Amyloid beta plaques are a primary pathology of Alzheimer’s disease. Extensive research has been performed using mouse models, but there has been limited translatability to human disease. In an effort to bridge this gap in knowledge, we are studying the impact of human microglia on amyloid beta plaque progression in vivo using humanized mouse models of Alzheimer’s disease. Our work will contribute to a growing understanding of the disease mechanisms and could be used to develop and test novel therapeutics.
