liu SM; Neal-Perry G; Chua SC Jr. 2013. Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproduction. Am J Physiol Endocrinol Metab 305(12):E1512-20. PubMed: 24169048 MGI: J:206185
Shen E; Li Y; Li Y; Shan L; Zhu H; Feng Q; Arnold JM; Peng T. 2009. Rac1 is required for cardiomyocyte apoptosis during hyperglycemia. Diabetes 58(10):2386-95. PubMed: 19592621 MGI: J:154395
Shen Y; Guo Y; Mikus P; Sulniute R; Wilczynska M; Ny T; Li J. 2012. Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Blood 119(24):5879-87. PubMed: 22563086 MGI: J:189054
Sheng L; Zhou Y; Chen Z; Ren D; Cho KW; Jiang L; Shen H; Sasaki Y; Rui L. 2012. NF-kappaB-inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. Nat Med 18(6):943-9. PubMed: 22581287 MGI: J:187458
Sherry CL; O'Connor JC; Kramer JM; Freund GG. 2007. Augmented lipopolysaccharide-induced TNF-alpha production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and requires p38 MAPK. J Immunol 178(2):663-70. PubMed: 17202326 MGI: J:142637
Shi H; Tzameli I; Bjorbaek C; Flier JS. 2004. Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling. J Biol Chem 279(33):34733-40. PubMed: 15181014 MGI: J:121205
Shi TJ; Zhang MD; Zeberg H; Nilsson J; Grunler J; Liu SX; Xiang Q; Persson J; Fried KJ; Catrina SB; Watanabe M; Arhem P; Brismar K; Hokfelt TG. 2013. Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db-/db- mouse, a type 2 diabetes model. Proc Natl Acad Sci U S A 110(2):690-5. PubMed: 23267110 MGI: J:193280
Shibata R; Ouchi N; Ito M; Kihara S; Shiojima I; Pimentel DR; Kumada M; Sato K; Schiekofer S; Ohashi K; Funahashi T; Colucci WS; Walsh K. 2004. Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med 10(12):1384-9. PubMed: 15558058 MGI: J:120016
Shibata S; Tada Y; Asano Y; Hau CS; Kato T; Saeki H; Yamauchi T; Kubota N; Kadowaki T; Sato S. 2012. Adiponectin regulates cutaneous wound healing by promoting keratinocyte proliferation and migration via the ERK signaling pathway. J Immunol 189(6):3231-41. PubMed: 22904306 MGI: J:189913
Shigemura N; Ohta R; Kusakabe Y; Miura H; Hino A; Koyano K; Nakashima K; Ninomiya Y. 2004. Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures. Endocrinology 145(2):839-47. PubMed: 14592964 MGI: J:96388
Shim CY; Kim S; Chadderdon S; Wu M; Qi Y; Xie A; Alkayed NJ; Davidson BP; Lindner JR. 2014. Epoxyeicosatrienoic acids mediate insulin-mediated augmentation in skeletal muscle perfusion and blood volume. Am J Physiol Endocrinol Metab 307(12):E1097-104. PubMed: 25336524 MGI: J:218402
Shimaya A; Kurosaki E; Nakano R; Hirayama R; Shibasaki M; Shikama H. 2000. The novel hypoglycemic agent YM440 normalizes hyperglycemia without changing body fat weight in diabetic db/db mice. Metabolism 49(3):411-7. PubMed: 10726922 MGI: J:60944
Shimizu H; Mori M; Kobayashi I. 1991. Altered Synaptosomal Norepinephrine Uptake of the Hypothalamus in Genetically Obese (ob/ob) and Diabetic (db/ db) Mice Neuroendocrinol Lett 13(6):425-430. MGI: J:1325
Shimoda M; Kanda Y; Hamamoto S; Tawaramoto K; Hashiramoto M; Matsuki M; Kaku K. 2011. The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes. Diabetologia :. PubMed: 21340625 MGI: J:169587
Shimoni Y. 2001. Inhibition of the formation or action of angiotensin II reverses attenuated K+ currents in type 1 and type 2 diabetes. J Physiol 537(Pt 1):83-92. PubMed: 11711563 MGI: J:109861
Shiraishi A; Sakumi K; Nakatsu Y; Hayakawa H; Sekiguchi M. 1992. Isolation and characterization of cDNA and genomic sequences for mouse O6-methylguanine-DNA methyltransferase. Carcinogenesis 13(2):289-96. PubMed: 1371245 MGI: J:11958
Shirakawa J; Togashi Y; Sakamoto E; Kaji M; Tajima K; Orime K; Inoue H; Kubota N; Kadowaki T; Terauchi Y. 2013. Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic beta-cells. Diabetes 62(10):3448-58. PubMed: 23801577 MGI: J:208951
Shirasaki N; Rosenbluth J. 1991. Structural abnormalities in freeze-fractured sciatic nerve fibres of diabetic mice. J Neurocytol 20(7):573-84. PubMed: 1919605 MGI: J:121257
Shojima N; Hara K; Fujita H; Horikoshi M; Takahashi N; Takamoto I; Ohsugi M; Aburatani H; Noda M; Kubota N; Yamauchi T; Ueki K; Kadowaki T. 2012. Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice. Diabetologia 55(12):3318-30. PubMed: 22983607 MGI: J:194563
Shojima N; Ogihara T; Inukai K; Fujishiro M; Sakoda H; Kushiyama A; Katagiri H; Anai M; Ono H; Fukushima Y; Horike N; Viana AY; Uchijima Y; Kurihara H; Asano T. 2005. Serum concentrations of resistin-like molecules beta and gamma are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow. Diabetologia 48(5):984-92. PubMed: 15834545 MGI: J:105211
Shore SA; Lang JE; Kasahara DI; Lu FL; Verbout NG; Si H; Williams ES; Terry RD; Lee A; Johnston RA. 2009. Pulmonary responses to subacute ozone exposure in obese vs. lean mice. J Appl Physiol 107(5):1445-52. PubMed: 19745193 MGI: J:177975
Shutter JR; Graham M; Kinsey AC; Scully S; Luthy R; Stark KL. 1997. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev 11(5):593-602. PubMed: 9119224 MGI: J:39234
Silver DL; Jiang XC; Tall AR. 1999. Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover. J Biol Chem 274(7):4140-6. PubMed: 9933608 MGI: J:115228
Sims-Robinson C; Zhao S; Hur J; Feldman EL. 2012. Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes. Diabetologia 55(8):2276-84. PubMed: 22581041 MGI: J:186441
Sloan C; Tuinei J; Nemetz K; Frandsen J; Soto J; Wride N; Sempokuya T; Alegria L; Bugger H; Abel ED. 2011. Central Leptin Signaling Is Required to Normalize Myocardial Fatty Acid Oxidation Rates in Caloric-Restricted ob/ob Mice. Diabetes 60(5):1424-34. PubMed: 21441440 MGI: J:171744
Soeda Y; Tsuneki H; Muranaka H; Mori N; Hosoh S; Ichihara Y; Kagawa S; Wang X; Toyooka N; Takamura Y; Uwano T; Nishijo H; Wada T; Sasaoka T. 2010. The inositol phosphatase SHIP2 negatively regulates insulin/IGF-I actions implicated in neuroprotection and memory function in mouse brain. Mol Endocrinol 24(10):1965-77. PubMed: 20829391 MGI: J:182821
Sohn EH; van Dijk HW; Jiao C; Kok PH; Jeong W; Demirkaya N; Garmager A; Wit F; Kucukevcilioglu M; van Velthoven ME; DeVries JH; Mullins RF; Kuehn MH; Schlingemann RO; Sonka M; Verbraak FD; Abramoff MD. 2016. Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus. Proc Natl Acad Sci U S A 113(19):E2655-64. PubMed: 27114552 MGI: J:232193
Solloway MJ; Madjidi A; Gu C; Eastham-Anderson J; Clarke HJ; Kljavin N; Zavala-Solorio J; Kates L; Friedman B; Brauer M; Wang J; Fiehn O; Kolumam G; Stern H; Lowe JB; Peterson AS; Allan BB. 2015. Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of alpha-Cell Mass. Cell Rep 12(3):495-510. PubMed: 26166562 MGI: J:224840
Song B; Scheuner D; Ron D; Pennathur S; Kaufman RJ. 2008. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest 118(10):3378-89. PubMed: 18776938 MGI: J:141141
Song MJ; Kim KH; Yoon JM; Kim JB. 2006. Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun 346(3):739-45. PubMed: 16781673 MGI: J:110515
Song R; Peng W; Zhang Y; Lv F; Wu HK; Guo J; Cao Y; Pi Y; Zhang X; Jin L; Zhang M; Jiang P; Liu F; Meng S; Zhang X; Jiang P; Cao CM; Xiao RP. 2013. Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. Nature 494(7437):375-9. PubMed: 23354051 MGI: J:194550
Song WC; Moore R; McLachlan JA; Negishi M. 1995. Molecular characterization of a testis-specific estrogen sulfotransferase and aberrant liver expression in obese and diabetogenic C57BL/KsJ-db/db mice. Endocrinology 136(6):2477-84. PubMed: 7750469 MGI: J:25937
Song WJ; Mondal P; Wolfe A; Alonso LC; Stamateris R; Ong BW; Lim OC; Yang KS; Radovick S; Novaira HJ; Farber EA; Farber CR; Turner SD; Hussain MA. 2014. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab 19(4):667-81. PubMed: 24703698 MGI: J:213148
Sourris KC; Harcourt BE; Tang PH; Morley AL; Huynh K; Penfold SA; Coughlan MT; Cooper ME; Nguyen TV; Ritchie RH; Forbes JM. 2012. Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes. Free Radic Biol Med 52(3):716-23. PubMed: 22172526 MGI: J:180299
Souza-Smith FM; Katz PS; Trask AJ; Stewart JA Jr; Lord KC; Varner KJ; Vassallo DV; Lucchesi PA. 2011. Mesenteric resistance arteries in type 2 diabetic db/db mice undergo outward remodeling. PLoS One 6(8):e23337. PubMed: 21829729 MGI: J:176520
Spegel P; Chawade A; Nielsen S; Kjellbom P; Rutzler M. 2015. Deletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice. Physiol Rep 3(9):. PubMed: 26416971 MGI: J:229410
Srinivasan S; Bolick DT; Hatley ME; Natarajan R; Reilly KB; Yeh M; Chrestensen C; Sturgill TW; Hedrick CC. 2004. Glucose regulates interleukin-8 production in aortic endothelial cells through activation of the p38 mitogen-activated protein kinase pathway in diabetes. J Biol Chem 279(30):31930-6. PubMed: 15145956 MGI: J:91901
Stanley JL; Sankaralingam S; Baker PN; Davidge ST. 2010. PREVIOUS GESTATIONAL DIABETES IMPAIRS LONG-TERM ENDOTHELIAL FUNCTION IN A MOUSE MODEL OF COMPLICATED PREGNANCY. Am J Physiol Regul Integr Comp Physiol :. PubMed: 20554929 MGI: J:163337
Starkey JM; Haidacher SJ; LeJeune WS; Zhang X; Tieu BC; Choudhary S; Brasier AR; Denner LA; Tilton RG. 2006. Diabetes-induced activation of canonical and noncanonical nuclear factor-kappaB pathways in renal cortex. Diabetes 55(5):1252-9. PubMed: 16644679 MGI: J:108658
