These MMTV/NIC transgenic mice express activated, oncogenic human ERBB2 (neu8342, NDL2-5, neu deletion) and Cre recombinase under control of the mammalian mammary tumor virus (MMTV) promoter. Transgene expression is detected in mammary gland, with lower expression detected in adrenal gland, lung, ovary, pancreas and salivary gland. Hemizygous mice develop mammary tumors with a mean latency of 146 days. Tumors develop only in mammary gland. The tumors are histologically characterized as solid/nodular adenocarcinomas, molecularly resembling human luminal breast cancer. Hemizygotes are viable and fertile. Homozygous viability/fertility has not been tested.

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These MMTV-NeuNDL2-5-IRES-Cre transgenic mice express an activated Erbb2 (oncogenic form NDL2-5, neu deletion, neu8342) and Cre recombinase under control of the mammalian mammary tumor virus (MMTV) promoter, and develop mammary tumors with a mean latency of 146 days.

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