Mouse Disease Information System

The Sundberg Lab at The Jackson Laboratory is developing database tools for recording mouse pathology diagnoses/phenotypes. The team's goal is to develop record keeping for necropsy results that uses a standardized ontology of terms and is also easy to use. 

MoDIS Software Download

MoDIS links to the Pathbase.net website to provide detailed information and annotated images of similar lesions in laboratory mice, making it a unique and useful training aid.

Please cite this page as: https://www.jax.org/research-and-faculty/resources/mouse-disease-information-system

Current Version 3.6 (8/13/08)

Introduction

The Mouse Disease Information System (MoDIS) is a relational database program written for Microsoft Access® and is used for storing and analyzing necropsy cases.

System requirement:

Windows 2000, XP, Vista, or 7 and Microsoft Access 2003, 2007, or 2010. The software is not tested on Windows 8 or Microsoft Access 2013.

Installation:

The installation steps are described in the MoDIS Program Documentation. This software may be run stand-alone or in a multi-user environment with a client-server setup. Normal configuration requires the server and workstations to be using Windows. It is possible to use a Mac as a client workstation by employing application delivery software such as Citrix XenApp™, remote access via Microsoft's Remote Desktop Client for Mac, or Microsoft Virtual PC.

Manual:

The user guide and program documentation is included with the download as Microsoft Word® 2003 documents.

Authors:

MoDIS was developed by John P. Sundberg, D.V.M., Ph.D., Dipl. A.C.V.P., and Beth A. Sundberg, M.S., at The Jackson Laboratory in Bar Harbor, Maine USA. 

Planned Future Developments:

This database is being integrated into Pathbase with the European Mouse Pathology Consortium to expand to higher level ontologies. Data on all lesions identified in 32 inbred strains at 12 and 20 months of age are summarized in Pathbase, Mouse Tumor Biology, and Mouse Phenome databases with images and disease frequency, which provides several accessible resources to find online case materials for lesions with similar diagnoses in both inbred strains (spontaneous diseases) as well as many different genetically engineered mice. This is a constantly developing series of databases that provide resources for confirmation of diagnoses, information on other strains, stocks, and mutant mice with similar types of diseases, and opportunities for investigators and pathologists to report (provide images and data) their work online and solicit expert opinions from collaborating pathologists worldwide.

References:

Sundberg BA, Sundberg JP.  A database system for small diagnostic pathology laboratories.  Lab Anim 19:55-58, 1990.

Sundberg BA, Sundberg JP.  Medical record keeping for project analysis.  In: Systematic approach to evaluation of mouse mutations.  Sundberg JP, Boggess D (eds.), CRC Press, Inc., Boca Raton, FL, pp. 47-55, 2000.

Schofield PN, Bard JBL, Rozell B, Sundberg JP: Computational pathology: challenges in the informatics of phenotype description in mutant mice. In: Handbook on genetically engineered mice, eds. Sundberg JP, Ichiki T (ed.), pp. 61-81. CRC Press, Boca Raton, 2005

Krupke DM, Begley DA, Sundberg JP, Bult CJ, Eppig JT. The Mouse Tumor Biology database. Nature Rev Cancer Advance Online Publication 24 April 2008; doi:10.1038/nrc2390.

Bogue MA, Grubb SC, Maddatu TP, Bult CJ: Mouse Phenome Database (MPD). Nucleic Acids Res 35: D643-649, 2007.

Sundberg JP, Sundberg BA, Schofield P. Integrating Mouse Anatomy and Pathology Ontologies into a Phenotyping Database: Tools for Data Capture and Training. Mamm Genome. 19:413-9, 2008. doi: 10.1007/s00335-008-9123-z.

Sundberg, B. A., Schofield, P. N., Gruenberger, M., Sundberg, J.P. A data-capture tool for mouse pathology phenotyping. Vet Pathol, 46(6):1230-40, 2009.

Download

In order to receive a copy of the current version of MoDIS and documentation please read and accept the following notice.