The Msra (methionine sulfoxide reductase A) gene encodes an enzyme involved in the reduction of methionine sulfoxide to methionine and functions as a regulator of antioxidant defense by scavenging intracellular reactive oxygen species (ROS). MsrA knock-out mice contain a neomycin cassette inserted into exon 2 (containing active site of the protein). Mice that are homozygous for the targeted mutation are viable and fertile with no overt phenotype. Mice exhibit enhanced sensitivity to oxidative stress (100% oxygen) including higher tissue levels of oxidized protein (carbonyl derivative) in liver, kidney and lung (and to a lesser extent in brain) and a decreased ability to up-regulate expression of thioredoxin reductase in the brain and liver. These mice may be useful for studying oxidative stress.

MsrA (methionine sulfoxide reductase A) knock-out mice exhibit enhanced sensitivity to oxidative stress.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.