A comprehensive list of publications that utilize
NSG™ variant mouse models to advance research.
Wu Q, Bhole A, Qin H, Karp J, Malek S, Cowell JK, Ren M. 2016. SCLLTargeting FGFR1 to suppress leukemogenesis in syndromic and de novo AML in murine models. Oncotarget. Jul 6. doi: 10.18632/oncotarget.10438. [Epub ahead of print] [PMID: 27391347]
Vivier, D., Sharma, S.K., Adumeau, P., Rodriguez, C., Fung, K., Zeglis, B., 2019. The Impact of FcγRI Binding on ImmunoPET. J. Nucl. Med. [PMID: 30733320]
Barruet, E., Garcia, S. M., Wu, J., Morales, B. M., Tamaki, S., Moody, T., Pomerantz, J. H., & Hsiao, E. C. (n.d.). Modeling the ACVR1R206H mutation in human skeletal muscle stem cells. ELife, 10, e66107. [PMID: 34755602]
Bevacqua, R. J., Dai, X., Lam, J. Y., Gu, X., Friedlander, M. S. H., Tellez, K., Miguel-Escalada, I., Bonàs-Guarch, S., Atla, G., Zhao, W., Kim, S. H., Dominguez, A. A., Qi, L. S., Ferrer, J., MacDonald, P. E., & Kim, S. K. (2021). CRISPR-based genome editing in primary human pancreatic islet cells. Nature Communications, 12, 2397. [PMID: 33893274]
Blaine-Sauer, S., Shin, M.-K., Matkowskyj, K. A., Ward-Shaw, E., & Lambert, P. F. (2021). A Novel Model for Papillomavirus-Mediated Anal Disease and Cancer Using the Mouse Papillomavirus. MBio, 12(4), e0161121. [PMID: 34281391]
Braun, H., Hauke, M., Ripperger, A., Ihling, C., Fuszard, M., Eckenstaler, R., & Benndorf, R. A. (2021). Impact of DICER1 and DROSHA on the Angiogenic Capacity of Human Endothelial Cells. International Journal of Molecular Sciences, 22(18), 9855. [PMID: 34576018]
de Castro, L. F., Sworder, B. J., Mui, B., Futrega, K., Berendsen, A., Phillips, M. D., Burbach, N. J., Cherman, N., Kuznetsov, S., Gabet, Y., Holmbeck, K., & Robey, P. G. (2021). Secreted frizzled related-protein 2 (Sfrp2) deficiency decreases adult skeletal stem cell function in mice. Bone Research, 9, 49. [PMID: 34857734]
Ebner-Peking, P., Krisch, L., Wolf, M., Hochmann, S., Hoog, A., Vári, B., Muigg, K., Poupardin, R., Scharler, C., Schmidhuber, S., Russe, E., Stachelscheid, H., Schneeberger, A., Schallmoser, K., & Strunk, D. (2021). Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration. Theranostics, 11(17), 8430–8447. [PMID: 34373751]
Escobar, H., Krause, A., Keiper, S., Kieshauer, J., Müthel, S., de Paredes, M. G., Metzler, E., Kühn, R., Heyd, F., & Spuler, S. (n.d.). Base editing repairs an SGCA mutation in human primary muscle stem cells. JCI Insight, 6(10), e145994. [PMID: 33848270]
Forsberg, M. H., Kink, J. A., Thickens, A. S., Lewis, B. M., Childs, C. J., Hematti, P., & Capitini, C. M. (2021). Exosomes from primed MSCs can educate monocytes as a cellular therapy for hematopoietic acute radiation syndrome. Stem Cell Research & Therapy, 12(1), 459. [PMID: 34407878]
Genestine, M., Ambriz, D., Crabtree, G. W., Dummer, P., Molotkova, A., Quintero, M., Mela, A., Biswas, S., Feng, H., Zhang, C., Canoll, P., Hargus, G., Agalliu, D., Gogos, J. A., & Au, E. (n.d.). Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and accelerate functional maturation of human stem cell-derived interneurons. ELife, 10, e56063. [PMID: 33904394]
Hamie, M., Tawil, N., El Hajj, R., Najm, R., Moodad, S., Hleihel, R., Karam, M., El Sayyed, S., Besteiro, S., El-Sabban, M., Dubremetz, J.-F., Lebrun, M., & El Hajj, H. (2021). P18 (SRS35/TgSAG4) Plays a Role in the Invasion and Virulence of Toxoplasma gondii. Frontiers in Immunology, 12, 643292. [PMID: 34262559]
Harada, A., Goto, M., Kato, A., Takenaka-Ninagawa, N., Tanaka, A., Noguchi, S., Ikeya, M., & Sakurai, H. (2021). Systemic Supplementation of Collagen VI by Neonatal Transplantation of iPSC-Derived MSCs Improves Histological Phenotype and Function of Col6-Deficient Model Mice. Frontiers in Cell and Developmental Biology, 9, 790341. [PMID: 34888314]
