| MODEL | JAX # | TYPE | DESCRIPTION | SOURCE | NOMENCLATURE | REFERENCE |
|---|
| APOE2 | 29017 | Knock-in | mouse exons 2-5 and introns replaced with human APOE2 sequence | MODEL-AD | B6.Cg-Apoeem3(APOE*)Adiuj/J | |
| APOE3 | 29018 | Knock-in | mouse exons 2-5 and introns replaced with human APOE3 sequence | MODEL-AD | B6.Cg-Apoeem2(APOE*)Adiuj/J | PMID:35370604
|
| APOE4 | 27894 | Knock-in | mouse exons 2-5 and introns replaced with human APOE4 sequence | MODEL-AD | B6(SJL)-Apoetm1.1(APOE*4)Adiuj/J | PMID:35370604
|
| APOE3-GR (TOMM40VL) | 38623 | Genome replacement | 20kB human construct including entire TOMM40-S/APOE3 loci | Gottschalk | C57BL/6-Tc(HSA19*)VLDkn/J | PMID:37458041 |
| APOE3-GR (TOMM40S) | 38624 | Genome replacement | 20kB human construct including entire TOMM40-VL/APOE3 loci | Gottschalk | C57BL/6-Tc(HSA19*)SDkn/J | PMID:37458041 |
| APOE3-GR | 38918 | Genome replacement | A 30kB deletion including mouse Apoe to Apoc2 is replaced by the syntenic 47kB region from human chromosome 19 including human APOE (isoform E3) to APOC. | Koob | B6J.B6N-Tc(HSA19*APOE_i3)1Mdk/J | PMID:38343132
|
| APOE4-GR | 38919 | Genome replacement | A 30kB deletion including mouse Apoe to Apoc2 is replaced by the syntenic 47kB region from human chromosome 19 including human APOE (isoform E4) to APOC. | Koob | B6J.B6N-Tc(HSA19*APOE_i4)1Mdk/J | PMID:38343132
|
| APOE3-Christchurch | 39778 | Knock-in | The Christchurch AD protective variant (R154S) was knocked in to humanized APOE3 (#29018) | Sasner | B6.Cg-Apoeem4(APOE*)Msasn/J | |
| APOE4-Christchurch | 39777 | Knock-in | The Christchurch AD protective variant (R154S) was knocked in to humanized APOE4 (#27894) | Sasner | B6.Cg-Apoeem3(APOE*4)Msasn/J | |
| APOE-Christchurch | 39301 | Knock-in | The Christchurch AD protective variant (R136S) was knocked in to the mouse APOE locus | MacGregor | C57BL/6J-Apoeem1Aduci/J | |
| APOE3-Jacksonville | 39776 | Knock-in | The Jacksonville AD protective variant (V236E) was knocked in to humanized APOE3 (#29018) | Sasner | BB6.Cg-Apoeem1(APOE*)Msasn/J | |
| APOE switch, 4s2 | 34676 | cre-inducible human isoform swap | expresses hAPOE4; hAPOE2 expressed post-cre | Johnson | B6.129S(Cg)-Apoetm1(APOE*)Ljohn/J | |
| APOE switch, 4s3 | 38051 | cre-inducible human isoform swap | expresses hAPOE4; hAPOE3 expressed post-cre | Sasner | C57BL/6J-Apoeem8(APOE*)Msasn/J | |
| APOE switch, 3s4 | 38050 | cre-inducible human isoform swap | expresses hAPOE3; hAPOE4 expressed post-cre | Sasner | C57BL/6J-Apoeem7(APOE*)Msasn/J | |
| APOE switch, 3s2 | 38052 | cre-inducible human isoform swap | expresses hAPOE3; hAPOE2 expressed post-cre | Sasner | C57BL/6J-Apoeem10(APOE*)Msasn/J | |
| APOE reporter | 39779 | Knock-in | A P2A-floxed stop GFP was inserted downstream of the Apoe coding region | Sasner | C57BL/6J-Apoeem5Msasn/J | |