Stec DF; Wang S; Stothers C; Avance J; Denson D; Harris R; Voziyan P. 2015. Alterations of urinary metabolite profile in model diabetic nephropathy. Biochem Biophys Res Commun 456(2):610-4. PubMed: 25499815 MGI: J:220367
Stienstra R; Joosten LA; Koenen T; van Tits B; van Diepen JA; van den Berg SA; Rensen PC; Voshol PJ; Fantuzzi G; Hijmans A; Kersten S; Muller M; van den Berg WB; van Rooijen N; Wabitsch M; Kullberg BJ; van der Meer JW; Kanneganti T; Tack CJ; Netea MG. 2010. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab 12(6):593-605. PubMed: 21109192 MGI: J:168117
Stolen TO; Hoydal MA; Kemi OJ; Catalucci D; Ceci M; Aasum E; Larsen T; Rolim N; Condorelli G; Smith GL; Wisloff U. 2009. Interval training normalizes cardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circ Res 105(6):527-36. PubMed: 19679837 MGI: J:169968
Stranahan AM; Arumugam TV; Cutler RG; Lee K; Egan JM; Mattson MP. 2008. Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat Neurosci 11(3):309-17. PubMed: 18278039 MGI: J:135292
Stratigopoulos G; Padilla SL; Leduc CA; Watson E; Hattersley AT; McCarthy MI; Zeltser LM; Chung WK; Leibel RL. 2008. Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol 294(4):R1185-96. PubMed: 18256137 MGI: J:133509
Su D; Coudriet GM; Hyun Kim D; Lu Y; Perdomo G; Qu S; Slusher S; Tse HM; Piganelli J; Giannoukakis N; Zhang J; Henry Dong H. 2009. FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages. Diabetes 58(11):2624-33. PubMed: 19651810 MGI: J:154390
Su J; Lucchesi PA; Gonzalez-Villalobos RA; Palen DI; Rezk BM; Suzuki Y; Boulares HA; Matrougui K. 2008. Role of advanced glycation end products with oxidative stress in resistance artery dysfunction in type 2 diabetic mice. Arterioscler Thromb Vasc Biol 28(8):1432-8. PubMed: 18483403 MGI: J:159809
Su W; Guo Z; Randall DC; Cassis L; Brown DR; Gong MC. 2008. Hypertension and disrupted blood pressure circadian rhythm in Type 2 diabetic db/db mice. Am J Physiol Heart Circ Physiol 295(4):H1634-41. PubMed: 18708447 MGI: J:141313
Su W; Xie Z; Guo Z; Duncan MJ; Lutshumba J; Gong MC. 2012. Altered clock gene expression and vascular smooth muscle diurnal contractile variations in type 2 diabetic db/db mice. Am J Physiol Heart Circ Physiol 302(3):H621-33. PubMed: 22140039 MGI: J:182465
Suganami T; Yuan X; Shimoda Y; Uchio-Yamada K; Nakagawa N; Shirakawa I; Usami T; Tsukahara T; Nakayama K; Miyamoto Y; Yasuda K; Matsuda J; Kamei Y; Kitajima S; Ogawa Y. 2009. Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated Fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue. Circ Res 105(1):25-32. PubMed: 19478204 MGI: J:164755
Sukma Rita R; Dezaki K; Kurashina T; Kakei M; Yada T. 2015. Partial blockade of Kv2.1 channel potentiates GLP-1's insulinotropic effects in islets and reduces its dose required for improving glucose tolerance in type 2 diabetic male mice. Endocrinology 156(1):114-23. PubMed: 25337656 MGI: J:219665
Sullivan T; Miao Z; Dairaghi DJ; Krasinski A; Wang Y; Zhao BN; Baumgart T; Ertl LS; Pennell A; Seitz L; Powers J; Zhao R; Ungashe S; Wei Z; Boring L; Tsou CL; Charo I; Berahovich RD; Schall TJ; Jaen JC. 2013. CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice. Am J Physiol Renal Physiol 305(9):F1288-97. PubMed: 23986513 MGI: J:203000
Sun D; Li H; Zolkiewska A. 2008. The role of Delta-like 1 shedding in muscle cell self-renewal and differentiation. J Cell Sci 121(Pt 22):3815-23. PubMed: 18957511 MGI: J:145774
Sun H; He J; Ru Y; Yin S; Xie Y; Yin L; Wei H; Wu L; Liu S. 2011. Monitoring succinyl-CoA:3-oxoacid CoA transferase nitration in mitochondria using monoclonal antibodies. Biochem Biophys Res Commun 415(2):239-44. PubMed: 22020096 MGI: J:178761
Sun P; Wang T; Zhou Y; Liu H; Jiang H; Zhu W; Wang H. 2013. DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic beta-Cells dysfunction in db/db mice. PLoS One 8(6):e66744. PubMed: 23776696 MGI: J:204223
Surendran S; Kondapaka SB. 2005. Altered expression of neuronal nitric oxide synthase in the duodenum longitudinal muscle-myenteric plexus of obesity induced diabetes mouse: implications on enteric neurodegeneration. Biochem Biophys Res Commun 338(2):919-22. PubMed: 16256069 MGI: J:102835
Surendran S; Matalon R; Tyring SK. 2006. Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: Implications on diabetic neuropathy. Biochem Biophys Res Commun 345(3):973-5. PubMed: 16707098 MGI: J:109646
Surmi BK; Atkinson RD; Gruen ML; Coenen KR; Hasty AH. 2008. The role of macrophage leptin receptor in aortic root lesion formation. Am J Physiol Endocrinol Metab 294(3):E488-95. PubMed: 18182468 MGI: J:133462
Suzuki R; Ferris HA; Chee MJ; Maratos-Flier E; Kahn CR. 2013. Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function. PLoS Biol 11(4):e1001532. PubMed: 23585733 MGI: J:197684
Suzuki R; Lee K; Jing E; Biddinger SB; McDonald JG; Montine TJ; Craft S; Kahn CR. 2010. Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metab 12(6):567-79. PubMed: 21109190 MGI: J:168119
Swisa A; Avrahami D; Eden N; Zhang J; Feleke E; Dahan T; Cohen-Tayar Y; Stolovich-Rain M; Kaestner KH; Glaser B; Ashery-Padan R; Dor Y. 2017. PAX6 maintains beta cell identity by repressing genes of alternative islet cell types. J Clin Invest 127(1):230-243. PubMed: 27941241 MGI: J:239845
Syeda MM; Jing X; Mirza RH; Yu H; Sellers RS; Chi Y. 2012. Prostaglandin transporter modulates wound healing in diabetes by regulating prostaglandin-induced angiogenesis. Am J Pathol 181(1):334-46. PubMed: 22609345 MGI: J:185546
Szabo C; Biser A; Benko R; Bottinger E; Susztak K. 2006. Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. Diabetes 55(11):3004-12. PubMed: 17065336 MGI: J:116551
Tadayoni R; Paques M; Gaudric A; Vicaut E. 2003. Erythrocyte and leukocyte dynamics in the retinal capillaries of diabetic mice. Exp Eye Res 77(4):497-504. PubMed: 12957148 MGI: J:85594
Takahashi M; Okimura Y; Iguchi G; Nishizawa H; Yamamoto M; Suda K; Kitazawa R; Fujimoto W; Takahashi K; Zolotaryov FN; Hong KS; Kiyonari H; Abe T; Kaji H; Kitazawa S; Kasuga M; Chihara K; Takahashi Y. 2011. Chemerin regulates beta-cell function in mice. Sci Rep 1:123. PubMed: 22355640 MGI: J:206120
Takahashi N; Waelput W; Guisez Y. 1999. Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor. J Exp Med 189(1):207-12. PubMed: 9874578 MGI: J:52060
Takashima M; Ogawa W; Hayashi K; Inoue H; Kinoshita S; Okamoto Y; Sakaue H; Wataoka Y; Emi A; Senga Y; Matsuki Y; Watanabe E; Hiramatsu R; Kasuga M. 2010. Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action. Diabetes 59(7):1608-15. PubMed: 20393151 MGI: J:169650
Taleb S; Herbin O; Ait-Oufella H; Verreth W; Gourdy P; Barateau V; Merval R; Esposito B; Clement K; Holvoet P; Tedgui A; Mallat Z. 2007. Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis. Arterioscler Thromb Vasc Biol 27(12):2691-8. PubMed: 17690315 MGI: J:147531
Talton OO; Pennington KA; Pollock KE; Bates K; Ma L; Ellersieck MR; Schulz LC. 2016. Maternal Hyperleptinemia Improves Offspring Insulin Sensitivity in Mice. Endocrinology 157(7):2636-48. PubMed: 27145007 MGI: J:239468
Tang T; Reed MJ. 2001. Exercise adds to metformin and acarbose efficacy in db/db mice. Metabolism 50(9):1049-53. PubMed: 11555837 MGI: J:71891
Tang Y; Osawa H; Onuma H; Nishimiya T; Ochi M; Sugita A; Makino H. 2001. Phosphodiesterase 3B gene expression is enhanced in the liver but reduced in the adipose tissue of obese insulin resistant db/db mouse. Diabetes Res Clin Pract 54(3):145-55. PubMed: 11689269 MGI: J:102595
Tanioka T; Tamura Y; Fukaya M; Shinozaki S; Mao J; Kim M; Shimizu N; Kitamura T; Kaneki M. 2011. Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta. J Biol Chem 286(33):29388-96. PubMed: 21700708 MGI: J:175918
Tao R; Xiong X; DePinho RA; Deng CX; Dong XC. 2013. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res 54(10):2745-53. PubMed: 23881913 MGI: J:202625
Tateya S; Rizzo-De Leon N; Handa P; Cheng AM; Morgan-Stevenson V; Ogimoto K; Kanter JE; Bornfeldt KE; Daum G; Clowes AW; Chait A; Kim F. 2013. VASP increases hepatic fatty acid oxidation by activating AMPK in mice. Diabetes 62(6):1913-22. PubMed: 23349495 MGI: J:208564
Tattikota SG; Rathjen T; McAnulty SJ; Wessels HH; Akerman I; van de Bunt M; Hausser J; Esguerra JL; Musahl A; Pandey AK; You X; Chen W; Herrera PL; Johnson PR; O'Carroll D; Eliasson L; Zavolan M; Gloyn AL; Ferrer J; Shalom-Feuerstein R; Aberdam D; Poy MN. 2014. Argonaute2 mediates compensatory expansion of the pancreatic beta cell. Cell Metab 19(1):122-34. PubMed: 24361012 MGI: J:210552
Taylor KR; Costanzo AE; Jameson JM. 2011. Dysfunctional gammadelta T cells contribute to impaired keratinocyte homeostasis in mouse models of obesity. J Invest Dermatol 131(12):2409-18. PubMed: 21833015 MGI: J:182173
Taylor KR; Mills RE; Costanzo AE; Jameson JM. 2010. Gammadelta T cells are reduced and rendered unresponsive by hyperglycemia and chronic TNFalpha in mouse models of obesity and metabolic disease. PLoS One 5(7):e11422. PubMed: 20625397 MGI: J:163283
Teixeira SR; Tappenden KA; Erdman JW Jr. 2003. Altering dietary protein type and quantity reduces urinary albumin excretion without affecting plasma glucose concentrations in BKS.cg-m +Lepr db/+Lepr db (db/db) mice. J Nutr 133(3):673-8. PubMed: 12612136 MGI: J:82219
