Ilya Kruglikov, Ph.D., is a senior principal scientist at The Jackson Laboratory in New York, where he develops and evaluates human stem cell–based models of neurodegenerative diseases, including Parkinson’s and Alzheimer’s. His work aims to improve mechanistic understanding, translational relevance and reproducibility, providing tools that empower the global biomedical community.
His research uses human induced pluripotent stem cell–derived neurons, glia, brain organoids and assembloids to study neuronal circuit development and disease-associated phenotypes. Kruglikov applies single-cell and multielectrode array electrophysiology, along with functional imaging, to assess population activity dynamics and identify electrical and functional signatures linked to disease. His recent work includes an in vitro cortical assembloid system in which structural variants associated with schizophrenia produced variant-specific electrophysiological phenotypes, including changes in gamma-band oscillation power.
Kruglikov earned his degree in applied physics and mathematics from the Moscow Institute of Physics and Technology and completed a doctoral degree in biophysics at the Institute of Physiology of the Ukrainian Academy of Sciences. After postdoctoral and faculty roles at New York University focused on brain circuit dynamics and disease modeling, he joined the New York Stem Cell Foundation Research Institute in 2015. He became part of JAX in 2025 following its acquisition of NYSCF.