Breakthrough Research Using NSG ™ Mice

Aging

da Silva, P.F.L., Ogrodnik, M., Kucheryavenko, O., Glibert, J., Miwa, S., Cameron, K., Ishaq, A., Saretzki, G., Nagaraja-Grellscheid, S., Nelson, G., von Zglinicki, T., 2018. The bystander effect contributes to the accumulation of senescent cells in vivo. Aging Cell e12848. [PMID: 30462359]

Diabetes

Brehm MA; Powers AC; Shultz LD; Greiner DL. 2012. Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice. Cold Spring Harb Perspect Med May;2(5):a007757. [PMID: 22553498]
Buerck, L.W., Schuster, M., Oduncu, F.S., Baehr, A., Mayr, T., Guethoff, S., Abicht, J., Reichart, B., Klymiuk, N., Wolf, E., Seissler, J., 2017. LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy. Sci. Rep. 7, 3572. doi:10.1038/s41598-017-03913-4. [PMID: 28620237]
Dhawan S, Dirice E, Kulkarni RN, Bhushan A. Inhibition of TGF-beta signaling promotes human pancreatic beta cell replication. Diabetes. 2016 Mar 2. pii: db151331. [PMID: 26936960]
Friedline RH, Ko HJ, Jung DY, Lee Y, Bortell R, Dagdeviren S, Patel PR, Hu X, Inashima K, Kearns C, Tsitsilianos N, Shafiq U, Shultz LD, Lee KW, Greiner DL, Kim JK. Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance. FASEB J. 2015 Dec 7. pii: fj.15-280610. [PMID: 26644351]
Guo T; Landsman L; Li N; Hebrok M. 2013. Factors Expressed by Murine Embryonic Pancreatic Mesenchyme Enhance Generation of Insulin-Producing Cells From hESCs. Diabetes. May;62(5):1581-92. [PMID: 23305648]
Hickey RD; Galivo F; Schug J; Brehm MA; Haft A; Wang Y; Benedetti E; Gu G; Magnuson MA; Shultz LD; Lagasse E; Greiner DL; Kaestner KH; Grompe M. 2013. Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Res. Feb 18;11(1):503-515. [PMID: 23562832]
Huang, D., Wang, Y., Hawthorne, W.J., Hu, M., Hawkes, J., Burns, H., Davies, S., Gao, F., Chew, Y.V., Yi, S., O’Connell, P.J., 2017. Ex vivo-expanded baboon CD39 + regulatory T cells prevent rejection of porcine islet xenografts in NOD-SCID IL-2rγ(-/-) mice reconstituted with baboon peripheral blood mononuclear cells. Xenotransplantation. doi:10.1111/xen.12344. [PMID: 28963731]
King M; Pearson T; Shultz LD; Leif J; Bottino R; Trucco M; Atkinson MA; Wasserfall C; Herold KC; Woodland RT; Schmidt MR; Woda BA; Thompson MJ; Rossini AA; Greiner DL. 2008. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol. Mar;126(3):303-14. [PMID: 18096436]
King M; Pearson T; Rossini AA; Shultz LD; Greiner DL. 2008. Humanized mice for the study of type 1 diabetes and beta cell function. Ann N Y Acad Sci Dec;1150:46-53. [PMID: 19120266]
Klymiuk N; van Buerck L; Bähr A; Offers M; Kessler B; Wuensch A; Kurome M; Thormann M; Lochner K; Nagashima H; Herbach N; Wanke R; Seissler J; Wolf E. 2012. Xenografted Islet Cell Clusters From INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice. Diabetes Jun;61(6):1527-32. [PMID: 22522620]
Liu G; Dou S; Akalin A; Rusckowski M; Streeter PR; Shultz LD; Greiner DL. 2012. Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody. Nucl Med Biol Jul;39(5):645-51. [PMID: 22316614]
Min SY, Kady J, Nam M, Rojas-Rodriguez R, Berkenwald A, Kim JH, Noh HL, Kim JK, Cooper MP, Fitzgibbons T, Brehm MA, Corvera S. Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice. Nat Med. 2016 Jan 25. doi: 10.1038/nm.4031. [Epub ahead of print]. [PMID: 26808348]
Pearson T; Shultz LD; Lief J; Burzenski L; Gott B; Chase T; Foreman O; Rossini AA; Bottino R; Trucco M; Greiner DL. 2008. A new immunodeficient hyperglycaemic mouse model based on the Ins2 ( Akita ) mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia 51(8):1449-56. [PMID: 18563383]
Presa M, Chen YG, Grier AE, Leiter EH, Brehm MA, Greiner DL, Shultz LD, Serreze DV. The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice. J Immunol. 2015 Aug 17. [PMID: 26283479]
Serr I, Fürst RW, Achenbach P, Scherm MG, Gökmen F, Haupt F, Sedlmeier EM, Knopff A, Shultz L, Willis RA, Ziegler AG, Daniel C. 2016. Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice. Nat Commun. 2016 Mar 15;7:10991. [PMID: 26975663]
Shultz LD; Pearson T; King M; Giassi L; Carney L; Gott B; Lyons B; Rossini AA; Greiner DL. 2007. Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research. Ann N Y Acad Sci Apr;1103:77-89. Review. [PMID: 17332083]
Unger WW; Pearson T; Abreu JR; Laban S; van der Slik AR; der Kracht SM; Kester MG; Serreze DV; Shultz LD; Griffioen M; Drijfhout JW; Greiner DL; Roep BO. 2012. Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice. PLoS One. 7(11):e49213. [PMID: 23155466]
Whitfield-Larry F; Young EF; Talmage G; Fudge E; Azam A; Patel S; Largay J; Byrd W; Buse J; Calikoglu AS; Shultz LD; Frelinger JA. 2011. HLA-A2-Matched Peripheral Blood Mononuclear Cells From Type 1 Diabetic Patients, but not Nondiabetic Donors, Transfer Insulitis to NOD-scid/{gamma}cnull/HLA-A2 Transgenic Mice Concurrent With the Expansion of Islet-Specific CD8+ T cells. Diabetes Jun;60(6):1726-33. [PMID: 21521873]
Wolf-van Buerck L, Schuster M, Baehr A, Mayr T, Guethoff S, Abicht J, Reichart B, Nam-Apostolopoulos YC, Klymiuk N, Wolf E, Seissler J. Engraftment and reversal of diabetes after intramuscular transplantation of neonatal porcine islet-like clusters. Xenotransplantation. 2015 Oct 21. [PMID: 26490671]
Yi S; Ji M; Wu J; Ma X; Phillips P; Hawthorne WJ; O'Connell PJ. 2012. Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice. Diabetes May;61(5):1180-91. [PMID: 22403295]
Zhao Y; Guo C; Hwang D; Lin B; Dingeldein M; Mihailescu D; Sam S; Sidhwani S; Zhang Y; Jain S; Skidgel RA; Prabhakar BS; Mazzone T; Holterman MJ. 2010. Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model. Biochem Biophys Res Commun Sep 3;399(4):629-36. [PMID: 20691153]

Hematological Cancers

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Acute megakaryocytic leukemia (AMKL)

Thiollier C; Lopez CK; Gerby B; Ignacimouttou C; Poglio S; Duffourd Y; Guégan J; Rivera-Munoz P; Bluteau O; Mabialah V; Diop M; Wen Q; Petit A; Bauchet AL; Reinhardt D; Bornhauser B; Gautheret D; Lecluse Y; Landman-Parker J; Radford I; Vainchenker W; Dastugue N; de Botton S; Dessen P; Bourquin JP; Crispino JD; Ballerini P; Bernard OA; Pflumio F; Mercher T. 2012. Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models. J Exp Med. Oct 22;209(11):2017-31. [PMID: 23045605]
Wen Q; Goldenson B; Silver SJ; Schenone M; Dancik V; Huang Z; Wang LZ; Lewis TA; An WF; Li X; Bray MA; Thiollier C; Diebold L; Gilles L; Vokes MS; Moore CB; Bliss-Moreau M; Verplank L; Tolliday NJ; Mishra R; Vemula S; Shi J; Wei L; Kapur R; Lopez CK; Gerby B; Ballerini P; Pflumio F; Gilliland DG; Goldberg L; Birger Y; Izraeli S; Gamis AS; Smith FO; Woods WG; Taub J; Scherer CA; Bradner JE; Goh BC; Mercher T; Carpenter AE; Gould RJ; Clemons PA; Carr SA; Root DE; Schreiber SL; Stern AM; Crispino JD. 2012. Identification of Regulators of Polyploidization Presents Therapeutic Targets for Treatment of AMKL. Cell Aug 3;150(3):575-89. [PMID: 22655268]

Acute myeloid leukemia (AML)

Aigner, P., Mizutani, T., Horvath, J., Eder, T., Heber, S., Lind, K., Just, V., Moll, H.P., Yeroslaviz, A., Fischer, M.J.M., Kenner, L., Győrffy, B., Sill, H., Grebien, F., Moriggl, R., Casanova, E., Stoiber, D., 2019. STAT3β is a tumor suppressor in acute myeloid leukemia. Blood Adv 3, 1989–2002. [PMID: 31270081]
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Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer 123(9):2222-7. [PMID: 18688847]
Alberich-Jordà M; Wouters B; Balastik M; Shapiro-Koss C; Zhang H; Diruscio A; Radomska HS; Ebralidze AK; Amabile G; Ye M; Zhang J; Lowers I; Avellino R; Melnick A; Figueroa ME; Valk PJ; Delwel R; Tenen DG. 2012. C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia. J Clin Invest. Dec 3;122(12):4490-504. [PMID: 23160200]
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Bonnet, D., 2017. Acute myeloid leukemia including favorable-risk group samples engraft in NSG mice: just be patient. Haematologica 102, 805–806. doi:10.3324/haematol.2017.165159. [PMID: 28458252]
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Acute lymphoblastic leukemia (ALL)

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Leclerc, G.M., Zheng, S., Leclerc, G.J., DeSalvo, J., Swords, R.T., Barredo, J.C., 2016. The NEDD8-activating enzyme inhibitor pevonedistat activates the eIF2α and mTOR pathways inducing UPR-mediated cell death in acute lymphoblastic leukemia. Leuk. Res. 50, 1–10. doi:10.1016/j.leukres.2016.09.007. [PMID: 27626202]
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Mangolini M; de Boer J; Walf-Vorderwülbecke V; Pieters R; den Boer ML; Williams O. 2013. STAT3 mediates oncogenic addiction to TEL-AML1 in t(12;21) acute lymphoblastic leukemia. Blood. Jul 25;122(4):542-9.[PMID: 23741012]
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Müller, F., Cunningham, T., Stookey, S., Tai, C.-H., Burkett, S., Jailwala, P., Stetler Stevenson, M., Cam, M.C., Wayne, A.S., Pastan, I., 2018. 5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox. Proc. Natl. Acad. Sci. U.S.A. 115, E1867–E1875. [PMID: 29432154]
Parameswaran R; Lim M; Arutyunyan A; Abdel-Azim H; Hurtz C; Lau K; Müschen M; Yu RK; von Itzstein M; Heisterkamp N; Groffen J. 2013. O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia. J Exp Med. Apr 8;210(4):805-19. [PMID: 23478187]
Park E; Gang EJ; Hsieh YT; Schaefer P; Chae S; Klemm L; Huantes S; Loh M; Conway EM; Kang ES; Koo HH; Hofmann WK; Heisterkamp N; Pelus L; Keerthivasan G; Crispino J; Kahn M; Müschen M; Kim YM. 2011. Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia. Blood Aug 25;118(8):2191-9. [PMID: 21715311]
Rehe K; Wilson K; Bomken S; Williamson D; Irving J; den Boer ML; Stanulla M; Schrappe M; Hall AG; Heidenreich O; Vormoor J. 2013. Acute B lymphoblastic leukaemia-propagating cells are present at high frequency in diverse lymphoblast populations. EMBO Mol Med. Jan;5(1):38-51. [PMID: 23229821]
Roberts KG; Morin RD; Zhang J; Hirst M; Zhao Y; Su X; Chen SC; Payne-Turner D; Churchman ML; Harvey RC; Chen X; Kasap C; Yan C; Becksfort J; Finney RP; Teachey DT; Maude SL; Tse K; Moore R; Jones S; Mungall K; Birol I; Edmonson MN; Hu Y; Buetow KE; Chen IM; Carroll WL; Wei L; Ma J; Kleppe M; Levine RL; Garcia-Manero G; Larsen E; Shah NP; Devidas M; Reaman G; Smith M; Paugh SW; Evans WE; Grupp SA; Jeha S; Pui CH; Gerhard DS; Downing JR; Willman CL; Loh M; Hunger SP; Marra MA; Mullighan CG. 2012. Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. Cancer Cell. Aug 14;22(2):153-66. [PMID: 22897847]
Roti G; Carlton A; Ross KN; Markstein M; Pajcini K; Su AH; Perrimon N; Pear WS; Kung AL; Blacklow SC; Aster JC; Stegmaier K. 2013. Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer. Cancer Cell. Mar 18;23(3):390-405 [PMID: 23434461]
Schewe, D.M., Alsadeq, A., Sattler, C., Lenk, L., Vogiatzi, F., Cario, G., Vieth, S., Valerius, T., Rosskopf, S., Meyersieck, F., Alten, J., Schrappe, M., Gramatzki, M., Peipp, M., Kellner, C., 2017. An Fc engineered CD19 antibody eradicates MRD in patient-derived MLL-rearranged acute lymphoblastic leukemia xenografts. Blood. doi:10.1182/blood-2017-01-764316. [PMID: 28698205]
Schmitz M; Breithaupt P; Scheidegger N; Cario G; Bonapace L; Meissner B; Mirkowska P; Tchinda J; Niggli FK; Stanulla M; Schrappe M; Schrauder A; Bornhauser BC; Bourquin JP. 2011. Xenografts of highly resistant leukemia recapitulate the clonal composition of the leukemogenic compartment. Blood Aug 18;118(7):1854-64. [PMID: 21670474]
Seif AE; Barrett DM; Milone M; Brown VI; Grupp SA; Reid GS. 2009. Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses. Blood Sep 17;114(12):2459-66. [PMID: 19636062]
Watanabe, A., Inukai, T., Kagami, K., Abe, M., Takagi, M., Fukushima, T., Fukushima, H., Nanmoku, T., Terui, K., Ito, T., Toki, T., Ito, E., Fujimura, J., Goto, H., Endo, M., Look, T., Kamps, M., Minegishi, M., Takita, J., Inaba, T., Takahashi, H., Ohara, A., Harama, D., Shinohara, T., Somazu, S., Oshiro, H., Akahane, K., Goi, K., Sugita, K., 2019. Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy. Cancer Med. [PMID: 31305009]
Weigert O; Lane AA; Bird L; Kopp N; Chapuy B; van Bodegom D; Toms AV; Marubayashi S; Christie AL; McKeown M; Paranal RM; Bradner JE; Yoda A; Gaul C; Vangrevelinghe E; Romanet V; Murakami M; Tiedt R; Ebel N; Evrot E; De Pover A; Régnier CH; Erdmann D; Hofmann F; Eck MJ; Sallan SE; Levine RL; Kung AL; Baffert F; Radimerski T; Weinstock DM. 2012. Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. J Exp Med Feb 13;209(2):259-73. [PMID: 22271575]
Woiterski J; Ebinger M; Witte KE; Goecke B; Heininger V; Philippek M; Bonin M; Schrauder A; Röttgers S; Herr W; Lang P; Handgretinger R; Hartwig UF; André MC. 2013. Engraftment of low numbers of pediatric acute lymphoid and myeloid leukemias into NOD/SCID/IL2Rcγnull mice reflects individual leukemogenecity and highly correlates with clinical outcome. Int J. Cancer. Oct 1;133(7):1547-56. [PMID: 23526331]

Chronic lymphocytic leukemia (CLL)

Bagnara D; Kaufman MS; Calissano C; Marsilio S; Patten P; Simone R; Chum P; Yan XJ; Allen SL; Kolitz JE; Baskar S; Rader C; Mellstedt H; Rabbani H; Lee A; Gregersen PK; Rai KR; Chiorazzi N. 2011. A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease. Blood May 19;117(20):5463-72. [PMID: 21385850]
Chang DK, Kurella VB, Biswas S, Avnir Y, Sui J, Wang X, Sun J, Wang Y, Panditrao M, Peterson E, Tallarico A, Fernandes S, Goodall M, Zhu Q, Brown JR, Jefferis R, Marasco WA. 2016. Humanized mouse G6 anti-idiotypic monoclonal antibody has therapeutic potential against IGHV1-69 germline gene-based B-CLL. MAbs. 2016 Mar 10:0. [PMID: 2696373]
Cutrona, G., Matis, S., Colombo, M., Massucco, C., Baio, G., Valdora, F., Emionite, L., Fabris, S., Recchia, A.G., Gentile, M., Neumaier, C.E., Reverberi, D., Massara, R., Boccardo, S., Basso, L., Salvi, S., Rosa, F., Cilli, M., Zupo, S., Truini, M., Tassone, P., Calabrese, M., Negrini, M., Neri, A., Morabito, F., Fais, F., Ferrarini, M., 2017. Effects of miRNA-15 and miRNA-16 expression replacement in chronic lymphocytic leukemia: Implication for therapy. Leukemia. doi:10.1038/leu.2016.394. [PMID: 28053325]
Decker WK; Shah N; Xing D; Lapushin R; Li S; Robinson SN; Yang H; Parmar S; Halpert MM; Keating MJ; Gribben JG; Molldrem JJ; Shpall EJ; Wierda WG. 2012. Generation of Functional CLL-Specific Cord Blood CTL Using CD40-Ligated CLL APC. PLoS One. 7(12):e51390. [PMID: 23284688]
Herman SE; Sun X; McAuley EM; Hsieh MM; Pittaluga S; Raffeld M; Liu D; Keyvanfar K; Chapman CM; Chen J; Buggy JJ; Aue G; Tisdale JF; Pérez-Galán P; Wiestner A. 2013. Modeling tumor-host interactions of chronic lymphocytic leukemia in xenografted mice to study tumor biology and evaluate targeted therapy. Leukemia. [Epub ahead of print] [PMID:23619564]
Herman, S.E.M., Montraveta, A., Niemann, C.U., Mora-Jensen, H., Gulrajani, M., Krantz, F., Mantel, R., Smith, L.L., McClanahan, F., Harrington, B.K., Colomer, D., Covey, T., Byrd, J.C., Izumi, R., Kaptein, A., Ulrich, R., Johnson, A.J., Lannutti, B.J., Wiestner, A., Woyach, J.A., 2017. The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. 23, 2831–2841. doi:10.1158/1078-0432.CCR-16-0463. [PMID:27903679]
Kaucka M; Plevova K; Pavlova S; Janovska P; Mishra A; Verner J; Prochazkova J; Krejci P; Kotaskova J; Ovesna P; Tichy B; Brychtova Y; Doubek M; Kozubik A; Mayer J; Pospisilova S; Bryja V. 2013. The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration. Cancer Res. Mar 1;73(5):1491-501. [PMID: 23338609]
Kellner J, Wierda W, Shpall E, Keating M, McNiece I. Isolation of a novel chronic lymphocytic leukemic (CLL) cell line and development of an in vivo mouse model of CLL. Leuk Res. 2016 Jan;40:54-9. doi: 10.1016/j.leukres.2015.10.008. [PMID: 26601610]
Kikushige Y; Ishikawa F; Miyamoto T; Shima T; Urata S; Yoshimoto G; Mori Y; Iino T; Yamauchi T; Eto T; Niiro H; Iwasaki H; Takenaka K; Akashi K. 2011. Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell Aug 16;20(2):246-59. [PMID: 21840488]
Marini, C., Bruno, S., Fiz, F., Campi, C., Piva, R., Cutrona, G., Matis, S., Nieri, A., Miglino, M., Ibatici, A., Maria Orengo, A., Maria Massone, A., Neumaier, C.E., Totero, D. de, Giannoni, P., Bauckneht, M., Pennone, M., Tenca, C., Gugiatti, E., Bellini, A., Borra, A., Tedone, E., Efetürk, H., Rosa, F., Emionite, L., Cilli, M., Bagnara, D., Brucato, V., Bruzzi, P., Piana, M., Fais, F., Sambuceti, G., 2017. Functional Activation of Osteoclast Commitment in Chronic Lymphocytic Leukaemia: a Possible Role for RANK/RANKL Pathway. Sci Rep 7, 14159. [PMID: 29074954]
Matas-Céspedes, A., Vidal-Crespo, A., Rodriguez, V., Villamor, N., Delgado, J., Giné, E., Roca-Ho, H., Menéndez, P., Campo, E., López-Guillermo, A., Colomer, D., Roué, G., Wiestner, A., Parren, P.W.H.I., Doshi, P., van Bueren, J.L., Pérez-Galán, P., 2017. The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia-Microenvironment Interactions in Chronic Lymphocytic Leukemia. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. 23, 1493–1505. [PMID: 27637890]
Os A; Bürgler S; Ribes AP; Funderud A; Wang D; Thompson KM; Tjønnfjord GE; Bogen B; Munthe LA. 2013. Chronic Lymphocytic Leukemia Cells Are Activated and Proliferate in Response to Specific T Helper Cells. Cell Rep. Aug 15;4(3):566-77. [PMID: 23933259]
Verner J; Trbusek M; Chovancova J; Jaskova Z; Moulis M; Folber F; Halouzka R; Mayer J; Pospisilova S; Doubek M. NOD/SCID IL2Rγ-null mouse xenograft model of human p53-mutated chronic lymphocytic leukemia and ATM-mutated mantle cell lymphoma using permanent cell lines. Leuk Lymphoma. 2015 Apr 1. Epub ahead of print. [PMID: 25827173]
Wong K; Brenneman F; Chesney A; Spaner DE; Gorczynski RM. 2012. Soluble CD200 is critical to engraft Chronic Lymphocytic Leukemia cells in immunocompromised mice. Cancer Res. Oct 1;72(19):4931-43. [PMID: 22875025]
Zhu, F., Khatri, I., Spaner, D., Gorczynski, R.M., 2018. An autologous tumor vaccine for CLL. Leuk. Res. 68, 40–47. [PMID: 29525600]

Chronic myeloid leukemia (CML)

Chen M; Gallipoli P; Degeer D; Sloma I; Forrest DL; Chan M; Lai D; Jorgensen H; Ringrose A; Wang HM; Lambie K; Nakamoto H; Saw KM; Turhan A; Arlinghaus R; Paul J; Stobo J; Barnett MJ; Eaves A; Eaves CJ; Holyoake TL; Jiang X. 2013. Targeting Primitive Chronic Myeloid Leukemia Cells by Effective Inhibition of a New AHI-1-BCR-ABL-JAK2 Complex. J Natl Cancer Inst. Mar 20;105(6):405-23. [PMID: 23446755]
Heaney NB; Pellicano F; Zhang B; Crawford L; Chu S; Kazmi SM; Allan EK; Jorgensen HG; Irvine AE; Bhatia R; Holyoake TL. 2010. Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells. Blood Mar 18;115(11):2241-50. [PMID: 20068223]
Herrmann H; Sadovnik I; Cerny-Reiterer S; Rülicke T; Stefanzl G; Willmann M; Hoermann G; Bilban M; Blatt K; Herndlhofer S; Mayerhofer M; Streubel B; Sperr WR; Holyoake TL; Mannhalter C; Valent P. 2014. Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia. Blood. Jun 19; 123(25):3951-62. [PMID:24778155]
Irvine DA, Zhang B, Kinstrie R, Tarafdar A, Morrison H, Campbell VL, Moka HA, Ho Y, Nixon C, Manley PW, Wheadon H, Goodlad JR, Holyoake TL, Bhatia R, Copland M. 2016. Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Sci Rep. 2016 May 9;6:25476. doi: 10.1038/srep25476. [PMID: 27157927]
Li L; Wang L; Li L; Wang Z; Ho Y; McDonald T; Holyoake TL; Chen W; Bhatia R. 2012. Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell Feb 14;21(2):266-81. [PMID: 22340598]
Neviani P; Harb JG; Oaks JJ; Santhanam R; Walker CJ; Ellis JJ; Ferenchak G; Dorrance AM; Paisie CA; Eiring AM; Ma Y; Mao HC; Zhang B; Wunderlich M; May PC; Sun C; Saddoughi SA; Bielawski J; Blum W; Klisovic RB; Solt JA; Byrd JC; Volinia S; Cortes J; Huettner CS; Koschmieder S; Holyoake TL; Devine S; Caligiuri MA; Croce CM; Garzon R; Ogretmen B; Arlinghaus RB; Chen CS; Bittman R; Hokland P; Roy DC; Milojkovic D; Apperley J; Goldman JM; Reid A; Mulloy JC; Bhatia R; Marcucci G; Perrotti D. 2013. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. J Clin Invest. [Epub ahead of print] [PPMID: 23999433]
Sloma I; Jang X; Eaves AC; Eaves CJ. 2010. Insights into the stem cells of chronic myeloid leukemia. Leukemia Review Nov;24(11):1823-33 [PMID: 20861912]
Sloma I; Beer PA; Saw KM; Chan M; Leung D; Raghuram K; Brimacombe C; Johnston B; Lambie K; Forrest D; Jiang X; Eaves CJ. 2013. Genotypic and functional diversity of phenotypically defined primitive hematopoietic cells in patients with chronic myeloid leukemia. Exp Hematol. [Epub ahead of print] [PMID: 23851302]
Steinman RA; Yang Q; Gasparetto M; Robinson LJ; Liu X; Lenzner DE; Hou J; Smith C; Wang Q. 2012. Deletion of the RNA-editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in mice. Int J Cancer. Apr 15;132(8):1741-50. [PMID: 22987615]
Willmann, M., Sadovnik, I., Eisenwort, G., Entner, M., Bernthaler, T., Stefanzl, G., Hadzijusufovic, E., Berger, D., Herrmann, H., Hoermann, G., Valent, P., Rülicke, T., 2017. Evaluation of cooperative anti-leukemic effects of nilotinib and vildagliptin in Ph(+) chronic myeloid leukemia. Exp. Hematol. [PMID: 29031704]
Zhang B; Strauss AC; Chu S; Li M; Ho Y; Shiang K.-D; Snyder D.S; Huettner, C.S; Shultz L; Holyoake T; Bhatia, R. 2010. Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate. Cancer Cell May 18;17(5):427-42. [PMID: 20478526]
Zhang B; Li M; McDonald T; Holyoake TL; Moon RT; Campana D; Shultz L; Bhatia R. 2013. Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-Cadherin and Wnt-β-catenin signaling. Blood. Mar 7;121(10):1824-38. [PMID: 23299311]
Zhao Y, Masiello D, McMillian M, Nguyen C, Wu Y, Melendez E, Smbatyan G, Kida A, He Y, Teo JL, Kahn M. CBP/catenin antagonist safely eliminates drug-resistant leukemia-initiating cells. Oncogene. 2015 Dec 14. doi: 10.1038/onc.2015.438. [PMID: 26657156]