Tejada T; Catanuto P; Ijaz A; Santos JV; Xia X; Sanchez P; Sanabria N; Lenz O; Elliot SJ; Fornoni A. 2008. Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death. Kidney Int 73(12):1385-93. PubMed: 18385666 MGI: J:152875
Templin AT; Maier B; Nishiki Y; Tersey SA; Mirmira RG. 2011. Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling. Cell Cycle 10(7):1043-9. PubMed: 21389784 MGI: J:232390
Tepper OM; Carr J; Allen RJ Jr; Chang CC; Lin CD; Tanaka R; Gupta SM; Levine JP; Saadeh PB; Warren SM. 2010. Decreased circulating progenitor cell number and failed mechanisms of stromal cell-derived factor-1alpha mediated bone marrow mobilization impair diabetic tissue repair. Diabetes 59(8):1974-83. PubMed: 20484135 MGI: J:169645
Terakura D; Shimizu M; Iwasa J; Baba A; Kochi T; Ohno T; Kubota M; Shirakami Y; Shiraki M; Takai K; Tsurumi H; Tanaka T; Moriwaki H. 2012. Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice. Carcinogenesis 33(12):2499-506. PubMed: 23027617 MGI: J:193655
Terami N; Ogawa D; Tachibana H; Hatanaka T; Wada J; Nakatsuka A; Eguchi J; Horiguchi CS; Nishii N; Yamada H; Takei K; Makino H. 2014. Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice. PLoS One 9(6):e100777. PubMed: 24960177 MGI: J:218948
Tesch GH; Lim AK. 2011. Recent insights into diabetic renal injury from the db/db mouse model of type 2 diabetic nephropathy. Am J Physiol Renal Physiol 300(2):F301-10. PubMed: 21147843 MGI: J:169041
Thangarajah H; Yao D; Chang EI; Shi Y; Jazayeri L; Vial IN; Galiano RD; Du XL; Grogan R; Galvez MG; Januszyk M; Brownlee M; Gurtner GC. 2009. The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues. Proc Natl Acad Sci U S A 106(32):13505-10. PubMed: 19666581 MGI: J:151949
Tian XY; Wong WT; Wang N; Lu Y; Cheang WS; Liu J; Liu L; Liu Y; Lee SS; Chen ZY; Cooke JP; Yao X; Huang Y. 2012. PPARdelta activation protects endothelial function in diabetic mice. Diabetes 61(12):3285-93. PubMed: 22933110 MGI: J:208492
Tian Y; Wong VW; Wong GL; Yang W; Sun H; Shen J; Tong JH; Go MY; Cheung YS; Lai PB; Zhou M; Xu G; Huang TH; Yu J; To KF; Cheng AS; Chan HL. 2015. Histone Deacetylase HDAC8 Promotes Insulin Resistance and beta-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma. Cancer Res 75(22):4803-16. PubMed: 26383163 MGI: J:226779
Tian Z; Sun R; Wei H; Gao B. 2002. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem Biophys Res Commun 298(3):297-302. PubMed: 12413939 MGI: J:80037
Tocchetti CG; Caceres V; Stanley BA; Xie C; Shi S; Watson WH; O'Rourke B; Spadari-Bratfisch RC; Cortassa S; Akar FG; Paolocci N; Aon MA. 2012. GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice. Diabetes 61(12):3094-105. PubMed: 22807033 MGI: J:208512
Togawa K; Moritani M; Yaguchi H; Itakura M. 2006. Multidimensional genome scans identify the combinations of genetic loci linked to diabetes-related phenotypes in mice. Hum Mol Genet 15(1):113-28. PubMed: 16321990 MGI: J:104466
Tong Z; Yang Z; Patel S; Chen H; Gibbs D; Yang X; Hau VS; Kaminoh Y; Harmon J; Pearson E; Buehler J; Chen Y; Yu B; Tinkham NH; Zabriskie NA; Zeng J; Luo L; Sun JK; Prakash M; Hamam RN; Tonna S; Constantine R; Ronquillo CC; Sadda S; Avery RL; Brand JM; London N; Anduze AL; King GL; Bernstein PS; Watkins S; Jorde LB; Li DY; Aiello LP; Pollak MR; Zhang K. 2008. Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci U S A 105(19):6998-7003. PubMed: 18458324 MGI: J:134862
Tornovsky-Babeay S; Dadon D; Ziv O; Tzipilevich E; Kadosh T; Schyr-Ben Haroush R; Hija A; Stolovich-Rain M; Furth-Lavi J; Granot Z; Porat S; Philipson LH; Herold KC; Bhatti TR; Stanley C; Ashcroft FM; In't Veld P; Saada A; Magnuson MA; Glaser B; Dor Y. 2014. Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in beta cells. Cell Metab 19(1):109-21. PubMed: 24332968 MGI: J:210493
Toshinai K; Mondal MS; Nakazato M; Date Y; Murakami N; Kojima M; Kangawa K; Matsukura S. 2001. Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun 281(5):1220-5. PubMed: 11243865 MGI: J:114290
Toyoda T; An D; Witczak CA; Koh HJ; Hirshman MF; Fujii N; Goodyear LJ. 2011. Myo1c regulates glucose uptake in mouse skeletal muscle. J Biol Chem 286(6):4133-40. PubMed: 21127070 MGI: J:169488
Tran KQ; Graewin SJ; Swartz-Basile DA; Nakeeb A; Svatek CL; Pitt HA. 2003. Leptin-resistant obese mice have paradoxically low biliary cholesterol saturation. Surgery 134(2):372-7. PubMed: 12947343 MGI: J:109844
Tran KQ; Swartz-Basile DA; Nakeeb A; Pitt HA. 2003. Gallbladder motility in agouti-yellow and leptin-resistant obese mice. J Surg Res 113(1):56-61. PubMed: 12943811 MGI: J:119065
Trayhurn P. 1979. Thermoregulation in the diabetic-obese (db/db) mouse. The role of non-shivering thermogenesis in energy balance. Pflugers Arch 380(3):227-32. PubMed: 573463 MGI: J:6202
Trotter-Mayo RN; Roberts MR. 2008. Leptin acts in the periphery to protect thymocytes from glucocorticoid-mediated apoptosis in the absence of weight loss. Endocrinology 149(10):5209-18. PubMed: 18583419 MGI: J:145495
Tsai WW; Matsumura S; Liu W; Phillips NG; Sonntag T; Hao E; Lee S; Hai T; Montminy M. 2015. ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis. Proc Natl Acad Sci U S A 112(9):2699-704. PubMed: 25730876 MGI: J:220317
Tschop J; Nogueiras R; Haas-Lockie S; Kasten KR; Castaneda TR; Huber N; Guanciale K; Perez-Tilve D; Habegger K; Ottaway N; Woods SC; Oldfield B; Clarke I; Chua S Jr; Farooqi IS; O'Rahilly S; Caldwell CC; Tschop MH. 2010. CNS leptin action modulates immune response and survival in sepsis. J Neurosci 30(17):6036-47. PubMed: 20427662 MGI: J:159827
Tsen F; Bhatia A; O'Brien K; Cheng CF; Chen M; Hay N; Stiles B; Woodley DT; Li W. 2013. Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. Mol Cell Biol 33(24):4947-59. PubMed: 24126057 MGI: J:206064
Tsuchida A; Nakagawa T; Itakura Y; Ichihara J; Ogawa W; Kasuga M; Taiji M; Noguchi H. 2001. The effects of brain-derived neurotrophic factor on insulin signal transduction in the liver of diabetic mice. Diabetologia 44(5):555-66. PubMed: 11380073 MGI: J:69546
Tsuneki H; Kon K; Ito H; Yamazaki M; Takahara S; Toyooka N; Ishii Y; Sasahara M; Wada T; Yanagisawa M; Sakurai T; Sasaoka T. 2016. Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice. Endocrinology 157(11):4146-4157. PubMed: 27631554 MGI: J:240478
Tsuneki H; Nagata T; Fujita M; Kon K; Wu N; Takatsuki M; Yamaguchi K; Wada T; Nishijo H; Yanagisawa M; Sakurai T; Sasaoka T. 2016. Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice. Endocrinology 157(1):195-206. PubMed: 26492471 MGI: J:232865
Turban S; Liu X; Ramage L; Webster SP; Walker BR; Dunbar DR; Mullins JJ; Seckl JR; Morton NM. 2012. Optimal elevation of beta-cell 11beta-hydroxysteroid dehydrogenase type 1 is a compensatory mechanism that prevents high-fat diet-induced beta-cell failure. Diabetes 61(3):642-52. PubMed: 22315313 MGI: J:196749
Turner RT; Kalra SP; Wong CP; Philbrick KA; Lindenmaier LB; Boghossian S; Iwaniec UT. 2013. Peripheral leptin regulates bone formation. J Bone Miner Res 28(1):22-34. PubMed: 22887758 MGI: J:233261
Uchida T; Nakamura T; Hashimoto N; Matsuda T; Kotani K; Sakaue H; Kido Y; Hayashi Y; Nakayama KI; White MF; Kasuga M. 2005. Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med 11(2):175-82. PubMed: 15685168 MGI: J:96047
Udagawa J; Hashimoto R; Hioki K; Otani H. 2006. The role of leptin in the development of the cortical neuron in mouse embryos. Brain Res 1120(1):74-82. PubMed: 17020752 MGI: J:116065
Udagawa J; Hashimoto R; Suzuki H; Hatta T; Sotomaru Y; Hioki K; Kagohashi Y; Nomura T; Minami Y; Otani H. 2006. The role of leptin in the development of the cerebral cortex in mouse embryos. Endocrinology 147(2):647-58. PubMed: 16282354 MGI: J:105139
Underwood RA; Gibran NS; Muffley LA; Usui ML; Olerud JE. 2001. Color subtractive-computer-assisted image analysis for quantification of cutaneous nerves in a diabetic mouse model. J Histochem Cytochem 49(10):1285-91. PubMed: 11561013 MGI: J:71584
Uruno A; Furusawa Y; Yagishita Y; Fukutomi T; Muramatsu H; Negishi T; Sugawara A; Kensler TW; Yamamoto M. 2013. The Keap1-Nrf2 system prevents onset of diabetes mellitus. Mol Cell Biol 33(15):2996-3010. PubMed: 23716596 MGI: J:204575
Uruno A; Yagishita Y; Katsuoka F; Kitajima Y; Nunomiya A; Nagatomi R; Pi J; Biswal SS; Yamamoto M. 2016. Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism. Mol Cell Biol 36(11):1655-72. PubMed: 27044864 MGI: J:236187
Valerio A; Ghisi V; Dossena M; Tonello C; Giordano A; Frontini A; Ferrario M; Pizzi M; Spano P; Carruba MO; Nisoli E. 2006. Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3beta. J Biol Chem 281(18):12950-8. PubMed: 16522636 MGI: J:112680
Vallon V; Rose M; Gerasimova M; Satriano J; Platt KA; Koepsell H; Cunard R; Sharma K; Thomson SC; Rieg T. 2013. Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am J Physiol Renal Physiol 304(2):F156-67. PubMed: 23152292 MGI: J:192346
Vannucci SJ; Koehler-Stec EM; Li K; Reynolds TH; Clark R; Simpson IA. 1998. GLUT4 glucose transporter expression in rodent brain: effect of diabetes. Brain Res 797(1):1-11. PubMed: 9630471 MGI: J:48718
