Fxr2 (fragile X mental retardation, autosomal homolog 2) may play a role in the development of fragile X mental retardation syndrome and is crucial for dendritic maturation and network integration of new neurons. 

Exon 7 of the mouse Fxr2 gene has been replaced with a neomycin cassette to create this knock-out allele. Western blot analysis of testis and brain tissue indicate that homozygous knockout mice do not express the protein.

Homozygotes develop normally, and are viable and fertile. They are hyperactive in open-field tests, impaired on rotarod tests, have reduced levels of repulse inhibition, display less contextual conditioned fear, are impaired at locating the hidden platform in the Morris water tank, and are less sensitive to heat stimulus. Fxr2 knockout mice display a shorter free-running period of locomotor activity in total darkness.

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These mice carry a knockout allele of the Fxr2 (fragile X mental retardation, autosomal homolog 2) associated with a range of behavioral phenotypes.

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