The Tlr5 gene encodes toll-like receptor 5, which has a fundamental role in bacteria recognition and activation of innate immune responses. TLR5 is the receptor for bacterial flagellin, acting via MYD88 and TRAF6; leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
The TLR5 null allele (TLR5-) has exon 4 of the toll-like receptor 5 gene deleted throughout the germline. No functional protein is expressed from this knockout allele. Homozygous mice (TLR5-/-) are expected to exhibit increased levels of flagellated bacteria in the intestine, that will promote low-grade inflammation, metabolic syndrome and colitis.
In response to scientific interest, we may offer floxed alleles as well as their resulting germline-knockout alleles. The knockout phenotype described above was for C57BL/6-congenic TLR5fl mice (Stock No. 028599) bred to C57BL/6-congenic mice expressing non-germline Cre recombinase. It should be noted that the phenotype of these C57BL/6-congenic TLR5 null mice (Stock No. 028909) could vary from that expected/inferred from other similar models. We may modify this strain description if necessary as published results become available.
