These MMTV/NIC transgenic mice express activated, oncogenic human ERBB2 (neu8342, NDL2-5, neu deletion) and cre recombinase under control of the mammalian mammary tumor virus (MMTV) promoter. Transgene expression is detected in mammary gland, with lower expression detected in adrenal gland, lung, ovary, pancreas and salivary gland. Hemizygous mice develop mammary tumors with a mean latency of 146 days. Tumors develop only in mammary gland. The tumors are histologically characterized as solid/nodular adenocarcinomas, molecularly resembling human luminal breast cancer. During backcrossing, the Y chromosome may not have been fixed to the FVB genetic background Hemizygotes are viable and fertile. Homozygous viability/fertility has not been tested (February 2019).

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These MMTV-NeuNDL2-5-IRES-Cre transgenic mice express an activated Erbb2 (oncogenic form NDL2-5, neu deletion, neu8342) and cre recombinase under control of the mammalian mammary tumor virus (MMTV) promoter, and develop mammary tumors with a mean latency of 146 days.

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