A comprehensive list of publications that utilize
NSG™ variant mouse models to advance research.
Brehm MA; Powers AC; Shultz LD; Greiner DL. 2012. Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice. Cold Spring Harb Perspect Med May;2(5):a007757. [PMID: 22553498]
Buerck, L.W., Schuster, M., Oduncu, F.S., Baehr, A., Mayr, T., Guethoff, S., Abicht, J., Reichart, B., Klymiuk, N., Wolf, E., Seissler, J., 2017. LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy. Sci. Rep. 7, 3572. doi:10.1038/s41598-017-03913-4. [PMID: 28620237]
Dhawan S, Dirice E, Kulkarni RN, Bhushan A. Inhibition of TGF-beta signaling promotes human pancreatic beta cell replication. Diabetes. 2016 Mar 2. pii: db151331. [PMID: 26936960]
Friedline RH, Ko HJ, Jung DY, Lee Y, Bortell R, Dagdeviren S, Patel PR, Hu X, Inashima K, Kearns C, Tsitsilianos N, Shafiq U, Shultz LD, Lee KW, Greiner DL, Kim JK. Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance. FASEB J. 2015 Dec 7. pii: fj.15-280610. [PMID: 26644351]
Guo T; Landsman L; Li N; Hebrok M. 2013. Factors Expressed by Murine Embryonic Pancreatic Mesenchyme Enhance Generation of Insulin-Producing Cells From hESCs. Diabetes. May;62(5):1581-92. [PMID: 23305648]
Hickey RD; Galivo F; Schug J; Brehm MA; Haft A; Wang Y; Benedetti E; Gu G; Magnuson MA; Shultz LD; Lagasse E; Greiner DL; Kaestner KH; Grompe M. 2013. Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Res. Feb 18;11(1):503-515. [PMID: 23562832]
Huang, D., Wang, Y., Hawthorne, W.J., Hu, M., Hawkes, J., Burns, H., Davies, S., Gao, F., Chew, Y.V., Yi, S., O’Connell, P.J., 2017. Ex vivo-expanded baboon CD39 + regulatory T cells prevent rejection of porcine islet xenografts in NOD-SCID IL-2rγ(-/-) mice reconstituted with baboon peripheral blood mononuclear cells. Xenotransplantation. doi:10.1111/xen.12344. [PMID: 28963731]
King M; Pearson T; Shultz LD; Leif J; Bottino R; Trucco M; Atkinson MA; Wasserfall C; Herold KC; Woodland RT; Schmidt MR; Woda BA; Thompson MJ; Rossini AA; Greiner DL. 2008. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol. Mar;126(3):303-14. [PMID: 18096436]
King M; Pearson T; Rossini AA; Shultz LD; Greiner DL. 2008. Humanized mice for the study of type 1 diabetes and beta cell function. Ann N Y Acad Sci Dec;1150:46-53. [PMID: 19120266]
Klymiuk N; van Buerck L; Bähr A; Offers M; Kessler B; Wuensch A; Kurome M; Thormann M; Lochner K; Nagashima H; Herbach N; Wanke R; Seissler J; Wolf E. 2012. Xenografted Islet Cell Clusters From INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice. Diabetes Jun;61(6):1527-32. [PMID: 22522620]
Liu G; Dou S; Akalin A; Rusckowski M; Streeter PR; Shultz LD; Greiner DL. 2012. Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody. Nucl Med Biol Jul;39(5):645-51. [PMID: 22316614]
Min SY, Kady J, Nam M, Rojas-Rodriguez R, Berkenwald A, Kim JH, Noh HL, Kim JK, Cooper MP, Fitzgibbons T, Brehm MA, Corvera S. Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice. Nat Med. 2016 Jan 25. doi: 10.1038/nm.4031. [Epub ahead of print]. [PMID: 26808348]
Pearson T; Shultz LD; Lief J; Burzenski L; Gott B; Chase T; Foreman O; Rossini AA; Bottino R; Trucco M; Greiner DL. 2008. A new immunodeficient hyperglycaemic mouse model based on the Ins2 ( Akita ) mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia 51(8):1449-56. [PMID: 18563383]
Presa M, Chen YG, Grier AE, Leiter EH, Brehm MA, Greiner DL, Shultz LD, Serreze DV. The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice. J Immunol. 2015 Aug 17. [PMID: 26283479]