Leukemia: Other

Agliano A; Martin-Padura I; Marighetti P; Calleri A; Prior C; Redrado M; Calvo A; Bertolini F. 2011. Therapeutic effect of Lenalidomide in a novel xenograft mouse model of human Blastic NK cell lymphoma/blastic plasmacytoid dendritic cell neoplasm. Clin Cancer Res. Oct 1;17(19):6163-73. [PMID: 21856771]
Andre MC, Witte KE, Hoerrmann RA, Schmitt A, Handgretinger R, Ebinger M. Hoechst 33342 Staining Identifies the Progenitor Side Population in NOD.Cg-PrkdcscidIL2rgtmWjl/Sz Mice Harboring Pediatric Leukemias. In Vivo. 2015 11-12;29(6):661-669. [PMID: 26546522]
Borkin D; He S; Miao H; Kempinska K; Pollock J; Chase J; Purohit T; Malik B; Zhao T; Wang J; Wen B; Zong H; Jones M; Danet-Desnoyers G; Guzman ML; Talpaz M; Bixby DL; Sun D; Hess JL; Muntean AG; Maillard I; Cierpicki T; Grembecka J. Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo. Cancer Cell. 2015 Mar 25. Epub ahead of print. [PMID: 25817203]
Daigle SR; Olhava EJ; Therkelsen CA; Majer CR; Sneeringer CJ; Song J; Johnston LD; Scott MP; Smith JJ; Xiao Y; Jin L; Kuntz KW; Chesworth R; Moyer MP; Bernt KM; Tseng JC; Kung AL; Armstrong SA; Copeland RA; Richon VM; Pollock RM. 2011. Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor. Cancer Cell Jul 12;20(1):53-65. [PMID: 21741596]
Gunasekara, D.C., Zheng, M.M., Mojtahed, T., Woods, J.R., Fandy, T.E., Riofski, M.V., Glackin, C.A., Hassan, H.E., Kirshner, J., Colby, D.A., 2016. 15-Methylene-Eburnamonine Kills Leukemic Stem Cells and Reduces Engraftment in a Humanized Bone Marrow Xenograft Mouse Model of Leukemia. ChemMedChem. doi:10.1002/cmdc.201600334 PMID: 27677525
Hatcher CL, Mott TM, Muruato LA, Sbrana E, Torres AG. Burkholderia mallei CLH001 attenuated vaccine strain is immunogenic and protects against acute respiratory glanders. Infect Immun. 2016 Jun 6. pii: IAI.00328-16. [PMID: 27271739]
Huey, D.D., Bolon, B., La Perle, K.M.D., Kannian, P., Jacobson, S., Ratner, L., Green, P.L., Niewiesk, S., 2018. Role of Wild-type and Recombinant Human T-cell Leukemia Viruses in Lymphoproliferative Disease in Humanized NSG Mice. Comp. Med. 68, 4–14. [PMID: 29460716]
Kovacic B; Hoelbl A; Litos G; Alacakaptan M; Schuster C; Fischhuber KM; Kerenyi MA; Stengl G; Moriggl R; Sexl V; Beug H. 2012. Diverging fates of cells of origin in acute and chronic leukaemia. EMBO Mol Med Apr;4(4):283-97. [PMID: 22323443]
Leiva-Juárez MM, Ware HH, Kulkarni VV, Zweidler-McKay PA, Tuvim MJ, Evans SE. 2016. Inducible epithelial resistance protects mice against leukemia-associated pneumonia. Blood. Jun 17. pii: blood-2016-03-708511. [PMID: 27317793]
Meyer LH; Debatin KM. 2011. Diversity of human leukemia xenograft mouse models: implications for disease biology. Cancer Res Dec 1;71(23):7141-4. Review. [PMID: 22088964]
Montes R; Ayllón; Gutierrez-Aranda I; Prat I; Hernandez-Lamas MC; Ponce L; Bresolin S; Te Kronnie G; Greaves M; Bueno C; Menendez P. 2011. Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia. Blood May 5;117(18):4746-58. [PMID: 21389315]
O'Callaghan K; Lee L; Nguyen N; Hsieh MY; Kaneider NC; Klein AK; Sprague K; Van Etten RA; Kuliopulos A; Covic L. 2012. Targeting CXCR4 with cell-penetrating pepducins in lymphoma and lymphocytic leukemia. Blood Feb 16;119(7):1717-25. [PMID: 22186993]
Rhyasen GW; Bolanos L; Fang J; Jerez A; Wunderlich M; Rigolino C; Mathews L; Ferrer M; Southall N; Guha R; Keller J; Thomas C; Beverly LJ; Cortelezzi A; Oliva EN; Cuzzola M; Maciejewski JP; Mulloy JC; Starczynowski DT. 2013. Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome. Cancer Cell. Jul 8;24(1):90-104. [PMID: 23845443]
Sontakke P, Carretta M, Jaques J, Brouwers-Vos AZ, Lubbers-Aalders L, Yuan H, de Bruijn JD, Martens AC, Vellenga E, Groen RW, Schuringa JJ. Modeling BCR-ABL and MLL-AF9 leukemia in a human bone marrow-like scaffold-based xenograft model. Leukemia. 2016 May 17. doi: 10.1038/leu.2016.108. [PMID: 27125308]
Tirado-Gonzalez, I., Czlonka, E., Nevmerzhitskaya, A., Soetopo, D., Bergonzani, E., Mahmoud, A., Contreras, A., Jeremias, I., Platzbecker, U., Bourquin, J.P., Kloz, U., Van der Hoeven, F., Medyouf, H., 2017. CRISPR/Cas9 edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC. Leukemia. [PMID: 29209043]

Lymphoma

Arita K; Maeda-Kasugai Y; Ohshima K; Tsuzuki S; Suguro-Katayama M; Karube K; Yoshida N; Sugiyama T; Seto M. 2013. Generation of mouse models of lymphoid neoplasm using retroviral gene transduction of in vitro-induced germinal center B and T cells. Exp Hematol. Aug;41(8):731-741. [PMID: 23583576]
Birkenmeier K, Moll K, Newrzela S, Hartmann S, Dröse S, Hansmann ML. 2016. Basal autophagy is pivotal for Hodgkin and Reed-Sternberg cells' survival and growth revealing a new strategy for Hodgkin lymphoma treatment. Oncotarget. Jun 27. doi: 10.18632/oncotarget.10300. [PMID: 27366944]
Boss IW; Nadeau PE; Abbott JR; Yang Y; Mergia A; Renne R. 2011. A KSHV encoded ortholog of miR-155 induces human splenic B-cell expansion in NOD/LtSz-scid IL2R{gamma}null mice. J Virol. Oct;85(19):9877-86. [PMID: 21813606]
Christoph S; Schlegel J; Alvarez-Calderon F; Kim YM; Brandao LN; Deryckere D; Graham DK. 2013. Bioluminescence imaging of leukemia cell lines in vitro and in mouse xenografts: effects of monoclonal and polyclonal cell populations on intensity and kinetics of photon emission. J Hematol Oncol. Jan 23;6:10. [PMID: 23343252]
Chu, Y., Lee, S., Shah, T., Yin, C., Barth, M., Miles, R.R., Ayello, J., Morris, E., Harrison, L., Van de Ven, C., Galardy, P., Goldman, S.C., Lim, M.S., Hermiston, M., McAllister-Lucas, L.M., Giulino-Roth, L., Perkins, S.L., Cairo, M.S., 2019. Ibrutinib significantly inhibited Bruton's tyrosine kinase (BTK) phosphorylation,in-vitro proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model. Oncoimmunology 8, e1512455. [PMID: 30546948]
Deutsch, A.J., Rinner, B., Pichler, M., Troppan, K., Pansy, K., Bischof, M., Fechter, K., Hatzl, S., Feichtinger, J., Wenzl, K., Frisch, M.-T., Stiegelbauer, V., Prokesch, A., Krogsdam, A.M., Sill, H., Thallinger, G.G., Greinix, H.T., Wang, C., Beham-Schmid, C., Neumeister, P., 2017. NR4A3 suppresses lymphomagenesis through induction of pro-apoptotic genes. Cancer Res. [PMID: 28249906]
Kittipongdaja W; Wu X; Garner J; Liu X; Komas SM; Hwang ST; Schieke SM. Rapamycin Suppresses Tumor Growth and Alters the Metabolic Phenotype in T-Cell Lymphoma. J Invest Dermatol. 2015. doi: 10.1038/jid.2015.153. [Epub ahead of print. [PMID: 25897830]
Luster TA; Mukherjee I; Carrell JA; Cho YH; Gill J; Kelly L; Garcia A; Ward C; Oh L; Ullrich SJ; Migone TS; Humphreys R. 2012. Fusion Toxin BLyS-Gelonin Inhibits Growth of Malignant Human B Cell Lines In Vitro and In Vivo. PLoS One. 7(10):e47361. [PMID: 23056634]
Manfè V; Biskup E; Willumsgaard A; Skov AG; Palmieri D; Gasparini P; Laganá A; Woetmann A; Odum N; Croce CM; Gniadecki R. 2013. cMyc/miR-125b-5p Signaling Determines Sensitivity to Bortezomib in Preclinical Model of Cutaneous T-Cell Lymphomas. PLoS One. 8(3):e59390. [PMID: 23527180]
M’kacher, R., Frenzel, M., Al Jawhari, M., Junker, S., Cuceu, C., Morat, L., Bauchet, A.-L., Stimmer, L., Lenain, A., Dechamps, N., Hempel, W.M., Pottier, G., Heidingsfelder, L., Laplagne, E., Borie, C., Oudrhiri, N., Jouni, D., Bennaceur-Griscelli, A., Colicchio, B., Dieterlen, A., Girinsky, T., Boisgard, R., Bourhis, J., Bosq, J., Mehrling, T., Jeandidier, E., Carde, P., 2018. Establishment and Characterization of a Reliable Xenograft Model of Hodgkin Lymphoma Suitable for the Study of Tumor Origin and the Design of New Therapies. Cancers (Basel) 10. [PMID: 30384446]
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Non-Hodgkin Lymphoma

Ayello, J., Hochberg, J., Flower, A., Chu, Y., Baxi, L.V., Quish, W., van de Ven, C., Cairo, M.S., 2016. Genetically re-engineered K562 cells significantly expand and functionally activate cord blood natural killer cells: Potential for adoptive cellular immunotherapy. Exp. Hematol. doi:10.1016/j.exphem.2016.10.003. [PMID: 27765614]
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Mastocytoma

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Multiple Myeloma

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Myelodysplastic Syndrome

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Humanized NSG References

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Immunology

Humanized immune system: hematopoiesis and stem cell engraftment

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Humanized immune system: T cell function

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Humanized immune system: B cell function

Cantaert T, Schickel JN, Bannock JM, Ng YS, Massad C, Oe T, Wu R, Lavoie A, Walter JE, Notarangelo LD, Al-Herz W, Kilic SS, Ochs HD, Nonoyama S, Durandy A, Meffre E. Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance. Immunity. 2015 Nov 2. [PMID: 26546282]
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Ishikawa Y; Usui T; Shiomi A; Shimizu M; Murakami K; Mimori T. 2014. Functional engraftment of human peripheral T and B cells and sustained production of autoantibodies in NOD/LtSzscid/IL-2Rγ(-/-) mice. Eur J Immunol. Nov;44(11):3453-63. [PMID: 25154613]
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Humanized immune system: myeloerythroid lineages

Chen P, Huang Y, Womer KL. Effects of mesenchymal stromal cells on human myeloid dendritic cell differentiation and maturation in a humanized mouse model. J Immunol Methods. 2015 Oct 30. [PMID: 26522667]
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Coughlan AM; Freeley SJ; Robson MG. 2012. Humanised mice have functional human neutrophils. J Immunol Methods. Nov 30;385(1-2):96-104 [PMID: 22917930]
de Graaff MA, Yu JS, Beird HC, Ingram DR, Nguyen T, Juehui Liu J, Bolshakov S, Szuhai K, Åman P, Torres KE, Lev D, Nielsen TO, Bovée JV, Lazar AJ, Somaiah N. 2016. Establishment and characterization of a new human myxoid liposarcoma cell line (DL-221) with the FUS-DDIT3 translocation. Lab Invest. Jun 6. doi: 10.1038/labinvest.2016.64. [Epub ahead of print] [PMID: 27270875]
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Hu Z; Van Rooijen N; Yang YG. 2011. Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood Nov 24;118(22):5938-46. [PMID: 21926352]
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Kundu, K., Ghosh, S., Sarkar, R., Edri, A., Brusilovsky, M., Gershoni-Yahalom, O., Yossef, R., Shemesh, A., Soria, J.-C., Lazar, V., Joshua, B.-Z., S Campbell, K., Elkabets, M., Porgador, A., 2019. Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA. Cancer Immunol Res. [PMID: 31164357]
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Meixlsperger S; Leung CS; Rämer PC; Pack M; Vanoaica LD; Breton G; Pascolo S; Salazar AM; Dzionek A; Schmitz J; Steinman RM; Münz C. 2013. CD141+ dendritic cells produce prominent amounts of IFN-α after dsRNA recognition and can be targeted via DEC-205 in humanized mice. Blood. Jun 20;121(25):5034-44. [PMID: 23482932]
Miller PH; Cheung AM; Beer PA; Knapp DJ; Dhillon K; Rabu G; Rostamirad S; Humphries RK; Eaves CJ. 2013. Enhanced normal short term human myelopoiesis in mice engineered to express human-specific myeloid growth factors. Blood. Jan 31;121(5):e1-4. [PMID: 23233660]
Parekh C; Sahaghian A; Kim W; Scholes J; Ge S; Zhu Y; Asgharzadeh S; Hollis R; Kohn D; Ji L; Malvar J; Wang X; Crooks G. 2012. Novel pathways to erythropoiesis induced by dimerization of intracellular C-mpl in human hematopoietic progenitors. Stem Cells Apr;30(4):697-708. [PMID: 22290824]
Shin JW; Swift J; Spinler KR; Discher DE. 2011. Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes. Proc Natl Acad Sci U S A. Jul 12;108(28):11458-63. [PMID: 21709232]
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Tanaka S; Saito Y; Kunisawa J; Kurashima Y; Wake T; Suzuki N; Shultz LD; Kiyono H; Ishikawa F. 2012. Development of Mature and Functional Human Myeloid Subsets in Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2rγKO Mice. J Immunol. Jun 15;188(12):6145-55 [PMID: 22611244]
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NSG as a superior host for human immune system components

Brehm MA; Cuthbert A; Yang C; Miller DM; DiIorio P; Laning J; Burzenski L; Gott B; Foreman O; Kavirayani A; Herlihy M; Rossini AA; Shultz LD; Greiner DL. 2010. Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clin Immunol Apr;135(1):84-98. [PMID: 20096637]
Carpenter RS, Kigerl KA, Marbourg JM, Gaudet AD, Huey D, Niewiesk S, Popovich PG. Traumatic spinal cord injury in mice with human immune systems. Exp Neurol. 2015 Jul 17;271:432-444. Epub ahead of print. [PMID: 26193167]
Carriglio, N., Klapwijk, J., Hernandez, R.J., Vezzoli, M., Chanut, F., Lowe, R., Elena, D., Nord, M., Albertini, P., Cristofori, P., Richards, J., Staton, H., Appleby, J., Aiuti, A., Sauer, A.V., 2017. Good Laboratory Practice Preclinical Safety Studies for GSK2696273 (MLV Vector-Based Ex Vivo Gene Therapy for Adenosine Deaminase Deficiency Severe Combined Immunodeficiency) in NSG Mice. Hum. Gene Ther. Clin. Dev. 28, 17–27. [PMID: 28319446]
Durost, P., Aryee, K.-E., Manzoor, F., Tisch, R., Mueller, C., Jurczyk, A., Shultz, L., Brehm, M., 2017. Gene therapy with an AAV vector expressing human IL-2 alters immune system homeostasis in humanized mice. Hum. Gene Ther. doi:10.1089/hum.2017.072. [PMID: 28826231]
Knibbe-Hollinger JS, Fields NR, Chaudoin TR, Epstein AA, Makarov E, Akhter SP, Gorantla S, Bonasera SJ, Gendelman HE, Poluektova LY. Influence of age, irradiation and humanization on NSG mouse phenotypes. Biol Open. 2015 Sep 9. [PMID: 26353862]
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McDermott SP; Eppert K; Lechman E; Doedens M; Dick JE. 2010. Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood Jul 15;116(2):193-200 [PMID: 20404133]
Pearson, F.E., Chang, K., Minoda, Y., Rojas, I.M.L., Haigh, O.L., Daraj, G., Tullett, K.M., Radford, K.J., 2018. Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR3 and TLR7/8 ligation. Immunol. Cell Biol. 96, 390–400. [PMID: 20404133]
Roy L. Maute, Sydney R. Gordon, Aaron T. Mayer, Melissa N. McCracken, Arutselvan Natarajan, Nan Guo Ring, Richard Kimura, Jonathan M. Tsai, Aashish Manglik, Andrew C. Kruse, Sanjiv S. Gambhir, Irving L. Weissman, Aaron M. Ring. Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging. PNAS Early Edition. http://www.pnas.org/content/early/2015/11/09/1519623112
Shultz LD; Lyons BL; Burzenski LM; Gott B; Chen X; Chaleff S; Kotb M; Gillies SD; King M; Mangada J; Greiner DL; Handgretinger R. 2005. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 174(10):6477-89. [PMID: 15879151]
Valentinuzzi, D., Simoncic, U., Ursic, K., Vrankar, M., Turk, M., Jeraj, R., 2018. Predicting tumour response to anti-PD-1 immunotherapy with computational modelling. Phys Med Biol. [PMID:30561383
Wang, M., Yao, L.-C., Cheng, M., Cai, D., Martinek, J., Pan, C.-X., Shi, W., Ma, A.-H., De Vere White, R.W., Airhart, S., Liu, E.T., Banchereau, J., Brehm, M.A., Greiner, D.L., Shultz, L.D., Palucka, K., Keck, J.G., 2017. Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. FASEB J. [PMID: 29146734]
Wunderlich, M., Chou, F.-S., Sexton, C., Presicce, P., Chougnet, C.A., Aliberti, J., Mulloy, J.C., 2018. Improved multilineage human hematopoietic reconstitution and function in NSGS mice. PLoS ONE 13, e0209034. [PMID: 30540841]

NSG strains expressing human cytokine transgenes

Ali R, Babad J, Follenzi A, Gebe JA, Brehm MA, Nepom GT, Shultz LD, Greiner DL, DiLorenzo TP. 2016. Genetically Modified Human CD4+ T Cells Can Be Evaluated In Vivo Without Lethal Graft Versus Host Disease. Immunology. Apr 28. doi: 10.1111/imm.12613. [PMID: 27124592]
Billerbeck E; Barry WT; Mu K; Dorner M; Rice CM; Ploss A. 2011. Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor, GM-CSF and interleukin 3 expressing NOD SCID IL2R{gamma}NULL humanized mice. Blood Mar 17;117(11):3076-86. [PMID: 21252091]
Brehm MA; Racki WJ; Leif J; Burzenski L; Hosur V; Wetmore A; Gott B; Herlihy M; Ignotz R; Dunn R; Shultz LD; Greiner DL. 2012. Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγnull mice is enhanced by transgenic expression of membrane-bound human SCF. Blood Mar 22;119(12):2778-88. [PMID: 22246028]
Montano Almendras, C.P., Thudium, C.S., Löfvall, H., Moscatelli, I., Schambach, A., Henriksen, K., Richter, J., 2017. Forced expression of human M-CSF in CD34+ cells promotes monocyte differentiation in vitro and in vivo but blunts osteoclastogenesis in vitro. Eur. J. Haematol. doi:10.1111/ejh.12867. [PMID: 28160330]
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NSG strains expressing HLA transgenes

Herr, W., Eichinger, Y., Beshay, J., Bloetz, A., Vatter, S., Mirbeth, C., Distler, E., Hartwig, U.F., Thomas, S., 2017. HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell transplantation. Leukemia 31, 434–445. doi:10.1038/leu.2016.210. [PMID: 27479183]
Huang Y, Elliott MJ, Yolcu ES, Miller TO, Ratajczak J, Bozulic LD, Wen Y, Xu H, Ratajczak MZ, Ildstad ST. Characterization of Human CD8(+) TCR(-) Facilitating Cells In Vitro and In Vivo in a NOD/SCID/IL2rγ(null) Mouse Model. Am J Transplant. 2016 Feb;16(2):440-53. doi: 10.1111/ajt.13511. Epub 2015 Nov 9. [PMID: 26550777]
Pearson, F.E., Chang, K., Minoda, Y., Leal Rojas, I.M., Haigh, O.L., Daraj, G., Tullett, K.M., Radford, K.J., 2018. Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR 3 and TLR 7/8 ligation. Immunol. Cell Biol. [PMID: 29344995]
Shultz LD; Saito Y; Najima Y; Tanaka S; Ochi T; Tomizawa M; Doi T; Sone A; Suzuki N; Fujiwara H; Yasukawa M; Ishikawa F. 2010. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma-null humanized mice. Proc Natl Acad Sci U S A Jul 20;107(29):13022-7. [PMID: 20615947]
Sun YQ, Zhang Y, Li X, Deng MX, Gao WX, Yao Y, Chiu SM, Liang X, Gao F, Chan CW, Tse HF, Shi J, Fu QL, Lian Q. Insensitivity of Human iPS Cells-Derived Mesenchymal Stem Cells to Interferon-γ-induced HLA Expression Potentiates Repair Efficiency of Hind Limb Ischemia in Immune Humanized NOD Scid Gamma Mice. Stem Cells. 2015 Jul 14. [PMID: 26175298]

Reviews and protocols

Duchez, P., Rodriguez, L., Chevaleyre, J., De La Grange, P.B., Ivanovic, Z., 2016. Clinical-scale validation of a new efficient procedure for cryopreservation of ex vivo expanded cord blood hematopoietic stem and progenitor cells. Cytotherapy 18, 1543–1547. [PMID: 27592406]
Hosur, V., Low, B.E., Avery, C., Shultz, L.D., Wiles, M.V., 2017. Development of Humanized Mice in the Age of Genome Editing. J. Cell. Biochem. [PMID: 28332231]
Ishikawa F; Saito Y; Yoshida S; Harada M; Shultz LD. 2008. The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in NOD-SCID/IL2rgamma(null) mice. Curr Top Microbiol Immunol 324:87-94. [PMID: 18481454]
Li, F., Ulrich, M.L., Shih, V.F.-S., Cochran, J.H., Hunter, J.H., Westendorf, L., Neale, J., Benjamin, D.R., 2019. Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody-Drug Conjugate Via Fc-FcγR Interaction. Mol. Cancer Ther. 18, 780—787. [PMID: 30824607
Pearson T; Greiner DL; Shultz LD. 2008. Creation of "humanized" mice to study human immunity. Curr Protoc Immunol May;Chapter 15:Unit 15.21. [PMID: 18491294]
Shultz LD; Ishikawa F; Greiner DL. 2007. Humanized mice in translational biomedical research. Nat Rev Immunol 7(2):118-30. [PMID: 17259968]
Shultz LD; Brehm MA; Garcia-Martinez JV; Greiner DL. 2012. Humanized mice for immune system investigation: progress; promise and challenges. Nat Rev Immunol. Nov;12(11):786-98. [PMID: 23059428]
Skelton, J.K., Ortega-Prieto, A.M., Dorner, M., 2018. A Hitchhiker’s Guide to Humanized Mice: new pathways to studying viral infections. Immunology. [PMID: 29446074]

