| MODEL |
JAX # |
TYPE |
DESCRIPTION |
SOURCE |
NOMENCLATURE |
REFERENCE |
| APOE2 |
29017 |
Knock-in |
mouse exons 2-5 and introns replaced with human APOE2 sequence |
MODEL-AD |
B6.Cg-Apoeem3(APOE*)Adiuj/J |
|
| APOE3 |
29018 |
Knock-in |
mouse exons 2-5 and introns replaced with human APOE3 sequence |
MODEL-AD |
B6.Cg-Apoeem2(APOE*)Adiuj/J |
PMID:35370604
|
| APOE4 |
27894 |
Knock-in |
mouse exons 2-5 and introns replaced with human APOE4 sequence |
MODEL-AD |
B6(SJL)-Apoetm1.1(APOE*4)Adiuj/J |
PMID:35370604
|
| APOE3-GR (TOMM40VL) |
38623 |
Genome replacement |
20kB human construct including entire TOMM40-S/APOE3 loci |
Gottschalk |
C57BL/6-Tc(HSA19*)VLDkn/J |
PMID:37458041 |
| APOE3-GR (TOMM40S) |
38624 |
Genome replacement |
20kB human construct including entire TOMM40-VL/APOE3 loci |
Gottschalk |
C57BL/6-Tc(HSA19*)SDkn/J |
PMID:37458041 |
| APOE3-GR |
38918 |
Genome replacement |
A 30kB deletion including mouse Apoe to Apoc2 is replaced by the syntenic 47kB region from human chromosome 19 including human APOE (isoform E3) to APOC. |
Koob |
B6J.B6N-Tc(HSA19*APOE_i3)1Mdk/J |
PMID:38343132
|
| APOE4-GR |
38919 |
Genome replacement |
A 30kB deletion including mouse Apoe to Apoc2 is replaced by the syntenic 47kB region from human chromosome 19 including human APOE (isoform E4) to APOC. |
Koob |
B6J.B6N-Tc(HSA19*APOE_i4)1Mdk/J |
PMID:38343132
|
| APOE switch, 4s2 |
34676 |
cre-inducible human isoform swap |
expresses hAPOE4; hAPOE2 expressed post-cre |
Johnson |
STOCK Apoetm1(APOE*)Ljohn/J |
|