These F1 (first filial generation) hybrid mice are the offspring of a cross between C57BL/6J females (B6) and CBA/J males (CBA). Uses include hybrid vigor, as a background for deleterious mutations, to create or enhance expression of polygenic diseases, to determine the mode of inheritance, and to provide physiological buffering (present a broader array of responses to various stresses).
Read More +These F1 (first filial generation) hybrid mice are the offspring of a cross between C57BL/6J females (B6) and CBA/J males (CBA). F1 hybrid mice are heterozygous at all loci (assuming the parental strains have different alleles), and like inbred mice they are genetically and phenotypically uniform. F1 hybrids are often used for hybrid vigor, as a background for some deleterious mutations, for tissue transplantation, to determine the mode of inheritance, to create or enhance expression of polygenic diseases, and to provide physiological buffering (present a broader array of responses to various stresses).
These F1 (first filial generation) hybrid mice are the offspring of a cross between C57BL/6J females (B6) and CBA/J males (CBA).
Currently there are no related genes or alleles for this strain.
Wean-aged mice may show signs of barbering that include whisker picking and hair loss. Affected mice typically regrow whiskers and hair within two weeks after weaning. Older animals may show signs of barbering that can resolve when mice are housed at reduced density or individually.
When using the B6CBAF1/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #100011 in your Materials and Methods section.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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