Transplantation research / graft-versus-host disease (GVHD) / PBMC engraftment

Abraham, M., Pereg, Y., Bulvik, B., Klein, S., Mishalian, I., Wald, H., Eizenberg, O., Beider, K., Nagler, A., Golan, R., Vainstein, A., Aharon, A., Galun, E., Caraco, Y., Or, R., Peled, A., 2017. Single Dose of the CXCR4 Antagonist BL-8040 Induces Rapid Mobilization for the Collection of Human CD34(+) Cells in Healthy Volunteers. Clin. Cancer Res. 23, 6790–6801. [PMID: 28835380]
Abraham, S., Guo, H., Choi, J.-G., Ye, C., Thomas, M.B., Ortega, N., Dwivedi, A., Manjunath, N., Yi, G., Shankar, P., 2017. Combination of IL-10 and IL-2 induces oligoclonal human CD4 T cell expansion during xenogeneic and allogeneic GVHD in humanized mice. Heliyon 3, e00276. doi:10.1016/j.heliyon.2017.e00276. [PMID: 28409183]
Ali N; Flutter B; Sanchez Rodriguez R; Sharif-Paghaleh E; Barber LD; Lombardi G; Nestle FO. 2012. Xenogeneic Graft-versus-Host-Disease in NOD-scid IL-2Rγ(null) Mice Display a T-Effector Memory Phenotype. PLoS One 7(8):e44219. [PMID: 22937164]
Bohana-Kashtan O; Morisot S; Hildreth R; Brayton C; Levitsky HI; Civin CI. 2009. Selective reduction of graft-versus-host disease-mediating human T cells by ex vivo treatment with soluble Fas ligand. J Immunol Jul 1;183(1):696-705. [PMID:19535642]
Borel, F., Tang, Q., Gernoux, G., Greer, C., Wang, Z., Barzel, A., Kay, M.A., Shultz, L.D., Greiner, D.L., Flotte, T.R., Brehm, M.A., Mueller, C., 2017. Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency. Mol. Ther. 25, 2477–2489. [PMID: 29032169]
Brehm, M.A., Kenney, L.L., Wiles, M.V., Low, B.E., Tisch, R.M., Burzenski, L., Mueller, C., Greiner, D.L., Shultz, L.D., 2018. Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression. FASEB J. fj201800636R. [PMID: 30383447]
Bruck F; Belle L; Lechanteur C; De Leval L; Hannon M; Dubois S; Castermans E; Humblet-Baron S; Rahmouni S; Beguin Y; Briquet A; Baron F. 2013. Impact of bone marrow-derived mesenchymal stromal cells on experimental xenogeneic graft-versus-host disease. Cytotherapy. Mar;15(3):267-79. [PMID: 23265769]
Burger, D.R., Parker, Y., Guinta, K., Lindner, D., 2017. PRO 140 Monoclonal Antibody to CCR5 Prevents Acute Xenogeneic Graft-Versus-Host Disease in NOD-Scid IL-2Ry(null) Mice. Biol. Blood Marrow Transplant. [PMID: 29128556]
Chandra, S., Cristofori, P., Fonck, C., O'Neill, C.A., 2019. Ex Vivo Gene Therapy: Graft-versus-host Disease (GVHD) in NSG™ (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ) Mice Transplanted with CD34+ Human Hematopoietic Stem Cells. Toxicol Pathol 192623319844484. [PMID: 31064282]
Chu CC; Ali N; Karagiannis P; Di Meglio P; Skowera A; Napolitano L; Barinaga G; Grys K; Sharif-Paghaleh E; Karagiannis SN; Peakman M; Lombardi G; Nestle FO. 2012 Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation. J Exp Med May 7;209(5):935-45. [PMID: 22547651]
Cimbro R; Vassena L; Arthos J; Cicala C; Kehrl JH; Park C; Sereti I; Lederman MM; Fauci AS; Lusso P. 2012. Interleukin-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa. Blood.Sep 27;120(13):2610-9.[PMID: 22896005]
Covassin L; Jangalwe S; Jouvet N; Laning J; Burzenski L; Shultz LD; Brehm MA. 2013. Human immune system development and survival of NOD-scid IL2rγnull (NSG) mice engrafted with human thymus and autologous hematopoietic stem cells. Clin Exp Immunol. Dec;174(3):372-88. [PMID: 23869841]
Delens, L., Ehx, G., Somja, J., Vrancken, L., Belle, L., Seidel, L., Grégoire, C., Fransolet, G., Ritacco, C., Hannon, M., Dubois, S., Beguin, Y., Baron, F., Servais, S., 2018. In vitro Th17-polarized human CD4+ T cells exacerbate xenogeneic graft-versus-host disease. Biol. Blood Marrow Transplant.[PMID: 30326279]
Del Papa, B., Ruggeri, L., Urbani, E., Baldoni, S., Cecchini, D., Zei, T., Iacucci Ostini, R., Crescenzi, B., Carotti, A., Pierini, A., Sportoletti, P., Di Bartolomeo, P., Falzetti, F., Mecucci, C., Velardi, A., Martelli, M.F., Di Ianni, M., 2017. Clinical-Grade Expanded Tregs Prevent GvHD While Allowing a Powerful T-Cell Dependent GvL Effect in Murine Models. Biol. Blood Marrow Transplant. J. Am. Soc. Blood Marrow Transplant. doi:10.1016/j.bbmt.2017.07.009. [PMID: 28729148]
Fujii H; Luo ZJ; Kim HJ; Newbigging S; Gassas A; Keating A; Egeler RM. Humanized Chronic Graft-versus-Host Disease in NOD-SCID il2rγ-/- (NSG) Mice with G-CSF-Mobilized Peripheral Blood Mononuclear Cells following Cyclophosphamide and Total Body Irradiation. PLoS One. 2015 Jul 15;10(7):e0133216. [PMID: 26176698]
Geraghty, N.J., Belfiore, L., Ly, D., Adhikary, S.R., Fuller, S.J., Varikatt, W., Sanderson-Smith, M.L., Sluyter, V., Alexander, S.I., Sluyter, R., Watson, D., 2017. The P2X7 receptor antagonist Brilliant Blue G reduces serum human interferon-γ in a humanized mouse model of graft-versus-host disease. Clin. Exp. Immunol. doi:10.1111/cei.13005. [PMID: 28665482]
Geraghty, N.J., Belfiore, L., Adhikary, S.R., Alexander, S.I., Sluyter, R., Watson, D., 2019. Increased splenic human CD4+:CD8+ T cell ratios, serum human interferon-γ and intestinal human interleukin-17 are associated with clinical graft-versus-host disease in humanized mice. Transpl. Immunol. [PMID: 30743002]
Grégoire, C., Ritacco, C., Hannon, M., Seidel, L., Delens, L., Belle, L., Dubois, S., Vériter, S., Lechanteur, C., Briquet, A., Servais, S., Ehx, G., Beguin, Y., Baron, F., 2019. Comparison of Mesenchymal Stromal Cells From Different Origins for the Treatment of Graft-vs.-Host-Disease in a Humanized Mouse Model. Front Immunol 10, 619. [PMID: 31001253]
Gregoire-Gauthier J; Durrieu L; Duval A; Fontaine F; Dieng MM; Bourgey M; Patey-Mariaud de Serre N; Louis I; Haddad E. 2012. Use of immunoglobulins in the prevention of GvHD in a xenogeneic NOD/SCID/γc- mouse model. Bone Marrow Transplant. Mar;47(3):439-50. [PMID: 21572464]
Gregoire-Gauthier J; Fontaine F; Benchimol L; Nicoletti S; Selleri S; Dieng MM; Haddad E. 2015. Role of Natural Killer Cells in Intravenous Immunoglobulin-Induced Graft-versus-Host Disease Inhibition in NOD/LtSz-scidIL2rg-/- (NSG) Mice. Biol Blood Marrow Transplant. Jan 14; Epub ahead of print. [PMID: 25596424]
Hemmerling J; Wegner-Kops J; von Stebut E; Wolff D; Wagner EM; Hartwig UF; André MC; Theobald M; Schopf RE; Herr W; Meyer RG. 2011. Human Epidermal Langerhans Cells Replenish Skin Xenografts and Are Depleted by Alloreactive T Cells In Vivo. J Immunol Aug 1;187(3):1142-9. [PMID: 21697461]
Ito S; Barrett AJ; Dutra A; Pak E; Miner S; Keyvanfar K; Hensel NF; Rezvani K; Muranski P; Liu P; Melenhorst JJ; Larochelle A. 2015. Long term maintenance of myeloid leukemic stem cells cultured with unrelated human mesenchymal stromal cells. Stem Cell Res. Jan;14(1):95-104. [PMID: 25535865]
Janikashvili N; Trad M; Gautheron A; Samson M; Lamarthée B; Bonnefoy F; Lemaire-Ewing S; Ciudad M; Rekhviashvili K; Seaphanh F; Gaugler B; Perruche S; Bateman A; Martin L; Audia S; Saas P; Larmonier N; Bonnotte B. 2015. Human monocyte-derived suppressor cells control graft-versus-host disease by inducing regulatory forkhead box protein 3-positive CD8+ T lymphocytes. J Allergy Clin Immunol. Jan 25; Epub ahead of print. [PMID: 25630940]
King MA; Covassin L; Brehm MA; Racki W; Pearson T; Leif J; Laning J; Fodor W; Foreman O; Burzenski L; Chase TH; Gott B; Rossini AA; Bortell R; Shultz LD; Greiner DL. 2009. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol Jul;157(1):104-18. [PMID: 19659776]
Kirkiles-Smith NC; Harding MJ; Shepherd BR; Fader SA; Yi T; Wang Y; McNiff JM; Snyder EL; Lorber MI; Tellides G; Pober JS. 2010. Development of a humanized mouse model to study the role of macrophages in allograft injury. Transplantation Jan 27;87(2):189-97. [PMID: 19155972]
Laing ST; Griffey SM; Moreno ME; Stoddart CA. J Comp Pathol. CD8-positive Lymphocytes in Graft-Versus-Host Disease of Humanized NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ Mice. 2015 Feb 7. Epub ahead of print. [PMID: 25670669]
McIntosh BE; Brown ME; Duffin BM; Maufort JP; Vereide DT; Slukvin II; Thomson JA. 2015. Nonirradiated NOD;B6.SCID Il2rγ-/-KitW41/W41 (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells. Stem Cell Reports. Epub ahead of print. [PMID: 25601207]
Nolte T; Zadeh-Khorasani M; Safarov O; Rueff F; Varga R; Herbach N; Wanke R; Wollenberg A; Mueller T; Gropp R; Wolf E; Siebeck M. 2013. Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rγnull mice engrafted with human peripheral blood mononuclear cells. Dis Model Mech. Jan;6(1):125-34. [PMID: 22822046]
Ono, R., Watanabe, T., Kawakami, E., Iwasaki, M., Tomizawa-Murasawa, M., Matsuda, M., Najima, Y., Takagi, S., Fujiki, S., Sato, R., Mochizuki, Y., Yoshida, H., Sato, K., Yabe, H., Kato, S., Saito, Y., Taniguchi, S., Shultz, L.D., Ohara, O., Amagai, M., Koseki, H., Ishikawa, F., 2019. Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model. EBioMedicine. [PMID: 30772305]
Pino S; Brehm MA; Covassin-Barberis L; King M; Gott B; Chase TH; Wagner J; Burzenski L; Foreman O; Greiner DL; Shultz LD. 2010. Development of Novel Major Histocompatibility Complex Class I and Class II-Deficient NOD-SCID IL2R Gamma Chain Knockout Mice for Modeling Human Xenogeneic Graft-Versus-Host Disease. Methods Mol Biol 602:105-17. [PMID: 20012395]
Racki WJ; Covassin L; Brehm M; Pino S; Ignotz R; Dunn R; Laning J; Graves SK; Rossini AA; Shultz LD; Greiner DL. 2010 NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection. Transplantation Mar 15;89(5):527-36. [PMID: 20134397]
Ranjan, S., Goihl, A., Kohli, S., Gadi, I., Pierau, M., Shahzad, K., Gupta, D., Bock, F., Wang, H., Shaikh, H., Kähne, T., Reinhold, D., Bank, U., Zenclussen, A.C., Niemz, J., Schnöder, T.M., Brunner-Weinzierl, M., Fischer, T., Kalinski, T., Schraven, B., Luft, T., Huehn, J., Naumann, M., Heidel, F.H., Isermann, B., 2017. Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells. Nat. Commun. 8, 311. doi:10.1038/s41467-017-00169-4. [PMID: 28827518]
Scalley-Kim ML; Hess BW; Kelly RL; Krostag AR; Lustig KH; Marken JS; Ovendale PJ; Posey AR; Smolak PJ; Taylor JD; Wood CL; Bienvenue DL; Probst P; Salmon RA; Allison DS; Foy TM; Raport CJ. 2012. A novel highly potent therapeutic antibody neutralizes multiple human chemokines and mimics viral immune modulation. PLoS One. 7(8):e43332. [PMID: 22912856]
Sonntag K; Eckert F; Welker C; Müller H, Müller F; Zips D; Sipos B; Klein R; Blank G; Feuchtinger T; Schumm M; Handgretinger R; Schilbach K. Chronic graft-versus-host-disease in CD34+-humanized NSG mice is associated with human susceptibility HLA haplotypes for autoimmune disease. J Autoimmun. 2015 Jul 2. Epub ahead of print. [PMID: 26143958]
Tobin LM; Healy ME; English K; Mahon BP. 2013. Human mesenchymal stem cells suppress donor CD4(+) T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease. Clin Exp Immunol. May;172(2):333-48. [PMID: 23574329]
Touil S; Rosenzwajg M; Landau DA; Le Corvoisier P; Frédéric C; Klatzmann D; Maury S; Cohen JL. 2012. Depletion of T regulatory cells through selection of CD127-positive cells results in a population enriched in memory T cells: implications for anti-tumor cell therapy. Haematologica. Nov;97(11):1678-85. [PMID: 22581007]
Van Elssen, C.H.M.J., Rashidian, M., Vrbanac, V., Wucherpfennig, K.W., El Habre, Z., Sticht, J., Freund, C., Jacobsen, J., Cragnolini, J., Ingram, J., Plaisier, L., Spierings, E., Tager, A.M., Ploegh, H., 2017. Noninvasive imaging of human immune responses in a human xenograft model of graft-versus-host disease. J. Nucl. Med. Off. Publ. Soc. Nucl. Med. doi:10.2967/jnumed.116.186007. [PMID: 28209904]
Vlad G; Stokes MB; Liu Z; Chang CC; Sondermeijer H; Vasilescu ER; Colovai AI; Berloco P; D'Agati VD; Ratner L; Cortesini R; Suciu-Foca N. 2009. Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc. Hum Immunol Sep;70(9):663-9. PMID: 19501624]
Walcher, L., Müller, C., Hilger, N., Kretschmer, A., Stahl, L., Wigge, S., Rengelshausen, J., Müller, A.M., Fricke, S., 2018. Effect of combined sublethal X-ray irradiation and cyclosporine A treatment in NOD scid gamma (NSG) mice. Exp. Anim. [PMID:30078790]
Zadeh-Khorasani M; Nolte T; Mueller TD; Pechlivanis M; Rueff F; Wollenberg A; Fricker G; Wolf E; Siebeck M; Gropp R. 2013. NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways. J Transl Med. Jan 7;11:4. [PMID: 23294516]
Zhou F, Fortin J, Chen H, Martinez-Diaz H, Chang L, Reynolds B, Roper S. Functional integration of human neural precursor cells in mouse cortex. Plos One. 2015 Mar 12; 10(3): e0120281. [PMID: 25763840]

Vaccines

Ivanova, I.I., Mihaylova, N.M., Manoylov, I.K., Makatsori, D., Lolov, S., Nikolova, M.H., Mamalaki, A., Prechl, J., Tchorbanov, A.I., 2018. Targeting of Influenza Viral Epitopes to Antigen-Presenting Cells by Genetically Engineered Chimeric Molecules in a Humanized NOD SCID Gamma Transfer Model. Hum. Gene Ther. 29, 1056–1070. [PMID: 30191743]
Khalaf, O.H., Chaki, S.P., Garcia-Gonzalez, D.G., Ficht, T.A., Arenas-Gamboa, A.M., 2019. The NOD-scid IL2rγnull Mouse Model Is Suitable for the Study of Osteoarticular Brucellosis and Vaccine Safety. Infect. Immun. 87. [PMID: 30936160]
Pagovich, O.E., Wang, B., Chiuchiolo, M.J., Kaminsky, S.M., Sondhi, D., Jose, C.L., Price, C.C., Brooks, S.F., Mezey, J.G., Crystal, R.G., 2016. Anti-hIgE gene therapy of peanut-induced anaphylaxis in a humanized murine model of peanut allergy. J. Allergy Clin. Immunol. 138, 1652–1662.e7. [PMID: 27372563]
Spranger S; Frankenberger B; Schendel DJ. 2012. NOD/scid IL-2Rgnull mice: a preclinical model system to evaluate human dendritic cell-based vaccine strategies in vivo. J Transl Med Feb 25;10:30. [PMID: 22364226]

Autoimmunity

Ishikawa Y; Usui T; Shiomi A; Shimizu M; Murakami K; Mimori T. 2014. Functional engraftment of human peripheral T and B cells and sustained production of autoantibodies in NOD/LtSzscid/IL-2Rgamma mice. Eur J Immunol. Aug 22. [PMID: 25154613] [PMID: 25154613]
Little MA; Al-Ani B; Ren S; Al-Nuaimi H; Leite M Jr; Alpers CE; Savage CO; Duffield JS. 2012. Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system. PLoS One 7(1):e28626. [PMID: 22247758]
Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M. Innate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity. J Immunol. 2015 Aug 15;195(4):1883-90. [PMID: 26170385]

Inflammation

Goettel, J., Kotlarz, D., Illig, D., Canavan, J., Allegretti, J., Hamilton, M., Kelly, R., Griffith, A., Carellas, M., Nelina, A., Bousvaros, A., Korzenik, J., Snapper, S., 2017. O-011 Low-dose IL-2 Administration Expands Human Regulatory T Cells in Patients with UC and Humanized Mice and Protects Against Experimental Colitis. Inflamm. Bowel Dis. 23 Suppl 1, S4. doi:10.1097/01.MIB.0000512521.84210.0b. [PMID: 28125559]
Jodeleit, H., Palamides, P., Beigel, F., Mueller, T., Wolf, E., Siebeck, M., Gropp, R., 2017. Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model. J Transl Med 15, 265. [PMID: 29282132]
Lee, J.S., Jeong, S.-J., Kim, S., Chalifour, L., Yun, T.J., Miah, M.A., Li, B., Majdoubi, A., Sabourin, A., Keler, T., Guimond, J.V., Haddad, E., Choi, E.-Y., Epelman, S., Choi, J.-H., Thibodeau, J., Oh, G.T., Cheong, C., 2018. Conventional Dendritic Cells Impair Recovery after Myocardial Infarction. J. Immunol. [PMID: 30097529]
Li-Ping Thio, C., Chuan-Ying Lai, A., Chi, P.-Y., Webster, G., Chang, Y.-J., 2019. TLR9-dependent interferon production prevents group 2 innate lymphoid cell-driven airway hyperreactivity. J. Allergy Clin. Immunol.[PMID: 30914379]
Manocha, G.D., Floden, A.M., Puig, K.L., Nagamoto-Combs, K., Scherzer, C.R., Combs, C.K., 2017. Defining the contribution of neuroinflammation to Parkinson’s disease in humanized immune system mice. Mol. Neurodegener. 12, 17. doi:10.1186/s13024-017-0158-z. [PMID: 28196514]
Vizzardelli, C., Gindl, M., Roos, S., Möbs, C., Nagl, B., Zimmann, F., Sexl, V., Kenner, L., Neunkirchner, A., Zlabinger, G.J., Pickl, W.F., Pfützner, W., Bohle, B., 2018. Blocking antibodies induced by allergen-specific immunotherapy ameliorate allergic airway disease in a human/mouse chimeric model. Allergy 73, 851–861. [PMID: 29159964]

Infectious Disease

Malaria

Arnold L; Tyagi RK; Meija P; Swetman C; Gleeson J; Pérignon JL; Druilhe P. 2011 Further Improvements of the P. falciparum Humanized Mouse Model. PLoS ONE Mar 31;6(3):e18045. [PMID: 21483851]
Jiménez-Díaz MB; Viera S; Ibáñez J; Mulet T; Magán-Marchal N; Garuti H; Gómez V; Cortés-Gil L; Martínez A; Ferrer S; Fraile MT; Calderón F; Fernández E; Shultz LD; Leroy D; Wilson DM; García-Bustos JF; Gamo FJ; Angulo-Barturen I. 2013. A new in vivo screening paradigm to accelerate antimalarial drug discovery. PLoS One. Jun 25;8(6):e66967. [PMID: 23825598]
Jiménez-Díaz MB; Mulet T; Viera S; Gómez V; Garuti H; Ibáñez J; Alvarez-Doval A; Shultz LD; Martínez A; Gargallo-Viola D; Angulo-Barturen I. 2009. Improved murine model of malaria using P. falciparum competent strains and non-myelodepleted NOD-scid IL2R{gamma}null mice engrafted with human erythrocytes. Antimicrob Agents Chemother Oct;53(10):4533-6 [PMID: 19596869]
McCarthy JS, Marquart L, Sekuloski S, Trenholme K, Elliott S, Griffin P, Rockett R, O'Rourke P, Sloots T, Angulo-Barturen I, Ferrer S, Jiménez-Díaz MB, Martínez MS, van Huijsduijnen RH, Duparc S, Leroy D, Wells TN, Baker M, Möhrle JJ. 2016. Linking murine and human Plasmodium falciparum challenge models in a translational path for antimalarial drug development. Antimicrob Agents Chemother. Apr 4. pii: AAC.02883-15. [PMID: 27044554]
Tyagi, R.K., Gleeson, P.J., Arnold, L., Tahar, R., Prieur, E., Decosterd, L., Pérignon, J.-L., Olliaro, P., Druilhe, P., 2018. High-level artemisinin-resistance with quinine co-resistance emerges in P. falciparum malaria under in vivo artesunate pressure. BMC Med 16, 181. [PMID: 30269689]

Candida albicans

Quintin J; Voigt J; van der Voort R; Jacobsen ID; Verschueren I; Hube B; Giamarellos-Bourboulis EJ; van der Meer JW; Joosten LA; Kurzai O; Netea MG. 2014. Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice. Eur J Immunol. May 27; 44(8):2405-14. [PMID: 24802993]

Cytomegalovirus

Dogra, P., Miller-Kittrell, M., Pitt, E., Jackson, J.W., Masi, T., Copeland, C., Wu, S., Miller, W., Sparer, T., 2016. A Little Cooperation Helps Murine Cytomegalovirus Go a Long Way - Co-infection Between MCMVs Rescues A Viral Chemokine Salivary Gland Defect. J. Gen. Virol. doi:10.1099/jgv.0.000603 [PMID: 27638684]
Livingston-Rosanoff D; Daley-Bauer LP; Garcia A; McCormick AL; Huang J; Mocarski ES. 2012. Antiviral T cell response triggers cytomegalovirus hepatitis in mice. J Virol. Dec;86(23):12879-90. [PMID: 22993151]
Smith MS; Goldman DC; Bailey AS; Pfaffle DL; Kreklywich CN; Spencer DB; Othieno FA; Streblow DN; Garcia JV; Fleming WH; Nelson JA. 2010. Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model. Cell Host Microbe Sep 16;8(3):284-91. [PMID: 20833379]

Dengue virus

Cox J; Mota J; Sukupolvi-Petty S; Diamond MS; Rico-Hesse R. 2012. Mosquito bite delivery of dengue virus enhances immunogenicity and pathogenesis in humanized mice. J Virol Jul;86(14):7637-49.[PMID: 22573866]
Jaiswal S; Pearson T; Friberg H; Shultz LD; Greiner DL; Rothman A; Mathew A. 2009. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS One 2009 Oct 5;4(10):e7251. [PMID: 19802382]
Mota J; Rico-Hesse R. 2009. Humanized mice show clinical signs of dengue fever according to infecting virus genotype. J Virol Sep;83(17):8638-45. [PMID: 19535452]
Subramanya S; Kim SS; Abraham S; Yao J; Kumar M; Kumar P; Haridas V; Lee SK; Shultz L; Greiner D; N M; Shankar P. 2009. Targeted delivery of siRNA to human dendritic cells to suppress Dengue viral infection and associated proinflammatory cytokine production. J Virol Mar;84(5):2490-501. [PMID: 20015996]
Sridharan A; Chen Q; Tang KF; Ooi EE; Hibberd ML; Chen J. 2013. Inhibition of Megakaryocyte Development in the Bone Marrow Underlies Dengue Virus-induced Thrombocytopenia in Humanized Mice. J Virol. [Epub ahead of print][PMID:23966397]

Ebola Virus

Lüdtke A, Oestereich L, Ruibal P, Wurr S, Pallasch E, Bockholt S, Ip WH, Rieger T, Gómez-Medina S, Stocking C, Rodríguez E, Günther S, Muñoz-Fontela C. Ebola virus disease in mice with transplanted human hematopoietic stem cells. J Virol. 2015 Apr;89(8):4700-4. [PMID: 25673711]
Spengler, J.R., Saturday, G., Lavender, K.J., Martellaro, C., Keck, J.G., Nichol, S.T., Spiropoulou, C.F., Feldmann, H., Prescott, J., 2017. Severity of Disease in Humanized Mice Infected with Ebola Virus or Reston Virus is Associated with Magnitude of Early Viral Replication in Liver. J. Infect. Dis. [PMID: 29087482]