Serr I, Fürst RW, Achenbach P, Scherm MG, Gökmen F, Haupt F, Sedlmeier EM, Knopff A, Shultz L, Willis RA, Ziegler AG, Daniel C. 2016. Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice. Nat Commun. 2016 Mar 15;7:10991. [PMID: 26975663]
Shultz LD; Pearson T; King M; Giassi L; Carney L; Gott B; Lyons B; Rossini AA; Greiner DL. 2007. Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research. Ann N Y Acad Sci Apr;1103:77-89. Review. [PMID: 17332083]
Unger WW; Pearson T; Abreu JR; Laban S; van der Slik AR; der Kracht SM; Kester MG; Serreze DV; Shultz LD; Griffioen M; Drijfhout JW; Greiner DL; Roep BO. 2012. Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice. PLoS One. 7(11):e49213. [PMID: 23155466]
Whitfield-Larry F; Young EF; Talmage G; Fudge E; Azam A; Patel S; Largay J; Byrd W; Buse J; Calikoglu AS; Shultz LD; Frelinger JA. 2011. HLA-A2-Matched Peripheral Blood Mononuclear Cells From Type 1 Diabetic Patients, but not Nondiabetic Donors, Transfer Insulitis to NOD-scid/{gamma}cnull/HLA-A2 Transgenic Mice Concurrent With the Expansion of Islet-Specific CD8+ T cells. Diabetes Jun;60(6):1726-33. [PMID: 21521873]
Wolf-van Buerck L, Schuster M, Baehr A, Mayr T, Guethoff S, Abicht J, Reichart B, Nam-Apostolopoulos YC, Klymiuk N, Wolf E, Seissler J. Engraftment and reversal of diabetes after intramuscular transplantation of neonatal porcine islet-like clusters. Xenotransplantation. 2015 Oct 21. [PMID: 26490671]
Yi S; Ji M; Wu J; Ma X; Phillips P; Hawthorne WJ; O'Connell PJ. 2012. Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice. Diabetes May;61(5):1180-91. [PMID: 22403295]
Zhao Y; Guo C; Hwang D; Lin B; Dingeldein M; Mihailescu D; Sam S; Sidhwani S; Zhang Y; Jain S; Skidgel RA; Prabhakar BS; Mazzone T; Holterman MJ. 2010. Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model. Biochem Biophys Res Commun Sep 3;399(4):629-36. [PMID: 20691153]
Thiollier C; Lopez CK; Gerby B; Ignacimouttou C; Poglio S; Duffourd Y; Guégan J; Rivera-Munoz P; Bluteau O; Mabialah V; Diop M; Wen Q; Petit A; Bauchet AL; Reinhardt D; Bornhauser B; Gautheret D; Lecluse Y; Landman-Parker J; Radford I; Vainchenker W; Dastugue N; de Botton S; Dessen P; Bourquin JP; Crispino JD; Ballerini P; Bernard OA; Pflumio F; Mercher T. 2012. Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models. J Exp Med. Oct 22;209(11):2017-31. [PMID: 23045605]
Wen Q; Goldenson B; Silver SJ; Schenone M; Dancik V; Huang Z; Wang LZ; Lewis TA; An WF; Li X; Bray MA; Thiollier C; Diebold L; Gilles L; Vokes MS; Moore CB; Bliss-Moreau M; Verplank L; Tolliday NJ; Mishra R; Vemula S; Shi J; Wei L; Kapur R; Lopez CK; Gerby B; Ballerini P; Pflumio F; Gilliland DG; Goldberg L; Birger Y; Izraeli S; Gamis AS; Smith FO; Woods WG; Taub J; Scherer CA; Bradner JE; Goh BC; Mercher T; Carpenter AE; Gould RJ; Clemons PA; Carr SA; Root DE; Schreiber SL; Stern AM; Crispino JD. 2012. Identification of Regulators of Polyploidization Presents Therapeutic Targets for Treatment of AMKL. Cell Aug 3;150(3):575-89. [PMID: 22655268]
Aigner, P., Mizutani, T., Horvath, J., Eder, T., Heber, S., Lind, K., Just, V., Moll, H.P., Yeroslaviz, A., Fischer, M.J.M., Kenner, L., Győrffy, B., Sill, H., Grebien, F., Moriggl, R., Casanova, E., Stoiber, D., 2019. STAT3β is a tumor suppressor in acute myeloid leukemia. Blood Adv 3, 1989–2002. [PMID: 31270081]
Ågerstam H, Karlsson C, Hansen N, Sandén C, Askmyr M, von Palffy S, Högberg C, Rissler M, Wunderlich M, Juliusson G, Richter J, Sjöström K, Bhatia R, Mulloy JC, Järås M, Fioretos T. 2015. Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia. Proc Natl Acad Sci U S A. 112(34):10786-91. [PMID: 26261316]
Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer 123(9):2222-7. [PMID: 18688847]
Alberich-Jordà M; Wouters B; Balastik M; Shapiro-Koss C; Zhang H; Diruscio A; Radomska HS; Ebralidze AK; Amabile G; Ye M; Zhang J; Lowers I; Avellino R; Melnick A; Figueroa ME; Valk PJ; Delwel R; Tenen DG. 2012. C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia. J Clin Invest. Dec 3;122(12):4490-504. [PMID: 23160200]
Alachkar H; Santhanam R; Harb JG; Lucas DM; Oaks JJ; Hickey CJ; Pan L; Kinghorn AD; Caligiuri MA; Perrotti D; Byrd JC; Garzon R; Grever MR; Marcucci G. 2013. Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia. J Hematol Oncol. Mar 16;6:21. [PMID: 23497456]
Arteaga MF; Mikesch JH; Qiu J; Christensen J; Helin K; Kogan SC; Dong S; So CW. 2013. The Histone Demethylase PHF8 Governs Retinoic Acid Response in Acute Promyelocytic Leukemia. Cancer Cell. Mar 18;23(3):376-89. [PMID: 23518351]
Banerji V; Frumm SM; Ross KN; Li LS; Schinzel AC; Hahn CK; Kakoza RM; Chow KT; Ross L; Alexe G; Tolliday N; Inguilizian H; Galinsky I; Stone RM; DeAngelo DJ; Roti G; Aster JC; Hahn WC; Kung AL; Stegmaier K.2012. The intersection of genetic and chemical genomic screens identifies GSK-3a; as a target in human acute myeloid leukemia. J Clin Invest Mar 1;122(3):935-47. [PMID: 22326953]
Barve, A., Casson, L., Krem, M., Wunderlich, M., Mulloy, J.C., Beverly, L.J., 2018. Comparative utility of NRG and NRGS mice for the study of normal hematopoiesis, leukemogenesis, and therapeutic response. Exp. Hematol. [PMID: 30125602]
Bonnet, D., 2017. Acute myeloid leukemia including favorable-risk group samples engraft in NSG mice: just be patient. Haematologica 102, 805–806. doi:10.3324/haematol.2017.165159. [PMID: 28458252]
Buettner, R., Nguyen, L.X.T., Kumar, B., Morales, C., Liu, C., Chen, L.S., Pemovska, T., Synold, T.W., Palmer, J., Thompson, R., Li, L., Hoang, D.H., Zhang, B., Ghoda, L., Kowolik, C., Kontro, M., Leitch, C., Wennerberg, K., Xu, X., Chen, C.-C., Horne, D., Gandhi, V., Pullarkat, V., Marcucci, G., Rosen, S.T., 2019. 8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia. J. Cell. Physiol. [PMID: 30770553]
Cany J; van der Waart AB; Tordoir M; Franssen GM; Hangalapura BN; de Vries J; Boerman O; Schaap N; van der Voort R; Spanholtz J; Dolstra H. 2013. Natural killer cells generated from cord blood hematopoietic progenitor cells efficiently target bone marrow-residing human leukemia cells in NOD/SCID/IL2Rg(null) mice. PLoS One. Jun 5;8(6):e64384. [PMID: 23755121]
Carter-Cooper, B.A., Fletcher, S., Ferraris, D., Choi, E.Y., Kronfli, D., Dash, S., Truong, P., Sausville, E.A., Lapidus, R.G., Emadi, A., 2017. Synthesis, characterization and antineoplastic activity of bis-aziridinyl dimeric naphthoquinone - A novel class of compounds with potent activity against acute myeloid leukemia cells. Bioorg. Med. Chem. Lett. 27, 6–10. doi:10.1016/j.bmcl.2016.11.045. [PMID: 27890379]
Casucci M; Nicolis di Robilant B; Falcone L; Camisa B; Norelli M; Genovese P; Gentner B; Gullotta F; Ponzoni M; Bernardi M; Marcatti M; Saudemont A; Bordignon C; Savoldo B; Ciceri F; Naldini L; Dotti G; Bonini C; Bondanza A. 2013. CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma. Blood [Epub ahead of print] [PMID: 24016461]
Chen Y; Jacamo R; Konopleva M; Garzon R; Croce C; Andreeff M. 2013. CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia. J Clin Invest. Jun 3;123(6):2395-407. [PMID: 23676502]
