Pou2f3 (POU domain, class 2, transcription factor 3) encodes a member of the POU domain family of transcription factors. Pou2f3 is essential for development of tuft cells and taste receptor cells. Pou2f3-/- knock-out mice were created using CRISPR/cas9 genome editing to delete 8 base pairs in exon 4 of the Pou2f3 locus. Homozygous mice are viable and fertile. Pou2f3-deficient mice lack the ability to taste, have impaired ability to sense helminth and parasite infection, and are resistant to persistent murine norovirus. These mice be useful in studies of norovirus and parasite pathogenicity and tuft cells.

Pou2f3-/- knock-out mice have 8 base pairs deleted from exon 4 of Pou2f3 (POU domain, class 2, transcription factor 3) locus. Mice homozygous for the mutation lack the ability to taste, have impaired ability to sense helminth and parasite infection, and are resistant to persistent murine norovirus. These mice be useful in studies of norovirus and parasite pathogenicity, tuft cells, and taste.