Epstein Barr virus

Kraus, R.J., Yu, X., Cordes, B.-L.A., Sathiamoorthi, S., Iempridee, T., Nawandar, D.M., Ma, S., Romero-Masters, J.C., McChesney, K.G., Lin, Z., Makielski, K.R., Lee, D.L., Lambert, P.F., Johannsen, E.C., Kenney, S.C., Mertz, J.E., 2017. Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus’s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter. PLoS Pathog. 13, e1006404. doi:10.1371/journal.ppat.1006404 [PMID: 28617871]
Lai J, Tan WJ, Too CT, Choo JA, Wong LH Bte Mustafa F, Srinivasan N, Lim AP, Zhong Y, Gascoigne NR, Hanson BJ, Chan SH, Chen J, MacAry PA. 2016. Targeting Epstein-Barr virus transformed B lymphoblastoid cells using antibodies with T cell receptor-like specificities. Blood. Jun 23. pii: blood-2016-03-707836. [Epub ahead of print] [PMID: 27338099]
Ma SD, Xu X, Jones R, Delecluse HJ, Zumwalde NA, Sharma A, Gumperz JE, Kenney SC. 2016. PD-1/CTLA-4 Blockade Inhibits Epstein-Barr Virus-Induced Lymphoma Growth in a Cord Blood Humanized-Mouse Model. PLoS Pathog. May 17;12(5):e1005642. doi: 10.1371/journal.ppat.1005642. [PMID: 27186886]
Ma SD; Yu X; Mertz JE; Gumperz JE; Reinheim E; Zhou Y; Tang W; Burlingham WJ; Gulley ML; Kenney SC. 2012. An Epstein-Barr virus (EBV) mutant with enhanced BZLF1 expression causes lymphomas with abortive lytic EBV infection in a humanized mouse model. J Virol Aug;86(15):7976-87. [PMID: 22623780]
Strowig T; Gurer C; Ploss A; Liu YF; Arrey F; Sashihara J; Koo G; Rice CM; Young JW; Chadburn A; Cohen JI; Münz C. 2009. Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. J Exp Med Jun 8;206(6):1423-34. [PMID: 19487422]
Wahl A; Linnstaedt SD; Esoda C; Krisko JF; Martinez-Torres F; Delecluse HJ; Cullen BR; Garcia JV. 2013. A Cluster of Virus-encoded microRNAs Accelerates Acute Systemic Epstein-Barr Virus Infection but does not Significantly Enhance Virus-induced Oncogenesis In Vivo. J Virol. May;87(10):5437-46. [PMID: 23468485]
White RE; Rämer PC; Naresh KN; Meixlsperger S; Pinaud L; Rooney C; Savoldo B; Coutinho R; Bödör C; Gribben J; Ibrahim HA; Bower M; Nourse JP; Gandhi MK; Middeldorp J; Cader FZ; Murray P; Münz C; Allday MJ. 2012. EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors. J Clin Invest Apr 2;122(4):1487-502. [PMID: 22406538]

Hepatitis

Bility MT; Cheng L; Zhang Z; Luan Y; Li F; Chi L; Zhang L; Tu Z; Gao Y; Fu Y; Niu J; Wang F; Su L. 2014. Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages. PLoS Pathog. Mar 20; 10(3):e1004032. [PMID: 24651854]
Billerbeck E; Horwitz JA; Labitt RN; Donovan BM; Vega K; Budell WC; Koo GC; Rice CM; Ploss A. 2013. Characterization of Human Antiviral Adaptive Immune Responses during Hepatotropic Virus Infection in HLA-Transgenic Human Immune System Mice. J Immunol. Aug 15;191(4):1753-64. [PMID: 23833235]
Sonntag K, Eckert F, Welker C, Müller H, Müller F, Zips D, Sipos B, Klein R, Blank G, Feuchtinger T, Schumm M, Handgretinger R, Schilbach K. Chronic graft-versus-host-disease in CD34+-humanized NSG mice is associated with human susceptibility HLA haplotypes for autoimmune disease. J Autoimmun. 2015 Jul 2. Epub ahead of print. [PMID: 26143958]

HIV modeling

Akkina RK, Allam A, Balazs AB, Blankson J, Burnett JC, Casares S, Garcia JV, Hasenkrug K, Kashanchi F, Kitchen S, Klein F, Kumar P, Luster AD, Poluektova LY, Rao M, Sanders BE, Shultz LD, Zack JA. Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary. AIDS Res Hum Retroviruses. 2015 Dec 16. [PMID: 26670361]
Beloor J, Kudalkar SN, Buzzelli G, Yang F, Mandl HK, Rajashekar JK, et al. Long-acting and extended-release implant and nanoformulations with a synergistic antiretroviral two-drug combination controls HIV-1 infection in a humanized mouse model. Bioeng Transl Med. 2022;7(1):e10237. [PMID: 35079625]
Bhargavan, B., Kanmogne, G.D., 2019. Epigenetics, N-myrystoyltransferase-1 and casein kinase-2-alpha modulates the increased replication of HIV-1 CRF02_AG, compared to subtype-B viruses. Sci Rep 9. [PMID: 31337802]
Boska MD; Dash PK; Knibbe J; Epstein AA; Akhter SP; Fields N; High R; Makarov E; Bonasera S; Gelbard HA; Poluektova LY; Gendelman HE; Gorantla S. 2015. Associations between brain microstructures; metabolites; and cognitive deficits during chronic HIV-1 infection of humanized mice. Mol Neurodegener. Dec 18;9(1):58. [PMID: 25523287]
Dagur, R.S., Branch-Woods, A., Mathews, S., Joshi, P.S., Quadros, R.M., Harms, D.W., Cheng, Y., Miles, S.M., Pirruccello, S.J., Gurumurthy, C.B., Gorantla, S., Poluektova, L.Y., 2019. Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection. BMC Immunol. 20, 2. [PMID: 30616506]
Dash PK; Gorantla S; Gendelman HE; Knibbe J; Casale GP; Makarov E; Epstein AA; Gelbard HA; Boska MD; Poluektova LY. 2011. Loss of Neuronal Integrity during Progressive HIV-1 Infection of Humanized Mice. J Neurosci Mar 2;31(9):3148-57. [PMID: 21368026]
Dash, P.K., Kaminski, R., Bella, R., Su, H., Mathews, S., Ahooyi, T.M., Chen, C., Mancuso, P., Sariyer, R., Ferrante, P., Donadoni, M., Robinson, J.A., Sillman, B., Lin, Z., Hilaire, J.R., Banoub, M., Elango, M., Gautam, N., Mosley, R.L., Poluektova, L.Y., McMillan, J., Bade, A.N., Gorantla, S., Sariyer, I.K., Burdo, T.H., Young, W.-B., Amini, S., Gordon, J., Jacobson, J.M., Edagwa, B., Khalili, K., Gendelman, H.E., 2019. Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice. Nat Commun 10. [PMID: 31266936]
Garg H; Joshi A; Ye C; Shankar P; Manjunath N. 2011. Single amino acid change in gp41 region of HIV-1 alters bystander apoptosis and CD4 decline in humanized mice. Virol J Jan 21;8(1):34. [PMID: 21255440]
Gorantla S; Makarov E; Finke-Dwyer J; Castanedo A; Holguin A; Gebhart CL; Gendelman HE; Poluektova L. 2010. Links between Progressive HIV-1 Infection of Humanized Mice and Viral Neuropathogenesis. Am J Pathol Dec;177(6):2938-49 [PMID: 21088215]
Hioe CE, Li G, Liu X, Tsahouridis O, He X, Funaki M, et al. Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice. PLoS Pathog. 2022;18(1):e1010183. [PMID: 34986207]
Holguin L, Echavarria L, Burnett JC. Novel Humanized Peripheral Blood Mononuclear Cell Mouse Model with Delayed Onset of Graft-versus-Host Disease for Preclinical HIV Research. J Virol. 2022;96(3):e0139421-e. [PMID: 34818071]
Latinovic, O.S., Neal, L.M., Tagaya, Y., Heredia, A., Medina-Moreno, S., Zapata, J.C., Reitz, M., Bryant, J., Redfield, R.R., 2019. Suppression of Active HIV-1 Infection in CD34+ Hematopoietic Humanized NSG Mice by a Combination of cART Therapy and CCR5 Targeting Drugs. AIDS Res. Hum. Retroviruses. [PMID: 31099257]
Li, W., Gorantla, S., Gendelman, H.E., Poluektova, L.Y., 2017. Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains. Dis Model Mech. [PMID: 29084769]
Llewellyn, G.N., Alvarez-Carbonell, D., Chateau, M., Karn, J., Cannon, P.M., 2017. HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. J. Neurovirol. [PMID: 29256041]
Lu R; Wu S; Zhang Y; Xia Y; Huelsmann EJ; Lacek AT; Nabatiyan A; Richards MH; Narasipura SD; Lutgen V; Chen H; Kaufman HL; Chen D; Al-Harthi L; Zloza A; Sun J. 2014. HIV Infection Accelerates Gastrointestinal Tumor Outgrowth in NSG-HuPBL Mice. AIDS Res Hum Retroviruses. Apr 3. [PMID: 24593860]
Kovarova M, Swanson MD, Sanchez RI, Baker CE, Steve J, Spagnuolo RA, Howell BJ, Hazuda DJ, Garcia JV. 2016. A long-acting formulation of the integrase inhibitor raltegravir protects humanized BLT mice from repeated high-dose vaginal HIV challenges. J Antimicrob Chemother. Mar 21. pii: dkw042. [PMID: 27002074]
Nixon CC; Vatakis DN; Reichelderfer SN; Dixit D; Kim SG; Uittenbogaart CH; Zack JA. 2013. HIV-1 Infection of hematopoietic progenitor cells in vivo in humanized mice. Blood. [Epub ahead of print] [PMID: 23886835]
Sampey GC, Saifuddin M, Schwab A, Barclay R, Punya S, Chung MC, Hakami RM, Asad Zadeh M, Lepene B, Klase ZA, El-Hage N, Young M, Iordanskiy S, Kashanchi F. Exosomes from HIV-1 infected cells stimulate production of pro-inflammatory cytokines through TAR RNA. J Biol Chem. 2015 Nov 9. [PMID: 26553869]
Schmitt, K., Akkina, R., 2018. Ultra-Sensitive HIV-1 Latency Viral Outgrowth Assays Using Humanized Mice. Front Immunol 9, 344. [PMID: 29556230]
Sharma A, Wu W, Sung B, Huang J, Tsao T, Li X, Gomi R, Tsuji M, Worgall S. 2016. RSV Pulmonary Infection in Humanized Mice Induces Human Anti-RSV Immune Responses and Pathology. J Virol. 2016 Mar 9. pii: JVI.00259-16. [PMID: 26962219]
Thomas T, Seay K, Zheng JH, Zhang C, Ochsenbauer C, Kappes JC, Goldstein H. High-Throughput Humanized Mouse Models for Evaluation of HIV-1 Therapeutics and Pathogenesis. Methods Mol Biol. 2016; 1354:221-35. [PMID: 26714715]
Xu, S.X., Leontyev, D., Kaul, R., Gray-Owen, S.D., 2018. Neisseria gonorrhoeae co-infection exacerbates vaginal HIV shedding without affecting systemic viral loads in human CD34+ engrafted mice. PLoS ONE 13, e0191672. [PMID: 29360873]
Yu, C., Narasipura, S.D., Richards, M.H., Hu, X.-T., Yamamoto, B., Al-Harthi, L., 2017. HIV and drug abuse mediate astrocyte senescence in a β-catenin-dependent manner leading to neuronal toxicity. Aging Cell. doi:10.1111/acel.12593 [PMID: 28612507]

HIV therapies

Balazs AB; Chen J; Hong CM; Rao DS; Yang L; Baltimore D. 2011. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature Nov 30;481(7379):81-4. [PMID: 22139420]
Dubrovsky L; Duyne RV; Senina S; Guendel I; Pushkarsky T; Sviridov D; Kashanchi F; Bukrinsky M. 2012. Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection. Biochem Biophys Res Commun Mar 2;419(1):95-8. [PMID: 22326260]
Falkenhagen, A., Singh, J., Asad, S., Leontyev, D., Read, S., Zúñiga-Pflücker, J.C., Joshi, S., 2017. Control of HIV Infection In Vivo Using Gene Therapy with a Secreted Entry Inhibitor. Mol Ther Nucleic Acids 9, 132–144. [PMID: 29246292]
Gorantla S; Makarov E; Finke-Dwyer J; Gebhart CL; Domm W; Dewhurst S; Gendelman HE; Poluektova LY. 2010. CD8+ Cell Depletion Accelerates HIV-1 Immunopathology in Humanized Mice. J Immunol Jun 15 184(12):7082-91. [PMID: 20495069]
Heredia, A., Hassounah, S., Medina-Moreno, S., Zapata, J.C., Le, N.M., Han, Y., Foulke, J.S., Davis, C., Bryant, J., Redfield, R.R., Wainberg, M.A., 2017. Monotherapy with either dolutegravir or raltegravir fails to durably suppress HIV viraemia in humanized mice. J. Antimicrob. Chemother. doi:10.1093/jac/dkx195 [PMID: 28637235]
Holt N; Wang J; Kim K; Friedman G; Wang X; Taupin V; Crooks GM; Kohn DB; Gregory PD; Holmes MC; Cannon PM. 2010. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol Aug;28(8):839-47 [PMID: 20601939]
Hur EM; Patel SN; Shimizu S; Rao DS; Gnanapragasam PN; An DS; Yang L; Baltimore D. 2012. Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice. Blood Nov 29;120(23):4571-82. [PMID: 23065154]
Joseph A; Zheng JH; Chen K; Dutta M; Chen C; Stiegler G; Kunert R; Follenzi A; Goldstein H. 2010. Inhibition of In Vivo HIV Infection In Humanized Mice By Gene Therapy of Human Hematopoietic Stem Cells with a Lentiviral Vector Encoding a Broadly Neutralizing Anti-HIV Antibody. J Virol Jul;84(13):6645-53. [PMID: 20410262]
Joshi P, Maidji E, Stoddart CA. 2016. Inhibition of Heat Shock Protein 90 Prevents HIV Rebound. J Biol Chem. 2016 Mar 8. pii: jbc.M116.717538. [PMID: 26957545]
Kiem HP; Jerome KR; Deeks SG; McCune JM. 2012. Hematopoietic-stem-cell-based gene therapy for HIV disease. Cell Stem Cell Feb 3;10(2):137-47. [PMID: 22305563]
Kitchen SG; Levin BR; Bristol G; Rezek V; Kim S; Aguilera-Sandoval C; Balamurugan A; Yang OO; Zack JA. 2012. In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells. PLoS Pathog Apr;8(4):e1002649. [PMID: 22511873]
Kumar P; Ban HS; Kim SS; Wu H; Pearson T; Greiner DL; Laouar A; Yao J; Haridas V; Habiro K; Yang YG; Jeong JH; Lee KY; Kim YH; Kim SW; Peipp M; Fey GH; Manjunath N; Shultz LD; Lee SK; Shankar P. 2008. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell 134(4):577-86. [PMID: 18691745]
Li L; Krymskaya L; Wang J; Henley J; Rao A; Cao LF; Tran CA; Torres-Coronado M; Gardner A; Gonzalez N; Kim K; Liu PQ; Hofer U; Lopez E; Gregory PD; Liu Q; Holmes MC; Cannon PM; Zaia JA; Digiusto DL. 2013. Genomic Editing of the HIV-1 Coreceptor CCR5 in Adult Hematopoietic Stem and Progenitor Cells Using Zinc Finger Nucleases. Mol Ther. Jun;21(6):1259-69. [PMID: 23587921]
Mandal, S., Kang, G., Prathipati, P.K., Zhou, Y., Fan, W., Li, Q., Destache, C.J., 2018. Nanoencapsulation introduces long-acting phenomenon to tenofovir alafenamide and emtricitabine drug combination: A comparative pre-exposure prophylaxis efficacy study against HIV-1 vaginal transmission. J Control Release 294, 216–225. [PMID: 30576746 ]
Medina-Moreno, S., Dowling, T.C., Zapata, J.C., Le, N.M., Sausville, E., Bryant, J., Redfield, R.R., Heredia, A., 2017. Targeting of CDK9 with indirubin 3’-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice. PloS One 12, e0183425. doi:10.1371/journal.pone.0183425 [PMID: 28817720]
Mukherjee R; Plesa G; Sherrill-Mix S; Richardson MW; Riley JL; Bushman FD. 2010. HIV sequence variation associated with env antisense adoptive T-cell therapy in the hNSG mouse model. Mol Ther Apr;18(4):803-11. [PMID: 20104212]
Perdomo-Celis, F., Medina-Moreno, S., Davis, H., Bryant, J., Zapata, J.C., 2019. HIV Replication in Humanized IL-3/GM-CSF-Transgenic NOG Mice. Pathogens 8. [PMID: 30871027]
Poonia B. 2016. Adoptive transfer of aminobisphonate-expanded Vγ9Vδ2+ T cells does not control HIV replication in a humanized mouse model. Immunotherapy. 2016 May;8(5):521-6. doi: 10.2217/imt-2015-0003. [PMID: 27140407]
Prathipati, P.K., Mandal, S., Pon, G., Vivekanandan, R., Destache, C.J., 2017. Pharmacokinetic and Tissue Distribution Profile of Long Acting Tenofovir Alafenamide and Elvitegravir Loaded Nanoparticles in Humanized Mice Model. Pharm. Res. doi:10.1007/s11095-017-2255-7 [PMID: 28905173]
Quispe Calla, N.E., Vicetti Miguel, R.D., Glick, M.E., Kwiek, J.J., Gabriel, J.M., Cherpes, T.L., 2018. Exogenous oestrogen inhibits genital transmission of cell-associated HIV-1 in DMPA-treated humanized mice. J Int AIDS Soc 21. [PMID: 29334191]
Satheesan, S., Li, H., Burnett, J.C., Takahashi, M., Li, S., Wu, S.X., Synold, T.W., Rossi, J.J., Zhou, J., 2018. HIV Replication and Latency in a Humanized NSG Mouse Model during Suppressive Oral Combinational Antiretroviral Therapy. J. Virol. 92. [PMID: 29343582]
Seay K; Church C; Zheng JH; Deneroff K; Ochsenbauer C; Kappes JC; Liu B; Jeng EK; Wong HC; Goldstein H. In Vivo Activation of Human NK cells by Treatment with an IL-15 Superagonist Potently Inhibits Acute In Vivo HIV-1 Infection in Humanized Mice. J Virol. 2015 Apr 1. Epub ahead of print. [PMID: 25833053]
Singh M; Singh P; Gaudray G; Musumeci L; Thielen C; Vaira D; Vandergeeten C; Delacroix L; Van Gulck E; Vanham G; de Leval L; Rahmouni S; Moutschen M. 2012. An Improved Protocol for Efficient Engraftment in NOD/LTSZ-SCIDIL-2Rγ(NULL) Mice Allows HIV Replication and Development of Anti-HIV Immune Responses. PLoS One 7(6):e38491. [PMID: 22675567]
Wilen CB; Wang J; Tilton JC; Miller JC; Kim KA; Rebar EJ; Sherrill-Mix SA; Patro SC; Secreto AJ; Jordan AP; Lee G; Kahn J; Aye PP; Bunnell BA; Lackner AA; Hoxie JA; Danet-Desnoyers GA; Bushman FD; Riley JL; Gregory PD; June CH; Holmes MC; Doms RW. 2011. HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases. PLoS Pathog Apr;7(4):e1002020. [PMID: 21533216]
Wu X, Liu L, Cheung KW, Wang H, Lu X, Cheung AK, Liu W, Huang X, Li Y, Chen ZW, Chen SM, Zhang T, Wu H, Chen Z. Brain Invasion by CD4+ T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice. J Neuroimmune Pharmacol. 2016 Feb 2. [PMID: 26838362]
Yu, C., Narasipura, S.D., Richards, M.H., Hu, X.-T., Yamamoto, B., Al-Harthi, L., 2017. HIV and drug abuse mediate astrocyte senescence in a β-catenin-dependent manner leading to neuronal toxicity. Aging Cell 16, 956–965. doi:10.1111/acel.12593 [PMID: 28612507]
Yuan J; Wang J; Crain K; Fearns C; Kim KA; Hua KL; Gregory PD; Holmes MC; Torbett BE. 2012. Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment. Mol Ther. Apr;20(4):849-59. [PMID:22273578]
Zhang J; Mulvenon A; Makarov E; Wagoner J; Knibbe J; Kim JO; Osna N; Bronich TK; Poluektova LY. 2013. Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection. Biomaterials. May;34(15):3846-57. [PMID: 23403120]

HIV review articles

Gorantla S; Poluektova L; Gendelman HE. 2012. Rodent models for HIV-associated neurocognitive disorders. Trends Neurosci Mar;35(3):197-208. Review [PMID: 22305769]
Sato K; Koyanagi Y. The mouse is out of the bag: insights and perspectives on HIV-1-infected humanized mouse models.Exp Biol Med (Maywood) Aug 1;236(8):977-85. [PMID: 21750016]
Zhang L; Su L. 2012. HIV-1 immunopathogenesis in humanized mouse models. Cell Mol Immunol May;9(3):237-44. Review [PMID: 22504952]

Influenza

Balazs AB; Bloom JD; Hong CM; Rao DS; Baltimore D. 2013. Broad protection against influenza infection by vectored immunoprophylaxis in mice. Nat Biotechnol. Jul;31(7):647-52. [PMID: 23728362]

Leishmaniasis

Wege AK; Florian C; Ernst W; Zimara N; Schleicher U; Hanses F; Schmid M; Ritter U. 2012. Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response. PLoS Negl Trop Dis. Jul;6(7):e1741. [PMID: 22848771]

Measles

Boussaad I; Varagnolo L; Hornich V; Rieger L; Krockenberger M; Stuehmer T; Kranzfelder D; Mueller AM; Schneider-Schaulies S. 2011. Wild-type Measles Virus (MV) interferes with short term engraftment of human CD34+ hematopoietic progenitor cells. J Virol Aug;85(15):7710-8 [PMID: 21593150]

Pneumonia

Prince, A., Wang, H., Kitur, K., Parker, D., 2016. Humanized mice exhibit increased susceptibility to Staphylococcus aureus pneumonia. J. Infect. Dis. doi:10.1093/infdis/jiw425 [PMID: 27638942]

Review articles

Akkina R. 2013. New generation humanized mice for virus research: Comparative aspects and future prospects. Virology. Jan 5;435(1):14-28. [PMID: 23217612]
Akkina R. 2013. Human immune responses and potential for vaccine assessment in humanized mice. Curr Opin Immunol. Jun;25(3):403-9. [PMID: 23628166]
Rämer PC; Chijioke O; Meixlsperger S; Leung CS; Münz C. 2011. Mice with human immune system components as in vivo models for infections with human pathogens. Immunol Cell Biol Mar;89(3):408-16. [PMID: 21301484]
Xiang J, Zhang S, Leclercq G, Nauwynck H. 2016. Difference in replication of low-passage MCMV HaNa1 in BALB/c, C57BL/6 and NOD mice and role of different branches of immunity in susceptibility. Virus Res. May 9. pii: S0168-1702(16)30097-1. doi: 10.1016/j.virusres.2016.05.006. [PMID: 27173788]

Sepsis

Ernst W; Zimara N; Hanses F; Männel DN; Seelbach-Göbel B; Wege AK. 2013. Humanized Mice- a new Model to Study the Influence of Drug Treatment on Neonatal Sepsis. Infect Immun. May;81(5):1520-31. [PMID: 23439310]
Skirecki T, Kawiak J, Machaj E, Pojda Z, Wasilewska D, Czubak J, Hoser G. Early severe impairment of hematopoietic stem and progenitor cells from the bone marrow caused by CLP sepsis and endotoxemia in a humanized mice model. Stem Cell Res Ther. 2015 Aug 14;6(1):142. [PMID: 26272069]
Unsinger J; McDonough JS; Shultz LD; Ferguson TA; Hotchkiss RS. 2009. Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. J Leukoc Biol Aug;86(2):219-27. [PMID: 19369639]
Ye C; Choi JG; Abraham S; Wu H; Diaz D; Terreros D; Shankar P; Manjunath N. 2012. Human macrophage and dendritic cell-specific silencing of high-mobility group protein B1 ameliorates sepsis in a humanized mouse model. Proc Natl Acad Sci U S A. Dec 18;109(51):21052-7. [PMID: 23213216]

Tuberculosis

Calderon VE; Valbuena G; Goez Y; Judy BM; Huante MB; Sutjita P; Johnston RK; Estes DM; Hunter RL; Actor JK; Cirillo JD; Endsley JJ. 2013. A humanized mouse model of tuberculosis. PLoS One. May 17;8(5):e63331. [PMID: 23691024]
Heuts F; Gavier-Widén D; Carow B; Juarez J; Wigzell H; Rottenberg ME. 2013. CD4+ cell-dependent granuloma formation in humanized mice infected with mycobacteria. Proc Natl Acad Sci U S A. Apr 16;110(16):6482-7. [PMID: 23559373]
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Typhoid fever

Libby SJ; Brehm MA; Greiner DL; Shultz LD; McClelland M; Smith KD; Cookson BT; Karlinsey JE; Kinkel TL; Porwollik S; Canals R; Cummings LA; Fang FC. 2010. Humanized nonobese diabetic-scid IL2r{gamma}null mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A Aug 31;107(35):15589-94. [PMID: 20713716]

