APOE Models

MODEL JAX # TYPE DESCRIPTION REFERENCE SOURCE
APOE2 29017 Knock-in mouse exons 2-5 and introns replaced with human APOE2 sequence MODEL-AD
APOE3 29018 Knock-in mouse exons 2-5 and introns replaced with human APOE3 sequence PMID: 35370604 MODEL-AD
APOE4 27894 Knock-in mouse exons 2-5 and introns replaced with human APOE4 sequence PMID: 35370604 MODEL-AD
APOE3-GR (TOMM40VL) 38623 Genome replacement 20kB human construct including entire TOMM40-S/APOE3 loci PMID: 37458041 Gottschalk
APOE3-GR (TOMM40S) 38624 Genome replacement 20kB human construct including entire TOMM40-VL/APOE3 loci  PMID: 37458041 Gottschalk
APOE3-GR 38918 Genome replacement 47kB human construct including the full apolipoprotein E-C1-C4-C2 gene cluster Koob
APOE4-GR 38919 Genome replacement 47kB human construct including the full apolipoprotein E-C1-C4-C2 gene cluster Koob