Humanized Mice Solutions

Humanized PBMC (hu-PBMC) mice feature quick engraftment of adult peripheral blood mononuclear cells and enable short-term studies requiring mature human T cells. Hu-PBMC mice are used as in vivo models to study and evaluate compounds for T cell immune modulation, infectious diseases and graft rejection research. Large cohorts of humanized PBMC mice in the background of NSG or NSG MHC I/II Double Knockout are available for immediate delivery or to enroll in JAX drug efficacy testing services.

One of the primary uses of the hu-PBMC-NSG model is the study of acute graft-versus-host disease (GVHD) which is a major problem in clinical hematopoietic stem cell transplantation. NSG mice engrafted with human PBMCs develop an acute xenogeneic GVHD-like disease upon recognition of the murine cells and tissues by mature human T cells. The hu-PBMC-NSG MHC I/II Double Knockout mouse model improves upon the limited brief window available in the hu-PBMC model to conduct experiments before the PBMC engrafted mice become affected by GvHD. NSG mice deficient in murine MHC I/II when engrafted with human PBMCs show delayed development of GvHD and support long-term studies of human immunity requiring human T cell engraftment, human tumor xenograft models, and enable evaluation of immune modulators targeting human T cells.

Visit our PBMC page to learn more.