Varicella-zoster virus

Rowe J; Greenblatt RJ; Liu D; Moffat JF. 2010. Compounds that target host cell proteins prevent varicella-zoster virus replication in culture, ex vivo, and in SCID-Hu mice. Antiviral Res Jun;86(3):276-85. [PMID: 20307580]

Other infectious disease

Altamirano-Lagos, M.J., Díaz, F.E., Mansilla, M.A., Rivera-Pérez, D., Soto, D., McGill, J.L., Vasquez, A.E., Kalergis, A.M., 2019. Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus. Front Microbiol 10.[PMID: 31130923]
Bakkour, S., Chafets, D.M., Wen, L., Muench, M.O., Telford, S.R., Erwin, J.L., Levin, A.E., Self, D., Brès, V., Linnen, J.M., Lee, T.-H., Busch, M.P., 2018. Minimal infectious dose and dynamics of Babesia microti parasitemia in a murine model. Transfusion. [PMID: 30264498]
Lindquist, M.E., Zeng, X., Altamura, L.A., Daye, S.P., Delp, K.L., Blancett, C., Coffin, K.M., Koehler, J.W., Coyne, S., Shoemaker, C.J., Garrison, A.R., Golden, J.W., 2018. Exploring Crimean-Congo hemorrhagic fever virus-induced hepatic injury using antibody-mediated type I interferon blockade in mice. J. Virol. [PMID: 30111561]
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Patton, J.B., Bennuru, S., Eberhard, M.L., Hess, J.A., Torigian, A., Lustigman, S., Nutman, T.B., Abraham, D., 2018. Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum. PLoS Negl Trop Dis 12, e0006977. [PMID: 30540742 ]
Spengler, J.R., Keating, M.K., McElroy, A.K., Zivcec, M., Coleman-McCray, J.D., Harmon, J.R., Bollweg, B.C., Goldsmith, C.S., Bergeron, É., Keck, J.G., Zaki, S.R., Nichol, S.T., Spiropoulou, C.F., 2017. Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection. J. Infect. Dis. doi:10.1093/infdis/jix215 [PMID: 28482001]
Spengler, J.R., McElroy, A.K., Harmon, J.R., Coleman-McCray, J.D., Welch, S.R., Keck, J.G., Nichol, S.T., Spiropoulou, C.F., 2018. Human immune cell engraftment does not alter development of severe acute Rift Valley fever in mice. PLoS ONE 13, e0201104. [PMID: 30028878]
Zhao, J., Lee, E.E., Kim, J., Yang, R., Chamseddin, B., Ni, C., Gusho, E., Xie, Y., Chiang, C.-M., Buszczak, M., Zhan, X., Laimins, L., Wang, R.C., 2019. Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus. Nat Commun 10.[PMID: 31127091]

Miscellaneous

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Bufalieri, F., Infante, P., Bernardi, F., Caimano, M., Romania, P., Moretti, M., Lospinoso Severini, L., Talbot, J., Melaiu, O., Tanori, M., Di Magno, L., Bellavia, D., Capalbo, C., Puget, S., De Smaele, E., Canettieri, G., Guardavaccaro, D., Busino, L., Peschiaroli, A., Pazzaglia, S., Giannini, G., Melino, G., Locatelli, F., Gulino, A., Ayrault, O., Fruci, D., Di Marcotullio, L., 2019. ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP. Nat Commun 10. [PMID: 31341163]
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Habiel, D.M., Espindola, M.S., Jones, I.C., Coelho, A.L., Stripp, B., Hogaboam, C.M., 2018. CCR10+ epithelial cells from idiopathic pulmonary fibrosis lungs drive remodeling. JCI Insight 3. [PMID: 30135312]
Ho KS; Aman AM; Al-awar RS; Shoichet MS. 2012. Amphiphilic micelles of poly(2-methyl-2-carboxytrimethylene carbonate-co-D;L-lactide)-graft-poly(ethylene glycol) for anti-cancer drug delivery to solid tumours. Biomaterials Mar;33(7):2223-9. [PMID: 22182751]
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Landel CP; Dunlap J; Patton JB; Manser T. 2013. A germline-competent embryonic stem cell line from NOD.Cg-Prkdc ( scid ) Il2rg ( tm1Wjl )/SzJ (NSG) mice. Transgenic Res. Feb;22(1):179-85. [PMID: 22767020]
Lawson, M.A., Ebetino, F.H., Mazur, A., Chantry, A.D., Paton-Hough, J., Evans, H.R., Lath, D., Tsoumpra, M.K., Lundy, M.W., Dobson, R.L.M., Quijano, M., Kwaasi, A.A., Dunford, J.E., Duan, X., Triffitt, J.T., Jeans, G., Russell, R.G.G., 2017. The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-fluoro-2-(imidazo-[1,2-α]pyridin-3-yl)ethyl-bisphosphonate. J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res. [PMID: 28337806]
Ledet, M.M., Anderson, R., Harman, R., Muth, A., Thompson, P.R., Coonrod, S.A., Van de Walle, G.R., 2018. BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway. BMC Cancer 18, 412. [PMID: 29649984]
Li F; Cowley DO; Banner D; Holle E; Zhang L; Su L. 2014. Efficient genetic manipulation of the NOD-Rag1-/-IL2RgammaC-null mouse by combining in vitro fertilization and CRISPR/Cas9 technology. Sci Rep. Jun 17; 4:5290. [PMID: 24936832]
Li, F., Ulrich, M.L., Shih, V.F.-S., Cochran, J.H., Hunter, J.H., Westendorf, L., Neale, J., Benjamin, D.R., 2019. Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody-Drug Conjugate Via Fc-FcγR Interaction. Mol. Cancer Ther. 18, 780–787. [PMID: 30824607]
Lobachevsky, P.N., Ventura, J., Giannakandropoulou, L., Forrester, H., Palazzolo, J.S., Haynes, N.M., Stevenson, A.W., Hall, C.J., Mason, J., Pollakis, G., Pateras, I.S., Gorgoulis, V., Terzoudi, G.I., Hamilton, J.A., Sprung, C.N., Georgakilas, A.G., Martin, O.A., 2018. A Functional Immune System Is Required For The Systemic Genotoxic Effects Of Localised Irradiation. Int. J. Radiat. Oncol. Biol. Phys. [PMID: 30529375 ]
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Oncology NSG References

Abdelrasoul, H., Vadakumchery, A., Werner, M., Lenk, L., Khadour, A., Young, M., El Ayoubi, O., Vogiatzi, F., Krämer, M., Schmid, V., Chen, Z., Yousafzai, Y., Cario, G., Schrappe, M., Müschen, M., Halsey, C., Mulaw, M. A., Schewe, D. M., Hobeika, E., … Jumaa, H. (2020). Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia. Nature Communications, 11. [PMID: 32581241]
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Solid Tumors

Adrenal gland cancer

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Bladder cancer

Lin TY; Li YP; Zhang H; Luo J; Goodwin N; Gao T; White RD; Lam KS; Pan CX. 2012. Tumor-targeting multifunctional micelles for imaging and chemotherapy of advanced bladder cancer.Nanomedicine (Lond). Aug;8(8):1239-51. [PMID: 23199207]
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Breast cancer

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Mandriota, S.J., Tenan, M., Ferrari, P., Sappino, A.-P., 2016. Aluminium chloride promotes tumorigenesis and metastasis in normal murine mammary gland epithelial cells. Int. J. Cancer 139, 2781–2790. [PMID: 27541736]
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Shafiee, A., McGovern, J.A., Lahr, C.A., Meinert, C., Moi, D., Wagner, F., Landgraf, M., De-Juan-Pardo, E., Mazzieri, R., Hutmacher, D.W., 2018. Immune system augmentation via humanization using stem/progenitor cells and bioengineering in a breast cancer model study. Int. J. Cancer. [PMID: 29659011]
Shen, Y., Zhang, W., Liu, J., He, J., Cao, R., Chen, X., Peng, X., Xu, H., Zhao, Q., Zhong, J., Ding, W., Lei, X., Jiang, Y., Zu, X., 2018. Therapeutic Activity of DCC-2036, a Novel Tyrosine Kinase Inhibitor, against Triple-Negative Breast Cancer Patient-Derived Xenografts by Targeting AXL/MET. Int. J. Cancer. [PMID: 30289981]
Smith, H.W., Hirukawa, A., Sanguin-Gendreau, V., Nandi, I., Dufour, C.R., Zuo, D., Tandoc, K., Leibovitch, M., Singh, S., Rennhack, J.P., Swiatnicki, M., Lavoie, C., Papavasiliou, V., Temps, C., Carragher, N.O., Unciti-Broceta, A., Savage, P., Basik, M., van Hoef, V., Larsson, O., Cooper, C.L., Vargas Calderon, A.C., Beith, J., Millar, E., Selinger, C., Giguère, V., Park, M., Harris, L.N., Varadan, V., Andrechek, E.R., O’Toole, S.A., Topisirovic, I., Muller, W.J., 2019. An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis. Nat Commun 10. [PMID: 31263101]
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Tonsing-Carter E, Bailey BJ, Saadatzadeh MR, Ding J, Wang H, Sinn AL, Peterman KM, Spragins TK, Silver JM, Sprouse AA, Georgiadis TM, Gunter TZ, Long EC, Minto RE, Marchal CC, Batuello CN, Safa AR, Hanenberg H, Territo PR, Sandusky GE, Mayo LD, Eischen CM, Shannon HE, Pollok KE. Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model. Mol Cancer Ther. 2015 Oct 22. [PMID: 26494859]
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Wang, M., Yao, L.-C., Cheng, M., Cai, D., Martinek, J., Pan, C.-X., Shi, W., Ma, A.-H., De Vere White, R.W., Airhart, S., Liu, E.T., Banchereau, J., Brehm, M.A., Greiner, D.L., Shultz, L.D., Palucka, K., Keck, J.G., 2018. Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. FASEB J. fj201700740R. [PMID: 29146734]
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Brain cancer

Arora, P., Adams, C.H., Gudelsky, G., DasGupta, B., Desai, P.B., 2018. Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats. Cancer Chemother. Pharmacol. [PMID: 30357450]
Babic I; Anderson ES; Tanaka K; Guo D; Masui K; Li B; Zhu S; Gu Y; Villa GR; Akhavan D; Nathanson D; Gini B; Mareninov S; Li R; Camacho CE; Kurdistani SK; Eskin A; Nelson SF; Yong WH; Cavenee WK; Cloughesy TF; Christofk HR; Black DL; Mischel PS. 2013. EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer. Cell Metab. Jun 4;17(6):1000-8. [PMID: 23707073]
Bandopadhayay, P., Piccioni, F., O'Rourke, R., Ho, P., Gonzalez, E.M., Buchan, G., Qian, K., Gionet, G., Girard, E., Coxon, M., Rees, M.G., Brenan, L., Dubois, F., Shapira, O., Greenwald, N.F., Pages, M., Balboni Iniguez, A., Paolella, B.R., Meng, A., Sinai, C., Roti, G., Dharia, N.V., Creech, A., Tanenbaum, B., Khadka, P., Tracy, A., Tiv, H.L., Hong, A.L., Coy, S., Rashid, R., Lin, J.-R., Cowley, G.S., Lam, F.C., Goodale, A., Lee, Y., Schoolcraft, K., Vazquez, F., Hahn, W.C., Tsherniak, A., Bradner, J.E., Yaffe, M.B., Milde, T., Pfister, S.M., Qi, J., Schenone, M., Carr, S.A., Ligon, K.L., Kieran, M.W., Santagata, S., Olson, J.M., Gokhale, P.C., Jaffe, J.D., Root, D.E., Stegmaier, K., Johannessen, C.M., Beroukhim, R., 2019. Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nat Commun 10. [PMID: 31160565]
Bayer M, Schmitt J, Dittmann H, Handgretinger R, Bruchelt G, Sauter AW. 2016. Improved selectivity of mIBG uptake into neuroblastoma cells in vitro and in vivo by inhibition of organic cation transporter 3 uptake using clinically approved corticosteroids. Nucl Med Biol. May 27;43(9):543-551. doi: 0.1016/j.nucmedbio.2016.05.013. [Epub ahead of print] [PMID: 27376201]
Bijangi-Vishehsaraei, K., Reza Saadatzadeh, M., Wang, H., Nguyen, A., Kamocka, M.M., Cai, W., Cohen-Gadol, A.A., Halum, S.L., Sarkaria, J.N., Pollok, K.E., Safa, A.R., 2017. Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways. J. Neurosurg. 1–12. doi:10.3171/2016.8.JNS161197 [PMID: 28059653]
Braekeveldt N, Wigerup C, Tadeo I, Beckman S, Sandén C, Jönsson J, Erjefält JS, Berbegall AP, Börjesson A, Backman T, Øra I, Navarro S, Noguera R, Gisselsson D, Påhlman S, Bexell D. 2016. Neuroblastoma patient-derived orthotopic xenografts reflect the microenvironmental hallmarks of aggressive patient tumours. Cancer Lett. 2016 Mar 18. pii: S0304-3835(16)30124-0. [PMID: 27000989]
Brown, C.E., Aguilar, B., Starr, R., Yang, X., Chang, W.-C., Weng, L., Chang, B., Sarkissian, A., Brito, A., Sanchez, J.F., Ostberg, J.R., D’Apuzzo, M., Badie, B., Barish, M.E., Forman, S.J., 2018. Optimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma. Mol. Ther. 26, 31–44. [PMID: 29103912]
Brown CE; Starr R; Aguilar B; Shami A; Martinez C; D'Apuzzo M; Barish ME; Forman SJ; Jensen MC. 2012. Stem-like tumor initiating cells isolated from IL13Ra2-expressing gliomas are targeted and killed by IL13-zetakine redirected T cells. Clin Cancer Res Apr 15;18(8):2199-209 [PMID: 22407828]
Buchstaller J; McKeever PE; Morrison SJ. 2012. Tumorigenic cells are common in mouse MPNSTs but their frequency depends upon tumor genotype and assay conditions. Cancer Cell Feb 14;21(2):240-52. [PMID: 22340596]
Chan XH; Nama S; Gopal F; Rizk P; Ramasamy S; Sundaram G; Ow GS; Vladimirovna IA; Tanavde V; Haybaeck J; Kuznetsov V; Sampath P. 2012. Targeting Glioma Stem Cells by Functional Inhibition of a Prosurvival OncomiR-138 in Malignant Gliomas. Cell Rep. Sep 27;2(3):591-602. [PMID: 22921398]
Chandramohan V; Bao X; Keir ST; Pegram CN; Szafranski SE; Piao H; Wikstrand CJ; McLendon RE; Kuan CT; Pastan IH; Bigner DD. 2013. Construction of an Immunotoxin; D2C7-(scdsFv)-PE38KDEL; Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy. Clin Cancer Res Sep 1;19(17):4717-27. [PMID: 23857604]
Chaturvedi NK, McGuire TR, Coulter DW, Shukla A, McIntyre EM, Sharp JG, Joshi SS. Improved therapy for neuroblastoma using a combination approach: superior efficacy with vismodegib and topotecan. Oncotarget. 2016 Feb 25. doi: 10.18632/oncotarget.7714. [PMID: 26934655]
Choi BD; Kuan CT; Cai M; Archer GE; Mitchell DA; Gedeon PC; Sanchez-Perez L; Pastan I; Bigner DD; Sampson JH. 2013. Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma. Proc Natl Acad Sci U S A. Jan 2;110(1):270-5. [PMID: 23248284]
Chong YK, Sandanaraj E, Koh L, Thangaveloo M, Tan MS, Koh GR, Toh TB, Lim GG1, Holbrook JD, Kon OL1, Nadarajah M, Ng I, Ng WH, Tan NS, Lim KL, Tang C, Ang BT. ST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis. J Natl Cancer Inst. 2015 Nov 7;108(2). [PMID: 26547933]
Doloff JC; Waxman DJ. 2012. VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression. Cancer Res Mar 1;72(5):1103-15. [PMID: 22237627]
Jeitany M; Pineda JR; Liu Q; Porreca RM; Hoffschir F; Desmaze C; Silvestre DC; Mailliet P; Junier MP; Londoño-Vallejo A; Ségal-Bendirdjian E; Chneiweiss H; Boussin FD. 2014. A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT). Int J Cancer. Aug 30. [PMID: 25175359]
Lal, S., Carrera, D., Phillips, J.J., Weiss, W.A., Raffel, C., 2018. An oncolytic measles virus-sensitive Group 3 medulloblastoma model in immune-competent mice. Neuro-oncology. [PMID: 29912438]
Lang MF; Yang S; Zhao C; Sun G; Murai K; Wu X; Wang J; Gao H; Brown CE; Liu X; Zhou J; Peng L; Rossi JJ; Shi Y. 2012. Genome-Wide Profiling Identified a Set of miRNAs that Are Differentially Expressed in Glioblastoma Stem Cells and Normal Neural Stem Cells. PLoS One 7(4):e36248. [PMID: 22558405]
Lee SJ, Kang WY, Yoon Y, Jin JY, Song HJ, Her JH, Kang SM, Hwang YK, Kang KJ, Joo KM, Nam DH.Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain. BMC Cancer. 2015 Dec 24;15(1):1011. doi: 10.1186/s12885-015-2034-y. [PMID: 26704632]
Lim CY; Solter D; Knowles BB; Damjanov I. Development Of Teratocarcinomas And Teratomas In Severely Immunodeficient NOD.Cg-Prkdc<sup>scid</sup> Il2rg<sup>tm1Wjl</sup>/SzJ (NSG) Mice. Stem Cells Dev. 2015. Epub ahead of print [PMID: 25897827]
Liu C; Pham K; Luo D; Reynolds BA; Hothi P; Foltz G; Harrison JK. 2013. Expression and Functional Heterogeneity of Chemokine Receptors CXCR4 and CXCR7 in Primary Patient-Derived Glioblastoma Cells. PLoS One. 8(3):e59750. [PMID: 23555768]
Nellan, A., Rota, C., Majzner, R., Lester-McCully, C.M., Griesinger, A.M., Mulcahy Levy, J.M., Foreman, N.K., Warren, K.E., Lee, D.W., 2018. Durable regression of Medulloblastoma after regional and intravenous delivery of anti-HER2 chimeric antigen receptor T cells. J Immunother Cancer 6, 30. [PMID: 29712574]
Pei Y; Moore CE; Wang J; Tewari AK; Eroshkin A; Cho YJ; Witt H; Korshunov A; Read TA; Sun JL; Schmitt EM; Miller CR; Buckley AF; McLendon RE; Westbrook TF; Northcott PA; Taylor MD; Pfister SM; Febbo PG; Wechsler-Reya RJ. 2012. An animal model of MYC-driven medulloblastoma. Cancer Cell Feb 14;21(2):155-67. [PMID: 22340590]
Pierce, A.M., Witt, D.A., Donson, A.M., Gilani, A., Sanford, B., Sill, M., Van Court, B., Oweida, A., Prince, E.W., Steiner, J., Danis, E., Dorris, K., Hankinson, T., Handler, M.H., Jones, K.L., Karam, S.D., Serkova, N.J., Vibhakar, R., Foreman, N.K., Griesinger, A.M., 2019. Establishment of patient-derived orthotopic xenograft model of 1q+ posterior fossa group A ependymoma. Neuro-oncology. [PMID: 31276586]
Pirovano, G., Roberts, S., Brand, C., Donabedian, P.L., Mason, C., de Souza, P.D., Higgins, G.S., Reiner, T., 2018. [18F]FE-OTS964: a Small Molecule Targeting TOPK for In Vivo PET Imaging in a Glioblastoma Xenograft Model. Mol Imaging Biol. [PMID: 30357568]
Rampazzo E; Persano L; Pistollato F; Moro E; Frasson C; Porazzi P; Della Puppa A; Bresolin S; Battilana G; Indraccolo S; Te Kronnie G; Argenton F; Tiso N; Basso G. 2013. Wnt activation promotes neuronal differentiation of Glioblastoma. Cell Death Dis. Feb 21;4:e500. [PMID: 23429286]
Rivera M; Wu Q; Hamerlik P; Hjelmeland AB; Bao S; Rich JN. Acquisition of meiotic DNA repair regulators maintain genome stability in glioblastoma. Cell Death Dis. 2015 Apr 23;6:e1732. [PMID: 25906155]
Sciorra VA; Sanchez MA; Kunibe A; Wurmser AE. 2012. Suppression of glioma progression by egln3. PLoS One. 7(8):e40053. [PMID: 22905089]
Silvestre DC; Pineda JR; Hoffschir F; Studler JM; Mouthon MA; Pflumio F; Junier MP; Chneiweiss H; Boussin FD. 2011. Alternative lengthening of telomeres in human glioma stem cells. Stem Cells Mar;29(3):440-51. [PMID: 21425407]
Venkatesh HS; Johung TB; Caretti V; Noll A; Tang Y; Nagaraja S; Gibson EM; Mount CW; Polepalli J; Mitra SS; Woo PJ; Malenka RC; Vogel H; Bredel M; Mallick P; Monje M. Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion. Cell. 2015 Apr 21. Epub ahead of print. [PMID: 25913192]
Wang, H., Cai, S., Bailey, B.J., Reza Saadatzadeh, M., Ding, J., Tonsing-Carter, E., Georgiadis, T.M., Zachary Gunter, T., Long, E.C., Minto, R.E., Gordon, K.R., Sen, S.E., Cai, W., Eitel, J.A., Waning, D.L., Bringman, L.R., Wells, C.D., Murray, M.E., Sarkaria, J.N., Gelbert, L.M., Jones, D.R., Cohen-Gadol, A.A., Mayo, L.D., Shannon, H.E., Pollok, K.E., 2017. Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist. J. Neurosurg. 126, 446–459. doi:10.3171/2016.1.JNS152513 [PMID: 27177180]
Webb, M.W., Sun, J., Sheard, M.A., Liu, W.-Y., Wu, H.-W., Jackson, J.R., Malvar, J., Sposto, R., Daniel, D., Seeger, R.C., 2018. Colony stimulating factor 1 receptor blockade improves the efficacy of chemotherapy against human neuroblastoma in the absence of T lymphocytes. Int. J. Cancer. [PMID: 29665011]
Yost SE; Pastorino S; Rozenzhak S; Smith EN; Chao YS; Jiang P; Kesari S; Frazer KA; Harismendy O. 2013. High-resolution mutational profiling suggests the genetic validity of glioblastoma patient-derived pre-clinical models. PLoS One. 2013;8(2):e56185. [PMID: 23441165]
Zhai, L., Ladomersky, E., Lauing, K.L., Wu, M., Genet, M., Gritsina, G., Győrffy, B., Brastianos, P.K., Binder, D., Sosman, J.A., Giles, F.J., James, C.D., Horbinski, C., Stupp, R., Wainwright, D.A., 2017. Infiltrating T cells increase IDO1 expression in glioblastoma and contribute to decreased patient survival. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. doi:10.1158/1078-0432.CCR-17-0120 [PMID: 28751450]

Cancer stem cells

Ames E, Canter RJ, Grossenbacher SK, Mac S, Chen M, Smith RC, Hagino T, Perez-Cunningham J, Sckisel GD, Urayama S, Monjazeb AM, Fragoso RC, Sayers TJ, Murphy WJ. NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype. J Immunol. 2015 Sep 11. [PMID: 26363055]
Ishizawa K; Rasheed ZA; Karisch R; Wang Q; Kowalski J; Susky E; Pereira K; Karamboulas C; Moghal N; Rajeshkumar NV; Hidalgo M; Tsao M; Ailles L; Waddell TK; Maitra A; Neel BG; Matsui W. 2010. Tumor-Initiating Cells Are Rare in Many Human Tumors. Cell Stem Cell Sep 3;7(3):279-282. [PMID: 20804964]
Kumar SM; Liu S; Lu H; Zhang H; Zhang PJ; Gimotty PA; Guerra M; Guo W; Xu X. 2012. Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation. Oncogene. Nov 22;31(47):4898-911. [PMID: 22286766]
Sachlos E; Risueño RM; Laronde S; Shapovalova Z; Lee JH; Russell J; Malig M; McNicol JD; Fiebig-Comyn A; Graham M; Levadoux-Martin M; Lee JB; Giacomelli AO; Hassell JA; Fischer-Russell D; Trus MR; Foley R; Leber B; Xenocostas A; Brown ED; Collins TJ; Bhatia M. 2012. Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells. Cell Jun 8;149(6):1284-97. [PMID: 22632761]
Scaffidi P; Misteli T. 2011. In vitro generation of human cells with cancer stem cell properties. Nat Cell Biol Aug 21;13(9):1051-61. [PMID: 21857669]
Thirant C; Bessette B; Varlet P; Puget S; Cadusseau J; Tavares Sdos R; Studler JM; Silvestre DC; Susini A; Villa C; Miquel C; Bogeas A; Surena AL; Dias-Morais A; Léonard N; Pflumio F; Bieche I; Boussin FD; Sainte-Rose C; Grill J; Daumas-Duport C; Chneiweiss H; Junier MP. 2011. Clinical Relevance of Tumor Cells with Stem-Like Properties in Pediatric Brain Tumors. PLoS One 2011 Jan 28;6(1):e16375. [PMID: 21297991]