Hutson, C. L., Kondas, A. V., Ritter, J. M., Reed, Z., Ostergaard, S. D., Morgan, C. N., Gallardo-Romero, N., Tansey, C., Mauldin, M. R., Salzer, J. S., Hughes, C. M., Goldsmith, C. S., Carroll, D., & Olson, V. A. (2021). Teaching a new mouse old tricks: Humanized mice as an infection model for Variola virus. PLoS Pathogens, 17(9), e1009633. [PMID: 34547055]
Ibrahim, M. R., Medhat, W., El-Fakahany, H., Abdel-Raouf, H., & Snyder, E. Y. (2021). The Developmental & Molecular Requirements for Ensuring that Human Pluripotent Stem Cell-Derived Hair Follicle Bulge Stem Cells Have Acquired Competence for Hair Follicle Generation Following Transplantation. Cell Transplantation, 30, 09636897211014820. [PMID: 34053245]
Jacoby, E., Ben Yakir-Blumkin, M., Blumenfeld-Kan, S., Brody, Y., Meir, A., Melamed-Book, N., Napso, T., Pozner, G., Saadi, E., Shabtay-Orbach, A., Yivgi-Ohana, N., Sher, N., & Toren, A. (2021). Mitochondrial augmentation of CD34+ cells from healthy donors and patients with mitochondrial DNA disorders confers functional benefit. NPJ Regenerative Medicine, 6, 58. [PMID: 34561447]
Karimzadeh, A., Varady, E. S., Scarfone, V. M., Chao, C., Grathwohl, K., Nguyen, P. U., Ghorbanian, Y., Weissman, I. L., Serwold, T., & Inlay, M. A. (2021). Absence of CD11a Expression Identifies Embryonic Hematopoietic Stem Cell Precursors via Competitive Neonatal Transplantation Assay. Frontiers in Cell and Developmental Biology, 9, 734176. [PMID: 34513848]
Kuhn, H. W., Lasseter, A. G., Adams, P. P., Avile, C. F., Stone, B. L., Akins, D. R., Jewett, T. J., & Jewett, M. W. (2021). BB0562 is a nutritional virulence determinant with lipase activity important for Borrelia burgdorferi infection and survival in fatty acid deficient environments. PLoS Pathogens, 17(8), e1009869. [PMID: 34415955]
Leeth, C., Adkins, J., Hay, A., Bogers, S., Potter, A., Witonsky, S., & Zhu, J. (2021). Engrafting Horse Immune Cells into Mouse Hosts for the Study of the Acute Equine Immune Responses. Animals : An Open Access Journal from MDPI, 11(10), 2962. [PMID: 34679981]
Liu, H., Li, R., Liao, H.-K., Min, Z., Wang, C., Yu, Y., Shi, L., Dan, J., Hayek, A., Martinez Martinez, L., Nuñez Delicado, E., & Izpisua Belmonte, J. C. (2021). Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells. Nature Communications, 12, 3330.[PMID: 34099664]
Marlin, R., Godot, V., Cardinaud, S., Galhaut, M., Coleon, S., Zurawski, S., Dereuddre-Bosquet, N., Cavarelli, M., Gallouët, A.-S., Maisonnasse, P., Dupaty, L., Fenwick, C., Naninck, T., Lemaitre, J., Gomez-Pacheco, M., Kahlaoui, N., Contreras, V., Relouzat, F., Fang, R. H. T., … Grand, R. L. (2021). Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques. Nature Communications, 12, 5215. [PMID: 34471122]
Martínez, L. E., Daniels-Wells, T. R., Guo, Y., Magpantay, L. I., Candelaria, P. V., Penichet, M. L., Martínez-Maza, O., & Epeldegui, M. (2021). Targeting TfR1 with the ch128.1/IgG1 antibody inhibits EBV driven lymphomagenesis in immunosuppressed mice bearing EBV+ human primary B-cells. Molecular Cancer Therapeutics, molcanther.MCT-21-0074-A.2021. [PMID: 34158342]
Muller, Y. D., Ferreira, L. M. R., Ronin, E., Ho, P., Nguyen, V., Faleo, G., Zhou, Y., Lee, K., Leung, K. K., Skartsis, N., Kaul, A. M., Mulder, A., Claas, F. H. J., Wells, J. A., Bluestone, J. A., & Tang, Q. (2021). Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance. Frontiers in Immunology, 12, 686439. [PMID: 34616392]
Nitzahn, M., Truong, B., Khoja, S., Vega-Crespo, A., Le, C., Eliav, A., Makris, G., Pyle, A. D., Häberle, J., & Lipshutz, G. S. (2021). CRISPR-Mediated Genomic Addition to CPS1 Deficient iPSCs is Insufficient to Restore Nitrogen Homeostasis. The Yale Journal of Biology and Medicine, 94(4), 545–557. [PMID: 34970092]
Nowlan, B., Futrega, K., Williams, E. D., & Doran, M. R. (2021). Human bone marrow-derived stromal cell behavior when injected directly into the bone marrow of NOD-scid-gamma mice pre-conditioned with sub-lethal irradiation. Stem Cell Research & Therapy, 12(1), 231. [PMID: 33845908]