Varela-Rey M; Iruarrizaga-Lejarreta M; Lozano JJ; Aransay AM; Fernandez AF; Lavin JL; Mosen-Ansorena D; Berdasco M; Turmaine M; Luka Z; Wagner C; Lu SC; Esteller M; Mirsky R; Jessen KR; Fraga MF; Martinez-Chantar ML; Mato JM; Woodhoo A. 2014. S-adenosylmethionine levels regulate the schwann cell DNA methylome. Neuron 81(5):1024-39. PubMed: 24607226 MGI: J:221289
Velmurugan GV; Sundaresan NR; Gupta MP; White C. 2013. Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes. Cardiovasc Res 100(1):143-50. PubMed: 23715558 MGI: J:219478
Velmurugan GV; White C. 2012. Calcium homeostasis in vascular smooth muscle cells is altered in type 2 diabetes by Bcl-2 protein modulation of InsP3R calcium release channels. Am J Physiol Heart Circ Physiol 302(1):H124-34. PubMed: 22037186 MGI: J:181575
Vernooy JH; Bracke KR; Drummen NE; Pauwels NS; Zabeau L; van Suylen RJ; Tavernier J; Joos GF; Wouters EF; Brusselle GG. 2010. Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice. J Immunol 184(12):7169-77. PubMed: 20488786 MGI: J:161133
Vieira E; Marroqui L; Batista TM; Caballero-Garrido E; Carneiro EM; Boschero AC; Nadal A; Quesada I. 2012. The clock gene Rev-erbalpha regulates pancreatic beta-cell function: modulation by leptin and high-fat diet. Endocrinology 153(2):592-601. PubMed: 22166979 MGI: J:181732
Villanueva CJ; Waki H; Godio C; Nielsen R; Chou WL; Vargas L; Wroblewski K; Schmedt C; Chao LC; Boyadjian R; Mandrup S; Hevener A; Saez E; Tontonoz P. 2011. TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metab 13(4):413-27. PubMed: 21459326 MGI: J:172245
Villanueva EC; Munzberg H; Cota D; Leshan RL; Kopp K; Ishida-Takahashi R; Jones JC; Fingar DC; Seeley RJ; Myers MG Jr. 2009. Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status. Endocrinology 150(10):4541-51. PubMed: 19628573 MGI: J:157328
Villeneuve LM; Kato M; Reddy MA; Wang M; Lanting L; Natarajan R. 2010. Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1. Diabetes 59(11):2904-15. PubMed: 20699419 MGI: J:169615
Villeneuve LM; Reddy MA; Lanting LL; Wang M; Meng L; Natarajan R. 2008. Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc Natl Acad Sci U S A 105(26):9047-52. PubMed: 18579779 MGI: J:137387
Wall SJ; Bevan D; Thomas DW; Harding KG; Edwards DR; Murphy G. 2002. Differential expression of matrix metalloproteinases during impaired wound healing of the diabetes mouse. J Invest Dermatol 119(1):91-8. PubMed: 12164930 MGI: J:123421
Wang C; Chen Z; Li S; Zhang Y; Jia S; Li J; Chi Y; Miao Y; Guan Y; Yang J. 2014. Hepatic overexpression of ATP synthase beta subunit activates PI3K/Akt pathway to ameliorate hyperglycemia of diabetic mice. Diabetes 63(3):947-59. PubMed: 24296716 MGI: J:209077
Wang C; Li X; Mu K; Li L; Wang S; Zhu Y; Zhang M; Ryu J; Xie Z; Shi D; Zhang WJ; Dong LQ; Jia W. 2013. Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function. Diabetologia 56(9):1999-2009. PubMed: 23793716 MGI: J:202277
Wang F; Tong Q. 2008. Transcription factor PU.1 is expressed in white adipose and inhibits adipocyte differentiation. Am J Physiol Cell Physiol 295(1):C213-20. PubMed: 18463231 MGI: J:138523
Wang H; Liu A; Kuo Y; Chi E; Yang X; Zhang L; Yang CS. 2016. Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation of Apc. Carcinogenesis 37(7):723-30. PubMed: 27207656 MGI: J:232782
Wang H; Liu D; Cao P; Lecker S; Hu Z. 2010. Atrogin-1 affects muscle protein synthesis and degradation when energy metabolism is impaired by the antidiabetes drug berberine. Diabetes 59(8):1879-89. PubMed: 20522589 MGI: J:169643
Wang JM; Tao J; Chen DD; Cai JJ; Irani K; Wang Q; Yuan H; Chen AF. 2014. MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol 34(1):99-109. PubMed: 24177325 MGI: J:222834
Wang L; Chopp M; Szalad A; Liu Z; Bolz M; Alvarez FM; Lu M; Zhang L; Cui Y; Zhang RL; Zhang ZG. 2011. Phosphodiesterase-5 is a therapeutic target for peripheral neuropathy in diabetic mice. Neuroscience 193:399-410. PubMed: 21820491 MGI: J:180341
Wang L; Chopp M; Szalad A; Liu Z; Lu M; Zhang L; Zhang J; Zhang RL; Morris D; Zhang ZG. 2012. Thymosin beta4 promotes the recovery of peripheral neuropathy in type II diabetic mice. Neurobiol Dis 48(3):546-55. PubMed: 22922221 MGI: J:197503
Wang L; Chopp M; Szalad A; Zhang Y; Wang X; Zhang RL; Liu XS; Jia L; Zhang ZG. 2014. The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy. Neuroscience 259:155-63. PubMed: 24316060 MGI: J:207916
Wang L; Liu Y; Yan Lu S; Nguyen KT; Schroer SA; Suzuki A; Mak TW; Gaisano H; Woo M. 2010. Deletion of Pten in pancreatic ss-cells protects against deficient ss-cell mass and function in mouse models of type 2 diabetes. Diabetes 59(12):3117-26. PubMed: 20852026 MGI: J:170206
Wang M; Wang S; Yao D; Yan Q; Lu W. 2016. A novel long non-coding RNA CYP4B1-PS1-001 regulates proliferation and fibrosis in diabetic nephropathy. Mol Cell Endocrinol 426:136-45. PubMed: 26923441 MGI: J:241187
Wang P; Yan Z; Zhong J; Chen J; Ni Y; Li L; Ma L; Zhao Z; Liu D; Zhu Z. 2012. Transient receptor potential vanilloid 1 activation enhances gut glucagon-like peptide-1 secretion and improves glucose homeostasis. Diabetes 61(8):2155-65. PubMed: 22664955 MGI: J:208453
Wang W; Wang Y; Long J; Wang J; Haudek SB; Overbeek P; Chang BH; Schumacker PT; Danesh FR. 2012. Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metab 15(2):186-200. PubMed: 22326220 MGI: J:182287
Wang X; Hu Z; Hu J; Du J; Mitch WE. 2006. Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology 147(9):4160-8. PubMed: 16777975 MGI: J:129549
Wang X; Liu Y; Yang Z; Zhang Z; Zhou W; Ye Z; Zhang W; Zhang S; Yang Z; Feng X; Chen F; Hu R. 2011. Glucose metabolism-related protein 1 (GMRP1) regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway in rats and mice. Diabetologia :. PubMed: 21267538 MGI: J:168553
Wang X; Ota N; Manzanillo P; Kates L; Zavala-Solorio J; Eidenschenk C; Zhang J; Lesch J; Lee WP; Ross J; Diehl L; van Bruggen N; Kolumam G; Ouyang W. 2014. Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes. Nature 514(7521):237-41. PubMed: 25119041 MGI: J:217078
Wang X; Yang Z; Xue B; Shi H. 2011. Activation of the cholinergic antiinflammatory pathway ameliorates obesity-induced inflammation and insulin resistance. Endocrinology 152(3):836-46. PubMed: 21239433 MGI: J:173882
Wang Y; Heilig K; Saunders T; Minto A; Deb DK; Chang A; Brosius F; Monteiro C; Heilig CW. 2010. Transgenic overexpression of GLUT1 in mouse glomeruli produces renal disease resembling diabetic glomerulosclerosis. Am J Physiol Renal Physiol 299(1):F99-F111. PubMed: 20375117 MGI: J:160943
Wang Y; Lam KS; Chan L; Chan KW; Lam JB; Lam MC; Hoo RC; Mak WW; Cooper GJ; Xu A. 2006. Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex. J Biol Chem 281(24):16391-400. PubMed: 16621799 MGI: J:113740
Wang Y; Nakagawa Y; Liu L; Wang W; Ren X; Anghel A; Lutfy K; Friedman TC; Liu Y. 2010. Tissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes. Diabetologia :. PubMed: 21052977 MGI: J:166598
Wang Y; Zhou J; Minto AW; Hack BK; Alexander JJ; Haas M; Li YC; Heilig CW; Quigg RJ. 2006. Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy. Kidney Int 70(5):882-91. PubMed: 16820793 MGI: J:136491
Wang YX; Lee CH; Tiep S; Yu RT; Ham J; Kang H; Evans RM. 2003. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 113(2):159-70. PubMed: 12705865 MGI: J:83119
Wang Z; Jiang T; Li J; Proctor G; McManaman JL; Lucia S; Chua S; Levi M. 2005. Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Diabetes 54(8):2328-35. PubMed: 16046298 MGI: J:161126
Watanabe T; Ashida K; Goto K; Nawata H; Takayanagi R; Yanase T; Nomura M. 2015. Dehydroepiandrosterone-enhanced dual specificity protein phosphatase (DDSP) prevents diet-induced and genetic obesity. Biochem Biophys Res Commun 468(1-2):196-201. PubMed: 26523513 MGI: J:233200
Wei K; Piecewicz SM; McGinnis LM; Taniguchi CM; Wiegand SJ; Anderson K; Chan CW; Mulligan KX; Kuo D; Yuan J; Vallon M; Morton LC; Lefai E; Simon MC; Maher JJ; Mithieux G; Rajas F; Annes JP; McGuinness OP; Thurston G; Giaccia AJ; Kuo CJ. 2013. A liver Hif-2alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med 19(10):1331-7. PubMed: 24037094 MGI: J:202020
Wei X; Schneider JG; Shenouda SM; Lee A; Towler DA; Chakravarthy MV; Vita JA; Semenkovich CF. 2011. De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation. J Biol Chem 286(4):2933-45. PubMed: 21098489 MGI: J:168491
Weissmann L; Quaresma PG; Santos AC; de Matos AH; Pascoal VD; Zanotto TM; Castro G; Guadagnini D; da Silva JM; Velloso LA; Bittencourt JC; Lopes-Cendes I; Saad MJ; Prada PO. 2014. IKKepsilon is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity. Diabetes 63(10):3334-45. PubMed: 24812431 MGI: J:229836
Wendt TM; Tanji N; Guo J; Kislinger TR; Qu W; Lu Y; Bucciarelli LG; Rong LL; Moser B; Markowitz GS; Stein G; Bierhaus A; Liliensiek B; Arnold B; Nawroth PP; Stern DM; D'Agati VD; Schmidt AM. 2003. RAGE Drives the Development of Glomerulosclerosis and Implicates Podocyte Activation in the Pathogenesis of Diabetic Nephropathy. Am J Pathol 162(4):1123-37. PubMed: 12651605 MGI: J:82491
Werner S; Breeden M; Hubner G; Greenhalgh DG; Longaker MT. 1994. Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse. J Invest Dermatol 103(4):469-73. PubMed: 7930669 MGI: J:20802