Colon cancer

Calon A; Espinet E; Palomo-Ponce S; Tauriello DV; Iglesias M; Céspedes MV; Sevillano M; Nadal C; Jung P; Zhang XH; Byrom D; Riera A; Rossell D; Mangues R; Massagué J; Sancho E; Batlle E. 2012. Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation. Cancer Cell. Nov 13;22(5):571-84. [PMID: 23153532]
Dieter SM; Ball CR; Hoffmann CM; Nowrouzi A; Herbst F; Zavidij O; Abel U; Arens A; Weichert W; Brand K; Koch M; Weitz J; Schmidt M; von Kalle C; Glimm H. 2011. Distinct types of tumor-initiating cells form human colon cancer tumors and metastases. Cell Stem Cell Oct 4;9(4):357-65. [PMID: 21982235]
Lo, Y.-H., Noah, T.K., Chen, M.-S., Zou, W., Borras, E., Vilar, E., Shroyer, N.F., 2017. SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of β-catenin. Gastroenterology. doi:10.1053/j.gastro.2017.03.048 [PMID: 28390865]
Maykel J; Liu JH; Li H; Shultz LD; Greiner DL; Houghton J. 2014. NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer. Dig Dis Sci. June; 59(6):1169-79. [PMID: 24798995]
Merhautová, J., Vychytilová-Faltejsková, P., Demlová, R., Slabý, O., 2016. Systemic administration of miRNA mimics by liposomal delivery system in animal model of colorectal carcinoma. Physiol. Res. [PMID: 28006930]
Prall, F., Maletzki, C., Hühns, M., Krohn, M., Linnebacher, M., 2017. Colorectal carcinoma tumour budding and podia formation in the xenograft microenvironment. PLoS ONE 12, e0186271. [PMID: 29040282]
Vychytilova-Faltejskova, P., Merhautova, J., Machackova, T., Gutierrez-Garcia, I., Garcia-Solano, J., Radova, L., Brchnelova, D., Slaba, K., Svoboda, M., Halamkova, J., Demlova, R., Kiss, I., Vyzula, R., Conesa-Zamora, P., Slaby, O., 2017. MiR-215-5p is a tumor suppressor in colorectal cancer targeting EGFR ligand epiregulin and its transcriptional inducer HOXB9. Oncogenesis 6, 5. [PMID: 29199273]
Wang D, Fu L, Sun H, Guo L, DuBois RN. Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice. Gastroenterology. 2015 Aug 7. [PMID: 26261008]
Wimsatt, J.H., Montgomery, C., Thomas, L.S., Savard, C., Tallman, R., Innes, K., Jrebi, N., 2018. Assessment of a mouse xenograft model of primary colorectal cancer with special reference to perfluorooctane sulfonate. PeerJ 6, e5602. [PMID: 30405966]
Xu, H., Li, J., Chen, H., Ghishan, F.K., 2019. NHE8 Deficiency Promotes Colitis-Associated Cancer in Mice via Expansion of Lgr5-Expressing Cells. Cell Mol Gastroenterol Hepatol 7, 19—31. [PMID: 30465020]

Endometrial cancer

Winder, A., Unno, K., Yu, Y., Lurain, J., Kim, J.J., 2017. The allosteric AKT inhibitor, MK2206, decreases tumor growth and invasion in patient derived xenografts of endometrial cancer. Cancer Biol. Ther. 0. doi:10.1080/15384047.2017.1281496 [PMID: 28112582]

Esophageal cancer

Ahn J; Bishop JA; Akpeng B; Pai SI; Best SR. 2014. Xenograft Model for Therapeutic Drug Testing in Recurrent Respiratory Papillomatosis. Ann Otol Rhinol Laryngol. Aug; pii: 0003489414546400. [PMID: 25124839]
Ebbing, E.A., Steins, A., Fessler, E., Stathi, P., Lesterhuis, W.J., Krishnadath, K.K., Vermeulen, L., Medema, J.P., Bijlsma, M.F., van Laarhoven, H.W.M., 2017. Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition. Gastroenterology. [PMID: 28286209]
Predina JD; Judy B; Aliperti LA; Fridlender ZG; Blouin A; Kapoor V; Laguna B; Nakagawa H; Rustgi AK; Aguilar L; Aguilar-Cordova E; Albelda SM; Singhal S. 2011. Neoadjuvant in situ gene-mediated cytotoxic immunotherapy improves postoperative outcomes in novel syngeneic esophageal carcinoma models. Cancer Gene Ther. Dec;18(12):871-83. [PMID: 21869822]

Gastrointestinal cancer

Dieter, S.M., Giessler, K.M., Kriegsmann, M., Dubash, T.D., Möhrmann, L., Schulz, E.R., Siegl, C., Weber, S., Strakerjahn, H., Oberlack, A., Heger, U., Gao, J., Hartinger, E.-M., Oppel, F., Hoffmann, C.M., Ha, N., Brors, B., Lasitschka, F., Ulrich, A., Strobel, O., Schmidt, M., von Kalle, C., Schneider, M., Weichert, W., Ehrenberg, K.R., Glimm, H., Ball, C.R., 2016. Patient-derived Xenografts of Gastrointestinal Cancers Are Susceptible to Rapid and Delayed B-Lymphoproliferation. Int. J. Cancer. [PMID: 27935045]
Edris B; Willingham SB; Weiskopf K; Volkmer AK; Volkmer JP; Mühlenberg T; Montgomery KD; Contreras-Trujillo H; Czechowicz A; Fletcher JA; West RB; Weissman IL; van de Rijn M. 2013. Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth. Proc Natl Acad Sci U S A. Feb 26;110(9):3501-6. [PMID: 23382202]
Liu K; Jiang M; Lu Y; Chen H; Sun J; Wu S; Ku WY; Nakagawa H; Kita Y; Natsugoe S; Peters JH; Rustgi A; Onaitis MW; Kiernan A; Chen X; Que J. 2013. Sox2 cooperates with inflammation-mediated stat3 activation in the malignant transformation of foregut Basal progenitor cells. Cell Stem Cell. Mar 7;12(3):304-15. [PMID: 23472872]
Rad R; Cadiñanos J; Rad L; Varela I; Strong A; Kriegl L; Constantino-Casas F; Eser S; Hieber M; Seidler B; Price S; Fraga MF; Calvanese V; Hoffman G; Ponstingl H; Schneider G; Yusa K; Grove C; Schmid RM; Wang W; Vassiliou G; Kirchner T; McDermott U; Liu P; Saur D; Bradley A. 2013. A Genetic Progression Model of Braf(V600E)-Induced Intestinal Tumorigenesis Reveals Targets for Therapeutic Intervention. Cancer Cell. Jul 8;24(1):15-29. [PMID: 23845441]
Zhu, G., Foletti, D., Liu, X., Ding, S., Melton Witt, J., Hasa-Moreno, A., Rickert, M., Holz, C., Aschenbrenner, L., Yang, A.H., Kraynov, E., Evering, W., Obert, L., Lee, C., Sai, T., Mistry, T., Lindquist, K.C., Van Blarcom, T., Strop, P., Chaparro-Riggers, J., Liu, S.-H., 2019. Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer. Sci Rep 9, 8420. [PMID: 31182754]

Head and neck cancer

Baik FM, Hansen S, Knoblaugh SE, Sahetya D, Mitchell RM, Xu C, Parrish-Novak J, Méndez E. Fluorescence Identification of Head and Neck Squamous Cell Carcinoma and High-Risk Oral Dysplasia With BLZ-100, a Chlorotoxin-Indocyanine Green Conjugate. JAMA Otolaryngol Head Neck Surg. 2016 Feb 18. doi: 10.1001/jamaoto.2015.3617. [PMID: 26892902]
Behera, A.K., Kumar, M., Shanmugam, M.K., Bhattacharya, A., Rao, V.J., Bhat, A., Vasudevan, M., Gopinath, K.S., Mohiyuddin, A., Chatterjee, A., Sethi, G., Kundu, T.K., 2019. Functional interplay between YY1 and CARM1 promotes oral carcinogenesis. Oncotarget 10, 3709—3724. [PMID: 31217904]
Bragado P; Estrada Y; Sosa MS; Avivar-Valderas A; Cannan D; Genden E; Teng M; Ranganathan AC; Wen HC; Kapoor A; Bernstein E; Aguirre-Ghiso JA. 2012. Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties. PLoS One 7(1):e29974. [PMID: 22276135]
Facompre, N.D., Sahu, V., Montone, K.T., Harmeyer, K.M., Nakagawa, H., Rustgi, A.K., Weinstein, G.S., Gimotty, P.A., Basu, D., 2017. Barriers to generating PDX models of HPV-related head and neck cancer. Laryngoscope 127, 2777–2783. [PMID: 28561270]
Kimple RJ; Harari P; Torres AD; Yang RZ; Soriano BJ; Yu M; Armstrong EA; Blitzer GC; Smith MA; Lorenz LD; Lee D; Yang D; McCulloch TM; Hartig GK; Lambert PF. 2012. Development and characterization of HPV-positive and HPV-negative head and neck squamous cell carcinoma tumorgrafts. Clin Cancer Res. Feb 15;19(4):855-64. [PMID: 23251001]
Martens-de Kemp SR; Brink A; Stigter-van Walsum M; Damen JM; Rustenburg F; Wu T; van Wieringen WN; Schuurhuis GJ; Braakhuis BJ; Slijper M; Brakenhoff RH. 2013. CD98 marks a subpopulation of head and neck squamous cell carcinoma cells with stem cell properties. Stem Cell Res. May;10(3):477-88. [PMID: 23523931]
Shrivastava S; Steele R; Sowadski M; Crawford SE; Varvares M; Ray RB. 2015. Identification of molecular signature of head and neck cancer stem-like cells. Sci Rep. Epub ahead of print. [PMID: 25588898]

Hepatoblastoma

Ellerkamp V; Armeanu-Ebinger S; Wenz J; Warmann SW; Schafer J; Ruck P; Fuchs J. 2011. Successful Establishment of an Orthotopic Hepatoblastoma In Vivo Model in NOD/LtSz-scid IL2Rγnull Mice. PLoS One. 6(8):e23419. [PMID: 21853130]
Harmon, J.S., Kabinejadian, F., Seda, R., Fabiilli, M.L., Kuruvilla, S., Kuo, C.C., Greve, J.M., Fowlkes, J.B., Bull, J.L., 2019. Minimally invasive gas embolization using acoustic droplet vaporization in a rodent model of hepatocellular carcinoma. Sci Rep 9. [PMID: 31363130]
Lieber J; Eicher C; Wenz J; Kirchner B; Warmann SW; Fuchs J; Armeanu-Ebinger S. 2011. The BH3 mimetic ABT-737 increases treatment efficiency of paclitaxel against hepatoblastoma. BMC Cancer. Aug 19;11(1):362. [PMID: 21854558]

Hepatocellular carcinoma

Chen K; Ahmed S; Adeyi O; Dick JE; Ghanekar A. 2012. Human solid tumor xenografts in immunodeficient mice are vulnerable to lymphomagenesis associated with epstein-barr virus. PLoS One. 7(6):e39294. [PMID: 22723990]
Colombo F; Baldan F; Mazzucchelli S; Martin-Padura I; Marighetti P; Cattaneo A; Foglieni B; Spreafico M; Guerneri S; Baccarin M; Bertolini F; Rossi G; Mazzaferro V; Cadamuro M; Maggioni M; Agnelli L; Rebulla P; Prati D; Porretti L. 2011. Evidence of distinct tumour-propagating cell populations with different properties in primary human hepatocellular carcinoma. PLoS One 6(6):e21369. [PMID: 21731718]
Guo, X., Jiang, H., Shi, B., Zhou, M., Zhang, H., Shi, Z., Du, G., Luo, H., Wu, X., Wang, Y., Sun, R., Li, Z., 2018. Disruption of PD-1 Enhanced the Anti-tumor Activity of Chimeric Antigen Receptor T Cells Against Hepatocellular Carcinoma. Front Pharmacol 9, 1118. [PMID: 30327605]
Kumar, D.P., Santhekadur, P.K., Seneshaw, M., Mirshahi, F., Tuculescu, C.U., Sanyal, A.J., 2018. A Novel Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of NAFLD and HCC. Hepatology. [PMID: 30394550]
Martin-Padura I; Marighetti P; Agliano A; Colombo F; Larzabal L; Redrado M; Bleau AM; Prior C; Bertolini F; Calvo A. 2012. Residual dormant cancer stem-cell foci are responsible for tumor relapse after antiangiogenic metronomic therapy in hepatocellular carcinoma xenografts. Lab Invest Jul;92(7):952-66. [PMID: 22546866]
Tahtouh R; Azzi AS; Alaaeddine N; Chamat S; Bouharoun-Tayoun H; Wardi L; Raad I; Sarkis R; Antoun NA; Hilal G. Telomerase Inhibition Decreases Alpha-Fetoprotein Expression and Secretion by Hepatocellular Carcinoma Cell Lines: In Vitro and In Vivo Study. Plos One. 2015 Mar 30;10(3):e0119512. [PMID: 25822740]
Tischfield, D.J., Ackerman, D., Noji, M., Chen, J.X., Johnson, O., Perkons, N.R., Nadolski, G.J., Hunt, S.J., Soulen, M.C., Furth, E.E., Gade, T.P., 2019. Establishment of hepatocellular carcinoma patient-derived xenografts from image-guided percutaneous biopsies. Sci Rep 9. [PMID: 31332214]
Zhao, J., Wozniak, A., Adams, A., Cox, J., Vittal, A., Voss, J., Bridges, B., Weinman, S.A., Li, Z., 2019. SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway. J Exp Clin Cancer Res 38. [PMID: 31196136]
Zhao, Y., Shuen, T.W.H., Toh, T.B., Chan, X.Y., Liu, M., Tan, S.Y., Fan, Y., Yang, H., Lyer, S.G., Bonney, G.K., Loh, E., Chang, K.T.E., Tan, T.C., Zhai, W., Chan, J.K.Y., Chow, E.K.-H., Chee, C.E., Lee, G.H., Dan, Y.Y., Chow, P.K.-H., Toh, H.C., Lim, S.G., Chen, Q., 2018. Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy. Gut. [PMID: 29602780]
Zhu, W., Peng, Y., Wang, L., Hong, Y., Jiang, X., Li, Q., Liu, H., Huang, L., Wu, J., Celis, E., Merchen, T., Kruse, E., He, Y., 2018. Identification of α-fetoprotein-specific T cell receptors for hepatocellular carcinoma immunotherapy. Hepatology. [PMID: 29443377]

Lung cancer

Basak SK; Veena MS; Oh S; Lai C; Vangala S; Elashoff D; Fishbein MC; Sharma S; Rao NP; Rao D; Phan R; Srivatsan ES; Batra RK. 2013. The CD44(high) Tumorigenic Subsets in Lung Cancer Biospecimens Are Enriched for Low miR-34a Expression. PLoS One. Sep 3;8(9):e73195. [PMID: 24019906]
Gandara DR; Mack PC; Bult C; Li T; Lara PN Jr; Riess JW; Astrow SH; Gandour-Edwards R; Cooke DT; Yoneda KY; Moore EH; Pan CX; Burich RA; David EA; Keck JG; Airhart S; Goodwin N; de Vere White RW; Liu ET. Bridging tumor genomics to patient outcomes through an integrated patient-derived xenograft platform. Clin Lung Cancer. 2015 May;16(3):165-72. [PMID: 25838158]
Guerrera F, Tabbò F, Bessone L, Maletta F, Gaudiano M, Ercole E, Annaratone L, Todaro M, Boita M, Filosso PL, Solidoro P, Delsedime L, Oliaro A, Sapino A, Ruffini E, Inghirami G. The Influence of Tissue Ischemia Time on RNA Integrity and Patient-Derived Xenografts (PDX) Engraftment Rate in a Non-Small Cell Lung Cancer (NSCLC) Biobank. PLoS One. 2016 Jan 5;11(1):e0145100. doi: 10.1371/journal.pone.0145100. [PMID: 26731692]
Habiel, D.M., Espindola, M.S., Coelho, A.L., Hogaboam, C.M., 2018. Modeling Idiopathic Pulmonary Fibrosis in Humanized SCID Mice. Am. J. Pathol. [PMID: 29378172]
Holopainen T; Saharinen P; D'Amico G; Lampinen A; Eklund L; Sormunen R; Anisimov A; Zarkada G; Lohela M; Heloterä H; Tammela T; Benjamin LE; Ylä-Herttuala S; Leow CC; Koh GY; Alitalo K. 2012. Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis. J Natl Cancer Inst Mar 21;104(6):461-75. [PMID: 22343031]
Hung, W.-Y., Chang, J.-H., Cheng, Y., Chen, C.-K., Chen, J.-Q., Hua, K.-T., Cheng, C.-W., Hsiao, M., Chung, C.-L., Lee, W.-J., Chien, M.-H., 2018. Leukocyte Cell-Derived Chemotaxin 2 Retards Non-Small Cell Lung Cancer Progression Through Antagonizing MET and EGFR Activities. Cell. Physiol. Biochem. 51, 337–355. [PMID: 30453282]
Kalber TL; Campbell-Washburn AE; Siow BM; Sage E; Price AN; Ordidge KL; Walker-Samuel S; Janes SM; Lythgoe MF. 2013. Primed Infusion with Delayed Equilibrium of Gd.DTPA for Enhanced Imaging of Small Pulmonary Metastases. PLoS One. 8(1):e54903. [PMID: 23382996]
Morrison BJ; Steel JC; Morris JC. 2012. Sphere culture of murine lung cancer cell lines are enriched with cancer initiating cells. PLoS One. 7(11):e49752. [PMID: 23152931]
Pyo, K.H., Kim, J.H., Lee, J.-M., Kim, S.E., Cho, J.S., Lim, S.M., Cho, B.C., 2019. Promising preclinical platform for evaluation of immuno-oncology drugs using Hu-PBL-NSG lung cancer models. Lung Cancer 127, 112—121. [PMID: 30642538]
Serrano-Tejero D; Bleau AM; Fernandez-Garcia I; Fernandez-Marcelo T; Iniesta P; Ortiz-de-Solorzano C; Calvo A. 2011. Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer. Mol Cancer. Aug 9;10(1):96. [PMID: 21827695]
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Tavassoly, I., Hu, Y., Zhao, S., Mariottini, C., Boran, A., Chen, Y., Li, L., Tolentino, R.E., Jayaraman, G., Goldfarb, J., Gallo, J., Iyengar, R., 2019. Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses. Mol Oncol 13, 1725–1743. [PMID: 31116490<]
Toma, W., Kyte, S.L., Bagdas, D., Jackson, A., Meade, J.A., Rahman, F., Chen, Z.-J., Del Fabbro, E., Cantwell, L., Kulkarni, A., Thakur, G.A., Papke, R.L., Bigbee, J.W., Gewirtz, D.A., Damaj, M.I., 2019. The α7 nicotinic receptor silent agonist R-47 prevents and reverses paclitaxel-induced peripheral neuropathy in mice without tolerance or altering nicotine reward and withdrawal. Exp. Neurol. 320, 113010. [PMID: 31299179]
Tsai HY; Yang YF; Wu AT; Yang CJ; Liu YP; Jan YH; Lee CH; Hsiao YW; Yeh CT; Shen CN; Lu PJ; Huang MS; Hsiao M. 2013. Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78. Oncogene [Epub ahead of print] [PMID: 23318055]
Vaughan AE; Halbert CL; Wootton SK; Miller AD. 2012. Lung cancer in mice induced by the jaagsiekte sheep retrovirus envelope protein is not maintained by rare cancer stem cells; but tumorigenicity does correlate with Wnt pathway activation. Mol Cancer Res Jan;10(1):86-95. [PMID: 22064658]
Wang, D., Pham, N.-A., Tong, J., Sakashita, S., Allo, G., Kim, L., Yanagawa, N., Raghavan, V., Wei, Y., To, C., Trinh, Q.M., Starmans, M.H.W., Chan-Seng-Yue, M.A., Chadwick, D., Li, L., Zhu, C.-Q., Liu, N., Li, M., Lee, S., Ignatchenko, V., Strumpf, D., Taylor, P., Moghal, N., Liu, G., Boutros, P.C., Kislinger, T., Pintilie, M., Jurisica, I., Shepherd, F.A., McPherson, J.D., Muthuswamy, L., Moran, M.F., Tsao, M.-S., 2017. Molecular heterogeneity of non-small cell lung carcinoma patient-derived xenografts closely reflect their primary tumors. Int. J. Cancer 140, 662–673. doi:10.1002/ijc.30472 [PMID: 27177180]
Wang H, Wang L, Zhang Y, Wang J, Deng Y, Lin D. Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth. Cancer Cell Int. 2016 Feb 16;16:9. doi: 10.1186/s12935-016-0280-y. [PMID: 26884725]
Wang, X.-D., Hu, R., Ding, Q., Savage, T.K., Huffman, K.E., Williams, N., Cobb, M.H., Minna, J.D., Johnson, J.E., Yu, Y., 2019. Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells. Nat Commun 10. [PMID: 31324758]
Wu, L., Zhang, H., Jiang, Y., Gallo, R.C., Cheng, H., 2018. Induction of antitumor cytotoxic lymphocytes using engineered human primary blood dendritic cells. Proc. Natl. Acad. Sci. U.S.A. [PMID: 29674449]
Yeddula N, Xia Y, Ke E, Beumer J, Verma IM. Screening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinoma. Proc Natl Acad Sci U S A. 2015 Nov 5. [PMID: 26542681]
Zhang, L., Singh, A., Plaisier, C., Pruett, N., Ripley, R.T., Schrump, D.S., Hoang, C.D., 2019. Metadherin Is a Prognostic Apoptosis Modulator in Mesothelioma Induced via NF-κB-Mediated Signaling. Transl Oncol 12, 859—870. [PMID: 31054476]
Zhang WC; Shyh-Chang N; Yang H; Rai A; Umashankar S; Ma S; Soh BS; Sun LL; Tai BC; Nga ME; Bhakoo KK; Jayapal SR; Nichane M; Yu Q; Ahmed DA; Tan C; Sing WP; Tam J; Thirugananam A; Noghabi MS; Pang YH; Ang HS; Mitchell W; Robson P; Kaldis P; Soo RA; Swarup S; Lim EH; Lim B. 2012. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell Jan 20;148(1-2):259-72. [PMID: 22225612]
Zheng Y; de la Cruz CC; Sayles LC; Alleyne-Chin C; Vaka D; Knaak TD; Bigos M; Xu Y; Hoang CD; Shrager JB; Fehling HJ; French D; Forrest W; Jiang Z; Carano RA; Barck KH; Jackson EL; Sweet-Cordero EA. 2013. A Rare Population of CD24(+)ITGB4(+)Notch(hi) Cells Drives Tumor Propagation in NSCLC and Requires Notch3 for Self-Renewal. Cancer Cell. Jul 8;24(1):59-74. [PMID: 23845442]