Nunzi, E., Renga, G., Palmieri, M., Pieraccini, G., Pariano, M., Stincardini, C., D’Onofrio, F., Santarelli, I., Bellet, M. M., Bartoli, A., Costantini, C., & Romani, L. (2021). A Shifted Composition of the Lung Microbiota Conditions the Antifungal Response of Immunodeficient Mice. International Journal of Molecular Sciences, 22(16), 8474. [PMID: 34445184]
Ogawa, M., Jiang, J.-X., Xia, S., Yang, D., Ding, A., Laselva, O., Hernandez, M., Cui, C., Higuchi, Y., Suemizu, H., Dorrell, C., Grompe, M., Bear, C. E., & Ogawa, S. (2021). Generation of functional ciliated cholangiocytes from human pluripotent stem cells. Nature Communications, 12, 6504. [PMID: 34764255]
Olgasi, C., Borsotti, C., Merlin, S., Bergmann, T., Bittorf, P., Adewoye, A. B., Wragg, N., Patterson, K., Calabria, A., Benedicenti, F., Cucci, A., Borchiellini, A., Pollio, B., Montini, E., Mazzuca, D. M., Zierau, M., Stolzing, A., Toleikis, Philip. M., Braspenning, J., & Follenzi, A. (2021). Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device. Molecular Therapy. Methods & Clinical Development, 23, 551–566. [PMID: 34853801]
Peterson, C. W., Venkataraman, R., Reddy, S. S., Pande, D., Enstrom, M. R., Radtke, S., Humbert, O., & Kiem, H.-P. (2021). Intracellular RNase activity dampens zinc finger nuclease-mediated gene editing in hematopoietic stem and progenitor cells. Molecular Therapy. Methods & Clinical Development, 24, 30–39. [PMID: 34977270]
Pillai, V. V., Koganti, P. P., Kei, T. G., Gurung, S., Butler, W. R., & Selvaraj, V. (2021). Efficient induction and sustenance of pluripotent stem cells from bovine somatic cells. Biology Open, 10(10), bio058756. [PMID: 34719702]
Ratnapriya, S., Harris, M., Chov, A., Herbert, Z. T., Vrbanac, V., Deruaz, M., Achuthan, V., Engelman, A. N., Sodroski, J., & Herschhorn, A. (2021). Intra- and extra-cellular environments contribute to the fate of HIV-1 infection. Cell Reports, 36(9), 109622. [PMID: 34469717]
Roy, C. N., Benitez Moreno, M. A., Kline, C., & Ambrose, Z. (n.d.). CG Dinucleotide Removal in Bioluminescent and Fluorescent Reporters Improves HIV-1 Replication and Reporter Gene Expression for Dual Imaging in Humanized Mice. Journal of Virology, 95(19), e00449-21. [PMID: 34232063]
Shamseddin, M., De Martino, F., Constantin, C., Scabia, V., Lancelot, A., Laszlo, C., Ayyannan, A., Battista, L., Raffoul, W., Gailloud‐Matthieu, M., Bucher, P., Fiche, M., Ambrosini, G., Sflomos, G., & Brisken, C. (2021). Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation. EMBO Molecular Medicine, 13(7), e14314. [PMID: 34042278]
Shrivastava, S., Ray, R. M., Holguin, L., Echavarria, L., Grepo, N., Scott, T. A., Burnett, J., & Morris, K. V. (2021). Exosome-mediated stable epigenetic repression of HIV-1. Nature Communications, 12(1), 5541. [PMID: 34545097]
Unterweger, A.-L., Rüscher, A., Seuß, M., Winkelmann, P., Beigel, F., Koletzko, L., Breiteneicher, S., Siebeck, M., Gropp, R., & Aszodi, A. (2021). NOD/scid IL-2Rγnull mice reconstituted with peripheral blood mononuclear cells from patients with Crohn’s disease reflect the human pathological phenotype. Immunity, Inflammation and Disease. [PMID: 34499803]
Wiedenmann, S., Breunig, M., Merkle, J., von Toerne, C., Georgiev, T., Moussus, M., Schulte, L., Seufferlein, T., Sterr, M., Lickert, H., Weissinger, S. E., Möller, P., Hauck, S. M., Hohwieler, M., Kleger, A., & Meier, M. (2021). Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip. Nature Biomedical Engineering, 5(8), 897–913. [PMID: 34239116]
Yang, L., Xia, H., Smith, K., Gilbertsen, A., Beisang, D., Kuo, J., Bitterman, P. B., & Henke, C. A. (n.d.). A CD44/Brg1 nuclear complex confers mesenchymal progenitor cells with enhanced fibrogenicity in idiopathic pulmonary fibrosis. JCI Insight, 6(9), e144652. [PMID: 33822772]
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International database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data.