Williams GA; Callon KE; Watson M; Costa JL; Ding Y; Dickinson M; Wang Y; Naot D; Reid IR; Cornish J. 2011. Skeletal phenotype of the leptin receptor-deficient db/db mouse. J Bone Miner Res 26(8):1698-709. PubMed: 21328476 MGI: J:233114
Wolfrum C; Howell JJ; Ndungo E; Stoffel M. 2008. Foxa2 activity increases plasma high density lipoprotein levels by regulating apolipoprotein M. J Biol Chem 283(24):16940-9. PubMed: 18381283 MGI: J:138581
Won Hong S; Isono M; Chen S; Iglesias-De La Cruz MC; Han DC; Ziyadeh FN. 2001. Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse. Am J Pathol 158(5):1653-63. PubMed: 11337363 MGI: J:69101
Wong SL; Demers M; Martinod K; Gallant M; Wang Y; Goldfine AB; Kahn CR; Wagner DD. 2015. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Nat Med 21(7):815-9. PubMed: 26076037 MGI: J:224753
Wong WT; Tian XY; Xu A; Yu J; Lau CW; Hoo RL; Wang Y; Lee VW; Lam KS; Vanhoutte PM; Huang Y. 2011. Adiponectin is required for PPARgamma-mediated improvement of endothelial function in diabetic mice. Cell Metab 14(1):104-15. PubMed: 21723508 MGI: J:176078
Wrann CD; Eguchi J; Bozec A; Xu Z; Mikkelsen T; Gimble J; Nave H; Wagner EF; Ong SE; Rosen ED. 2012. FOSL2 promotes leptin gene expression in human and mouse adipocytes. J Clin Invest 122(3):1010-21. PubMed: 22326952 MGI: J:184483
Wright DE; Johnson MS; Arnett MG; Smittkamp SE; Ryals JM. 2007. Selective changes in nocifensive behavior despite normal cutaneous axon innervation in leptin receptor-null mutant (db/db) mice. J Peripher Nerv Syst 12(4):250-61. PubMed: 18042135 MGI: J:150180
Wu AL; Kolumam G; Stawicki S; Chen Y; Li J; Zavala-Solorio J; Phamluong K; Feng B; Li L; Marsters S; Kates L; van Bruggen N; Leabman M; Wong A; West D; Stern H; Luis E; Kim HS; Yansura D; Peterson AS; Filvaroff E; Wu Y; Sonoda J. 2011. Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci Transl Med 3(113):113ra126. PubMed: 22174314 MGI: J:183639
Wu D; Yang X; Zheng T; Xing S; Wang J; Chi J; Bian F; Li W; Xu G; Bai X; Wu G; Jin S. 2016. A novel mechanism of action for salidroside to alleviate diabetic albuminuria: effects on albumin transcytosis across glomerular endothelial cells. Am J Physiol Endocrinol Metab 310(3):E225-37. PubMed: 26646098 MGI: J:235899
Wu L; Parekh VV; Gabriel CL; Bracy DP; Marks-Shulman PA; Tamboli RA; Kim S; Mendez-Fernandez YV; Besra GS; Lomenick JP; Williams B; Wasserman DH; Van Kaer L. 2012. Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc Natl Acad Sci U S A 109(19):E1143-52. PubMed: 22493234 MGI: J:184702
Wu M; Singh SB; Wang J; Chung CC; Salituro G; Karanam BV; Lee SH; Powles M; Ellsworth KP; Lassman ME; Miller C; Myers RW; Tota MR; Zhang BB; Li C. 2011. Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes. Proc Natl Acad Sci U S A 108(13):5378-83. PubMed: 21389266 MGI: J:171243
Wu X; Williams KJ. 2012. NOX4 pathway as a source of selective insulin resistance and responsiveness. Arterioscler Thromb Vasc Biol 32(5):1236-45. PubMed: 22328777 MGI: J:196940
Wueest S; Rapold RA; Schumann DM; Rytka JM; Schildknecht A; Nov O; Chervonsky AV; Rudich A; Schoenle EJ; Donath MY; Konrad D. 2010. Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. J Clin Invest 120(1):191-202. PubMed: 19955656 MGI: J:156776
Wysocki J; Garcia-Halpin L; Ye M; Maier C; Sowers K; Burns KD; Batlle D. 2013. Regulation of urinary ACE2 in diabetic mice. Am J Physiol Renal Physiol 305(4):F600-11. PubMed: 23761674 MGI: J:200945
Wysocki J; Ye M; Soler MJ; Gurley SB; Xiao HD; Bernstein KE; Coffman TM; Chen S; Batlle D. 2006. ACE and ACE2 activity in diabetic mice. Diabetes 55(7):2132-9. PubMed: 16804085 MGI: J:111853
Xiao F; Deng J; Yu J; Guo Y; Chen S; Guo F. 2016. A novel function of B-cell translocation gene 1 (BTG1) in the regulation of hepatic insulin sensitivity in mice via c-Jun. FASEB J 30(1):348-59. PubMed: 26396236 MGI: J:230595
Xiao F; Huang Z; Li H; Yu J; Wang C; Chen S; Meng Q; Cheng Y; Gao X; Li J; Liu Y; Guo F. 2011. Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways. Diabetes 60(3):746-56. PubMed: 21282364 MGI: J:169781
Xiao F; Yu J; Liu B; Guo Y; Li K; Deng J; Zhang J; Wang C; Chen S; Du Y; Lu Y; Xiao Y; Zhang Z; Guo F. 2014. A novel function of microRNA 130a-3p in hepatic insulin sensitivity and liver steatosis. Diabetes 63(8):2631-42. PubMed: 24677715 MGI: J:229789
Xie Z; Su W; Guo Z; Pang H; Post SR; Gong MC. 2006. Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells. Cardiovasc Res 69(2):491-501. PubMed: 16336954 MGI: J:105719
Xiong X; Mei W; Xie Y; Liu J; Lu M; Peng X; Yang C; Zhang X; Xie M; Luo R; Yuan X; Huang L; Wu L; Qin J; Peng Y; Jia X; Hu G; Tang D; Tao L. 2014. Fluorofenidone offers improved renoprotection at early interventions during the course of diabetic nephropathy in db/db mice via multiple pathways. PLoS One 9(10):e111242. PubMed: 25347392 MGI: J:223541
Xu A; Lam MC; Chan KW; Wang Y; Zhang J; Hoo RL; Xu JY; Chen B; Chow WS; Tso AW; Lam KS. 2005. Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Proc Natl Acad Sci U S A 102(17):6086-91. PubMed: 15837923 MGI: J:98462
Xu G; Kaneto H; Laybutt DR; Duvivier-Kali VF; Trivedi N; Suzuma K; King GL; Weir GC; Bonner-Weir S. 2007. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes 56(6):1551-8. PubMed: 17360984 MGI: J:126498
Xu G; Li Z; Ding L; Tang H; Guo S; Liang H; Wang H; Zhang W. 2015. Intestinal mTOR regulates GLP-1 production in mouse L cells. Diabetologia 58(8):1887-97. PubMed: 26037201 MGI: J:225916
Xu G; Wang Z; Li Y; Li Z; Tang H; Zhao J; Xiang X; Ding L; Ma L; Yuan F; Fei J; Wang W; Wang N; Guan Y; Tang C; Mulholland M; Zhang W. 2012. Ghrelin contributes to derangements of glucose metabolism induced by rapamycin in mice. Diabetologia 55(6):1813-23. PubMed: 22391948 MGI: J:184991
Xu H; Barnes GT; Yang Q; Tan G; Yang D; Chou CJ; Sole J; Nichols A; Ross JS; Tartaglia LA; Chen H. 2003. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112(12):1821-30. PubMed: 14679177 MGI: J:86952
Xu J; Li L; Yun HF; Han YS. 2015. MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1. Biochem Biophys Res Commun 463(4):1159-64. PubMed: 26079878 MGI: J:228685
Xu J; Wang P; Li Y; Li G; Kaczmarek LK; Wu Y; Koni PA; Flavell RA; Desir GV. 2004. The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proc Natl Acad Sci U S A 101(9):3112-7. PubMed: 14981264 MGI: J:88651
Xu J; Wu W; Zhang L; Dorset-Martin W; Morris MW; Mitchell ME; Liechty KW. 2012. The role of microRNA-146a in the pathogenesis of the diabetic wound-healing impairment: correction with mesenchymal stem cell treatment. Diabetes 61(11):2906-12. PubMed: 22851573 MGI: J:208507
Xu J; Yin L; Xu Y; Li Y; Zalzala M; Cheng G; Zhang Y. 2014. Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels. PLoS One 9(10):e109663. PubMed: 25285996 MGI: J:223470
Xu L; Rensing N; Yang XF; Zhang HX; Thio LL; Rothman SM; Weisenfeld AE; Wong M; Yamada KA. 2008. Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. J Clin Invest 118(1):272-80. PubMed: 18097472 MGI: J:130891
Xu L; Scheenen WJ; Leshan RL; Patterson CM; Elias CF; Bouwhuis S; Roubos EW; Myers MG Jr; Kozicz T. 2011. Leptin signaling modulates the activity of urocortin 1 neurons in the mouse nonpreganglionic Edinger-Westphal nucleus. Endocrinology 152(3):979-88. PubMed: 21209012 MGI: J:173887
Xu N; Nilsson-Ehle P; Hurtig M; Ahren B. 2004. Both leptin and leptin-receptor are essential for apolipoprotein M expression in vivo. Biochem Biophys Res Commun 321(4):916-21. PubMed: 15358114 MGI: J:91738
Xu X; Zhao CX; Wang L; Tu L; Fang X; Zheng C; Edin ML; Zeldin DC; Wang DW. 2010. Increased CYP2J3 expression reduces insulin resistance in fructose-treated rats and db/db mice. Diabetes 59(4):997-1005. PubMed: 20068141 MGI: J:164334
Xue Y; Shen L; Cui Y; Zhang H; Chen Q; Cui A; Fang F; Chang Y. 2013. Tff3, as a novel peptide, regulates hepatic glucose metabolism. PLoS One 8(9):e75240. PubMed: 24086476 MGI: J:207742
Yaguchi H; Togawa K; Moritani M; Itakura M. 2005. Identification of candidate genes in the type 2 diabetes modifier locus using expression QTL. Genomics 85(5):591-9. PubMed: 15820311 MGI: J:97535
Yamagishi N; Ueda T; Mori A; Saito Y; Hatayama T. 2012. Decreased expression of endoplasmic reticulum chaperone GRP78 in liver of diabetic mice. Biochem Biophys Res Commun 417(1):364-70. PubMed: 22155243 MGI: J:180305
Yamamoto K; Matsuoka TA; Kawashima S; Takebe S; Kubo N; Miyatsuka T; Kaneto H; Shimomura I. 2013. A novel function of Onecut1 protein as a negative regulator of MafA gene expression. J Biol Chem 288(30):21648-58. PubMed: 23775071 MGI: J:201764
Yamamoto N; Matsubara T; Sobue K; Tanida M; Kasahara R; Naruse K; Taniura H; Sato T; Suzuki K. 2012. Brain insulin resistance accelerates Abeta fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes. J Neurochem 121(4):619-28. PubMed: 22260232 MGI: J:184309
Yamashita H; Shao J; Ishizuka T; Klepcyk PJ; Muhlenkamp P; Qiao L; Hoggard N; Friedman JE. 2001. Leptin administration prevents spontaneous gestational diabetes in heterozygous Lepr(db/+) mice: effects on placental leptin and fetal growth. Endocrinology 142(7):2888-97. PubMed: 11416008 MGI: J:71934
Yamashita H; Shao J; Qiao L; Pagliassotti M; Friedman JE. 2003. Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice. Pediatr Res 53(3):411-8. PubMed: 12595588 MGI: J:102264
Yamauchi T; Nio Y; Maki T; Kobayashi M; Takazawa T; Iwabu M; Okada-Iwabu M; Kawamoto S; Kubota N; Kubota T; Ito Y; Kamon J; Tsuchida A; Kumagai K; Kozono H; Hada Y; Ogata H; Tokuyama K; Tsunoda M; Ide T; Murakami K; Awazawa M; Takamoto I; Froguel P; HaraK; Tobe K; Nagai R; Ueki K; Kadowaki T. 2007. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions Nat Med 13(3):332-339. PubMed: 17268472 MGI: J:117919
Yan L; Guo S; Brault M; Harmon J; Robertson RP; Hamid R; Stein R; Yang E. 2012. The B55alpha-containing PP2A holoenzyme dephosphorylates FOXO1 in islet beta-cells under oxidative stress. Biochem J 444(2):239-47. PubMed: 22417654 MGI: J:185464
Yan QW; Yang Q; Mody N; Graham TE; Hsu CH; Xu Z; Houstis NE; Kahn BB; Rosen ED. 2007. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes 56(10):2533-40. PubMed: 17639021 MGI: J:126560
Yang G; Cancino GI; Zahr SK; Guskjolen A; Voronova A; Gallagher D; Frankland PW; Kaplan DR; Miller FD. 2016. A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring. Cell Rep 17(4):1022-1036. PubMed: 27760310 MGI: J:240757
Yang G; Wu Y; Ye S. 2017. MiR-181c restrains nitration stress of endothelial cells in diabetic db/db mice through inhibiting the expression of FoxO1. Biochem Biophys Res Commun 486(1):29-35. PubMed: 28223216 MGI: J:241952
Yang J; Park Y; Zhang H; Gao X; Wilson E; Zimmer W; Abbott L; Zhang C. 2009. Role of MCP-1 in tumor necrosis factor-alpha-induced endothelial dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol 297(4):H1208-16. PubMed: 19666844 MGI: J:154217
Yang J; Park Y; Zhang H; Xu X; Laine GA; Dellsperger KC; Zhang C. 2009. Feed-forward signaling of TNF-alpha and NF-kappaB via IKK-beta pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol 296(6):H1850-8. PubMed: 19363130 MGI: J:150876
Yang S; Chen C; Wang H; Rao X; Wang F; Duan Q; Chen F; Long G; Gong W; Zou MH; Wang DW. 2012. Protective effects of Acyl-coA thioesterase 1 on diabetic heart via PPARalpha/PGC1alpha signaling. PLoS One 7(11):e50376. PubMed: 23226270 MGI: J:195446
Yang Y; Gurung B; Wu T; Wang H; Stoffers DA; Hua X. 2010. Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene. Proc Natl Acad Sci U S A 107(47):20358-63. PubMed: 21059956 MGI: J:166586
Yano H; Kinoshita M; Fujino K; Nakashima M; Yamamoto Y; Miyazaki H; Hamada K; Ono S; Iwaya K; Saitoh D; Seki S; Tanaka Y. 2012. Insulin treatment directly restores neutrophil phagocytosis and bactericidal activity in diabetic mice and thereby improves surgical site Staphylococcus aureus infection. Infect Immun 80(12):4409-16. PubMed: 23027538 MGI: J:190600
Yatomi Y; Tanaka R; Shimada Y; Yamashiro K; Liu M; Mitome-Mishima Y; Miyamoto N; Ueno Y; Urabe T; Hattori N. 2015. Type 2 diabetes reduces the proliferation and survival of oligodendrocyte progenitor cells in ishchemic white matter lesions. Neuroscience 289:214-23. PubMed: 25592431 MGI: J:221438
Ye Y; Qian J; Castillo AC; Ling S; Ye H; Perez-Polo JR; Bajaj M; Birnbaum Y. 2013. Phosphodiesterase-3 inhibition augments the myocardial infarct size-limiting effects of exenatide in mice with type 2 diabetes. Am J Physiol Heart Circ Physiol 304(1):H131-41. PubMed: 23103492 MGI: J:192851
Yi P; Park JS; Melton DA. 2013. Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell 153(4):747-58. PubMed: 23623304 MGI: J:197679
Yin L; Ma H; Ge X; Edwards PA; Zhang Y. 2011. Hepatic hepatocyte nuclear factor 4alpha is essential for maintaining triglyceride and cholesterol homeostasis. Arterioscler Thromb Vasc Biol 31(2):328-36. PubMed: 21071704 MGI: J:184185
Yin W; Carballo-Jane E; McLaren DG; Mendoza VH; Gagen K; Geoghagen NS; McNamara LA; Gorski JN; Eiermann GJ; Petrov A; Wolff M; Tong X; Wilsie LC; Akiyama TE; Chen J; Thankappan A; Xue J; Ping X; Andrews G; Wickham LA; Gai CL; Trinh T; Kulick AA; DonnellyMJ; Voronin GO; Rosa R; Cumiskey AM; Bekkari K; Mitnaul LJ; Puig O; Chen F; Raubertas R; Wong PH; Hansen BC; Koblan KS; Roddy TP; Hubbard BK; Strack AM. 2012. Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia. J Lipid Res 53(1):51-65. PubMed: 22021650 MGI: J:179410
Yin Y; Gao L; Lin H; Wu Y; Han X; Zhu Y; Li J. 2017. Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c. Biochem Biophys Res Commun 482(4):720-726. PubMed: 27888103 MGI: J:241600
Yoshino S; Satoh T; Yamada M; Hashimoto K; Tomaru T; Katano-Toki A; Kakizaki S; Okada S; Shimizu H; Ozawa A; Tuchiya T; Ikota H; Nakazato Y; Mori M; Matozaki T; Sasaki T; Kitamura T; Mori M. 2014. Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor. Endocrinology 155(9):3459-72. PubMed: 25004093 MGI: J:218127
Youn JY; Zhou J; Cai H. 2015. Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction, and COX2 Induction in Type 2 Diabetes Mellitus. Mol Endocrinol 29(8):1123-33. PubMed: 26121233 MGI: J:233065
Yu F; Li BY; Li XL; Cai Q; Zhang Z; Cheng M; Yin M; Wang JF; Zhang JH; Lu WD; Zhou RH; Gao HQ. 2012. Proteomic analysis of aorta and protective effects of grape seed procyanidin B2 in db/db mice reveal a critical role of milk fat globule epidermal growth factor-8 in diabetic arterial damage. PLoS One 7(12):e52541. PubMed: 23285083 MGI: J:195760
Yu X; Shen N; Zhang ML; Pan FY; Wang C; Jia WP; Liu C; Gao Q; Gao X; Xue B; Li CJ. 2011. Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice. EMBO J 30(18):3754-65. PubMed: 21829168 MGI: J:179942
Yu Y; Liu Y; Shi FD; Zou H; Matarese G; La Cava A. 2013. Cutting Edge: Leptin-Induced RORgammat Expression in CD4+ T Cells Promotes Th17 Responses in Systemic Lupus Erythematosus. J Immunol 190(7):3054-8. PubMed: 23447682 MGI: J:194839
Yuan H; Reddy MA; Sun G; Lanting L; Wang M; Kato M; Natarajan R. 2013. Involvement of p300/CBP and epigenetic histone acetylation in TGF-beta1-mediated gene transcription in mesangial cells. Am J Physiol Renal Physiol 304(5):F601-13. PubMed: 23235480 MGI: J:193183
Yuan L; Luo X; Zeng M; Zhang Y; Yang M; Zhang L; Liu R; Boden G; Liu H; Ma ZA; Li L; Yang G. 2015. Transcription factor TIP27 regulates glucose homeostasis and insulin sensitivity in a PI3-kinase/Akt-dependent manner in mice. Int J Obes (Lond) 39(6):949-58. PubMed: 25614086 MGI: J:227163
Yuan T; Rafizadeh S; Gorrepati KD; Lupse B; Oberholzer J; Maedler K; Ardestani A. 2017. Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes. Diabetologia 60(4):668-678. PubMed: 28004151 MGI: J:240110
Yue P; Arai T; Terashima M; Sheikh AY; Cao F; Charo D; Hoyt G; Robbins RC; Ashley EA; Wu J; Yang PC; Tsao PS. 2007. Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mouse. Am J Physiol Heart Circ Physiol 292(5):H2106-18. PubMed: 17122193 MGI: J:126005
Yue P; Jin H; Aillaud M; Deng AC; Azuma J; Asagami T; Kundu RK; Reaven GM; Quertermous T; Tsao PS. 2010. Apelin is necessary for the maintenance of insulin sensitivity. Am J Physiol Endocrinol Metab 298(1):E59-67. PubMed: 19861585 MGI: J:170135
Yusta B; Baggio LL; Estall JL; Koehler JA; Holland DP; Li H; Pipeleers D; Ling Z; Drucker DJ. 2006. GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress. Cell Metab 4(5):391-406. PubMed: 17084712 MGI: J:129760
Zeng H; He X; Hou X; Li L; Chen JX. 2014. Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3. Am J Physiol Heart Circ Physiol 306(4):H585-97. PubMed: 24363305 MGI: J:208696
Zenker J; Poirot O; de Preux Charles AS; Arnaud E; Medard JJ; Lacroix C; Kuntzer T; Chrast R. 2012. Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus. J Neurosci 32(22):7493-8. PubMed: 22649228 MGI: J:184972
Zhai K; Gu L; Yang Z; Mao Y; Jin M; Chang Y; Yuan Q; Leblais V; Wang H; Fischmeister R; Ji G. 2016. RNA-binding protein CUGBP1 regulates insulin secretion via activation of phosphodiesterase 3B in mice. Diabetologia 59(9):1959-67. PubMed: 27255754 MGI: J:236270
Zhang F; Dey D; Branstrom R; Forsberg L; Lu M; Zhang Q; Sjoholm A. 2009. BLX-1002, a novel thiazolidinedione with no PPAR affinity, stimulates AMP-activated protein kinase activity, raises cytosolic Ca2+, and enhances glucose-stimulated insulin secretion in a PI3K-dependent manner. Am J Physiol Cell Physiol 296(2):C346-54. PubMed: 19052259 MGI: J:146323
Zhang H; Chen Q; Jiao T; Cui A; Sun X; Fang W; Xie L; Liu Y; Fang F; Chang Y. 2014. Involvement of KLF11 in hepatic glucose metabolism in mice via suppressing of PEPCK-C expression. PLoS One 9(2):e89552. PubMed: 24586865 MGI: J:213818
Zhang H; Park Y; Zhang C. 2010. Coronary and aortic endothelial function affected by feedback between adiponectin and tumor necrosis factor alpha in type 2 diabetic mice. Arterioscler Thromb Vasc Biol 30(11):2156-63. PubMed: 20814014 MGI: J:182099
Zhang H; Zhang J; Ungvari Z; Zhang C. 2009. Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress. Arterioscler Thromb Vasc Biol 29(8):1164-71. PubMed: 19478208 MGI: J:167814
Zhang HM; Dang H; Kamat A; Yeh CK; Zhang BX. 2012. Geldanamycin derivative ameliorates high fat diet-induced renal failure in diabetes. PLoS One 7(3):e32746. PubMed: 22412919 MGI: J:186932
Zhang K; Li L; Qi Y; Zhu X; Gan B; DePinho RA; Averitt T; Guo S. 2012. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology 153(2):631-46. PubMed: 22147007 MGI: J:181743
