The BXD set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes. The BXD strains are derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671) progenitor strains.
Robert Williams, University of Tennessee Health Science Center
The BXD RI strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also are used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density. This strain, BXD24TyRww/J, has been inbred an additional 16 generations as compared to BXD24/TyJ (005243).
The strain distribution pattern (SDP) for the BXD RI strains is available through the Mouse Genome Informatics Contributed Data Sets and Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network .
The BXD set of RI strains was developed in the laboratory of Benjamin Taylor and was transferred to The Jackson Laboratory from Dr. Taylor's research colony upon his retirement. Of 42 BXD RI strains originally derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671), a number have become extinct over the years. The other BXD RI strains now being distributed are listed under "Related Recombinant Inbred Strains."
This strain, BXD24TyRww/J, was transferred to the laboratory of Robert Williams at the University of Tennessee in 2014, it has been inbred an additional 16 generations as compared to BXD24/TyJ (005243). The strain was transferred to The Jackson Laboratory in 2019 at F121. It does not carry the Cep290rd16, the retinal degeneration 16 allele.
Currently there are no related genes or alleles for this strain.
Maintain by sibling x sibling mating.
When using the BXD24/TyRwwJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #032926 in your Materials and Methods section.
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