Beclin 1, encoded by the Becn1 gene, plays a central role in autophagy regulation and is involved in early embryonic development, tumorigenesis, tumor progression and neurodegeneration.
These mice carry a knock-out allele of the Becn1 gene in which exon 1, exon 2, and 1.6 kb of 5’ flanking sequence has been replaced by a NEO cassette.
Mice that are heterozygous for the targeted mutation are viable and fertile. Homozygous null mice have an embryonic lethal phenotype, failing to develop past E7.5 and E8.5.
No gene product (protein) is detected by Western blot analysis of homozygous embryonic stem cells. 
ES cells isolated from heterozygotes have a defective autophagic response to nutrient deprivation.

Heterozygotes aged 18 to 22 months, exhibit increased tumor incidence compared to wildtype controls. Heterozygotes display increased an immune response to respiratory viral infections.

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This Becn1, beclin 1, knock-out strain is useful in applications related to the regulation of autophagy, tumorigenesis, tumor progression and neurodegeneration.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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