Chou FS; Wunderlich M; Griesinger A; Mulloy JC. 2011. N-RasG12D induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene. Blood Feb 17;117(7):2237-2240. [PMID: 21200020]
Distler E; Wolfel C; Kohler S; Nonn M; Kaus N; Schnurer E; Meyer RG; Wehler TC; Huber C; Wolfel T; Hartwig UF; Herr W. 2008. Acute myeloid leukemia (AML)-reactive cytotoxic T lymphocyte clones rapidly expanded from CD8(+) CD62L((high)+) T cells of healthy donors prevent AML engraftment in NOD/SCID IL2Rgamma(null) mice. Exp Hematol 36(4):451-63. [PMID: 18261837]
Dos Santos C; McDonald T; Ho YW; Liu H; Lin A; Forman SJ; Kuo YH; Bhatia R. 2013. The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cell by chemotherapeutic agents. Blood. Sep 12;122(11):1900-13. [PMID: 23896410]
Drenberg, C.D., Shelat, A., Dang, J., Cotton, A., Orwick, S.J., Li, M., Jeon, J.Y., Fu, Q., Buelow, D.R., Pioso, M., Hu, S., Inaba, H., Ribeiro, R.C., Rubnitz, J.E., Gruber, T.A., Guy, R.K., Baker, S.D., 2019. A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML. Nat Commun 10. [PMID: 31097698]
Du W, Li XE, Sipple J, Pang Q. 2011. Overexpression of IL-3 Rα on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconic anemia AML. Blood. Apr 21;117(16):4243-52. [PMID: 21330473]
Endo, A., Tomizawa, D., Aoki, Y., Morio, T., Mizutani, S., Takagi, M., 2016. EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway. Cancer Sci. doi:10.1111/cas.13080 [PMID: 27627705]
Etchin J, Montero J, Berezovskaya A, Le BT, Kentsis A, Christie AL, Conway AS, Chen WC, Reed C, Mansour MR, Ng CE, Adamia S, Rodig SJ, Galinsky IA, Stone RM, Klebanov B, Landesman Y, Kauffman M, Shacham S, Kung AL, Wang JC, Letai A, Look AT. Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice. Leukemia. 2015 Jul 23. Epub ahead of print. [PMID: 26202935]
Folkerts, H., Hilgendorf, S., Wierenga, A.T.J., Jaques, J., Mulder, A.B., Coffer, P.J., Schuringa, J.J., Vellenga, E., 2017. Inhibition of autophagy as a treatment strategy for p53 wild-type acute myeloid leukemia. Cell Death Dis. 8, e2927. doi:10.1038/cddis.2017.317. [PMID: 28703806]
Fox JM, Moynihan JR, Mott BT, Mazzone JR, Anders NM, Brown PA, Rudek MA, Liu JO, Arav-Boger R, Posner GH, Civin CI, Chen X. Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs. Oncotarget. 2016 Jan 12. doi: 10.18632/oncotarget.6896. [Epub ahead of print] [PMID: 26771236]
Gao, S., Zhou, B., Li, H., Huang, X., Wu, Y., Xing, C., Yu, X., Ji, Y., 2018. Long non-coding RNA HOTAIR promotes the self-renewal of leukemia stem cell through epigenetic silencing of p15. Exp. Hematol. [PMID: 30172749]
Gausdal G; Wergeland A; Skavland J; Nguyen E; Pendino F; Rouhee N; McCormack E; Herfindal L; Kleppe R; Havemann U; Schwede F; Bruserud O; Gjertsen BT; Lanotte M; Ségal-Bendirdjian E; Døskeland SO. 2013. Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death Dis. Feb 28;4:e516. [PMID: 23449452]
Gerber JM; Smith BD; Ngwang B; Zhang H; Vala MS; Morsberger L; Galkin S; Collector MI; Perkins B; Levis MJ; Griffin CA; Sharkis SJ; Borowitz MJ; Karp JE; Jones RJ. 2012. A clinically relevant population of leukemic CD34+CD38- cells in acute myeloid leukemia. Blood Apr 12;119(15):3571-7. [PMID: 22262762]
Goardon N; Marchi E; Atzberger A; Quek L; Schuh A; Soneji S; Woll P; Mead A; Alford KA; Rout R; Chaudhury S; Gilkes A; Knapper S; Beldjord K; Begum S; Rose S; Geddes N; Griffiths M; Standen G; Sternberg A; Cavenagh J; Hunter H; Bowen D; Killick S; Robinson L; Price A; Macintyre E; Virgo P; Burnett A; Craddock C; Enver T; Jacobsen SE; Porcher C; Vyas P. 2011. Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia. Cancer Cell Jan 18;19(1):138-52. [PMID: 21251617]
