Yasmine Nonose is a postdoctoral fellow at JAX-NYSCF, where she develops in vitro human models of neurodegenerative diseases using human induced pluripotent stem cells (iPSCs). Her work supports The Jackson Laboratory’s mission by enabling scalable, human-relevant systems to study disease mechanisms, support therapeutic screening and advance collaborative biomedical research.
Her research integrates iPSC differentiation with high-content cell imaging, including real time live-cell imaging and high-throughput systems. Combined with automated stem cell production pipelines, these approaches reduce experimental variability, enable parallel processing of large sample sets and improve reproducibility and translational relevance.
Nonose developed a method coupling live-cell imaging with high-resolution 3D analysis to study alpha-synuclein preformed fibril phagocytosis in iPSC-derived microglia. This platform enables precise quantification of aggregate processing and can be adapted to other cell types and complex in vitro models, expanding its applicability across disease areas.
She earned her Ph.D. from the Universidade Federal do Rio Grande do Sul in Brazil, where she studied brain metabolism, astrocyte-neuron interactions, and neuroprotection in ischemia, shaping her interest in building human cellular models that capture biological complexity and enable translational research at scale.
Nonose hopes her research will enhance the predictive power of preclinical studies and help advance precision medicine for neurodegenerative disorders.