Caribou Biosciences Limited Use Label License: Research Use Only

This purchase of this Genetically Modified Mouse Model (“Model”) is subject to the following terms and conditions. The Model is sold subject to a license agreement for CRISPR-Cas9 technology by and between The Jackson Laboratory and Caribou Biosciences, Inc. 

The purchase of the Model conveys to the buyer a limited, non-transferable right to use (i) the Model, (ii) progeny or derivatives of the Model generated by the buyer, and (iii) cells, tissue, and other biological material extracted or derived from the Model or its corresponding progeny or derivatives (collectively, (i), (ii) and (iii) are referred to as “Material”) only to perform internal research for the sole benefit of the buyer

The buyer cannot sell or otherwise transfer Material to a third party, other than a third party under a contractual obligation to perform research for the sole benefit of the buyer or a third party that is a nonprofit performing collaborative research with the buyer, or otherwise use Material for any Excluded Use. “Excluded Use” means: (a) any commercial activity, including but not limited to any use in manufacturing, product or quality control; (b) any use to provide a service, information, or data; (c) any use for therapeutic, diagnostic, or prophylactic purposes; (d) any sale, resale, leasing, or licensing, whether or not for research purposes; (e) any activity in an agricultural field trial or any activity directed toward the submission of data to the U.S. Department of Agriculture or any other agriculture regulatory agency; (f) high throughput screening drug discovery purposes (i.e., the screening of more than 10,000 experiments per day) as well as scale-up production activities for commercialization; and/or (g) cell line development for purposes of bioproduction of recombinant protein.

For information on obtaining additional rights, please contact licensing@cariboubio.com or Caribou Biosciences, Inc., 2929 7th Street, Suite 105, Berkeley, CA 94710 USA, Attn: Licensing.


Exhibit A: Licensed Patent Rights

     
Compositions and Methods of Nucleic Acid-Targeting Nucleic Acids      
Owned by Caribou Biosciences, Inc.      
       
Country Application number Filing date Status
  Patent number Grant date  
US 14/416,338 42026 Granted
  9260752 02/16/2016 (exp. 03/12/2034)  
US 14/751,055 42180 Granted
  9410198 08/09/2016 (exp. 03/12/2034)  
US 14/751,058 42180 Pending
US 14/977,514 42359 Granted
  9909122 03/06/2018 (exp. 03/12/2034)  
US 15/159,619 42509 Granted
  9725714 08/08/2017 (exp. 03/12/2034)  
US 15/159,776 42509 Granted
  10125361 11/13/2018 (exp. 06/15/2034)  
US 15/202,518 42556 Granted
  9803194 10/31/2017 (exp. 03/12/2034)  
US 15/344,487 42678 Pending
US 15/660,906 42942 Granted
  9809814 11/07/2017 (exp. 03/12/2034)  
US 15/904,285 43154 Pending
AU 2014235794 41710 Abandoned
AU 2015101418 41710 Granted
  2015101418 10/29/2015 (exp. 03/12/2022)  
BR 112015022061-4 41710 Pending
CA 2905432 41710 Pending
CN 2.0148E+11 41710 Pending
EP 14771135.2 41710 Pending
GB 1517172.1 41710 Pending
HK(GB) 16100993.9 41710 Pending
IL 241563 41710 Pending
IN 5749/CHENP/2015 41710 Pending
JP 2016-501357 41710 Abandoned
JP 2017-250680 41710 Pending
KR 2015-7028606 41710 Granted
  10-1780885 09/15/2017 (exp. 03/12/2034)  
MX MX/a/2015/013057 41710 Pending
NZ 712727 41710 Granted
  712727 08/29/2017 (exp. 03/12/2034)  
NZ 725554 41710 Pending
RU 2015140276 41710 Granted
  2662932 07/31/2018 (exp. 03/12/2034)  
RU 2018122288 41710 Pending
       
SG 11201507378U 41710 Granted
  11201507378U 06/18/2018 (exp. 03/12/2034)  
ZA 2015/07006 41710 Granted
  2015/07006 02/22/2017 (exp. 03/12/2034)  
WO PCT/US2014/023828 41710 National phase
US 61/781,598 41347 Expired
US 61/818,382 41395 Expired
US 61/818,386 41395 Expired
US 61/822,002 41404 Expired
US 61/832,690 41432 Expired
US 61/845,714 41467 Expired
US 61/858,767 41481 Expired
US 61/859,661 41484 Expired
US 61/865,743 41500 Expired
US 61/883,804 41544 Expired
US 61/899,712 41582 Expired
US 61/900,311 41583 Expired
US 61/902,723 41589 Expired
US 61/903,232 41590 Expired
US 61/906,211 41597 Expired
US 61/906,335 41597 Expired
US 61/907,216 41599 Expired
US 61/907,777 41600 Expired
US 14/206,319 41710 Abandoned