PDX Live™ Tumors

Establishing PDX cohorts from frozen samples can delay drug efficacy studies 6-12 weeks or more. The inventoried PDX Live™ tumor models at JAX are ready for immediate enrollment in preclinical studies.

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JAX has partnered with more than 20 cancer clinics to provide access to a wider range of patient-derived xenograft (PDX) cancer models at earlier passage numbers than any other PDX collection available today.

Executing patient-derived xenograft studies is time consuming, with pre-study engraftment and growth of tumors representing a significant time investment. To streamline PDX cancer study execution, JAX offers a collection of PDX Live™ tumor-engrafted NSG™ mice.

This collection of readily available, off-the-shelf, tumor-engrafted cohorts of PDX mice is developed and maintained by experienced JAX scientific staff. Tumor-bearing mice are ready to quickly enroll on study.

Get your data up to 80% faster

Bringing tumors out of the freezer or passaging tumors between donor and on-study mice can delay PDX drug efficacy studies 6-12 weeks or more. Inventoried PDX Live™ tumors at JAX significantly shorten this time period by having tumor-engrafted live mice on the shelf and ready to enroll on study as soon as you are ready.

For most of our PDX tumors, gene expression data and genomic data (Affymetrix Human Gene 1.0 ST Exon Array), Genome-Wide Human SNP Array 6.0 from Affymetrix, including CNV data), standard of care data, and pathology images are available through the Mouse Tumor Biology Database.

Don’t see a tumor that you think should be included in the PDX Live™ Program? Let us know which tumors you think we should engraft next. 

JAX also offers a variety of tumors available for engraftment for breast cancer, lung cancer, bladder cancer, pancreatic cancer, acute myeloid leukemia, ovarian cancer and many others found in the Mouse Tumor Biology Database. Featured models are highlighted here.

Breast tumor models

JAX features off-the-shelf breast tumor models, including several invasive ductal carcinomas with available gene expression, gene CNV and drug response data. The following models are currently growing in mice for quick availability.

Model ID Primary site Diagnosis Tumor markers & additional details

TM00089

Breast

Triple-negative

PR-, ER-, HER2-. SOC available

TM00095

Breast

Invasive ductal carcinoma

PR-, ER-, HER2+; View data

TM00098

Breast

Invasive ductal carcinoma

KDR Q472H; Amplification of MYC & JAK2. SOC available

TM00103

Breast

Invasive ductal carcinoma

View Data

TM00129

Breast

Ductal carcinoma

PR-, ER-, HER2 (ERBB2)+

TM00284

Breast

Adenocarcinoma

View Data

TM00999

Breast

Invasive ductal carcinoma

SOC available; View Data

Lung tumor models

Our extensive collection of early passage lung tumor models features various combinations of variants including ALK,KRAS, TP53 and EGFR.

Model ID Primary site Diagnosis Tumor markers & additional details

TM00046

Lung

Adenocarcinoma

SOC available; View Data

TM00186

Lung

NSCLC

SOC Available; View Data

TM00193

Lung

NSCLC: Adenocarcinoma

EGFR exon 19 del

TM00194

Lung

Small cell carcinoma

View Data

TM00199

Lung

Adenocarcinoma

SOC available. EGFR L858R.

TM00202

Lung

NSCLC

View Data

TM00206

Lung

NSCLC: Adenocarcinoma

ELM4 ALK

TM00208

Lung

NSCLC: Squamous cell carcinoma

AURKA F31; KDR Q472H; RET G691S; Amplification of CCNE1 & EGFR 

TM00212

Lung

Large cell neuroendocrine carcinoma

View Data 

TM00214

Lung

NSCLC: Squamous cell carcinoma

View data

TM00219

Lung

NSCLC: Adenocarcinoma

CTNNB1, EGFR exon 19 del, T790M, KDR, TP53

TM00226

Lung

NSCLC: Adenocarcinoma

KRAS G13R

TM00231

Lung

Lung squamous cell carcinoma

SOC available; view Data

TM00233

Lung

NSCLC

View Data

TM00256

Lung

NSCLC

View Data

TM00302

Lung

NSCLC: Metastatic adenocarcinoma

KRAS G12D; ALK

TM00784

Lung

NSCLC: Adenocarcinoma

SOC available; View data

Lymphomas and hematological tumor models

JAX features a patient-derived xenograft model of AML positive for internal tandem duplication mutations of FMS-like tyrosine kinase-3 (FLT3-IDT).

Model ID Primary site Diagnosis Tumor markers & additional details

TM01595*

Bone marrow

Acute myeloid leukemia

IDH1; FAB-M5; NPM1 
* Out of stock

Bladder tumor models

Our live bladder tumor models features early passage urothelial carcinomas with available gene expression, gene CNV and drug response data..

Model ID Primary site Diagnosis Tumor markers & additional details

TM00024

Bladder

Urothelial carcinoma

SOC available; View data

Brain tumor models

JAX features a gliobastoma tumor model with available variant summary, gene expression, CNV, histology and tumor growth data.

Model ID Primary site Diagnosis Tumor markers & additional details

TM00058

Brain

Gliobastoma multiforme

View Data

TM01087

Brain

Neuroblastoma

SOC available

Bone tumor models

Our featured live bone tumor model is an early passage spindle cell sarcoma with variant summary, gene expression, CNV, histology and tumor growth data.

Model ID Primary site Diagnosis Tumor markers & additional details

TM00381

Bone

Spindle cell sarcoma

View data

TM01165

Soft Tissue

Rhabdomyosarcoma

View data

Ovarian tumor models

Our featured live ovarian tumor PDX models is an early passage carcinoma with gene expression, gene CNV, histology and tumor growth data.

Model ID Primary site Diagnosis Tumor markers & additional details

TM00324

Ovary

Papillary serous adenocarcinoma

View data

TM00334

Ovary

Carcinosarcoma

View data

TM00335

Ovary

Papillary serous adenocarcinoma

View data

Pancreas tumor models

JAX features a pancreatic ductal adenocarcinoma tumor model with available variant summary and gene expression data.

Model ID Primary site Diagnosis Tumor markers & additional details

TM00314

Pancreas

Pancreatic ductal adenocarcinoma

View Data

Colon tumor models

Our featured live colon tumor PDX models are early passage colon adenocarcinomas with gene expression, gene CNV, histology and tumor growth data.

Model ID Primary site Diagnosis Tumor markers & additional details

TM00165

Colon

Anal adenocarcinoma

HER2+; View Data