Mouse Strain Datasheet - 030898
Mouse Strain Datasheet - 030898
This "humanized" App knock-in strain in which 3 point mutations were introduced into exon 14 of the mouse App gene produces a mutant protein that is expected to more readily aggregate. Exon 14 is also flanked by loxP sites. This strain may be useful for studying late-onset sporadic Alzheimer’s disease.
hAbeta-loxP-KI mice are also available on a C57BL/6NJ congenic background (Stock No. 032013).
Frank LaFerla, University of California, Irvine
| Genetic Background | Generation |
|---|---|
|
?+pN1
|
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Conditional ready (e.g. floxed), Humanized sequence) | App | amyloid beta (A4) precursor protein |
Starting at:
| $255.00 Domestic price for female |
| 510.00 Domestic price for breeder pair |
| Service | Genotype | Price |
|---|---|---|
| Heterozygous for App<tm1.1Lfa> |
We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.
| Frozen Mouse Embryo | $2,595.00 per straw or vial |