Zhang LL; Yan Liu D; Ma LQ; Luo ZD; Cao TB; Zhong J; Yan ZC; Wang LJ; Zhao ZG; Zhu SJ; Schrader M; Thilo F; Zhu ZM; Tepel M. 2007. Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity. Circ Res 100(7):1063-70. PubMed: 17347480 MGI: J:133914
Zhang LN; Zhou HY; Fu YY; Li YY; Wu F; Gu M; Wu LY; Xia CM; Dong TC; Li JY; Shen JK; Li J. 2013. Novel small-molecule PGC-1alpha transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes 62(4):1297-307. PubMed: 23250358 MGI: J:208587
Zhang M; Zhu Y; Mu K; Li L; Lu J; Zhao J; Huang X; Wang C; Jia W. 2013. Loss of beta-arrestin2 mediates pancreatic-islet dysfunction in mice. Biochem Biophys Res Commun 435(3):345-9. PubMed: 23660189 MGI: J:202642
Zhang Q; Zhu Y; Zhou W; Gao L; Yuan L; Han X. 2013. Serotonin receptor 2C and insulin secretion. PLoS One 8(1):e54250. PubMed: 23349838 MGI: J:195843
Zhang X; Li S; Zhou Y; Su W; Ruan X; Wang B; Zheng F; Warner M; Gustafsson JA; Guan Y. 2017. Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. Proc Natl Acad Sci U S A 114(12):3181-3185. PubMed: 28270609 MGI: J:241944
Zhang X; Yeung DC; Karpisek M; Stejskal D; Zhou ZG; Liu F; Wong RL; Chow WS; Tso AW; Lam KS; Xu A. 2008. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 57(5):1246-53. PubMed: 18252893 MGI: J:135319
Zhang X; Zhang G; Zhang H; Karin M; Bai H; Cai D. 2008. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135(1):61-73. PubMed: 18854155 MGI: J:149873
Zhang Y; Gan Z; Huang P; Zhou L; Mao T; Shao M; Jiang X; Chen Y; Ying H; Cao M; Li J; Li J; Zhang WJ; Yang L; Liu Y. 2012. A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors. J Biol Chem 287(45):37973-85. PubMed: 22969086 MGI: J:192963
Zhang Y; Lee FY; Barrera G; Lee H; Vales C; Gonzalez FJ; Willson TM; Edwards PA. 2006. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A 103(4):1006-11. PubMed: 16410358 MGI: J:105654
Zhang Y; Liu J; Tian XY; Wong WT; Chen Y; Wang L; Luo J; Cheang WS; Lau CW; Kwan KM; Wang N; Yao X; Huang Y. 2014. Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice. Arterioscler Thromb Vasc Biol 34(1):152-9. PubMed: 24202302 MGI: J:222832
Zhang Y; Yuen DA; Advani A; Thai K; Advani SL; Kepecs D; Kabir MG; Connelly KA; Gilbert RE. 2012. Early-outgrowth bone marrow cells attenuate renal injury and dysfunction via an antioxidant effect in a mouse model of type 2 diabetes. Diabetes 61(8):2114-25. PubMed: 22596053 MGI: J:208456
Zhang Z; Li BY; Li XL; Cheng M; Yu F; Lu WD; Cai Q; Wang JF; Zhou RH; Gao HQ; Shen L. 2013. Proteomic analysis of kidney and protective effects of grape seed procyanidin B2 in db/db mice indicate MFG-E8 as a key molecule in the development of diabetic nephropathy. Biochim Biophys Acta 1832(6):805-16. PubMed: 23474305 MGI: J:202424
Zhang Z; Luo X; Ding S; Chen J; Chen T; Chen X; Zha H; Yao L; He X; Peng H. 2012. MicroRNA-451 regulates p38 MAPK signaling by targeting of Ywhaz and suppresses the mesangial hypertrophy in early diabetic nephropathy. FEBS Lett 586(1):20-6. PubMed: 21827757 MGI: J:179943
Zhang Z; Peng H; Chen J; Chen X; Han F; Xu X; He X; Yan N. 2009. MicroRNA-21 protects from mesangial cell proliferation induced by diabetic nephropathy in db/db mice. FEBS Lett 583(12):2009-14. PubMed: 19450585 MGI: J:150000
Zhang Z; Turer E; Li X; Zhan X; Choi M; Tang M; Press A; Smith SR; Divoux A; Moresco EM; Beutler B. 2016. Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice. Proc Natl Acad Sci U S A 113(42):E6418-E6426. PubMed: 27708159 MGI: J:236520
Zhao HJ; Wang S; Cheng H; Zhang MZ; Takahashi T; Fogo AB; Breyer MD; Harris RC. 2006. Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. J Am Soc Nephrol 17(10):2664-9. PubMed: 16971655 MGI: J:135864
Zhao R; Ren S; Moghadasain MH; Rempel JD; Shen GX. 2014. Involvement of fibrinolytic regulators in adhesion of monocytes to vascular endothelial cells induced by glycated LDL and to aorta from diabetic mice. J Leukoc Biol 95(6):941-9. PubMed: 24496227 MGI: J:211922
Zhao S; Nishimura T; Chen Y; Azeloglu EU; Gottesman O; Giannarelli C; Zafar MU; Benard L; Badimon JJ; Hajjar RJ; Goldfarb J; Iyengar R. 2013. Systems pharmacology of adverse event mitigation by drug combinations. Sci Transl Med 5(206):206ra140. PubMed: 24107779 MGI: J:213547
Zhao Y; Banerjee S; Dey N; LeJeune WS; Sarkar PS; Brobey R; Rosenblatt KP; Tilton RG; Choudhary S. 2011. Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation. Diabetes 60(7):1907-16. PubMed: 21593200 MGI: J:186758
Zhao Y; Gao P; Sun F; Li Q; Chen J; Yu H; Li L; Wei X; He H; Lu Z; Wei X; Wang B; Cui Y; Xiong S; Shang Q; Xu A; Huang Y; Liu D; Zhu Z. 2016. Sodium Intake Regulates Glucose Homeostasis through the PPARdelta/Adiponectin-Mediated SGLT2 Pathway. Cell Metab 23(4):699-711. PubMed: 27053360 MGI: J:235404
Zhao Y; Yin Z; Li H; Fan J; Yang S; Chen C; Wang DW. 2017. MiR-30c protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition in db/db mice. Aging Cell 16(2):387-400. PubMed: 28127848 MGI: J:240950
Zheng D; Ma J; Yu Y; Li M; Ni R; Wang G; Chen R; Li J; Fan GC; Lacefield JC; Peng T. 2015. Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice. Diabetologia 58(8):1949-58. PubMed: 25994075 MGI: J:225924
Zhong X; Chung AC; Chen HY; Dong Y; Meng XM; Li R; Yang W; Hou FF; Lan HY. 2013. miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes. Diabetologia 56(3):663-74. PubMed: 23292313 MGI: J:194766
Zhou B; Feng B; Qin Z; Zhao Y; Chen Y; Shi Z; Gong Y; Zhang J; Yuan F; Mu J. 2016. Activation of farnesoid X receptor downregulates visfatin and attenuates diabetic nephropathy. Mol Cell Endocrinol 419:72-82. PubMed: 26450152 MGI: J:236357
Zhou L; Liu G; Jia Z; Yang KT; Sun Y; Kakizoe Y; Liu M; Zhou S; Chen R; Yang B; Yang T. 2013. Increased susceptibility of db/db mice to rosiglitazone-induced plasma volume expansion: role of dysregulation of renal water transporters. Am J Physiol Renal Physiol 305(10):F1491-7. PubMed: 24005472 MGI: J:202994
Zhou L; Liu M; Zhang J; Chen H; Dong LQ; Liu F. 2010. DsbA-L alleviates endoplasmic reticulum stress-induced adiponectin downregulation. Diabetes 59(11):2809-16. PubMed: 20699416 MGI: J:169617
Zhou M; Mok MT; Sun H; Chan AW; Huang Y; Cheng AS; Xu G. 2017. The anti-diabetic drug exenatide, a glucagon-like peptide-1 receptor agonist, counteracts hepatocarcinogenesis through cAMP-PKA-EGFR-STAT3 axis. Oncogene 36(29):4135-4149. PubMed: 28319060 MGI: J:243362
Zhou T; He X; Cheng R; Zhang B; Zhang RR; Chen Y; Takahashi Y; Murray AR; Lee K; Gao G; Ma JX. 2012. Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy. Diabetologia 55(1):255-66. PubMed: 22016045 MGI: J:179020
Zhou Y; Jia S; Wang C; Chen Z; Chi Y; Li J; Xu G; Guan Y; Yang J. 2013. FAM3A is a target gene of peroxisome proliferator-activated receptor gamma. Biochim Biophys Acta 1830(8):4160-70. PubMed: 23562554 MGI: J:202406
Zhou Y; Jiang L; Rui L. 2009. Identification of MUP1 as a regulator for glucose and lipid metabolism in mice. J Biol Chem 284(17):11152-9. PubMed: 19258313 MGI: J:149849
Zhou YP; Berggren PO; Grill V. 1996. A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse. Diabetes 45(5):580-6. PubMed: 8621007 MGI: J:32955
Zhu X; Hu R; Brissova M; Stein RW; Powers AC; Gu G; Kaverina I. 2015. Microtubules Negatively Regulate Insulin Secretion in Pancreatic beta Cells. Dev Cell 34(6):656-68. PubMed: 26418295 MGI: J:239770
Zimmermann C; Cederroth CR; Bourgoin L; Foti M; Nef S. 2012. Prevention of diabetes in db/db mice by dietary soy is independent of isoflavone levels. Endocrinology 153(11):5200-11. PubMed: 22962258 MGI: J:191798
Zykova SN; Jenssen TG; Berdal M; Olsen R; Myklebust R; Seljelid R. 2000. Altered cytokine and nitric oxide secretion in vitro by macrophages from diabetic type II-like db/db mice. Diabetes 49(9):1451-8. PubMed: 10969828 MGI: J:107166
Zyromski NJ; Mathur A; Pitt HA; Lu D; Gripe JT; Walker JJ; Yancey K; Wade TE; Swartz-Basile DA. 2008. A murine model of obesity implicates the adipokine milieu in the pathogenesis of severe acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 295(3):G552-8. PubMed: 18583460 MGI: J:141913
de Guia RM; Rose AJ; Sommerfeld A; Seibert O; Strzoda D; Zota A; Feuchter Y; Krones-Herzig A; Sijmonsma T; Kirilov M; Sticht C; Gretz N; Dallinga-Thie G; Diederichs S; Kloting N; Bluher M; Berriel Diaz M; Herzig S. 2015. microRNA-379 couples glucocorticoid hormones to dysfunctional lipid homeostasis. EMBO J 34(3):344-60. PubMed: 25510864 MGI: J:217874
de Luca C; Kowalski TJ; Zhang Y; Elmquist JK; Lee C; Kilimann MW; Ludwig T; Liu SM; Chua SC Jr. 2005. Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest 115(12):3484-93. PubMed: 16284652 MGI: J:104582
van Bilsen M; Daniels A; Brouwers O; Janssen BJ; Derks WJ; Brouns AE; Munts C; Schalkwijk CG; van der Vusse GJ; van Nieuwenhoven FA. 2014. Hypertension is a conditional factor for the development of cardiac hypertrophy in type 2 diabetic mice. PLoS One 9(1):e85078. PubMed: 24416343 MGI: J:212203
von Meyenn F; Porstmann T; Gasser E; Selevsek N; Schmidt A; Aebersold R; Stoffel M. 2013. Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism. Cell Metab 17(3):436-47. PubMed: 23416070 MGI: J:198161