Immunotherapy

Alatrash, G., Qiao, N., Zhang, M., Zope, M., Perakis, A.A., Sukhumalchandra, P., Philips, A.V., Garber, H.R., Kerros, C., John, L.S.S., Khouri, M.R., Khong, H., Clise-Dwyer, K., Miller, L.P., Wolpe, S.D., Overwijk, W.W., Molldrem, J.J., Ma, Q., Shpall, E.J., Mittendorf, E.A., 2019. Fucosylation enhances the efficacy of adoptively transferred antigen-specific cytotoxic T lymphocytes. Clin Cancer Res clincanres.1527.2018. [PMID: 30647079]
Barrett DM; Liu X; Jiang S; June CH; Grupp SA; Zhao Y. 2013. Regimen-Specific Effects of RNA-Modified Chimeric Antigen Receptor T Cells in Mice with Advanced Leukemia. Hum Gene Ther. Aug;24(8):717-27. [PMID: 23883116]
Braumüller H; Wieder T; Brenner E; Aßmann S; Hahn M; Alkhaled M; Schilbach K; Essmann F; Kneilling M; Griessinger C; Ranta F; Ullrich S; Mocikat R; Braungart K; Mehra T; Fehrenbacher B; Berdel J; Niessner H; Meier F; van den Broek M; Häring HU; Handgretinger R; Quintanilla-Martinez L; Fend F; Pesic M; Bauer J; Zender L; Schaller M; Schulze-Osthoff K; Röcken M. 2013. T-helper-1-cell cytokines drive cancer into senescence. Nature. Feb 21;494(7437):361-5. [PMID: 23376950]
Canale S; Cocco C; Frasson C; Seganfreddo E; Di Carlo E; Ognio E; Sorrentino C; Ribatti D; Zorzoli A; Basso G; Dufour C; Airoldi I. 2011. Interleukin-27 inhibits pediatric B-acute lymphoblastic leukemia cell spreading in a preclinical model.Leukemia Dec;25(12):1815-24.[PMID: 21701492]
Chang DK, Peterson E, Sun J, Goudie C, Drapkin RI, Liu JF, Matulonis U, Zhu Q, Marasco WA. 2015. Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model. Oncoimmunology. Dec 10;5(3):e1090075. [PMID: 27141347]
Edris B; Weiskopf K; Volkmer AK; Volkmer JP; Willingham SB; Contreras-Trujillo H; Liu J; Majeti R; West RB; Fletcher JA; Beck AH; Weissman IL; van de Rijn M. 2012. Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma. Proc Natl Acad Sci U S A Apr 24;109(17):6656-61 [PMID: 22451919]
Ferretti E; Montagna D; Di Carlo E; Cocco C; Ribatti D; Ognio E; Sorrentino C; Lisini D; Bertaina A; Locatelli F; Pistoia V; Airoldi I. 2011. Absence of IL-12Rβ2 in CD33(+)CD39(+) pediatric acute myeloid leukemia cells favours progression in NOD/SCID/IL2RγC-deficient mice. Leukemia Feb;26(2):225-35. [PMID: 21844875]
Fisher TS; Kamperschroer C; Oliphant T; Love VA; Lira PD; Doyonnas R; Bergqvist S; Baxi SM; Rohner A; Shen AC; Huang C; Sokolowski SA; Sharp LL. 2012. Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity. Cancer Immunol Immunother. Oct;61(10):1721-33. [PMID: 22406983]
Habiel, D.M., Espindola, M.S., Kitson, C., Azzara, A.V., Coelho, A.L., Stripp, B., Hogaboam, C.M., 2018. Characterization of CD28null T cells in idiopathic pulmonary fibrosis. Mucosal Immunol. [PMID: 30315241]
Hudecek M; Lupo Stanghellini MT; Kosasih PL; Sommermeyer D; Jensen M; Rader C; Riddell S. 2013. Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T-cells. Clin Cancer Res. Jun 15;19(12):3153-64. [PMID: 23620405]
Kloss CC; Condomines M; Cartellieri M; Bachmann M; Sadelain M. 2012. Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells. Nat Biotechnol. Dec 16;31(1):71-5. [PMID: 23242161]
Liu D; Song L; Wei J; Courtney AN; Gao X; Marinova E; Guo L; Heczey A; Asgharzadeh S; Kim E; Dotti G; Metelitsa LS. 2012. IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity. J Clin Invest Jun 1;122(6):2221-33. [PMID: 22565311]
Markley JC; Sadelain M. 2010. Interleukin (IL)-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice. Blood Apr 29;115(17):3508-19. [PMID: 20190192]
Mayer, A.T., Natarajan, A., Gordon, S., Maute, R., McCracken, M., Ring, A., Weissman, I., Gambhir, S.S., 2016. Practical ImmunoPET radiotracer design considerations for human immune checkpoint imaging. J. Nucl. Med. Off. Publ. Soc. Nucl. Med. [PMID: 27980047]
McCormack E; Adams KJ; Hassan NJ; Kotian A; Lissin NM; Sami M; Mujić M; Osdal T; Gjertsen BT; Baker D; Powlesland AS; Aleksic M; Vuidepot A; Morteau O; Sutton DH; June CH; Kalos M; Ashfield R; Jakobsen BK. 2012. Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors. Cancer Immunol Immunother. Apr;62(4):773-85. [PMID: 23263452]
Milone MC; Fish JD; Carpenito C; Carroll RG; Binder GK; Teachey D; Samanta M; Lakhal M; Gloss B; Danet-Desnoyers G; Campana D; Riley JL; Grupp SA; June CH. 2009. Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo. Mol Ther. Aug;17(8):1453-64. [PMID: 19384291]
Moon EK; Carpenito C; Sun J; Wang LC; Kapoor V; Predina JD; Powell DJ Jr; Riley J; June CH; Albelda SM. 2011. Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Eradication by Human T Cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor. Clin Cancer Res Jul 15;17(14):4719-30. [PMID: 21610146]
Orienti, I., Francescangeli, F., De Angelis, M.L., Fecchi, K., Bongiorno-Borbone, L., Signore, M., Peschiaroli, A., Boe, A., Bruselles, A., Costantino, A., Eramo, A., Salvati, V., Sette, G., Contavalli, P., Zolla, L., Oki, T., Kitamura, T., Spada, M., Giuliani, A., Baiocchi, M., La Torre, F., Melino, G., Tartaglia, M., De Maria, R., Zeuner, A., 2019. A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors. Cell Death Dis 10. [PMID: 31332161]
Otáhal P, Průková D, Král V, Fabry M, Vočková P, Latečková L, Trněný M, Klener P. 2016. Lenalidomide enhances antitumor functions of chimeric antigen receptor modified T cells. Oncoimmunology. 2015 Dec 3;5(4):e1115940. [PMID: 27141398]
Park J, Kim S, Joh J, Remick SC, Miller DM, Yan J, Kanaan Z, Chao JH, Krem MM, Basu SK, Hagiwara S, Kenner L, Moriggl R, Bunting KD, Tse W. 2016. MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling. Oncotarget. Jun 1. doi: 10.18632/oncotarget.9759. [Epub ahead of print] [PMID: 27259262]
Piccione EC, Juarez S, Tseng S, Liu J, Stafford M, Narayanan C, Wang L, Weiskopf K, Majeti R. 2016. SIRPα-Antibody Fusion Proteins Selectively Bind and Eliminate Dual Antigen-Expressing Tumor Cells. Clin Cancer Res. 2016 Apr 28. pii: clincanres.2503.2015. [PMID: 27126995]
Provasi E; Genovese P; Lombardo A; Magnani Z; Liu PQ; Reik A; Chu V; Paschon DE; Zhang L; Kuball J; Camisa B; Bondanza A; Casorati G; Ponzoni M; Ciceri F; Bordignon C; Greenberg PD; Holmes MC; Gregory PD; Naldini L; Bonini C. 2012. Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer. Nat Med May;18(5):807-15 [PMID: 22466705]
Reid GS; Shan X; Coughlin CM; Lassoued W; Pawel BR; Wexler LH; Thiele CJ; Tsokos M; Pinkus JL; Pinkus GS; Grupp SA; Vonderheide RH. 2009. Interferon-gamma-dependent infiltration of human T cells into neuroblastoma tumors in vivo.Clin Cancer Res 15(21):6602-8. [PMID: 19825945]
Song DG; Ye Q; Carpenito C; Poussin M; Wang LP; Ji C; Figini M; June CH; Coukos G; Powell DJ Jr. 2011. In Vivo Persistence, Tumor Localization, and Antitumor Activity of CAR-Engineered T Cells Is Enhanced by Costimulatory Signaling through CD137 (4-1BB). Cancer Res. Jul 1;71(13):4617-27. [PMID: 21546571]
Song DG; Ye Q; Poussin M; Harms GM; Figini M; Powell DJ Jr. 2012. CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo. Blood Jan 19;119(3):696-706. [PMID: 22117050]
Spranger S; Jeremias I; Wilde S; Leisegang M; Stärck L; Mosetter B; Uckert W; Heemskerk MH; Schendel DJ; Frankenberger B. 2012. T-cell receptor-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo. Blood Apr 12;119(15):3440-9 [PMID: 22371883]
Stadler CR, Bähr-Mahmud H, Plum LM, Schmoldt K, Kölsch AC, Türeci Ö, Sahin U. 2015. Characterization of the first-in-class T-cell-engaging bispecific single-chain antibody for targeted immunotherapy of solid tumors expressing the oncofetal protein claudin 6. Oncoimmunology. Oct 29;5(3):e1091555. [PMID: 27141353]
Tian G, Courtney AN, Jena B, Heczey A, Liu D, Marinova E, Guo L, Xu X, Torikai H, Mo Q, Dotti G, Cooper LJ, Metelitsa LS. 2016. CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo. J Clin Invest. 2016 May 16. pii: 83476. doi: 10.1172/JCI83476. [Epub ahead of print] [PMID: 27183388]
Urbanska K; Lanitis E; Poussin M; Lynn RC; Gavin BP; Kelderman S; Yu J; Scholler N; Powell DJ Jr. 2012. A Universal Strategy for Adoptive Immunotherapy of Cancer through Use of a Novel T-cell Antigen Receptor. Cancer Res Apr 1;72(7):1844-52. [PMID: 22315351]
Wang QJ, Yu Z, Griffith K, Hanada KI, Restifo NP, Yang JC. Identification of T-cell Receptors Targeting KRAS-mutated Human Tumors. Cancer Immunol Res. 2015 Dec 23. pii: canimm.0188.2015. [PMID: 26701267]
Wege AK; Ernst W; Eckl J; Frankenberger B; Vollmann-Zwerenz A; Mannel DN; Ortmann O; Kroemer A; Brockhoff G. 2011. Humanized tumor mice - a new model to study and manipulate the immune response in advanced cancer therapy. Int J Cancer Nov 1;129(9):2194-206 [PMID: 21544806]
Wege A; Schmidt MUeberham E; Ponnath M; Ortmann; Brockhoff G; Lehmann J. Co-transplantation of human hematopoietic stem cells and human breast cancer cells in NSG mice: a novel approach to generate tumor cell specific human antibodies.MAbs. 2014 Jul-Aug;6(4):968-77. [PMID: 24870377]
Willingham SB; Volkmer JP; Gentles AJ; Sahoo D; Dalerba P; Mitra SS; Wang J; Contreras-Trujillo H; Martin R; Cohen JD; Lovelace P; Scheeren FA; Chao MP; Weiskopf K; Tang C; Volkmer AK; Naik TJ; Storm TA; Mosley AR; Edris B; Schmid SM; Sun CK; Chua MS; Murillo O; Rajendran P; Cha AC; Chin RK; Kim D; Adorno M; Raveh T; Tseng D; Jaiswal S; Enger PO; Steinberg GK; Li G; So SK; Majeti R; Harsh GR; van de Rijn M; Teng NN; Sunwoo JB; Alizadeh AA; Clarke MF; Weissman IL. 2012. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A Apr 24;109(17):6662-6667. [PMID: 22451913]
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Zhao Y; Moon E; Carpenito C; Paulos C; Liu X; Brennan A; Chew A; Scholler J; Carroll RG; Levine BL; Albelda SM; June CH. Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor. Cancer Res. Nov 15;70(22):9053-61. [PMID: 20926399]
Zheng, Q., Wang, Zhaohui, Zhang, H., Huang, Q., Madsen, J.C., Sachs, D.H., Huang, C.A., Wang, Zhirui, 2017. Diphtheria toxin-based anti-human CD19 immunotoxin for targeting human CD19(+) tumors. Mol. Oncol. [PMID: 28306193]
Zorzoli A; Di Carlo E; Cocco C; Ognio E; Ribatti D; Ferretti E; Dufour C; Locatelli F; Montagna D; Airoldi I. 2012. Interleukin-27 Inhibits the Growth of Pediatric Acute Myeloid Leukemia in NOD/SCID/Il2rg-/- Mice. Clin Cancer Res Mar 15;18(6):1630-1640. [PMID: 22383738]

Melanoma

Benito-Jardón, L., Díaz-Martínez, M., Arellano-Sánchez, N., Vaquero-Morales, P., Esparís-Ogando, A., Teixidó, J., 2019. Resistance to MAPK inhibitors in melanoma involves activation of the IGF-1R-MEK5-Erk5 pathway. Cancer Res. [PMID: 30833419]
Boiko AD; Razorenova OV; van de Rijn M; Swetter SM; Johnson DL; Ly DP; Butler PD; Yang GP; Joshua B; Kaplan MJ; Longaker MT; Weissman IL. 2010. Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature Jul 1;466(7302):133-7. [PMID: 19052619]
Boonyaratanakornkit JB; Yue L; Strachan LR; Scalapino KJ; Leboit PE; Lu Y; Leong SP; Smith JE; Ghadially R. 2010. Selection of Tumorigenic Melanoma Cells Using ALDH. J Invest Dermatol Dec;130(12):2799-808. [PMID: 20739950]
Chen Y; Soong J; Mohanty S; Xu L; Scott G. 2012. The neural guidance receptor Plexin C1 delays melanoma progression. Oncogene. [Epub ahead of print] [PMID: 23160370]
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Melanoma metastasis

Carreno BM; Garbow JR; Kolar GR; Jackson EN; Engelbach JA; Becker-Hapak M; Carayannopoulos LN; Piwnica-Worms D; Linette GP. 2009. Immunodeficient mouse strains display marked variability in growth of human melanoma lung metastases. Clin Cancer Res May 15;15(10):3277-86. [PMID: 19447870]
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Quintana E; Piskounova E; Shackleton M; Weinberg D; Eskiocak U; Fullen DR; Johnson TM; Morrison SJ. 2012. Human Melanoma Metastasis in NSG Mice Correlates with Clinical Outcome in Patients. Sci Transl Med. Nov 7;4(159):159ra149. [PMID: 23136044]
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Metastasis

Abe, F., Kitadate, A., Ikeda, S., Yamashita, J., Nakanishi, H., Takahashi, N., Asaka, C., Teshima, K., Miyagaki, T., Sugaya, M., Tagawa, H., 2016. Histone deacetylase inhibitors inhibit metastasis by restoring a tumor suppressive microRNA-150 in advanced cutaneous T-cell lymphoma. Oncotarget. [PMID: 27935859]
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Mouse cancer allografts

Grim JE; Knoblaugh SE; Guthrie KA; Hagar A; Swanger J; Hespelt J; Delrow JJ; Small T; Grady WM; Nakayama KI; Clurman BE. 2012. Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. Mol Cell Biol Jun;32(11):2160-7 [PMID: 22473991]
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Neuroblastoma

Barry, W.E., Jackson, J.R., Asuelime, G.E., Wu, H.-W., Sun, J., Wan, Z., Malvar, J., Sheard, M.A., Wang, L., Seeger, R.C., Kim, E.S., 2018. Activated Natural Killer Cells in Combination with Anti-GD2 Antibody Dinutuximab Improve Survival of Mice after Surgical Resection of Primary Neuroblastoma. Clin. Cancer Res. [PMID: 30232225]
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Ovarian Cancer

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Hoarau-Véchot, J., Touboul, C., Halabi, N., Blot-Dupin, M., Lis, R., Abi Khalil, C., Rafii, S., Rafii, A., Pasquier, J., 2019. Akt-activated endothelium promotes ovarian cancer proliferation through notch activation. J Transl Med 17. [PMID: 31182109]
Khabele D; Fadare O; Liu AY; Wilson AJ; Wass E; Osteen K; Crispens MA. 2012. An orthotopic model of platinum-sensitive high grade serous fallopian tube carcinoma. Int J Clin Exp Pathol 5(1):37-45. [PMID: 22295145]
Magnotti, E., Marasco, W.A., 2018. The latest animal models of ovarian cancer for novel drug discovery. Expert Opin Drug Discov 1–9. [PMID: 29338446]
Mao, T.L., Miao, C.H., Liao, Y.J., Chen, Y.J., Yeh, C.Y., Liu, C.L., 2019. Ex Vivo Expanded Human Vγ9Vδ2 T-Cells Can Suppress Epithelial Ovarian Cancer Cell Growth. Int J Mol Sci 20. [PMID: 30845699]
Monk, B.J., Facciabene, A., Brady, W.E., Aghajanian, C.A., Fracasso, P.M., Walker, J.L., Lankes, H.A., Manjarrez, K.L., Danet-Desnoyers, G.-Ä.H., Bell-McGuinn, K.M., McCourt, C.K., Malykhin, A., Hershberg, R.M., Coukos, G., 2017. Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemoimmunotherapy. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. 23, 1955–1966. doi:10.1158/1078-0432.CCR-16-1453 [PMID: 27702821]
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Pancreatic Cancer

Almawash, S.A., Mondal, G., Mahato, R.I., 2018. Coadministration of Polymeric Conjugates of Docetaxel and Cyclopamine Synergistically Inhibits Orthotopic Pancreatic Cancer Growth and Metastasis. Pharm. Res. 35, 17. [PMID: 29305793]
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Fredebohm J; Boettcher M; Eisen C; Gaida MM; Heller A; Keleg S; Tost J; Greulich-Bode KM; Hotz-Wagenblatt A; Lathrop M; Giese NA; Hoheisel JD. 2012. Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system. PLoS One. 7(11):e48503. [PMID: 23152778]
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Golubovskaya, V., Berahovich, R., Zhou, H., Xu, S., Harto, H., Li, L., Chao, C.-C., Mao, M.M., Wu, L., 2017. CD47-CAR-T Cells Effectively Kill Target Cancer Cells and Block Pancreatic Tumor Growth. Cancers (Basel) 9. [PMID: 29065481]
Hussain, S.M., Reed, L.F., Krasnick, B.A., Miranda-Carboni, G., Fields, R.C., Bi, Y., Elahi, A., Ajidahun, A., Dickson, P.V., Deneve, J.L., Hawkins, W.G., Shibata, D., Glazer, E.S., 2018. IL23 and TGF-ß diminish macrophage associated metastasis in pancreatic carcinoma. Sci Rep 8, 5808. [PMID: 29643359]
Kattel, K., Mondal, G., Lin, F., Kumar, V., Mahato, R.I., 2017. Biodistribution of Self-Assembling Polymer-Gemcitabine Conjugate after Systemic Administration into Orthotopic Pancreatic Tumor Bearing Mice. Mol. Pharm. 14, 1365–1372. doi:10.1021/acs.molpharmaceut.6b00929 [PMID: 27798825]
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Mondal, G., Almawash, S., Chaudhary, A.K., Mahato, R.I., 2017. EGFR-Targeted Cationic Polymeric Mixed Micelles for Codelivery of Gemcitabine and miR-205 for Treating Advanced Pancreatic Cancer. Mol. Pharm. doi:10.1021/acs.molpharmaceut.7b00355 [PMID: 28719220]
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Singh S; Chitkara D; Kumar V; Behrman SW; Mahato RI. 2012. miRNA profiling in pancreatic cancer and restoration of chemosensitivity. Cancer Lett. Jul 1;334(2):211-20. [PMID: 23073476]
von Burstin J; Diersch S; Schneider G; Reichert M; Rustgi AK; Schmid RM. Detection of Tumor Suppressor Genes in Cancer Development by a Novel shRNA-based method. Mol Cancer Res. 2015 Feb 27. Epub ahead of print. [PMID: 25724428]
Zettlitz, K.A., Tsai, W.-T.K., Knowles, S.M., Kobayashi, N., Donahue, T.R., Reiter, R.E., Wu, A.M., 2018. Dual-modality immunoPET and near-infrared fluorescence (NIRF) imaging of pancreatic cancer using an anti-prostate cancer stem cell antigen (PSCA) cys-diabody. J. Nucl. Med. [PMID: 29602820]

Primary Myelofibrosis

Wang X; Zhang W; Tripodi J; Lu M; Xu M; Najfeld V; Li Y; Hoffman R. 2010. Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin modifying agents eliminate JAK2V617F positive NOD/SCID marrow repopulating cells. Blood Dec 23;116(26):5972-82. [PMID: 20858855]

Prostate Cancer

Chen X; Liu B; Li Q; Honorio S; Liu X; Liu C; Multani AS; Calhoun-Davis T; Tang DG. 2013. Dissociated Primary Human Prostate Cancer Cells Coinjected with the Immortalized Hs5 Bone Marrow Stromal Cells Generate Undifferentiated Tumors in NOD/SCID-γ Mice. PLoS One. 8(2):e56903. [PMID: 23451107]
Domingo-Domenech J; Vidal SJ; Rodriguez-Bravo V; Castillo-Martin M; Quinn SA; Rodriguez-Barrueco R; Bonal DM; Charytonowicz E; Gladoun N; de la Iglesia-Vicente J; Petrylak DP; Benson MC; Silva JM; Cordon-Cardo C. 2012. Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells. Cancer Cell. 2012 Sep 11;22(3):373-88. [PMID: 22975379]
Goldstein AS; Huang J; Guo C; Garraway IP; Witte ON. 2010. Identification of a cell of origin for human prostate cancer. Science Jul 30;329(5991):568-71. [PMID: 20671189]
Graham, M.K., Principessa, L., Antony, L., Meeker, A.K., Isaacs, J.T., 2017. Low p16(INK4a) Expression in Early Passage Human Prostate Basal Epithelial Cells Enables Immortalization by Telomerase Expression Alone. The Prostate 77, 374–384. [PMID: 27859428]
Hori, S., Wadhwa, K., Pisupati, V., Zecchini, V., Ramos-Montoya, A., Warren, A.Y., Neal, D.E., Gnanapragasam, V.J., 2017. Loss of hSef promotes metastasis through upregulation of EMT in prostate cancer. Int. J. Cancer. doi:10.1002/ijc.30604 [PMID: 28073170]
Hudson BD, Hum NR, Thomas CB, Kohlgruber A, Sebastian A, Collette NM, Coleman MA, Christiansen BA, Loots GG. SOST Inhibits Prostate Cancer Invasion. PLoS One. 2015 Nov 6;10(11):e0142058. [PMID: 26545120]
Lange, T., Oh-Hohenhorst, S.J., Joosse, S.A., Pantel, K., Hahn, O., Gosau, T., Dyshlovoy, S.A., Wellbrock, J., Feldhaus, S., Maar, H., Gehrcke, R., Kluth, M., Simon, R., Schlomm, T., Huland, H., Schumacher, U., 2018. Development and Characterization of a Spontaneously Metastatic Patient-Derived Xenograft Model of Human Prostate Cancer. Sci Rep 8, 17535. [PMID: 30510249]
Lawrence MG; Taylor RA; Toivanen R; Pedersen J; Norden S; Pook DW; Frydenberg M; Australian Prostate Cancer BioResource; Papargiris MM; Niranjan B; Richards MG; Wang H; Collins AT; Maitland NJ; Risbridger GP. 2013. A preclinical xenograft model of prostate cancer using human tumors. Nat Protoc. Apr 4;8(5):836-48. [PMID: 23558784]
Lillo Osuna, M.A., Garcia-Lopez, J., El Ayachi, I., Fatima, I., Khalid, A.B., Kumpati, J., Slayden, A.V., Seagroves, T.N., Miranda-Carboni, G.A., Krum, S.A., 2018. Activation of Estrogen Receptor Alpha by Decitabine Inhibits Osteosarcoma Growth and Metastasis. Cancer Res. [PMID: 30593524]
Lu, Z.H., Kaliberov, S., Sohn, R.E., Kaliberova, L., Du, Y., Prior, J.L., Leib, D.J., Chauchereau, A., Sehn, J.K., Curiel, D.T., Arbeit, J.M., 2017. A new model of multi-visceral and bone metastatic prostate cancer with perivascular niche targeting by a novel endothelial specific adenoviral vector. Oncotarget. doi:10.18632/oncotarget.14699 [PMID: 28103576]
McGovern, J.A., Shafiee, A., Wagner, F., Lahr, C.A., Landgraf, M., Meinert, C., Williams, E.D., Russell, P.J., Clements, J.A., Loessner, D., Holzapfel, B.M., Risbridger, G.P., Hutmacher, D.W., 2018. Humanization of the Prostate Microenvironment Reduces Homing of PC3 Prostate Cancer Cells to Human Tissue-Engineered Bone. Cancers (Basel) 10. [PMID: 30428629]
Mulholland DJ; Kobayashi N; Ruscetti M; Zhi A; Tran LM; Huang J; Gleave M; Wu H. 2012. Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells. Cancer Res Apr 1;72(7):1878-89. [PMID: 22350410]
Mussawy, H., Viezens, L., Schroeder, M., Hettenhausen, S., Sündermann, J., Wellbrock, J., Kossow, K., Schaefer, C., 2018. The bone microenvironment promotes tumor growth and tissue perfusion compared with striated muscle in a preclinical model of prostate cancer in vivo. BMC Cancer 18, 979. [PMID: 30326868]
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Sarcoma

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Solid cancer cell line xenografts

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Pillai, V. V., Koganti, P. P., Kei, T. G., Gurung, S., Butler, W. R., & Selvaraj, V. (2021). Efficient induction and sustenance of pluripotent stem cells from bovine somatic cells. Biology Open, 10(10), bio058756. [PMID: 34719702]
Ratnapriya, S., Harris, M., Chov, A., Herbert, Z. T., Vrbanac, V., Deruaz, M., Achuthan, V., Engelman, A. N., Sodroski, J., & Herschhorn, A. (2021). Intra- and extra-cellular environments contribute to the fate of HIV-1 infection. Cell Reports, 36(9), 109622. [PMID: 34469717]
Roy, C. N., Benitez Moreno, M. A., Kline, C., & Ambrose, Z. (n.d.). CG Dinucleotide Removal in Bioluminescent and Fluorescent Reporters Improves HIV-1 Replication and Reporter Gene Expression for Dual Imaging in Humanized Mice. Journal of Virology, 95(19), e00449-21. [PMID: 34232063]
Shamseddin, M., De Martino, F., Constantin, C., Scabia, V., Lancelot, A., Laszlo, C., Ayyannan, A., Battista, L., Raffoul, W., Gailloud‐Matthieu, M., Bucher, P., Fiche, M., Ambrosini, G., Sflomos, G., & Brisken, C. (2021). Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation. EMBO Molecular Medicine, 13(7), e14314. [PMID: 34042278]
Shrivastava, S., Ray, R. M., Holguin, L., Echavarria, L., Grepo, N., Scott, T. A., Burnett, J., & Morris, K. V. (2021). Exosome-mediated stable epigenetic repression of HIV-1. Nature Communications, 12(1), 5541. [PMID: 34545097]
Unterweger, A.-L., Rüscher, A., Seuß, M., Winkelmann, P., Beigel, F., Koletzko, L., Breiteneicher, S., Siebeck, M., Gropp, R., & Aszodi, A. (2021). NOD/scid IL-2Rγnull mice reconstituted with peripheral blood mononuclear cells from patients with Crohn’s disease reflect the human pathological phenotype. Immunity, Inflammation and Disease. [PMID: 34499803]
Wiedenmann, S., Breunig, M., Merkle, J., von Toerne, C., Georgiev, T., Moussus, M., Schulte, L., Seufferlein, T., Sterr, M., Lickert, H., Weissinger, S. E., Möller, P., Hauck, S. M., Hohwieler, M., Kleger, A., & Meier, M. (2021). Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip. Nature Biomedical Engineering, 5(8), 897–913. [PMID: 34239116]
Yang, L., Xia, H., Smith, K., Gilbertsen, A., Beisang, D., Kuo, J., Bitterman, P. B., & Henke, C. A. (n.d.). A CD44/Brg1 nuclear complex confers mesenchymal progenitor cells with enhanced fibrogenicity in idiopathic pulmonary fibrosis. JCI Insight, 6(9), e144652. [PMID: 33822772]

