TALLYHO/JngJ

Stock number: 005314
Strain synonyms: TH
Research areas: Diabetes and Obesity Research

Description

TALLYHO mimics many characteristics of human non-insulin-dependent type 2 diabetes mellitus (NIDDM). Male TALLYHO mice can develop hyperglycemia, hyperinsulinemia, hyperlipidemia, moderate obesity, and enlargement of the islets of Langerhans, however, the phenotype is less than 100% penetrant.

Detailed description

TALLYHO mimics many characteristics of human non-insulin-dependent type 2 diabetes mellitus (NIDDM). Male TALLYHO mice can develop hyperglycemia, hyperinsulinemia, hyperlipidemia, moderate obesity, and enlargement of the islets of Langerhans, however, the phenotype is less than 100% penetrant. Onset of hyperglycemia is delayed compared to ob/ob (B6.V-Lep^ob) and db/db (BKS.Cg-m +/+ Lepr^db) mice beginning between 10 and 14 weeks of age. Female mice display moderate hyperinsulinemia, hyperlipidemia, and obesity but do not manifest overt diabetes (i.e. hyperglycemia). Chromosomal mapping identified a major diabetes susceptibility locus on Chromosome 19, designated Tanidd1 for TH-associated NIDDM. Breeding and mapping data suggest Tanidd1 is a single recessively inherited gene primarily responsible for the hyperglycemia phenotype in TALLYHO mice. Tanidd1 interacts with other loci including Tanidd2 on Chromosome 13, Tanidd3 on Chromosome 15, Tabw2 (TallyHo-associated body weight) on Chromosome 7, and Tafat (TallyHo-associated fat pad)(Kim et al., 2001).

Development

The TallyHo strain originated from two outbred Theiler Original mice showing polyuria and glucosuria in the laboratory of Dr. E. Simpson (Harrow, UK). In 1994, Dr. Juergen Naggert established a research colony of mice at The Jackson Laboratory following importation of diabetic male mice and normal females. TallyHo was established by selective inbreeding based on the hyperglycemia phenotype of male mice. Following the seventh inbreeding generation, an intercross/backcross strategy was used for four backcross generations with selection for diabetic males mated to females proven to produce diabetic males. Brother x sister inbreeding was then resumed and the colony is currently seven generations following the four backcrosses (>F7NE4F7). Genetic analyses of TallyHo mice reported in Kim et al., 2001 were begun at the F7 generation prebackcrossing while the physiological analyses were carried out at the F1 and F2 postbackrossing generations. Genome scans at these generations detected no residual heterozygosity in the parental mice used for mapping. Scans were conducted using 92 polymorphic SSLP markers spanning the genome. This strain was donated to The Jackson Laboratory in 2004.

Allele

Symbol: Tanidd2^TALLYHO/Jng
Name: TALLYHO/Jng
MGI accession ID: MGI:2389324
Generation method: QTL
Marker symbol: Tanidd2
Marker name: TallyHo associated non-insulin dependent diabetes mellitus 2
Chromosome: 13
Strain of origin: TALLYHO/Jng
Molecular note: This allele confers susceptibility to hyperglycemia compared to C57BL/6.

Allele

Symbol: Tanidd3^TALLYHO/Jng
Name: TALLYHO/Jng
MGI accession ID: MGI:2429607
Generation method: QTL
Marker symbol: Tanidd3
Marker name: TallyHo associated non-insulin dependent diabetes mellitus 3
Chromosome: 16
Strain of origin: TALLYHO/Jng
Molecular note: This allele confers susceptibility to hyperglycemia compared to CAST/Ei.

Allele

Symbol: Tanidd1^TALLYHO/Jng
Name: TALLYHO/Jng
MGI accession ID: MGI:2429609
Generation method: QTL
Marker symbol: Tanidd1
Marker name: TallyHo associated non-insulin dependent diabetes mellitus 1
Chromosome: 19
Strain of origin: TALLYHO/Jng
Molecular note: This allele confers susceptibility to hyperglycemia compared to CAST/Ei and C57BL/6.

Allele

Symbol: Tabw2^TALLYHO/Jng
Name: TALLYHO/Jng
MGI accession ID: MGI:3603216
Generation method: QTL
Marker symbol: Tabw2
Marker name: tally ho associated body weight 2
Chromosome: 6
Strain of origin: TALLYHO/Jng
Molecular note: This allele confers increased body weight and increased plasma glucose compared to C57BL/6J.

Allele

Symbol: Tabw^TALLYHO/Jng
Name: TALLYHO/Jng
MGI accession ID: MGI:2156676
Generation method: QTL
Marker symbol: Tabw
Marker name: TallyHo associated body weight
Chromosome: 7
Strain of origin: TALLYHO/Jng
Molecular note: This allele confers decreased body weight compared to CAST/Ei and C57BL/6J.

Allele

Symbol: Tafat^TALLYHO/Jng
Name: TALLYHO/Jng
MGI accession ID: MGI:2155688
Generation method: QTL
Marker symbol: Tafat
Marker name: TallyHo associated mesenteric fat pad weight
Chromosome: 4
Strain of origin: TALLYHO/Jng
Molecular note: This allele confers decreased adiposity compared to CAST/Ei and C57BL/6J.