Onco-Hu® Mouse Models

Unrivaled translational platforms for immuno-oncology. 

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micetech@jax.org | 1.800.422.6423 (US) | 1.207.288.5845 (International)

  • Guide: Humanized Mice for Immuno-Oncology

    NSG™ mice are a proven host for engraftment of human tumors or establishment of human immunity following hematopoietic stem cell transplantation. This guide explains why the interactions between human immune cells and tumors are paramount when devising treatment strategies that prevent tumor evasion of immune cells and improve cytotoxic responses.

  • Guide: Comprehensive Evaluation of Human Immune System Reconstitution in NSG™ and NSG™-SGM3 Mouse Models

    NSG™ and NSG™-SGM3 mice engrafted with allogeneic human tumors represent a valuable preclinical testing platform for immuno-oncology. Here we employ four 14-color flow cytometry panels to perform a comprehensive and detailed analysis of the entire immune system. Our results indicate that the triple transgenic NSG™-SGM3 mice exhibit a more completely humanized immune system as compared to NSG™ mice, with specific improvements in the distribution of T-cell subsets and overall representation of the myeloid lineage.