CRISPR/Cas limited use license terms with the Broad Institute

The creation of your mouse strain (the "Licensed Product") using CRISPRCas9 technology is provided by The Jackson Laboratory ("Jackson") under a license agreement with the Broad Institute, Inc. ("Broad") that contains certain limitations and obligations. By purchasing this service, you, the Limited Licensee, hereby agree to be bound by the Limited License set forth below. Additional capitalized terms are defined below.

Limited Licensee is granted the non-transferable right to use the Licensed Product and Enabled Products created by Jackson solely for research conducted by such Limited Licensee in accordance with all of the following requirements:

(i) the Limited Licensee shall not sell or otherwise transfer the Licensed Product or Enabled Products (including without limitation any material that contains the Licensed Product or Enabled Products in whole or part) to any other person or entity or use the Licensed Product or Enabled Products to perform services for the benefit of any other person or entity other than bona fide research collaborators or contract research organizations,


(ii) the Limited Licensee shall use only the purchased amount of the Licensed Product and components of the Licensed Product and Enabled Products, only for its internal research within the Field and not for any Commercial Purposes, however the Limited License will not prevent breeding of the Licensed Product for use under the Limited License,

(iii) the Limited Licensee shall use the Licensed Product and Enabled Products in compliance with all applicable laws and regulations, including without limitation applicable human health and animal welfare laws and regulations,

(iv) Jackson, Broad, The Massachusetts Institute of Technology (MIT) and the President and Fellows of Harvard College (Harvard) provide no warranties of any kind to the Limited Licensee (statutory or implied) concerning the Patent Rights, the Licensed Product or Enabled Products, including without limitation, as to product quality, condition, description, merchantability, fitness for a particular purpose, non-infringement of intellectual property rights or the absence of latent or other defects, and all such warranties are hereby expressly disclaimed,

(v) Jackson, Broad, MIT and Harvard expressly disclaim any warranty regarding results obtained through the use of the Licensed Product or Enabled Products, including without limitation any claim of inaccurate, invalid or incomplete results,

(vi) Jackson, Broad, MITand Harvard, and their current and former directors, trustees, officers, employees, agents, faculty, affiliated investigators, and students, and their respective successors, heirs and assigns (collectively, the Indemnitees) shall have no liability to the Limited Licensee, including, without limitation, for any loss of use or profits, business interruption or any consequential, incidental, special or other indirect damages of any kind, regardless of how caused and regardless of whether an action in contract, tort, strict product liability or otherwise,

(vii) the Limited Licensee shall indemnify, defend and hold harmless the Indemnitees against any liability, damage, loss, or expense (including without limitation reasonable attorney’s fees and expenses) incurred by or imposed upon any of the Indemnitees in connection with any claims, suits, investigations, actions, demands or judgments arising out of or related to the exercise of any rights granted to the Limited Licensee under the Limited License or any breach of the Limited License by such Limited Licensee, provided, however, that the foregoing shall not apply to a Limited Licensee that is an academic, non-profit, or government entity or person, and such Limited Licensee. Instead agrees that it, and not the Indemnitees, shall be responsible for any liability, damage, loss or expense arising out of or related to the exercise of any rights grant to the Limited Licensee under the Limited License or any breach of the Limited License by the Limited Licensee, and

(viii) the Licensed Product and its use may be the subject of one or more issued patents and/or pending patent applications owned by Jackson, Broad, MIT and Harvard and the purchase of the Licensed Product does not convey a license under any claims in the foregoing patents or patent applications directed to the Licensed Product or use, production or commercialization thereof, other than the right to use the Licensed Product under the Limited License set forth above or as otherwise agreed between the parties in writing.

Definitions

Commercial Purpose means:

(a) the practice, performance or provision of any method, process or service, or 

(b) the manufacture, sale, use, distribution, disposition or importing of any product, in each case (a) or (b) for consideration, e.g., a fee, or on any other commercial basis. 

Enabled Product means: any product, that is not the Licensed Product, which is or incorporates

(a) any progeny, modification or derivative of the Licensed Product, or

(b) any cell, organism or animal made or modified through use of the Licensed Product, or any progeny, modification or derivative of such cell, organism or animal.