Griessinger E, Anjos-Afonso F, Vargaftig J, Taussig D, Lassailly F, Prebet T, Imbert V, Nebout M, Vey N, Chabannon C, Filby A, Bollet-Quivogne F, Gribben JG, Peyron JF, Bonnet D. 2016. Frequency and dynamics of leukemia-initiating cells during short-term ex vivo culture informs outcomes in acute myeloid leukemia patients. Cancer Res. 2016 Mar 9. pii: canres.2063.2015. [PMID: 26960976]
Griessinger, E., Vargaftig, J., Horswell, S., Taussig, D.C., Gribben, J., Bonnet, D., 2017. Acute myeloid leukemia xenograft success prediction: saving time. Exp. Hematol. [PMID: 29253573]
Gunasekara, D.C., Zheng, M.M., Mojtahed, T., Woods, J.R., Fandy, T.E., Riofski, M.V., Glackin, C.A., Hassan, H.E., Kirshner, J., Colby, D.A., 2016. 15-Methylene-Eburnamonine Kills Leukemic Stem Cells and Reduces Engraftment in a Humanized Bone Marrow Xenograft Mouse Model of Leukemia. ChemMedChem. doi:10.1002/cmdc.201600334 [PMID: 27677525]
Han, L., Jorgensen, J.L., Brooks, C., Shi, C., Zhang, Q., Nogueras González, G.M., Cavazos, A., Pan, R., Mu, H., Wang, S., Zhou, J., Alatrash, G., Ciurea, S.O., Rettig, M., DiPersio, J.F., Cortes, J.E., Huang, X., Kantarjian, H., Andreeff, M., Ravandi-Kashani, F., Konopleva, M., 2017. Anti-leukemia efficacy and mechanisms of action of SL-101, a novel anti-CD123 antibody-conjugate, in acute myeloid leukemia. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. doi:10.1158/1078-0432.CCR-16-1904. [PMID: 28096272]
Harris WJ; Huang X; Lynch JT; Spencer GJ; Hitchin JR; Li Y; Ciceri F; Blaser JG; Greystoke BF; Jordan AM; Miller CJ; Ogilvie DJ; Somervaille TC. 2012. The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells. Cancer Cell Apr 17;21(4):473-87. [PMID: 22464800]
Her, Z., Yong, K.S.M., Paramasivam, K., Tan, W.W.S., Chan, X.Y., Tan, S.Y., Liu, M., Fan, Y., Linn, Y.C., Hui, K.M., Surana, U., Chen, Q., 2017. An improved pre-clinical patient-derived liquid xenograft mouse model for acute myeloid leukemia. J Hematol Oncol 10, 162. [PMID: 28985760]
Hu S; Niu H; Inaba H; Orwick S; Rose C; Panetta JC; Yang S; Pounds S; Fan Y; Calabrese C; Rehg JE; Campana D; Rubnitz JE; Baker SD. 2011. Activity of the Multikinase Inhibitor Sorafenib in Combination With Cytarabine in Acute Myeloid Leukemia. J Natl Cancer Inst Jun 8;103(11):893-905. [PMID: 21487100]
Jacque N, Ronchetti AM, Larrue C, Meunier G, Birsen R, Willems L, Saland E, Decroocq J, Trovati Maciel T, Lambert M, Poulain L, Hospital MA, Sujobert P, Joseph L, Chapuis N, Lacombe C, Cruz Moura I, Demo S, Sarry JE, Recher C, Mayeux P, Tamburini J, Bouscary D. Targeting glutaminolysis has anti-leukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition. Blood. 2015 Jul 17. Epub ahead of print. [PMID: 26186940]
Jaiswal S; Jamieson CH; Pang WW; Park CY; Chao MP; Majeti R; Traver D; van Rooijen N; Weissman IL. 2009. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell Jul 23;138(2):271-85. [PMID: 19632178]
Johanna, I., Straetemans, T., Heijhuurs, S., Aarts-Riemens, T., Norell, H., Bongiovanni, L., de Bruin, A., Sebestyen, Z., Kuball, J., 2019. Evaluating in vivo efficacy - toxicity profile of TEG001 in humanized mice xenografts against primary human AML disease and healthy hematopoietic cells. J Immunother Cancer 7, 69. [PMID: 30871629 ]
Kannan S; Sutphin RM; Hall MG; Golfman LS; Fang W; Nolo RM; Akers LJ; Hammitt RA; McMurray JS; Kornblau SM; Melnick AM; Figueroa ME; Zweidler-McKay PA. 2013. Notch activation inhibits AML growth and survival: a potential therapeutic approach. J Exp Med Feb 11;210(2):321-37. [PMID: 23359069]
Kawahara M; Pandolfi A; Bartholdy B; Barreyro L; Will B; Roth M; Okoye-Okafor UC; Todorova TI; Figueroa ME; Melnick A; Mitsiades CS; Steidl U. 2012. H2.0-like Homeobox Regulates Early Hematopoiesis and Promotes Acute Myeloid Leukemia. Cancer Cell Aug 14;22(2):194-208. [PMID: 22897850]
Klco JM, Spencer DH, Miller CA, Griffith M, Lamprecht TL, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Fulton RS, Eades WC, Link DC, Graubert TA, Walter MJ, Mardis ER, Dipersio JF, Wilson RK, Ley TJ. 2014. Functional heterogeneity of genetically defined subclones in acute myeloid leukemia. Cancer Cell. 25(3):379–392. [PMID: 24613412]
Krevvata, M., Shan, X., Zhou, C., Dos Santos, C., Habineza Ndikuyeze, G., Secreto, A., Glover, J., Trotman, W., Brake-Silla, G., Nunez-Cruz, S., Wertheim, G., Ra, H.-J., Griffiths, E., Papachristou, C., Danet-Desnoyers, G., Carroll, M., 2018. Cytokines increase engraftment of human acute myeloid leukemia cells in immunocompromised mice but not engraftment of human myelodysplastic syndrome cells. Haematologica. [PMID: 29545344]
Labelle JL; Katz SG; Bird GH; Gavathiotis E; Stewart ML; Lawrence C; Fisher JK; Godes M; Pitter K; Kung AL; Walensky LD. 2012. A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. J Clin Invest Jun 1;122(6):2018-31. [PMID: 22622039]
Lagadinou ED; Sach A; Callahan K; Rossi RM; Neering SJ; Minhajuddin M; Ashton JM; Pei S; Grose V; O'Dwyer KM; Liesveld JL; Brookes PS; Becker MW; Jordan CT. 2013. BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells. Cell Stem Cell. Mar 7;12(3):329-41. [PMID: 23333149]
Leclerc, G.M., Zheng, S., Leclerc, G.J., DeSalvo, J., Swords, R.T., Barredo, J.C., 2016. The NEDD8-activating enzyme inhibitor pevonedistat activates the eIF2α and mTOR pathways inducing UPR-mediated cell death in acute lymphoblastic leukemia. Leuk. Res. 50, 1–10. doi:10.1016/j.leukres.2016.09.007. [PMID: 27626202]
Lee-Sherick AB; Eisenman KM; Sather S; McGranahan A; Armistead PM; McGary CS; Hunsucker SA; Schlegel J; Martinson H; Cannon C; Keating AK; Earp HS; Liang X; Deryckere D; Graham DK. 2013. Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia. Cytotherapy. [Epub ahead of print] [PMID: 23474756]
Madlambayan GJ; Bartee E; Kim M; Rahman MM; Meacham A; Scott EW; McFadden G; Cogle CR. 2012. Acute myeloid leukemia targeting by myxoma virus in vivo depends on cell binding but not permissiveness to infection in vitro. Leuk Res May;36(5):619-24. [PMID: 22341701]
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My ongoing research focuses on using systems Immunology-driven approaches to explore human aging and immune disorders including...
This two-day course will help emerging scientists equip themselves with the professional, interpersonal and communication skills that...
I am currently engaged in the investigation of the impact of mesenchymal lineage cells and immune-regulatory myeloid cells on adaptive...
Applying 3D genomic and computational approaches to investigate the profile of ecDNA-associated chromatin interactomes
In a new paper, Jennifer Trowbridge presents the factors and processes that contribute to Hematopoietic stem cells decline...
The development and providing of the cutting-edge Genome technologies methods for biomedical research.
Trowbridge has been recognized as an outstanding early-career scientist and will receive a $750,000 award.
I am interested in mammary tumors.