| MODEL |
JAX # |
TYPE |
DESCRIPTION |
SOURCE |
NOMENCLATURE |
REFERENCE |
| APOE2 |
29017 |
Knock-in |
mouse exons 2-5 and introns replaced with human APOE2 sequence |
MODEL-AD |
B6.Cg-Apoeem3(APOE*)Adiuj/J |
|
| APOE3 |
29018 |
Knock-in |
mouse exons 2-5 and introns replaced with human APOE3 sequence |
MODEL-AD |
B6.Cg-Apoeem2(APOE*)Adiuj/J |
PMID:35370604
|
| APOE4 |
27894 |
Knock-in |
mouse exons 2-5 and introns replaced with human APOE4 sequence |
MODEL-AD |
B6(SJL)-Apoetm1.1(APOE*4)Adiuj/J |
PMID:35370604
|
| APOE3-GR (TOMM40VL) |
38623 |
Genome replacement |
20kB human construct including entire TOMM40-S/APOE3 loci |
Gottschalk |
C57BL/6-Tc(HSA19*)VLDkn/J |
PMID:37458041 |
| APOE3-GR (TOMM40S) |
38624 |
Genome replacement |
20kB human construct including entire TOMM40-VL/APOE3 loci |
Gottschalk |
C57BL/6-Tc(HSA19*)SDkn/J |
PMID:37458041 |
| APOE3-GR |
38918 |
Genome replacement |
A 30kB deletion including mouse Apoe to Apoc2 is replaced by the syntenic 47kB region from human chromosome 19 including human APOE (isoform E3) to APOC. |
Koob |
B6J.B6N-Tc(HSA19*APOE_i3)1Mdk/J |
PMID:38343132
|
| APOE4-GR |
38919 |
Genome replacement |
A 30kB deletion including mouse Apoe to Apoc2 is replaced by the syntenic 47kB region from human chromosome 19 including human APOE (isoform E4) to APOC. |
Koob |
B6J.B6N-Tc(HSA19*APOE_i4)1Mdk/J |
PMID:38343132
|
| APOE3-Christchurch |
39778 |
Knock-in |
The Christchurch AD protective variant (R154S) was knocked in to humanized APOE3 (#29018) |
Sasner |
B6.Cg-Apoeem4(APOE*)Msasn/J |
|
| APOE4-Christchurch |
39777 |
Knock-in |
The Christchurch AD protective variant (R154S) was knocked in to humanized APOE4 (#27894) |
Sasner |
B6.Cg-Apoeem3(APOE*4)Msasn/J |
|
| APOE3-Jacksonville |
39776 |
Knock-in |
The Jacksonville AD protective variant (V236E) was knocked in to humanized APOE3 (#29018) |
Sasner |
BB6.Cg-Apoeem1(APOE*)Msasn/J |
|
| APOE switch, 4s2 |
34676 |
cre-inducible human isoform swap |
expresses hAPOE4; hAPOE2 expressed post-cre |
Johnson |
B6.129S(Cg)-Apoetm1(APOE*)Ljohn/J |
|
| APOE switch, 4s3 |
38051 |
cre-inducible human isoform swap |
expresses hAPOE4; hAPOE3 expressed post-cre |
Sasner |
C57BL/6J-Apoeem8(APOE*)Msasn/J |
|
| APOE switch, 3s4 |
38050 |
cre-inducible human isoform swap |
expresses hAPOE3; hAPOE4 expressed post-cre |
Sasner |
C57BL/6J-Apoeem7(APOE*)Msasn/J |
|
| APOE switch, 3s2 |
38052 |
cre-inducible human isoform swap |
expresses hAPOE3; hAPOE2 expressed post-cre |
Sasner |
C57BL/6J-Apoeem10(APOE*)Msasn/J |
|
| APOE reporter |
39779 |
Knock-in |
A P2A-floxed stop GFP was inserted downstream of the Apoe coding region |
Sasner |
C57BL/6J-Apoeem5Msasn/J |
|