Mice hemizygous for the hTau-A152T transgene, founder line line L1, are viable and fertile. Expression of the 1N4R isoform of human MAPT (microtubule associated protein tau) with an A152T substitution is regulated by a tetracycline operator (<i>tetO</i>); also called tetracycline-responsive element (TRE, TetRE) or tet-operator). When mated to a mutant strain expressing tetracycline-controlled transactivator protein (tTA), expression of mutant 1N4R isoform of human MAPT protein may be regulated with tetracycline or its analog doxycycline (dox) in the double mutant offspring. No human MAPT protein is detected in brain sections from singly transgenic mice by western blotting and immunohistochemical staining. When these line C11-1 hTau-A152T transgenic mice are crossed to CaMKII-tTA mice (see, for example, Stock No. <a href="https://www.jax.org/strain/007004"">007004</a>), the adult double mutant mice have a lower body weight than wildtype and single C11-1 hTau-A152T transgenic controls.  Hemizygotes are viable and fertile. Homozygous viability/fertility has not been tested (June 2016).

Expression of the human MAPT, hTau-A152T variant, is regulated by the tetracycline-responsive regulatory element (<i>tetO</i>) in these TRE-hTau-A152T line L1 mice. When mated with a strain expressing tetracycline-controlled transactivator protein (tTA), expression of the hTau-A152T protein may be regulated with the tetracycline analog doxycycline (dox) in the double-allelic offspring. This strain may be useful in studies related to frontotemporal dementia, Alzheimer’s disease, and other neurodegenerative diseases.

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