Also Known As: BKS db

Genetic overview

Research Applications

Base Price

Important Note

Detailed Description

Control Suggestions

Additional Information

Selected References

Dock7m

Allele Symbol: Dock7m

Leprdb

Allele Symbol: Leprdb

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Dock7m related

Genotype: Leprdb related

Mammalian Phenotype Terms by Genotype

Genotype: Dock7m/Dock7mBKS.Cg-Dock7m +/+ Leprdb/BomTac

behavior/neurological phenotype

Genotype: Leprdb/Lepr+involves: C57BLKS/J

cellular phenotype

homeostasis/metabolism phenotype

embryo phenotype

behavior/neurological phenotype

growth/size/body region phenotype

adipose tissue phenotype

Genotype: Leprdb/Lepr+BKS.Cg-Dock7m +/+ Leprdb/J

mortality/aging

Genotype: Leprdb/LeprdbC57BLKS/J

adipose tissue phenotype

hematopoietic system phenotype

cellular phenotype

muscle phenotype

mortality/aging

liver/biliary system phenotype

behavior/neurological phenotype

endocrine/exocrine gland phenotype

renal/urinary system phenotype

growth/size/body region phenotype

homeostasis/metabolism phenotype

cardiovascular system phenotype

Genotype: Leprdb/LeprdbBKS.Cg-Dock7m +/+ Leprdb/J

homeostasis/metabolism phenotype

cellular phenotype

growth/size/body region phenotype

renal/urinary system phenotype

nervous system phenotype

behavior/neurological phenotype

vision/eye phenotype

endocrine/exocrine gland phenotype

cardiovascular system phenotype

muscle phenotype

Genotype: Leprdb/LeprdbBKS.Cg-Dock7m +/+ Leprdb/OlaHsd

digestive/alimentary phenotype

immune system phenotype

liver/biliary system phenotype

Genotype: Leprdb/Leprdbinvolves: C57BLKS/J

homeostasis/metabolism phenotype

cardiovascular system phenotype

endocrine/exocrine gland phenotype

growth/size/body region phenotype

reproductive system phenotype

vision/eye phenotype

behavior/neurological phenotype

renal/urinary system phenotype

immune system phenotype

nervous system phenotype

adipose tissue phenotype

Genotype: Leprdb/LeprdbBKS.Cg-Dock7m +/+ Leprdb/Jcl

endocrine/exocrine gland phenotype

homeostasis/metabolism phenotype

adipose tissue phenotype

cellular phenotype

Genotype: Dock7m/Dock7mB6.D(Cg)-Dock7m

adipose tissue phenotype

growth/size/body region phenotype

hematopoietic system phenotype

homeostasis/metabolism phenotype

Dock7^m

Allele Symbol: Dock7^m

Lepr^db

Allele Symbol: Lepr^db

Genotype: Dock7^m related

Genotype: Lepr^db related

Genotype: Dock7^m/Dock7^m
BKS.Cg-Dock7^m +/+ Lepr^db/BomTac

Genotype: Lepr^db/Lepr⁺
involves: C57BLKS/J

Genotype: Lepr^db/Lepr⁺
BKS.Cg-Dock7^m +/+ Lepr^db/J

Genotype: Lepr^db/Lepr^db
C57BLKS/J

Genotype: Lepr^db/Lepr^db
BKS.Cg-Dock7^m +/+ Lepr^db/J

Genotype: Lepr^db/Lepr^db
BKS.Cg-Dock7^m +/+ Lepr^db/OlaHsd

Genotype: Lepr^db/Lepr^db
involves: C57BLKS/J

Genotype: Lepr^db/Lepr^db
BKS.Cg-Dock7^m +/+ Lepr^db/Jcl

Genotype: Dock7^m/Dock7^m
B6.D(Cg)-Dock7^m

Genotype: Dock7^m/Dock7^m
DBA/J

Genotype: Lepr^db/Lepr⁺
B6.Cg-Dock7^m +/+ Lepr^db/J

Genotype: Lepr^db/Lepr^db
involves: C57BL/6 * C57BLKS/J

Genotype: Lepr^db/Lepr^db
involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

Genotype: Lepr^db/Lepr^db
B6.BKS(D)-Lepr^db/J

Genotype: Lepr^db/Lepr^db
B6.Cg-Dock7^m +/+ Lepr^db/J

Genotype: Lepr^db/Lepr^db
FVB.BKS-Lepr^db

Additional - Dock7^m related

Additional - Lepr^db related