For clarity, any product that is made, produced or derived by use of the technology of the Patent Rights, such as a protein or a peptide from a cell line shall be deemed an Enabled Product; provided, however, that the term Enabled Product shall not include any large or small molecule that

(i) was identified or discovered through screening using technology covered by the Patent Rights and

(ii) does not otherwise fall within the foregoing clauses (a) through (b).

Field means: use as a research tool for research purposes; provided, however, that notwithstanding the foregoing, the Field shall expressly exclude

(a) any clinical use, including, without limitation, diagnostic and prognostic use,

(b) any human, veterinary, livestock or agricultural use, or

(c) the manufacture, distribution, importation, exportation, transportation, sale, offer for sale, marketing, promotion or other exploitation or use of, or as, a testing service, therapeutic or diagnostic for humans or animals.

Patent Rights means

(a) any patents and patent applications listed on Appendix A, which shall be updated from time-time.;

(b) any substitutions, divisions, continuations, reissues, renewals, reexaminations or extensions of any patents or patent applications of (a), any continuations-in-part of any patents or patent applications of (a) to the extent the claims are directed to subject matter specifically described in a patent or patent application set forth on Appendix A, and any application claiming priority to a provisional application set forth on Appendix A to the extent the claims are directed to subject matter specifically described in a provisional patent application set forth on Appendix A;

(c) any letters patents and/or the equivalent issuing therefrom in any jurisdiction based on any of the foregoing, and (d) any foreign or international equivalents of any of the foregoing, including without limitation any applications filed under the Patent Cooperation Treaty.

Appendix A.

Case Number Broad Ref# App Number File Date App Title
44790.AA.2003 BI-2011/008.PA1 61/736,527 12-Dec-12 SYSTEMS METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.BB.2003 BI-2011/008.PA2 61/748,427 2-Jan-13 SYSTEMS METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.00.2003 BI-2011/008.PA3 61/757,972 29-Jan-13 SYSTEMS METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.01.2003 BI-2011/008.PA4 61/768,959 25-Feb-13 SYSTEMS METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

44790.02.2003
BI-2011/008.PA5 61/791,409 15-Mar-13 SYSTEMS METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.03.2003 BI-2011/008.PA6 61/835,931 17-Jun-13 SYSTEMS METHODS AND COMPOSITION FOR SEQUENCE MANIPULATION
44790.07.2003 BI-2011/008.US1 14/105,035 12-Dec-13 CRISPR-CAS COMPONENT SYSTEMS,METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.99.2003 BI-2011/008.WO1 PCT/US2013/074611 12-Dec-13 CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