Stem Cells / Regenerative Medicine

Differentiation of embryonic stem cells into hematopoetic cells

Abraham, M., Pereg, Y., Bulvik, B., Klein, S., Mishalian, I., Wald, H., Eizenberg, O., Beider, K., Nagler, A., Golan, R., Vainstein, A., Aharon, A., Galun, E., Caraco, Y., Or, R., Peled, A., 2017. Single Dose of the CXCR4 Antagonist BL-8040 Induces Rapid Mobilization for the Collection of Human CD34+ Cells in Healthy Volunteers. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. doi:10.1158/1078-0432.CCR-16-2919 [PMID: 28835380]
Carretta, M., de Boer, B., Jaques, J., Antonelli, A., Horton, S.J., Yuan, H., de Bruijn, J.D., Groen, R.W.J., Vellenga, E., Schuringa, J.J., 2017. Genetically engineered mesenchymal stromal cells producing IL3 and TPO to further improve human scaffold-based xenograft models. Exp. Hematol. doi:10.1016/j.exphem.2017.04.008 [PMID: 28456746]
Futrega, K., Atkinson, K., Lott, W.B., Doran, M.R., 2017. Spheroid Coculture of Hematopoietic Stem/Progenitor Cells and Monolayer Expanded Mesenchymal Stem/Stromal Cells in Polydimethylsiloxane Microwells Modestly Improves In Vitro Hematopoietic Stem/Progenitor Cell Expansion. Tissue Eng. Part C Methods 23, 200–218. doi:10.1089/ten.tec.2016.0329 [PMID: 28406754]
Gori JL; Tian X; Swanson D; Gunther R; Shultz LD; McIvor RS; Kaufman DS. 2010. In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase. Gene Ther Feb;17(2):238-49. [PMID: 19829316]
Guo, B., Huang, X., Cooper, S., Broxmeyer, H.E., 2017. Glucocorticoid hormone-induced chromatin remodeling enhances human hematopoietic stem cell homing and engraftment. Nat. Med. doi:10.1038/nm.4298 [PMID: 28263313]
Janel, A., Berger, J., Bourgne, C., Lemal, R., Boiret-Dupré, N., Dubois-Galopin, F., Déchelotte, P., Bothorel, C., Hermet, E., Chabi, S., Bay, J.-O., Lambert, C., Pereira, B., Pflumio, F., Haddad, R., Berger, M.G., 2017. Bone Marrow Hematons: An Access Point to the Human Hematopoietic Niche. Am. J. Hematol. doi:10.1002/ajh.24830 [PMID: 28639326]
Ledran MH; Krassowska A; Armstrong L; Dimmick I; Renström J; Lang R; Yung S; Santibanez-Coref M; Dzierzak E; Stojkovic M; Oostendorp RA; Forrester L; Lako M. 2008. Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. Cell Stem Cell Jul 3;3(1):85-98 [PMID: 18593561]
Sumide, K., Matsuoka, Y., Kawamura, H., Nakatsuka, R., Fujioka, T., Asano, H., Takihara, Y., Sonoda, Y., 2018a. A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells. Nat Commun 9. [PMID: 29875383]
Svalgaard, J.D., Talkhoncheh, M.S., Haastrup, E.K., Munthe-Fog, L., Clausen, C., Hansen, M.B., Andersen, P., Gørløv, J.S., Larsson, J., Fischer-Nielsen, A., 2018. Pentaisomaltose, an Alternative to DMSO. Engraftment of Cryopreserved Human CD34+ Cells in Immunodeficient NSG Mice. Cell Transplant 963689718786226. [PMID: 30056762]
Szabo E; Rampalli S; Risueño RM; Schnerch A; Mitchell R; Fiebig-Comyn A; Levadoux-Martin M; Bhatia M. 2010. Direct conversion of human fibroblasts to multilineage blood progenitors. Nature Nov 25;468(7323):521-6. [PMID: 21057492]
Tormo, A., Khodayarian, F., Cui, Y., Al-Chami, E., Kanjarawi, R., Noé, B., Wang, H., Rafei, M., 2017. Interleukin-21 promotes thymopoiesis recovery following hematopoietic stem cell transplantation. J. Hematol. Oncol.J Hematol Oncol 10, 120. doi:10.1186/s13045-017-0490-3 [PMID: 28615039]

Differentiation of embryonic stem cells into endothelial cells

Chen VC; Couture SM; Ye J; Lin Z; Hua G; Huang HI; Wu J; Hsu D; Carpenter MK; Couture LA. 2012. Scalable GMP compliant suspension culture system for human ES cells. Stem Cell Res May;8(3):388-402. [PMID: 22459095]
Gori JL; Tian X; Swanson D; Gunther R; Shultz LD; McIvor RS; Kaufman DS. 2010. In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase. Gene Ther Feb;17(2):238-49. [PMID: 19829316]
Ma M; Ding S; Lundqvist A; San H; Fang F; Konoplyannikov M; Berry C; Beltran LE; Chen G; Kovacic JC; Boehm M. 2010. Major histocompatibility complex-I expression on embryonic stem cell-derived vascular progenitor cells is critical for syngeneic transplant survival. Stem Cells Sep;28(9):1465-75. [PMID: 20629173]
Papapetrou EP; Lee G; Malani N; Setty M; Riviere I; Tirunagari LM; Kadota K; Roth SL; Giardina P; Viale A; Leslie C; Bushman FD; Studer L; Sadelain M. 2011. Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells. Nat Biotechnol Jan;29(1):73-8. [PMID: 21151124]
Sullivan GJ; Hay DC; Park IH; Fletcher J; Hannoun Z; Payne CM; Dalgetty D; Black JR; Ross JA; Samuel K; Wang G; Daley GQ; Lee JH; Church GM; Forbes SJ; Iredale JP; Wilmut I. 2010. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology. Jan;51(1):329-35. [PMID: 19877180]
Tian X; Hexum MK; Penchev VR; Taylor RJ; Shultz LD; Kaufman DS. 2009. Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells. Stem Cells Nov;27(11):2675-85. [PMID: 19711457]

Hematopoietic stem cells

Baldwin K; Urbinati F; Romero Z; Campo-Fernandez B; Kaufman ML; Cooper AR; Masiuk K; Hollis RP; Kohn DB. 2015. Enrichment of Human Hematopoietic Stem/Progenitor Cells Facilitates Transduction for Stem Cell Gene Therapy. Stem Cells. Epub ahead of print. [PMID: 25588820]
Chang CH, Hale SJ, Cox CV, Blair A, Kronsteiner B, Grabowska R, Zhang Y, Cook D, Khoo CP, Schrader JB, Buglass Kabuga S, Martin-Rendon E, Watt SM. Jam-a is highly expressed on human hematopoietic repopulating cells and associates with the key hematopoietic chemokine receptor cxcr4. Stem Cells. 2016 Feb 11. doi: 10.1002/stem.2340. [PMID: 26866290]
De Luca L, Trino S, Laurenzana I, Simeon V, Calice G, Raimondo S, Podestà M, Santodirocco M, Di Mauro L, La Rocca F, Caivano A, Morano A, Frassoni F, Cilloni D, Del Vecchio L, Musto P. MiRNAs and piRNAs from bone marrow mesenchymal stem cell extracellular vesicles induce cell survival and inhibit cell differentiation of cord blood hematopoietic stem cells: a new insight in transplantation. Oncotarget. 2015 Dec 29. doi: 10.18632/oncotarget.6791. [Epub ahead of print] [PMID: 26760763]
De Ravin, S.S., Li, L., Wu, X., Choi, U., Allen, C., Koontz, S., Lee, J., Theobald-Whiting, N., Chu, J., Garofalo, M., Sweeney, C., Kardava, L., Moir, S., Viley, A., Natarajan, P., Su, L., Kuhns, D., Zarember, K.A., Peshwa, M.V., Malech, H.L., 2017. CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease. Sci. Transl. Med. 9. doi:10.1126/scitranslmed.aah3480 [PMID: 28077679]
Duinhouwer LE; Tüysüz N; Rombouts EW; Ter Borg MN; Mastrobattista E; Spanholtz J; Cornelissen JJ; Ten Berge D; Braakman E. Wnt3a protein reduces growth factor-driven expansion of human hematopoietic stem and progenitor cells in serum-free cultures. PLoS One. 2015 Mar 25;10(3):e0119086. [PMID: 25807521]
Futrega K, Lott WB, Doran MR. 2016. Direct bone marrow HSC transplantation enhances local engraftment at the expense of systemic engraftment in NSG mice. Sci Rep. Apr 11;6:23886. [PMID: 27065210]
Guenther, K.L., Cheruku, P.S., Cash, A., Smith, R.H., Alvarado, L.J., Burkett, S., Townsley, D.M., Winkler, T., Larochelle, A., 2019. Eltrombopag promotes DNA repair in human hematopoietic stem and progenitor cells. Exp. Hematol. [PMID: 30986494]
Guo, B., Huang, X., Cooper, S., Broxmeyer, H.E., 2017. Glucocorticoid hormone-induced chromatin remodeling enhances human hematopoietic stem cell homing and engraftment. Nat. Med. [PMID: 28263313]
Haemmerle R; Phaltane R; Rothe M; Schröder S; Schambach A; Moritz T; Modlich U. 2014. Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model. Mol Ther Nucleic Acids. Oct 7;3:e200. [PMID: 25291142]
Hasgur S, Aryee KE, Shultz LD, Greiner DL, Brehm MA. Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells. Methods Mol Biol. 2016;1438:67-78. doi: 10.1007/978-1-4939-3661-8_4. [PMID: 27150084]
Heffner, G.C., Bonner, M., Christiansen, L., Pierciey, F.J., Campbell, D., Smurnyy, Y., Zhang, W., Hamel, A., Shaw, S., Lewis, G., Goss, K.A., Garijo, O., Torbett, B.E., Horton, H., Finer, M.H., Gregory, P.D., Veres, G., 2018. Prostaglandin E2 Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells. Mol. Ther. 26, 320–328. [PMID: 29102562]
Huang, N., Lou, M., Liu, H., Avila, C., Ma, Y., 2016. Identification of a potent small molecule capable of regulating polyploidization, megakaryocyte maturation, and platelet production. J. Hematol. Oncol.J Hematol Oncol 9, 136. [PMID: 27927231]
Jangalwe, S., Shultz, L.D., Mathew, A., Brehm, M.A., 2016. Improved B cell development in humanized NOD-scid IL2Rγ(null) mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3. Immun. Inflamm. Dis. 4, 427–440 [PMID: 27980777]
Kang, K., Kim, Y., Lee, S.B., Kim, J.S., Park, S., Kim, W.-D., Yang, H.-M., Kim, S.-J., Jeong, J., Choi, D., 2017. Three-dimensional bio-printing of hepatic structures with direct-converted hepatocyte-like cells. Tissue Eng. Part A. doi:10.1089/ten.TEA.2017.0161 [PMID: 28726547]
Kao, R.L., Truscott, L.C., Chiou, T.-T., Tsai, W., Wu, A.M., De Oliveira, S.N., 2019. A Cetuximab-Mediated Suicide System in Chimeric Antigen Receptor-Modified Hematopoietic Stem Cells for Cancer Therapy. Hum. Gene Ther. 30, 413—428. [PMID: 30860401]
Kays SK; Kaufmann KB; Abel T; Brendel C; Bonig H; Grez M; Buchholz CJ; Kneissl S. 2014. CD105 is a surface marker for receptor-targeted gene transfer into human long-term repopulating hematopoietic stem cells. Stem Cells Dev. Dec 17; Epub ahead of print. [PMID: 25517513]
Lapostolle, V., Chevaleyre, J., Duchez, P., Rodriguez, L., Vlaski-Lafarge, M., Sandvig, I., Brunet de la Grange, P., Ivanovic, Z., 2018. Repopulating hematopoietic stem cells from steady-state blood before and after ex vivo culture are enriched in CD34+CD133+CXCR4low fraction. Haematologica. [PMID: 29858385]
Nowlan, B., Williams, E.D., Doran, M.R., Levesque, J.-P., 2019. CD27, CD201, FLT3, CD48, and CD150 cell surface staining identifies long-term mouse hematopoietic stem cells in immunodeficient non-obese diabetic severe combined immune deficient derived strains. Haematologica. [PMID: 31073070]
Radtke S, Haworth KG, Kiem HP. 2016. The frequency of multipotent CD133+CD45RA-CD34+ hematopoietic stem cells is not increased in fetal liver compared with adult stem cell sources. Exp Hematol. 2016 Mar 22. pii: S0301-472X(16)30023-6. [PMID: 27016273]
Sweeney, C.L., Choi, U., Liu, C., Koontz, S., Ha, S.-K., Malech, H.L., 2017. CRISPR-Mediated Knockout of Cybb in NSG Mice Establishes a Model of Chronic Granulomatous Disease for Human Stem-Cell Gene Therapy Transplants. Hum. Gene Ther. [PMID: 28264583]
Wang, W., Fujii, H., Kim, H.J., Hermans, K., Usenko, T., Xie, S., Luo, Z.-J., Ma, J., Celso, C.L., Dick, J.E., Schroeder, T., Krueger, J., Wall, D., Egeler, R.M., Zandstra, P.W., 2017. Enhanced human hematopoietic stem and progenitor cell engraftment by blocking donor T cell-mediated TNFα signaling. Sci Transl Med 9. [PMID: 29263228]

Human mammary stem cells

Eirew P; Stingl J; Raouf A; Turashvili G; Aparicio S; Emerman JT; Eaves CJ. 2008. A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med 14(12):1384-1389. [PMID: 19029987]

Induced pluripotent stem (iPS) cells

Amabile G; Welner RS; Nombela-Arrieta C; D'Alise AM; Di Ruscio A; Ebralidze AK; Kraytsberg Y; Ye M; Kocher O; Neuberg DS; Khrapko K; Silberstein LE; Tenen DG. 2013. In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells. Blood. Feb 21;121(8):1255-64. [PMID: 23212524]
Ben-David U; Gan QF; Golan-Lev T; Arora P; Yanuka O; Oren YS; Leikin-Frenkel A; Graf M; Garippa R; Boehringer M; Gromo G; Benvenisty N. 2013. Selective Elimination of Human Pluripotent Stem Cells by an Oleate Synthesis Inhibitor Discovered in a High-Throughput Screen. Cell Stem Cell. Feb 7;12(2):167-79. [PMID: 23318055]
Darabi R; Arpke RW; Irion S; Dimos JT; Grskovic M; Kyba M; Perlingeiro RC. 2012. Human ES- and iPS-Derived Myogenic Progenitors Restore DYSTROPHIN and Improve Contractility upon Transplantation in Dystrophic Mice. Cell Stem Cell May 4;10(5):610-9. [PMID: 22560081]
Fagoonee S; Bearzi C; Di Cunto F; Clohessy JG; Rizzi R; Reschke M; Tolosano E; Provero P; Pandolfi PP; Silengo L; Altruda F. 2013. The RNA Binding Protein ESRP1 Fine-Tunes the Expression of Pluripotency-Related Factors in Mouse Embryonic Stem Cells. PLoS One. Aug 27;8(8):e72300. [PMID: 24015231]
Gori JL; Butler JM; Chan YY; Chandrasekaran D; Poulos MG; Ginsberg M; Nolan DJ; Elemento O; Wood BL; Adair JE; Rafii S; Kiem HP. Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells. J Clin Invest. 2015 Feb 9. Epub ahead of print. [PMID: 25664855]
Kahler DJ; Ahmad FS; Ritz A; Hua H; Moroziewicz DN; Sproul AA; Dusenberry CR; Shang L; Paull D; Zimmer M; Weiss KA; Egli D; Noggle SA. 2013. Improved methods for reprogramming human dermal fibroblasts using fluorescence activated cell sorting. PLoS One. 8(3):e59867. [PMID: 23555815]
Liu J; Koscielska KA; Cao Z; Hulsizer S; Grace N; Mitchell G; Nacey C; Githinji J; McGee J; Garcia-Arocena D; Hagerman RJ; Nolta J; Pessah IN; Hagerman PJ. 2012. Signaling defects in iPSC-derived fragile X premutation neurons. Hum Mol Genet Sep 1;21(17):3795-805 [PMID: 22641815]
Merkl C; Saalfrank A; Riesen N; Kühn R; Pertek A; Eser S; Hardt MS; Kind A; Saur D; Wurst W; Iglesias A; Schnieke A. 2013. Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector. PLoS One. 8(1):e55170. [PMID: 23383095]
Mitchell, A., Wanczyk, H., Jensen, T., Finck, C., 2019. Assessment of iPSC teratogenicity throughout directed differentiation toward an alveolar-like phenotype. Differentiation 105, 45—53. [PMID: 30711828]
Noggle S; Fung HL; Gore A; Martinez H; Satriani KC; Prosser R; Oum K; Paull D; Druckenmiller S; Freeby M; Greenberg E; Zhang K; Goland R; Sauer MV; Leibel RL; Egli D. 2011. Human oocytes reprogram somatic cells to a pluripotent state. Nature Oct 5;478(7367):70-5. [PMID: 21979046]
Parameswaran S; Balasubramanian S; Babai N; Deldebbio CB; Harms DW; Gurumurthy CB; Rao MS; Sharp JG; Ahmad I. 2012. Nucleic Acid and non-nucleic Acid-based reprogramming of adult limbal progenitors to pluripotency. PLoS One. 7(10):e46734. [PMID: 23056428]
Pelosi E; Castelli G; Martin-Padura I; Bordoni V; Santoro S; Conigliaro A; Cerio AM; De Santis Puzzonia M; Marighetti P; Biffoni M; Alonzi T; Amicone L; Alcalay M; Bertolini F; Testa U; Tripodi M. 2012. Human Haemato-Endothelial Precursors: Cord Blood CD34+ Cells Produce Haemogenic Endothelium. PLoS One. 7(12):e51109. [PMID: 23226561]
Ruiz S; Brennand K; Panopoulos AD; Herrerías A; Gage FH; Izpisua-Belmonte JC. 2010. High-Efficient Generation of Induced Pluripotent Stem Cells from Human Astrocytes. PLoS ONE 5(12): e15526. [PMID: 21170306]
Su RJ; Yang Y; Neises A; Payne KJ; Wang J; Viswanathan K; Wakeland EK; Fang X; Zhang XB. 2013. Few single nucleotide variations in exomes of human cord blood induced pluripotent stem cells. PLoS One. 8(4):e59908. [PMID: 23573220]
Su RJ; Baylink DJ; Neises A; Kiroyan JB; Meng X; Payne KJ; y-Seney B; Duan Y; Appleby N; Kearns-Jonker M; Gridley DS; Wang J; Lau KH; Zhang XB. 2013. Efficient generation of integration-free ips cells from human adult peripheral blood using BCL-XL together with Yamanaka factors. PLoS One. May 21;8(5):e64496. [PMID: 23704989]
Tozawa, K., Ono-Uruga, Y., Yazawa, M., Mori, T., Murata, M., Okamoto, S., Ikeda, Y., Matsubara, Y., 2018. Unique megakaryocytes and platelets from novel human adipose-derived mesenchymal stem cell line. Blood. [PMID: 30487128]
Wang W; Yang J; Liu H; Lu D; Chen X; Zenonos Z; Campos LS; Rad R; Guo G; Zhang S; Bradley A; Liu P. 2011. Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proc Natl Acad Sci U S A Nov 8;108(45):18283-8. [PMID: 21990348]
Winkler T; Hong SG; Decker JE; Morgan MJ; Wu C; Hughes WM 5th; Yang Y; Wangsa D; Padilla-Nash HM; Ried T; Young NS; Dunbar CE; Calado RT. 2013. Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs. J Clin Invest. May 1;123(5):1952-63. [PMID: 23585473]
Wu, J., Matthias, N., Lo, J., Ortiz-Vitali, J.L., Shieh, A.W., Wang, S.H., Darabi, R., 2018. A Myogenic Double-Reporter Human Pluripotent Stem Cell Line Allows Prospective Isolation of Skeletal Muscle Progenitors. Cell Rep 25, 1966-1981.e4. [PMID: 30428361]

Intestinal stem cells

Lahar N; Lei NY; Wang J; Jabaji Z; Tung SC; Joshi V; Lewis M; Stelzner M; Martín MG; Dunn JC. 2011. Intestinal subepithelial myofibroblasts support in vitro and in vivo growth of human small intestinal epithelium. PLoS One 6(11):e26898 [PMID: 22125602]

Other stem cell publications

Baldwin K; Urbinati F; Romero Z; Campo-Fernandez B; Kaufman ML; Cooper AR; Masiuk K; Hollis RP; Kohn DB. 2015. Enrichment of Human Hematopoietic Stem/Progenitor Cells Facilitates Transduction for Stem Cell Gene Therapy. Stem Cells. Epub ahead of print. [PMID: 25588820]
Barclay GR; Tura O; Samuel K; Hadoke PW; Mills NL; Newby DE; Turner ML. 2012. Systematic assessment in an animal model of the angiogenic potential of different human cell sources for therapeutic revascularisation. Stem Cell Res Ther. 2012 Jul 3;3(4):23 [PMID: 22759659]
Beegle J; Lakatos K; Kalomoiris S; Stewart H; Isseroff RR; Nolta JA; Fierro FA. Hypoxic Preconditioning of Mesenchymal Stromal Cells Induces Metabolic Changes Enhances Survival and Promotes Cell Retention in Vivo. Stem Cells. 2015 Feb 19. Epub ahead of print. [PMID: 25702874]
Bono, B., Ostano, P., Peritore, M., Gregnanin, I., Belgiovine, C., Liguori, M., Allavena, P., Chiorino, G., Chiodi, I., Mondello, C., 2018. Cells with stemness features are generated from in vitro transformed human fibroblasts. Sci Rep 8, 13838. [PMID: 30218041]
Darzi, S., Deane, J.A., Nold, C.A., Edwards, S.E., Gough, D.J., Mukherjee, S., Gurung, S., Tan, K.S., Vashi, A.V., Werkmeister, J.A., Gargett, C.E., 2018. Endometrial Mesenchymal Stem/Stromal Cells Modulate the Macrophage Response to Implanted Polyamide/Gelatin Composite Mesh in Immunocompromised and Immunocompetent Mice. Sci Rep 8, 6554. [PMID: 29700360]
Foo, K.S., Lehtinen, M.L., Leung, C.Y., Lian, X., Xu, J., Keung, W., Geng, L., Kolstad, T.R.S., Thams, S., Wong, A.O.-T., Wong, N., Bylund, K., Zhou, C., He, X., Jin, S.-B., Clarke, J., Lendahl, U., Li, R.A., Louch, W.E., Chien, K.R., 2018. Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Mol. Ther. 26, 1644–1659. [PMID: 29606507]
Gedye C, Sirskyj D, Lobo NC, Meens J, Hyatt E, Robinette M, Fleshner N, Hamilton RJ, Kulkarni G, Zlotta A, Evans A, Finelli A, Jewett MA, Ailles LE. 2016. Cancer stem cells are underestimated by standard experimental methods in clear cell renal cell carcinoma. Sci Rep. 2016 Apr 28;6:25220. [PMID: 27121191]
Ginsberg M; James D; Ding BS; Nolan D; Geng F; Butler JM; Schachterle W; Pulijaal VR; Mathew S; Chasen ST; Xiang J; Rosenwaks Z; Shido K; Elemento O; Rabbany SY; Rafii S. 2012. Efficient Direct Reprogramming of Mature Amniotic Cells into Endothelial Cells by ETS Factors and TGFβ Suppression. Cell Oct 26;151(3):559-75. [PMID: 23084400]
Gurung, S., Deane, J.A., Darzi, S., Werkmeister, J.A., Gargett, C.E., 2017. In Vivo Survival of Human Endometrial Mesenchymal Stem Cells Transplanted Under the Kidney Capsule of Immunocompromised Mice. Stem Cells Dev. [PMID: 29105567]
Hofmann NA; Ortner A; Jacamo RO; Reinisch A; Schallmoser K; Rohban R; Etchart N; Fruehwirth M; Beham-Schmid C; Andreeff M; Strunk D. 2012. Oxygen sensing mesenchymal progenitors promote neo-vasculogenesis in a humanized mouse model in vivo. PLoS One. 7(9):e44468. [PMID: 22970226]
Izrael, M., Slutsky, S.G., Admoni, T., Cohen, L., Granit, A., Hasson, A., Itskovitz-Eldor, J., Krush Paker, L., Kuperstein, G., Lavon, N., Yehezkel Ionescu, S., Solmesky, L.J., Zaguri, R., Zhuravlev, A., Volman, E., Chebath, J., Revel, M., 2018. Safety and efficacy of human embryonic stem cell-derived astrocytes following intrathecal transplantation in SOD1G93A and NSG animal models. Stem Cell Res Ther 9, 152. [PMID: 29871694]
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