44790.80.2003
BI-2011/008.EP1 13812430 29-Sep-14 CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATIONCOMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.80.2044 BI-2011/008A.EP1 13824232.6 2-May-14 CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS
44790.04.2003 BI-2011/008A.US1 61/842,322 2-Jul-13 CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS
44790.05.2003 BI-2011/008A.US2 14/054,414 15-Oct-13 CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS (USP 8,697,359, issued April 15, 2014)
44790.11.2003 BI-2011/008A.US3 14/183,429 18-Feb-14 CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS (USP 8,771,945, issued July 8, 2014)
44790.10.2003 BI-2011/008A.US4 14/183,486 18-Feb-14 CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION (USP 8,795,965, issued August 5, 2014)
44790.13.2003 BI-2011/008A.US5 14/256,912 18-Apr-14 CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS
44790.14.2003 BI-2011/008A.US6 14/497,627 26-Sep-14 CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.99.2044 BI-2011/008A.WO1 PCT/US2013/074743 12-Dec-13 CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS
44790.06.2003 BI-2011/008B.US1 14/105,031 12-Dec-13 CRISPR-CAS NICKASE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION IN EUKARYOTES
44790.08.2003 BI-2011/008B.US2 14/183,471 18-Feb-14 CRISPR-CAS NICKASE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION IN EUKARYOTES (USP 8,889,356 to be issued November 18, 2014)
44790.09.2003 BI-2011/008B.US3 14/258,458 22-Apr-14 CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.12.2003 BI-2011/008B.US4 14/259,420 23-Apr-14 CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION (USP 8,871,445, issued October 28, 2014)
44790.99.2045 BI-2011/008B.WO1 PCT/US2013/074790 12-Dec-13 CRISPR-CAS NICKASE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION IN EUKARYOTES
44790.00.2005 BI-2011/020.PA1 61/675,778 25-Jul-12 INDUCIBLE DNA BINDING PROTEINS AND GENOME PERTURBATION TOOLS AND APPLICATIONS THEREOF
44790.01.2005 BI-2011/020.PA2 61/721,283 1-Nov-12 INDUCIBLE DNA BINDING PROTEINS AND GENOME PERTURBATION TOOLS AND APPLICATIONS THEREOF
44790.02.2005 BI-2011/020.PA3 61/736,465 12-Dec-12 INDUCIBLE DNA BINDING PROTEINS AND GENOME PERTURBATION TOOLS AND APPLICATIONS THEREOF
44790.03.2005 BI-2011/020.PA4 61/794,458 15-Mar-13 INDUCIBLE DNA BINDING PROTEINS AND GENOME PERTURBATION TOOLS AND APPLICATIONS THEREOF
44790.12.2022 BI-2011/020.PA5 61/835,973 17-Jun-13 INDUCIBLE DNA BINDING PROTEINS AND GENOME PERTURBATION TOOLS AND APPLICATIONS THEREOF
44790.99.2005 BI-2011/020.WO1 PCT/US13/051418 21-Jul-13 INDUCIBLE DNA BINDING PROTEINS AND GENOME PERTURBATION TOOLS AND APPLICATIONS THEREOF
44790.11.2022 BI-2012/084.PA1 61/836,080 17-Jun-13 METHODS, SYSTEMS, AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES OR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS THEREOF
44790.00.2040 BI-2012/084A.US1 14/104,900 12-Dec-13 METHODS, SYSTEMS, AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES OR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS THEREOF
44790.99.2040 BI-2012/084A.WO1 PCT/US2013/074825 12-Dec-13 METHODS, SYSTEMS, AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES OR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS THEREOF
44790.99.2046 BI-2012/084B.WO1 PCT/US2013/074812 12-Dec-13 METHODS, MODELS, SYSTEMS, AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES FOR CRISPRCAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS THEREOF
44790.00.2041 BI-2013/003.US1 14/104,837 12-Dec-13 DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS
44790.01.2041 BI-2013/003.US2 14/183,512 18-Feb-14 DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS
44790.02.2041 BI-2013/003.US3 14/481,339 9-Sep-14 DELIVERY, ENGINEERING, AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS
44790.99.2041 BI-2013/003.WO1 PCT/US2013/074667 12-Dec-13 DELIVERY, ENGINEERING, AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS
44790.00.2022 BI-2013/003/004.PA1 61/758,468 30-Jan-13 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.01.2022 BI-2013/003/004.PA2 61/769,046 25-Feb-13 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.02.2022 BI-2013/003/004.PA3 61/802,174 15-Mar-13 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.03.2022 BI-2013/003/004.PA4 61/806,375 28-Mar-13 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.04.2022 BI-2013/003/004.PA5 61/814,263 20-Apr-13 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.05.2022 BI-2013/003/004.PA6 61/819,803 6-May-13 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.06.2022 BI-2013/003/004.PA7 61/828,130 28-May-13 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.10.2022 BI-2013/003D.PA1 61/836,123 17-Jun-13 DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND APPLICATIONS
44790.13.2022 BI-2013/003D.PA2 61/847,537 17-Jul-13 DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND APPLICATIONS
44790.14.2022 BI-2013/003D.PA3 61/862,355 5-Aug-13 DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND APPLICATIONS
44790.15.2022 BI-2013/003D.PA4 61/871,301 28-Aug-13 DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND APPLICATIONS
44790.16.2022 BI-2013/003D.PA5 61/915,383 12-Dec-13 OPTIMIZED CRISPR-CAS DOUBLE NICKASE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

44790.99.2022
BI-2013/003D.WO1 PCT/US2014/041803 10-Jun-14 OPTIMIZED CRISPR-CAS DOUBLE NICKASE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.09.2022 BI-2013/004E.PA1 61/836,101 17-Jun-13 ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION

44790.00.2042
BI-2013/004E.US1 14/104,977 12-Dec-13 ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.01.2042 BI-2013/004E.US2 14/222,930 24-Mar-14 ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION (USP 8,865,406, issued October 21, 2014)
44790.02.2042 BI-2013/004E.US3 14/293,498 2-Jun-14 ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION

44790.03.2042
BI-2013/004E.US4 14/293,674 2-Jun-14 ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION (USP8,889,418, to be issued November 18, 2014)
44790.99.2042 BI-2013/004E.WO1 PCT/US2013/074691 12-Dec-13 ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.07.2022 BI-2013/004F.PA1 61/835,936 17-Jun-13 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS
44790.00.2043 BI-2013/004F.US1 14/105,017 12-Dec-13 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS
44790.01.2043 BI-2013/004F.US2 14/226,274 26-Mar-14 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS
44790.99.2043 BI-2013/004F.WO1 PCT/US2013/074736 12-Dec-13 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS
44790.80.2047 BI-2013/004G.EP1 13818570.7 27-May-14 ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION

44790.80.2075
BI-2013/004G.EP2 14170383.5 28-May-14 ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.08.2022 BI-2013/004G.PA1 61/836,127 17-Jun-13 ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.00.2047 BI-2013/004G.US1 14/104,990 12-Dec-13 ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.01.2047 BI-2013/004G.US2 14/290,575 29-May-14 ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.99.2047 BI-2013/004G.WO1 PCT/US2013/074819 12-Dec-13 ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.00.2024 BI-2013/007.PA1 61/799,800 15-Mar-13 RECOMBINANT VIRUS AND PREPARATIONS THEREOF

44790.01.2024
BI-2013/007.US1 14/213,991 14-Mar-14 RECOMBINANT VIRUS AND PREPARATIONS THEREOF
44790.99.2024 BI-2013/007.WO1 PCT/US2014/30394 17-Mar-14 RECOMBINANT VIRUS AND PREPARATIONS THEREOF
44790.00.2034 BI-2013/066.PA1 61/862,468 5-Aug-13 DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND OPTIMIZED COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.01.2034 BI-2013/066.PA2 61/915,407 12-Dec-13 DELIVERY, ENGINEERING AND OPTIMIZATION OF TANDEM GUIDE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.02.2034 BI-2013/066.PA3 61/979,942 15-Apr-14 DELIVERY, ENGINEERING AND OPTIMIZATION OF TANDEM GUIDE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
44790.99.2034 BI-2013/066.WO1 PCT/US2014/041800 10-Jun-14 DELIVERY, ENGINEERING AND OPTIMIZATION OF TANDEM GUIDE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

44790.00.2035
BI-2013/073.PA1 61/960,777 25-Sep-13 FUNCTIONAL GENOMICS USING CRISPRCAS SYSTEMS, COMPOSITIONS, METHODS, SCREENS AND APPLICATIONS THEREOF
44790.03.2035 BI-2013/073.PA2 61/995,636 15-Apr-14 FUNCTIONAL GENOMICS USING CRISPRCAS SYSTEMS, COMPOSITIONS, METHODS, SCREENS AND APPLICATIONS THEREOF
44790.99.2035 BI-2013/073.WO1 PCT/US2014/041806 10-Jun-14 FUNCTIONAL GENOMICS USING CRISPR-CAS SYSTEMS, COMPOSITIONS, METHODS, SCREENS AND APPLICATIONS THEREOF
44790.01.2035 BI-2013/073/078.PA1 61/961,980 28-Oct-13 FUNCTIONAL GENOMICS USING CRISPR-CAS SYSTEMS, COMPOSITIONS, METHODS, SCREENS AND APPLICATIONS THEREOF
44790.00.2065 BI-2013/112.US1 14/463,253 19-Aug-14 FUNCTIONAL GENOMICS USING CRISPRCAS SYSTEMS, COMPOSITIONS, METHODS, KNOCKOUT LIBRARIES AND APPLICATIONS THEREOF
44790.99.2065 BI-2013/112.WO1 PCT/US2013/074800 12-Dec-13 FUNCTIONAL GENOMICS USING CRISPR-CAS SYSTEMS, COMPOSITIONS, METHODS, KNOCKOUT LIBRARIES AND APPLICATIONS THEREOF
44790.02.2041 BI-2014/071 14/481,339 9-Sep-14 DELIVERY ENGINEERING, AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS